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1.
Journal of Shandong University ; 58(10):95-99, 2020.
Article in Chinese | GIM | ID: covidwho-1975282

ABSTRACT

Objective: To investigate the transmission characteristics of a family cluster outbreak of coronavirus disease 2019 (COVID-19) in Xi-an, in order to provide reference for prevention and control efforts.

2.
Journal of Business Research ; 150:491-502, 2022.
Article in English | ScienceDirect | ID: covidwho-1907260

ABSTRACT

Migrant workers face challenging work and lives, a situation particularly aggravated by the COVID-19 pandemic. Unlike previous theorizations predicting work intention from a self-focused approach, we focus on fundamental, family-focused reasons for engaging in a job. Our work explains why and how committing themselves to work helps migrant workers cope with the threat posed by the pandemic. Drawing on behavioral reasoning theory, we posit that this threat prompts migrant workers to think about the key reason for working, i.e., family motivation. Family motivation further enhances their intended work effort and actual job performance after returning to work. The results derived from two experiments and a two-source, two-wave field study conducted in China provide consistent support for our predictions.

3.
Nanotheranostics ; 5(4): 461-471, 2021.
Article in English | MEDLINE | ID: covidwho-1369901

ABSTRACT

The gold nanoclusters (Au NCs) are a special kind of gold nanomaterial containing several gold atoms. Because of their small size and large surface area, Au NCs possess macroscopic quantum tunneling and dielectric domain effects. Furthermore, Au NCs fluorescent materials have longer luminous time and better photobleaching resistance compared with other fluorescent materials. The synthetic process of traditional Au NCs is complicated. Traditional Au NCs are prepared mainly by using polyamide amine type dendrites, and sixteen alkyl trimethylamine bromide or sulfhydryl small molecule as stabilizers. They are consequently synthesized by the reduction of strong reducing agents such as sodium borohydride. Notably, these materials are toxic and environmental-unfriendly. Therefore, there is an urgent need to develop more effective methods for synthesizing Au NCs via a green approach. On the other hand, the self-assembly of protein gold cluster-based materials, and their biomedical applications have become research hotspots in this field. We have been working on the synthesis, assembly and application of protein conjugated gold clusters for a long time. In this review, the synthesis and assembly of protein-gold nanoclusters and their usage in cell imaging and other medical research are discussed.


Subject(s)
Fluorescent Dyes , Gold , Green Fluorescent Proteins , Metal Nanoparticles , Optical Imaging , Theranostic Nanomedicine , Fluorescent Dyes/chemistry , Fluorescent Dyes/therapeutic use , Gold/chemistry , Gold/therapeutic use , Green Fluorescent Proteins/chemistry , Green Fluorescent Proteins/therapeutic use , Humans , Metal Nanoparticles/chemistry , Metal Nanoparticles/therapeutic use
4.
Med Sci Monit ; 27: e929701, 2021 Jun 14.
Article in English | MEDLINE | ID: covidwho-1292186

ABSTRACT

BACKGROUND At the beginning of the COVID-19 pandemic, a cluster outbreak caused by an imported case from Hubei Province was reported in Xi'an City, Shaanxi Province, China. Ten patients from 2 families and 1 hospital were involved in the transmission. MATERIAL AND METHODS We conducted an epidemiological investigation to identify the cluster transmission of COVID-19. The demographic, epidemiological, clinical, laboratory, and cluster characteristics were described and analyzed. RESULTS From January 27 to February 13, 2020, a total of 10 individuals were confirmed to be infected with SARS-CoV-2 by the nucleic acid testing of nasopharyngeal swabs from 2 families and 1 hospital. Among the confirmed cases, 7 had atypical clinical symptoms and 3 were asymptomatic. The median times from onset to diagnosis and to discharge were 3.5 days (range, 1-5 days) and 19.5 days (range, 16-38 days), respectively. There were 4 patients whose exposure dates were 1, 3, 3, and 2 days earlier than the onset dates of their previous-generation cases, respectively. Four prevention and control measures were effectively used to interrupt the disease transmission. CONCLUSIONS SARS-CoV-2 can be easily transmitted within families and in hospitals, and asymptomatic patients could act as a source of disease transmission. The results of this outbreak at the early epidemic stage support the recommendation that individuals with confirmed COVID-19 and all their close contacts should be subjected to medical quarantined observation and nucleic acid screening as early as possible, even if they do not have any symptoms. Meanwhile, people in high-risk areas should improve their protective measures.


