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1.
Children (Basel) ; 9(4)2022 Apr 07.
Article in English | MEDLINE | ID: covidwho-1809741

ABSTRACT

Hereditary neuropathy with liability to pressure palsy (HNPP) makes nerves increasingly susceptible to mechanical pressure at entrapment sites. Neuralgic amyotrophy (NA) can cause sudden regional weakness following events to which the patient is immunologically predisposed, such as vaccination. However, NA related to human papilloma virus (HPV) vaccination is seldom reported. We describe the case of a child with NA as the cause of a dropped shoulder following the administration of the HPV vaccine. Underlying asymptomatic HNPP was confirmed in this patient based on the electrodiagnostic findings and genetic analysis. We speculate that HPV vaccination elicited an immune-mediated inflammatory response, resulting in NA. Our patient with pre-existing HNPP might be vulnerable to the occurrence of an immune-mediated NA, which caused the dropped shoulder.

2.
J Int Med Res ; 49(11): 3000605211056783, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1533180

ABSTRACT

The ongoing global administration of vaccines for coronavirus disease 2019 (COVID-19) means that increasing numbers of patients are likely to present with post-vaccination complications. We describe the first reported case of neuralgic amyotrophy (NA) involving the lumbosacral plexus occurring after AstraZeneca COVID-19 vaccination. The patient presented with acute-onset leg paralysis following administration of the vaccine. Based on the clinical, electrodiagnostic, and radiologic findings, the patient was diagnosed with post-vaccination NA. We speculate that the COVID-19 vaccine elicited an immune-mediated inflammatory response to the injected antigen due to inflammatory immunity in a patient with predisposed susceptibility to NA.


Subject(s)
Brachial Plexus Neuritis , COVID-19 , Brachial Plexus Neuritis/chemically induced , Brachial Plexus Neuritis/diagnosis , COVID-19 Vaccines , Humans , Leg , Lumbosacral Plexus , Paraplegia , SARS-CoV-2 , Vaccination/adverse effects
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