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1.
PLoS Pathogens ; 18(9):e1010807, 2022.
Article in English | MEDLINE | ID: covidwho-2021985

ABSTRACT

Understanding the host pathways that define susceptibility to Severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) infection and disease are essential for the design of new therapies. Oxygen levels in the microenvironment define the transcriptional landscape, however the influence of hypoxia on virus replication and disease in animal models is not well understood. In this study, we identify a role for the hypoxic inducible factor (HIF) signalling axis to inhibit SARS-CoV-2 infection, epithelial damage and respiratory symptoms in the Syrian hamster model. Pharmacological activation of HIF with the prolyl-hydroxylase inhibitor FG-4592 significantly reduced infectious virus in the upper and lower respiratory tract. Nasal and lung epithelia showed a reduction in SARS-CoV-2 RNA and nucleocapsid expression in treated animals. Transcriptomic and pathological analysis showed reduced epithelial damage and increased expression of ciliated cells. Our study provides new insights on the intrinsic antiviral properties of the HIF signalling pathway in SARS-CoV-2 replication that may be applicable to other respiratory pathogens and identifies new therapeutic opportunities.

2.
IEEE Transactions on Intelligent Transportation Systems ; : 1-10, 2022.
Article in English | Scopus | ID: covidwho-2019013

ABSTRACT

Multi-object tracking is of great importance in autonomous driving. However, with the outbreak of COVID-19, multi-object tracking faces new challenges in areas gripped by epidemics because of complex motion blur, frequent occlusions, and appearance deformations. To reliably improve object trajectory association in epidemic-plagued areas, we propose a temporal-spatial aggregation embedding network (TSAEN) for multi-object tracking. Our embedding network contains a temporal-aware correlation module (TACM) and spatial-aggregate embedding module (SAEM) that can fully obtain and aggregate appearance clues related to moving objects in previous frames. The TACM learns the temporal homogeneity features of the current and previous frames to perceive features with correlated appearance cues. Then, the SAEM adjusts the spatial deformation for each perceived temporal homogeneity feature and aggregates them for re-ID embedding learning. The experimental results demonstrate that our proposed method is able to achieve excellent overall performance. IEEE

3.
Concurrency and Computation: Practice and Experience ; 2022.
Article in English | Scopus | ID: covidwho-1958725

ABSTRACT

There is a growing need for next-generation science gateways to increase the accessibility of emerging large-scale datasets for data consumers (e.g., clinicians, researchers) who aim to combat COVID-19-related challenges. Such science gateways that enable access to distributed computing resources for large-scale data management need to be made more programmable, extensible, and scalable. In this article, we propose a novel socio-technical approach for developing a next-generation healthcare science gateway, namely, OnTimeEvidence that addresses data consumer challenges surrounding the COVID-19 pandemic related data analytics. OnTimeEvidence implements an intelligent agent, namely, Vidura Advisor that integrates an evidence-based filtering method to transform manual practices and improve scalability of data analytics. It also features a plug-in management middleware that improves the programmability and extensibility of the science gateway capabilities using microservices. Lastly, we present a usability study that shows the important factors from data consumers' perspective to adopt OnTimeEvidence with chatbot-assisted middleware support to increase their productivity and collaborations to access vast publication archives for rapid knowledge discovery tasks. © 2022 John Wiley & Sons, Ltd.