Subject(s)
Asymptomatic Infections/epidemiology , COVID-19/epidemiology , COVID-19/transmission , Carrier State/prevention & control , Carrier State/transmission , Pandemics/prevention & control , SARS-CoV-2/genetics , Adolescent , Adult , Aged , Aged, 80 and over , COVID-19/prevention & control , COVID-19/virology , COVID-19 Nucleic Acid Testing/methods , China/epidemiology , Female , Humans , Male , Mass Screening/methods , Middle Aged , Quarantine/methods , Real-Time Polymerase Chain Reaction , Reverse Transcriptase Polymerase Chain Reaction , Young Adult
5.
China Tropical Medicine ; 20(9):853-856, 2020.
Article in Chinese | GIM | ID: covidwho-890728

ABSTRACT

Objective: To explore the transmission characteristics of the typical clusters of coronavirus diseases 2019 (COVID-19) in Xi'an, so as to provide scientific basis for optimizing the control strategy of COVID-19.

6.
Chinese Journal of Nosocomiology ; 30(6):834-838, 2020.
Article in Chinese | GIM | ID: covidwho-822403

ABSTRACT

OBJECTIVE: To explore the early features of COVID-19 epidemic in Shaanxi Province so as to provide scientific basis for optimizing the prevention strategies and evaluating the effects of interventions. METHODS: The epidemic data that were reported through official networks of Shaanxi Province from Dec. 31, 2019 to Feb. 13, 2020 and the case data from Chinese Information System for Disease Control and Prevention were collected, the population data during the same period were obtained from Shaanxi Statistical Yearbook. The descriptive epidemiological analysis was performed by using Excel and ArcGIS software, the transmission dynamics model of COVID-19 was built based on Berkeley Madonna software experiment platform, and the rules of occurrence and progression of the disease were observed. RESULTS: By Feb. 13, 2020, the accumulative confirmed cases of COVID-19 reached 230 in Shaanxi Province, and the incidence rate was about 0.59 per 100 000. The male cases were more than the female cases, and the patients aged between 40 and 50 years old were dominant. The COVID-19 was highly prevalent in Xi'an, Ankang and Hanzhong. The SEIAR model showed that the basic regeneration index(R0) of the epidemic in Shaanxi Province was about 2.95, concluding that the beginning of Feb. 2020 was the peak period of outbreak of COVID-19 in Shaanxi Province. CONCLUSION: The COVID-19 epidemic in Shaanxi province shows a fast spreading trend. The theoretical number of confirmed cases that is predicted based on the SEIAR model can provide basis for prevention and control of the COVID-19 epidemic and curb the spread of the epidemic.

7.
J. Xi'An Jiaotong Univ. Med. Sci. ; 4(41): 502-505, 20200705.
Article in Chinese | WHO COVID, ELSEVIER | ID: covidwho-684103

ABSTRACT

Objective To explore the epidemic characteristics of close contacts of corona virus disease 2019(COVID-19) in Xi'an so as to provide reference for further prevention and control of the epidemic. Methods Data of the close contacts of COVID-19 in Xi'an was collected. We analyzed the distribution of close contacts in the population and isolation measures of close contacts and confirmed cases among different exposure conditions. Results By 0: 00 February 28, the cumulative number of confirmed cases and close contacts in Xi'an had been 120 and 5 241, respectively.Medical workers accounted for 7.92% of the close contacts. Across different age groups, the proportion of the youth group was the highest (56%). Indifferent areas of Xi'an, Yanta District had the largest number of close contacts(913) while Huyi District had the lowest number (29). The main contact route was contact within the family (1 875). The majority of the confirmed cases were infected within the family (35), followed by shopping places (26). Conclusion By 0: 00 February 28, close contacts of COVID-19 in Xi'an had mostly been found in Yanta District. The young constituted the main group, and close contacts within the family had a high risk of infection. In view of the above characteristics, it is necessary to improve the screening of people having close contact with COVID-19 in key areas and populations.

