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1.
Basic Clin Pharmacol Toxicol ; 2021 Nov 22.
Article in English | MEDLINE | ID: covidwho-1528358

ABSTRACT

The COVID-19 pandemic is a highly dramatic concern for mankind. In Italy, the pandemic exerted its major impact throughout the period of February to June 2020. To date, the awkward amount of more than 131,000 deaths have been reported. Post-mortem autopsy was performed on a very modest number of patients who died from COVID-19 infection, leading to a first confirmation of an immune-thrombosis of the lungs as the major COVID-19 pathogenesis, likewise for SARS. Since then (June-August 2020), no targeted early therapy considering this pathogenetic issue was approached. The patients treated with early anti-inflammatory, anti-platelet, anticoagulant, and antibiotic therapy confirmed that COVID-19 was an endothelial inflammation with immuno-thrombosis. Patients not treated or scarcely treated with the most proper and appropriate therapy and in the earliest, increased the hospitalization rate in the intensive care units and also mortality, due to immune-thrombosis from the pulmonary capillary district and alveoli. The disease causes widespread endothelial inflammation, which can induce damage to various organs and systems. Therapy must be targeted in this consideration and in this review, we demonstrate how early anti-inflammatory therapy treats endothelia inflammation and immune-thrombosis caused by COVID-19, by using drugs we are going to recommend in this paper.

2.
J Med Virol ; 2021 Nov 15.
Article in English | MEDLINE | ID: covidwho-1527441
4.
Internal and emergency medicine ; : 1-4, 2021.
Article in English | EuropePMC | ID: covidwho-1479271
5.
Nutrition ; : 111494, 2021 Sep 20.
Article in English | MEDLINE | ID: covidwho-1415688
6.
Basic Clin Pharmacol Toxicol ; 129(6): 395-396, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1398355
7.
Clin Appl Thromb Hemost ; 27: 10760296211020829, 2021.
Article in English | MEDLINE | ID: covidwho-1242659
9.
Int Immunopharmacol ; 96: 107777, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1225264

ABSTRACT

An increasing amount of reports in the literature is showing that medical ozone (O3) is used, with encouraging results, in treating COVID-19 patients, optimizing pain and symptoms relief, respiratory parameters, inflammatory and coagulation markers and the overall health status, so reducing significantly how much time patients underwent hospitalization and intensive care. To date, aside from mechanisms taking into account the ability of O3 to activate a rapid oxidative stress response, by up-regulating antioxidant and scavenging enzymes, no sound hypothesis was addressed to attempt a synopsis of how O3 should act on COVID-19. The knowledge on how O3 works on inflammation and thrombosis mechanisms is of the utmost importance to make physicians endowed with new guns against SARS-CoV2 pandemic. This review tries to address this issue, so to expand the debate in the scientific community.


Subject(s)
COVID-19/drug therapy , Oxidants, Photochemical/pharmacology , Ozone/pharmacology , SARS-CoV-2/drug effects , Humans , Oxidative Stress/drug effects
10.
Int Immunopharmacol ; 96: 107629, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1188657

ABSTRACT

Lethal or critical COVID-19 occurs most in infected hosts with certain risk factors such as advanced age or pre-existing disease. Host metabolic status significantly affects the clinical presentations of SARS-CoV-2 infection. Individual risk management is thus crucial for preventing severe COVID-19. Such susceptibility is individual, depending on a multitude of factors. Personalized risk assessment requires the inclusive analysis of big health data to stratify individual risk and derive a customized action plan. Personalized medicine requires shifting from the virology aspect per se to the whole individual's consideration, including dietary pattern, nutritional status, supporting lifestyle, co-existing diseases, and environmental factors. In this short communication, we discuss the individual management strategy for SARS-CoV2 infection as a step towards future personalized healthcare.


Subject(s)
COVID-19 , Precision Medicine , Comorbidity , Humans , Life Style , Nutritional Status , Risk Assessment/methods , Risk Factors , SARS-CoV-2
11.
Int J Cancer ; 149(5): 1199-1200, 2021 09 01.
Article in English | MEDLINE | ID: covidwho-1187992

Subject(s)
COVID-19 , Neoplasms , Humans , SARS-CoV-2
13.
J Med Virol ; 93(7): 4049-4053, 2021 07.
Article in English | MEDLINE | ID: covidwho-1118170

ABSTRACT

Coronavirus disease 2019 (COVID-19) vaccination campaign in Italy has started with a huge perplexity about vaccine efficacy, vaccine-borne adverse effects and vaccine clinical trial studies. In this commentary I tried to elucidate these issues, which represent a fundamental topic to be thoroughly addressed in COVID-19 pandemic.