4.
Journal of Electronic Commerce Research ; 23(1), 2022.
Article in English | Scopus | ID: covidwho-1772360

ABSTRACT

The Covid-19 pandemic has dramatically changed social and economic life in almost all countries due to strict physical restrictions, such as social distancing and local or national lockdowns, required to promote public health and save lives. The policies implemented by most countries during each wave of the Covid-19 pandemic placed great pressure on global supply chains, bringing unprecedented challenges to international business (Mena et al., 2022), including cross-border e-commerce (Wang et al., 2021). Even with domestic markets, customers have changed consumption behaviors due to uncertainties of the pandemic and policies of quarantine. They are reducing their frequency of outdoor activities and preferring online shopping (Kawasaki et al., 2021). The Covid-19 pandemic has thus fueled the growth of e-commerce (Beckers et al., 2021), and forced traditional enterprises to rapidly convert from offline to online channels and respond with digital transformation of their business models to meet customer preferences (Amankwah-Amoah et al., 2021). Changing customer preferences and behaviors caused by the Covid-19 pandemic has been a catalyst for innovation in the platform economy (Chan & Gao, 2021) and financial technology (FinTech) (Chen et al., 2021). As consumers craved greater social presence during the Covid-19 pandemic, live streaming on social networking sites and e-commerce platforms became more popular. However, the pandemic has also negatively affected sharing economy and traditional industries such as the restaurant industry, tourism and retail. Obviously, the development of the digital economy, typified by e-commerce, faces unprecedented opportunities and challenges during the Covid-19 pandemic, presenting interesting research questions for the field. © 2022, Journal of Electronic Commerce Research. All rights reserved.

5.
2021 International Conference on Information and Communication Technologies for Disaster Management, ICT-DM 2021 ; : 65-71, 2021.
Article in English | Scopus | ID: covidwho-1714061

ABSTRACT

In April 2020, with the development of the nationwide epidemic prevention and control work, the epidemic situation of New Coronavirus has entered a stable stage. However, the resumption of production and recovery is crucial to maintain the stable development of economy and society. Imminent. Therefore, how to co-ordinate the epidemic prevention and control and return to work has become another major challenge for governments at all levels. The joint prevention and control mechanism of the State Council issued a document requiring all localities to 'conduct accurate prevention and control in different regions and levels, and coordinate the prevention and control of epidemic situation and the restoration of economic and social order'. In this context, China Unicom gives full play to the unique advantages of multi-source, massive and integrated big data of operators, and helps enterprises to resume work and production from four aspects: real-time insight of regional return to work rate, grid risk index assessment, risk analysis of regional population inflow, and risk analysis of employees' travel mode, so as to provide support for enterprise decision makers and formulate scientific policies and means, gradually realize the full return to work. © 2021 IEEE.

6.
Journal of Biomaterials and Tissue Engineering ; 12(4):778-787, 2022.
Article in English | Web of Science | ID: covidwho-1666523

ABSTRACT

Background and purpose: Coronavirus disease 2019 (COVID-19) was spreading all over the world. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) primarily invades and infects the lungs of humans leading to COVID-19. Mild to severe clinical symptoms such as fever, cough, and shortness of breath were existed in those patients. One of the most common changes in these patients was abnormal blood routine. However, uncertainty remains regarding the dynamic characteristics of platelet in COVID-19 patients due to limited data. Therefore, we aimed to analyze the association between dynamic characteristics of blood platelet and disease severity, and to identify new monitoring indicators to treat the COVID-19 patients.Methods:In this cohort study, 398 COVID19 patients treated in the Shenzhen Third People's hospital from December 16, 2019 to March 26, IP: 182.75.148.10 On: Thu, 20 Jan 2022 08:58:32 Copyright: American Scientific Publishers 2020 were collected and participated. All data of participants including the clinical characteristics, Delivered by Ingenta imaging and laboratory information were collected. All patients included in our study were classified as four groups (mild, common, severe, and critical types) regarding clinical symptoms and relevant severe failures based on the Diagnosis Criteria. Platelet count was examined at the baseline and every 3-5 days during hospitalization. Results: The platelet count varied with clinical classifications. The platelet count in mild type was normal without significant fluctuation. While the blood platelet count of most common and severe patients had obvious fluctuations, showing as a dynamic change that first rose and then fell to the level at admission, which was consistent with the trend of lung inflammation. Bone marrow smears further showed that bone marrow hyperplasia was normal in mild, common and severe type patients, and megakaryocytes and their platelet-producing functions were not abnormal. Conclusions: Our results suggested that the dynamic changes of platelet count might be a predictor of lung inflammation alteration for COVID-19 patients. The changes in platelet count might be a responsive pattern secondary to lung inflammation. The function of bone marrow may be slightly affected by SARS-CoV-2 infection.