8.
Nan Fang Yi Ke Da Xue Xue Bao ; 40(3): 337-341, 2020 Mar 30.
Article in Chinese | MEDLINE | ID: covidwho-211202

ABSTRACT

OBJECTIVE: To analyze the clinical characteristics of patients with severe or critical coronavirus disease 2019 (COVID-19) receiving tracheal intubation. METHODS: We analyzed clinical characteristics of 18 severely or critically ill patients with COVID-19 undergoing tracheal intubation. The general demographic and clinical data of the patients including their age, gender, pre- intubation state of consciousness and the ventilation mode were recorded. The anesthesiologists performing the tracheal intubation procedure evaluated and recorded the tracheal intubation conditions of the patients. The changes in the vital signs of the patients before anesthesia induction and after intubation were recorded. RESULTS: The average ages of these patients were 70.39±8.02 years. Fifteen patients (83.33%) received non- invasive ventilation before tracheal intubation, and 13 patients (72.22%) were conscious before tracheal intubation. After induction of anesthesia, the blood pressure and heart rate of the patients decreased significantly (P < 0.05). Most of the patients (94.44%) were in excellent or good conditions for tracheal intubation, and the first-attempt success rate of tracheal intubation was 100%. Five patients died within 3 weeks following the intubation. Tracheotomy was performed in one patient. Twelve patients were still on endotracheal mechanical ventilation in the intensive care unit, and one of them received ECMO treatment due to poor oxygenation. A total of 16 experienced anesthesiologists participated in tracheal intubation, all with third-level protection during the operation, and no medical staff infection has been detected so far. CONCLUSIONS: For patients with severe and critical COVID-19 and indications of tracheal intubation, we recommend early intubation with invasive respiratory support to improve the treatment efficacy and reduce the mortality. Anesthetic agents should be used carefully during tracheal intubation to ensure patients' safety. The medical staff should have a high-level protection during the intubation to maximally ensure their safety.


Subject(s)
Coronavirus Infections/therapy , Intubation, Intratracheal , Pneumonia, Viral/therapy , Aged , Betacoronavirus , COVID-19 , Humans , Middle Aged , Pandemics , SARS-CoV-2
9.
J Anesth ; 34(4): 599-606, 2020 08.
Article in English | MEDLINE | ID: covidwho-72193

ABSTRACT

SARS-CoV-2 pandemic is announced and it is very important to share our experience to the critical care community in the early stage. Urgent intubation team was organized by anesthesiologists and was dispatched upon request. We have retrospectively reviewed medical charts of 20 critically ill patients with Covid-19 pneumonia who required tracheal intubation from February 17 to March 19 in Wuhan No.1 hospital, China. We collected their demographics, vital signs, blood gas analysis before and after tracheal intubation, and 7-day outcome after tracheal intubation. Out of 20 patients, 90% were over 60 years old and 15 were with at least one comorbidity. All meet the indication for tracheal intubation announced by treatment expert group. We had successfully intubated all patients using personal protective equipment without circulatory collapse during tracheal intubation. During the observational period, none of 17 anesthesiologists were infected. Although intubation improved SPO2, reduced PaCO2 and blood lactate, seven of 20 patients died within 7-days after tracheal intubation. Non-survivors showed significantly lower SPO2 and higher PaCO2 and blood lactate compared to survivors. For those who are anticipated to deteriorate severe pneumonia with poor prognosis, earlier respiratory support with tracheal intubation may be advised to improve outcome.


Subject(s)
Betacoronavirus , Coronavirus Infections/complications , Intubation, Intratracheal , Pneumonia, Viral/therapy , Respiratory Insufficiency/therapy , Aged , Aged, 80 and over , Anesthesiologists , Blood Gas Analysis , COVID-19 , China/epidemiology , Coronavirus Infections/blood , Coronavirus Infections/mortality , Critical Care , Critical Illness , Female , Hospital Mortality , Humans , Male , Middle Aged , Oxygen/blood , Pandemics , Pneumonia, Viral/blood , Pneumonia, Viral/complications , Pneumonia, Viral/etiology , Pneumonia, Viral/mortality , Respiratory Insufficiency/etiology , Retrospective Studies , SARS-CoV-2 , Survival Rate , Time-to-Treatment
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