Subject(s)
COVID-19 Vaccines , COVID-19/prevention & control , Vaccination Refusal , Vaccines, Synthetic , Anaphylaxis/etiology , COVID-19/epidemiology , COVID-19/immunology , COVID-19 Vaccines/adverse effects , COVID-19 Vaccines/immunology , Health Knowledge, Attitudes, Practice , Humans , Italy/epidemiology , Liposomes/adverse effects , Mass Vaccination , Nanoparticles/adverse effects , Pandemics/prevention & control , Polyethylene Glycols/adverse effects , Vaccines, Synthetic/adverse effects , Vaccines, Synthetic/immunology
14.
J Med Virol ; 93(3): 1247-1249, 2021 03.
Article in English | MEDLINE | ID: covidwho-1074338
17.
Virusdisease ; 31(2): 85-93, 2020 Jun.
Article in English | MEDLINE | ID: covidwho-959397

ABSTRACT

The COVID19 outbreak in Italy is still a big concern. The Italian Government has recommended citizens to respect faithfully any compulsory legal disposition in order to stay home and so contributing in escaping viral contacts and slowing down epidemic. Emergency has raised a widely animated debate about how to read and comprehend the daily case numbers, the medical and caregivers availability, the needs to swab asymptomatic subjects. In this review the authors discuss about the many wheat and chaffs of how this virus disease is addressed .

18.
Int Immunopharmacol ; 88: 106879, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-919641

ABSTRACT

OBJECTIVE: This study evaluated the potential efficacy of a novel approach to treat COVID-19 patients, using an oxygen-ozone (O2-O3) mixture, via a process called Oxygen-Ozone- Immunoceutical Therapy. The methodology met the criteria of a novel, promising approach to treat successfully elderly COVID-19 patients, particularly when hospitalized in intensive care units (ICUs) Experimental design: We investigated the therapeutic effect of 4 cycles of O2-O3 in 50 hospitalized COVID-19 subjects suffering from acute respiratory disease syndrome (ARDS), aged more than 60 years, all males and undergoing non invasive mechanical ventilation in ICUs. RESULTS: Following O2-O3 treatment a significant improvement in inflammation and oxygenation indexes occurred rapidly and within the first 9 days after the treatment, despite the expected 14-20 days. A significant reduction of inflammatory and thromboembolic markers (CRP, IL-6, D-dimer) was observed. Furthermore, amelioration in the major respiratory indexes, such as respiratory and gas exchange markers (SatO2%, PaO2/FiO2 ratio), was reported. CONCLUSION: Our results show that O2-O3 treatment would be a promising therapy for COVID-19 patients. It leads patients to a fast recovery from ARDS via the improvement of major respiratory indexes and blood gas parameters, following a relatively short time of dispensed forced ventilation (about one to two weeks). This study may encourage the scientific community to further investigate and evaluate the proposed method for the treatment of COVID-19 patients.


Subject(s)
Coronavirus Infections/therapy , Immunotherapy/methods , Oxygen/therapeutic use , Ozone/therapeutic use , Pneumonia, Viral/therapy , Respiratory Distress Syndrome/therapy , Aged , Betacoronavirus , Blood Gas Analysis , COVID-19 , Coronavirus Infections/immunology , Humans , Immunotherapy/instrumentation , Infusions, Intravenous , Intensive Care Units , Oxygen/administration & dosage , Ozone/administration & dosage , Pandemics , Pneumonia, Viral/immunology , Respiration, Artificial , Respiratory Distress Syndrome/immunology , SARS-CoV-2 , Treatment Outcome
19.
Curr Microbiol ; 77(11): 3680-3684, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-722253

ABSTRACT

Thorough swabbing is becoming an increasing approach to fight COVID-19 transmission, particularly among asymptomatic subjects, who are thought to represent the majority of potentially-contacting people. Particularly in the current management of COVID-19 emergency, the 3T approach, i.e., testing, tracing and treating, is felt as particularly crucial to fight COVID-19 pandemic. Aside from the time-consuming, cost expensive and the many burdensome issues associated with a thorough swabbing, adopting easy-to-make criteria such as "drive-thru-swab" may exacerbate the burden of critical biases and pre-analytical errors, which may impair the analytical reliability of these tests. This manuscript addresses some major points about.


Subject(s)
Betacoronavirus/genetics , Clinical Laboratory Techniques/methods , Coronavirus Infections/diagnosis , Coronavirus Infections/epidemiology , Pandemics , Pneumonia, Viral/diagnosis , Pneumonia, Viral/epidemiology , RNA, Viral/analysis , Betacoronavirus/pathogenicity , Biomarkers/analysis , COVID-19 , COVID-19 Testing , Contact Tracing/statistics & numerical data , Coronavirus Infections/transmission , Coronavirus Infections/virology , False Negative Reactions , Hospitalization , Humans , Italy/epidemiology , Personal Protective Equipment/supply & distribution , Pneumonia, Viral/transmission , Pneumonia, Viral/virology , Psychological Distance , RNA, Viral/genetics , Reverse Transcriptase Polymerase Chain Reaction , SARS-CoV-2 , Specimen Handling/standards
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