7.
Chinese General Practice ; 24(31):4003-4008, 2021.
Article in Chinese | Scopus | ID: covidwho-1502778

ABSTRACT

Background: Primary healthcare workers have played an important role in combating the COVID-19 pandemic. Beginning in 2010, China initiated a national policy of implementing the rural-oriented tuition-free medical education(RTME) program, aiming to train general practitioners(GPs) with a medical undergraduate degree to work in rural areas to address the shortage of rural physicians. Since 2015, many graduates with RTME returned to the contracted rural hospital to fulfill a 3-year obliged health services, and their performance in combating COVID-19 epidemic is worth to be concerned about. Objective: To compare the participation and role of target admission GPs and other graduates trained with a five-year undergraduate degree program for clinical medical students in combating COVID-19 pandemic, and to analyze the duties and challenges for target admission GPs during the anti-pandemic period, then based on this, to put forward policy recommendations for incentivizing target admission GPs. Methods The data were sourced from the Target Admission Medical Students Cohort Study Program. We conducted a follow-up survey among 1 631 target admission GPs and 1 009 other clinical medical graduates graduating from 4 medical colleges in central and western China using an online questionnaire in September 2020. Basic demographics, job information and work status during the COVID-19 pandemic were collected. Results Among those who were employed in the study period, target admission GPs had a higher rate of participating in combating COVID-19 pandemic than other clinical medical graduates〔70.18%(1 113/1 586)vs 51.58%(293/568), P<0.05〕. Among target admission GPs, men had a higher rate of being involved in combating COVID-19 pandemic than women(P<0.05);those admitted in 2015 and 2016 had a higher rate of being involved in combating COVID-19 pandemic than those admitted during 2017 to 2019(P<0.05);and those who were married had a higher rate of being involved in combating COVID-19 pandemic than those who were unmarried/divorced/other marital status(P<0.05). The top 3 types of work which most target admission GPs participated were "health promotion and education"〔88.59%(986/1 113)〕, "community epidemic prevention and management"〔85.62%(953/1 113)〕, and "SARS-CoV-2 nucleic acid testing and screening"〔67.30%(749/1 113)〕. The top three challenges most target admission GPs faced in combating COVID-19 pandemic were "lack of personal protective equipment"〔77.72% (865/1 113)〕, "too much workload and/or pressure"〔41.87%(466/1 113)〕, and "worrying about themselves and their family being infected"〔37.56%(418/1 113)〕. The prevalence of target admission GPs who reported that there was an increase in daily clinical work was 57.50%(640/1 113). And that of target admission GPs who reported that there was an increase in daily public health services was 62.26%(693/1 113). Conclusion: Target admission GPs have implemented multiple key services regarding COVID-19 containment, indicating that they have played a role in the national COVID-19 containment that cannot be ignored. However, they faced difficulties such as insufficient personal protective equipment and excessive work pressure. Measures need to be taken to improve the infrastructures in rural areas, and to provide more protection and support for primary healthcare workers. Copyright © 2021 by the Chinese General Practice.

8.
IEEE Access ; 9:138791-138802, 2021.
Article in English | Web of Science | ID: covidwho-1476038

ABSTRACT

Following societal events involving air, such as haze and COVID-19, Chinese people's need for air purifiers has skyrocketed. The matching degree between the appearance of air purifier and the user's subjective preference becomes an important factor affecting the user's purchase decision. In this paper, we utilize the portable desktop air purifier as an example of how to address customers' perceptual needs in the air purifier's product appearance design, based on the Kansei engineering. We established product sample space through market research and literature reading, extracted product design elements, collected perceptual image words, then used semantic difference method to measure users' perceptual needs, and obtained key perceptual image words by factor analysis. Then partial correlation analysis is conducted on the results of the above methods to determine the translation link between design elements and perceptual image space, and a set of design methodologies for a portable desktop air purifier based on Kansei engineering was obtained. Finally, a genuine development project is used to validate the method's practicality. The findings of this study not only aid in the design and development of air purifiers but also provide research ideas and methodologies for air purifier appearance design to fulfill the perceptual needs of consumers.

9.
2020 2nd International Conference on Computer Science Communication and Network Security ; 336, 2021.
Article in English | Web of Science | ID: covidwho-1313622

ABSTRACT

In 2020, the outbreak of COVID-19 seriously threatened many people's life and it had brought unexpected impacts upon the global economy. In order to understand the emergency response ability of cities with similar backgrounds, an evaluation method based on fuzzy comprehensive evaluation was proposed. First, we established the evaluation index system of urban epidemic response capability. Meantime, a combination way to calculate the index weights of the evaluation system was developed based on analytic hierarchy process. Finally, we have an empirical analysis on the evaluation activity of epidemic emergency management in area H, J province. The evaluation results can be used as the basis for selecting advanced cities. At the same time, it is of great importance for area H to improve urban resource allocation and emergency response capability.

10.
54th Annual Hawaii International Conference on System Sciences, HICSS 2021 ; 2020-January:1139-1148, 2021.
Article in English | Scopus | ID: covidwho-1283189

ABSTRACT

Online learning has been expanding for some time but the forced move to it due to the outbreak of COVID-19 has created new issues. This study set out to investigate the impact mechanism of online learning user satisfaction from the perspective of cognitive load in the era of COVID-19 and explore ways to optimize cognitive load in teaching practice. Semi-structured interviews were conducted for the empirical analysis. The coding process of the interviews yielded several antecedents of cognitive load in the online learning process. We also proposed a theoretical model based on the literature review and data analysis. Findings of the qualitative analysis indicate that the antecedents of cognitive load are multi-dimensional and the user's satisfaction with the online learning platform mainly consists of the expected confirmation of the information system and the perceived usefulness. These findings can help us think backward about optimizing user satisfaction with online learning in the context of COVID-19 breakout. © 2021 IEEE Computer Society. All rights reserved.

11.
2nd IEEE Asia-Pacific Conference on Image Processing, Electronics and Computers, IPEC 2021 ; : 728-732, 2021.
Article in English | Scopus | ID: covidwho-1247075

ABSTRACT

In face of COVID-19, it is very important to wear masks in public. In this article, we use a kind of improved convolutional neural network algorithm DFS (detection with feature fusion and segmentation supervision) for face detection, and YCrCb elliptic skin color model is used for mask recognition. We expect to better supervise the standardization of people wearing masks, through the application of this project in public places such as public transport. With the applying of this project, the risk of human infection can be reduced, so as to better prevent and control the epidemic. © 2021 IEEE.

12.
Asian Pacific Journal of Tropical Medicine ; 14(4):146-156, 2021.
Article in English | Scopus | ID: covidwho-1206393

ABSTRACT

The outbreak of coronavirus disease 2019 (COVID-19) was declared a global public health emergency on 31 January 2020. Emergency medicine procedures in Emergency Department should be optimized to cope with the current COVID-19 pandemic by providing subspecialty services, reducing the spread of nosocomial infections, and promoting its capabilities to handle emerging diseases. Thus, the Chinese Society of Emergency Medicine and Wuhan Society of Emergency Medicine drafted this consensus together to address concerns of medical staffs who work in Emergency Department. Based on in-depth review of COVID-19 diagnosis and treatment plans, literatures, as well as management approval, this consensus proposes recommendations for improving the rationalization and efficiency of emergency processes, reducing the risk of nosocomial infections, preventing hospital viral transmission, and ensuring patient safety. © 2021 Asian Pacific Journal of Tropical Medicine Produced by Wolters KluwerMedknow. All rights reserved.

13.
Journal of Thoracic Oncology ; 16(3):S326-S327, 2021.
Article in English | EMBASE | ID: covidwho-1160025

ABSTRACT

Introduction: Objective to summarize the work flow list during epidemic period, and to discuss and summarize the process management and prevention and control methods of each link in Tumor area during epidemic period of novel coronavirus pneumonia (NCP), in order to achieve the orderly completion of radiotherapy and chemotherapy for tumor patients, and prevent a tumor patient from contracting novel coronavirus pneumonia. Methods: According to the characteristics of the transmission of NCP and the relevant documents of the National Health Commission, the list of management work was carded out, to establish various prevention and control processes in tumor wards, control key population, establish correct infection control measures, scientifically protect key personnel and effectively manage protective materials. Results: During the epidemic period of NCP, the tumor inpatients could complete the radiotherapy and chemotherapy in time and effectively, and the infection of NCP was avoided. The ability and knowledge of prevention and control of hospital infection of new pneumonia were improved. [Formula presented] Conclusion: The nursing managers adopt and implement correct measures to prevent and control NCP infection through the management work list system, which can effectively ensure the safety of tumor patients and the occupational safety of medical workers. The purpose of this study is to provide practical experience for the establishment of infectious emergency nursing management system in common disease areas. Keywords: List of management, Oncology ward, coronavirus pneumonia

14.
Zhonghua Er Ke Za Zhi ; 58(0):E005-E005, 2020.
Article in Chinese | MEDLINE | ID: covidwho-1016703
15.
Chinese Journal of New Drugs ; 29(21):2425-2433, 2020.
Article in Chinese | EMBASE | ID: covidwho-984418

ABSTRACT

COVID-19 outbreak poses a serious threat to global public health. The research and development of COVID-19 vaccines around the world are moving forward with various technical tactics in a positive way. After the traditional live-attenuated virus vaccine, inactive virus vaccine and genetic engineering subunit vaccine, nucleic acid vaccine is called "the third generation vaccine technology" in the industry, including DNA vaccine and mRNA vaccine. Each has its own advantages. This article reviews the development history of DNA vaccine. With over ten years of improvement, the delivery efficiency of DNA vaccine has been greatly improved, especially in the treatment of emerging infectious diseases including SARS, highly pathogenic influenza, MERS, ZIKA and Rift Valley fever, the preliminary clinical benefit of which has been verified. This review aims to discuss the research and development of DNA vaccines against pandemics, especially the design, optimization, safety and effectiveness of COVID-19 DNA vaccines, and suggest the direction of improvement of DNA vaccine technology.

16.
Eur Rev Med Pharmacol Sci ; 24(23): 12545-12557, 2020 12.
Article in English | MEDLINE | ID: covidwho-995015

ABSTRACT

OBJECTIVE: Scientific research is an essential necessity for the prevention and control of COVID-19. Accelerated paper-sharing makes it possible to explore the responses of scientific communities of different countries and their research focus. This is achieved by examining relevant publications during the early stage of the pandemic. This paper explores a timely research assessment on COVID-19 among China, USA, and EU. MATERIALS AND METHODS: Papers indexed in PubMed and published from December 30, 2019, to March 11, 2020, were selected. Papers from China, USA, and EU were assessed by calculating the significance of items in the co-occurrence exported from VOSviewer. RESULTS: The results showed that Chinese studies focus more on clinical manifestations, while USA and EU focus on experimental research. Furthermore, US research is more geared toward detection techniques and mathematical models, China focuses more on monitoring the epidemic situation, and EU engages in both. CONCLUSIONS: This paper argues that the above distinctions are caused by differences in the stages of epidemic development, researchers' experience bases for formulating measures, traditions within the different medical cultures, and the distinction between "information" and "knowledge".


Subject(s)
Biomedical Research , COVID-19 , Internationality , COVID-19/drug therapy , COVID-19 Testing , COVID-19 Vaccines , China , Communicable Disease Control , Drug Development , Epidemiologic Studies , European Union , Humans , Publishing , SARS-CoV-2 , United States
17.
2020 6th International Conference on Energy, Environment and Materials Science, EEMS 2020 ; 585, 2020.
Article in English | Scopus | ID: covidwho-947641

ABSTRACT

Artificial seawall by silt squeezing with blasting dike, a small price for a good seawall than with mechanical dredging, and is effective in preventing this kind of accident from tsunami and typhoon disaster. This paper briefly discusses the pollution situation of poultry and mankind waste in China. For the first time gives the techniques for harmless (China patent ZL 201220109642.1, no flush heathy toilet.) and utilization of waste in China are presented and analysed for benefit utilization. Sanitary toilet without sewers -2019 world break-through technologies (no flush heathy toilet) driven reinvent the toilet challenge, RTTC. Authors also show the technique for harass and utilization of wastes in China. The authors suggest that all the mankind and animal waste, after harmless processing, should be used in a way of useful things as feed, fertilizer, etc. to benefit human society, prevent disease (covid-19, sars) propagation and reduce greenhouse gases. It is also can be used on ship, aircraft, coach and out space etc. (China patent ZL 201220109642.1 is one of several ways of human and livestock faeces harmless treatment, ultraviolet disinfection, ozone fumigation), its weight less than 15kg, volume less than 0.12m3. © Published under licence by IOP Publishing Ltd.

18.
Zhonghua Xin Xue Guan Bing Za Zhi ; 48(6): 472-476, 2020 Jun 24.
Article in Chinese | MEDLINE | ID: covidwho-683960

ABSTRACT

Objective: To evaluate the efficacy and safety of fibrinolysis strategy in patients with acute ST-segment elevation myocardial infarction (STEMI) during the COVID-19 epidemic, and to provide reference value for optimization of fibrinolytic process on the premise of prevention and control of COVID-19 transmission, including self-protection of medical staff. Methods: The efficacy and safety of fibrinolysis were retrospectively analyzed in 7 patients with acute STEM, who hospitalized from February 29, 2020 to April 3, 2020 in the Department of Cardiology, Wuhan Union Hospital of Tongji Medical College, Huazhong University of Science and Technology. To optimize the fibrinolytic process on the premise of prevention and control of COVID-19 transmission, including self-protection of medical staff, a full-time medical team in charge of fibrinolysis under third-grade protection was established. The acute STEMI patients were treated immediately in a fixed and isolated area in emergency department before receiving green channel fibrinolysis. Blood samples for complete blood count, COVID-19 antibody test and nasopharyngeal swab samples for COVID-19 nucleic acid test were made before fibrinolysis, while the chest CT examination was accomplished after fibrinolysis. By comparing differences of time from the first electrocardiogram (ECG) to fibrinolysis before and after the improvement of fibrinolytic process, the effect of optimization of the fibrinolytic process was evaluated. Results: In the present study, seven patients with acute STEMI received fibrinolysis therapy, 6 of them achieved reperfusion and no bleeding was observed in all of the patients. Five out of the 7 patients were hospitalized after fibrinolysis, and the hospitalization days were 19.6 days on average. By following up to April 14, 2020, none of the 7 patients died. The first 2 patients were treated according to the routine medical procedure and the time from the first ECG to fibrinolysis were 201 and 106 minutes, respectively. After the optimization of the fibrinolytic process, the time from the first ECG to fibrinolysis of the last 5 patients were 42, 46, 51, 43 and 54 minutes, respectively,which was significantly shorter than that before optimization. Conclusions: During the COVID-19 epidemic, fibrinolysis in patients with acute STEMI is safe, effective and easy to implement. Therefore, it is recommended as the top priority for the patients with acute STEMI with indications for fibrinolysis. On the premise of prevention and control of COVID-19 transmission, including self-protection of medical staff, the duration of myocardial ischemia can be shortened by optimization of the fibrinolytic process.


Subject(s)
Betacoronavirus , Coronavirus Infections , Fibrinolytic Agents/therapeutic use , Pandemics , Pneumonia, Viral , ST Elevation Myocardial Infarction , COVID-19 , Coronavirus Infections/epidemiology , Epidemics , Humans , Pneumonia, Viral/epidemiology , Retrospective Studies , SARS-CoV-2 , ST Elevation Myocardial Infarction/drug therapy , Thrombolytic Therapy , Time Factors , Treatment Outcome
19.
Chinese Journal of Pediatrics ; - (12):5-5, 2020.
Article | WHO COVID | ID: covidwho-7618

ABSTRACT

Summary One patient with a complaint of "intermittent diarrhea, vomiting for 6 days, fever with shortness of breath for half a day" was referred to the Department of Critical Medicine, Wuhan Children's Hospital, and was diagnosed with neonatal severe coronavirus pneumonia (NCP). Relevant databases such as China Knowledge Net, Weipu, Wanfang and other related databases were searched with the keywords of "new coronavirus pneumonia", "children", and "critical severity" as of February 8, 2020. This case is the first child with severe NCP in China. It started with gastrointestinal symptoms, early respiratory symptoms were not obvious, and rapidly progressed to acute respiratory distress syndrome, septic shock, and acute renal failure. The patient was negative for nucleic acid test of 2019 new-type coronavirus (2019-nCoV) for 2 consecutive consecutive throat swabs. For severe suspected cases, it is recommended to take samples of the lower respiratory tract or repeat samples of the upper respiratory tract for testing. Continuous blood purification technology can be applied to the treatment of children with severe NCP as early as possible.

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