Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 11 de 11
Filter
1.
Journal of Pure and Applied Microbiology ; 17(1):567-575, 2023.
Article in English | EMBASE | ID: covidwho-2276955

ABSTRACT

Individuals with comorbidities (i.e., Diabetes Mellitus, hypertension, heart diseases) are more likely to develop a more severe form of coronavirus disease 2019 (COVID-19), thus, they should take necessary precautions to avoid infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its emerging variants and subvariants by getting COVID-19 vaccination and booster doses. In this regard, we used text analytics techniques, specifically Natural Language Processing (NLP), to understand the perception of Twitter users having comorbidities (diabetes, hypertension, and heart diseases) towards the COVID-19 vaccine booster doses. Understanding and identifying Twitter users' perceptions and perspectives will help the members of medical fraternities, governments, and policymakers to frame and implement a suitable public health policy for promoting the uptake of booster shots by such vulnerable people. A total of 176,540 tweets were identified through the scrapping process to understand the perception of individuals with the mentioned comorbidities regarding the COVID-19 booster dose. From sentiment analysis, it was revealed that 57.6% out of 176,540 tweets expressed negative sentiments about the COVID-19 vaccine booster doses. The reasons for negative expressions have been found using the topic modeling approach (i.e., risk factors, fear of myocardial fibrosis, stroke, or death, and using vaccines as bio-weapons). Of note, enhancing the COVID-19 vaccination drive by administering its booster doses to more and more people is of paramount importance for rendering higher protective immunity under the current threats of recently emerging newer Omicron subvariants which are presently causing a rise in cases in a few countries, such as China and others, and might lead to a feasible new wave of the pandemic with the surge in cases at the global level. Copyright © The Author(s) 2023.

2.
Journal of Experimental Biology and Agricultural Sciences ; 11(1):54-61, 2023.
Article in English | Scopus | ID: covidwho-2284182

ABSTRACT

In the majority of the affected nations, suicidal behavior against COVID-19 leads to various concerns. This study aimed to analyze determinants affecting suicidal behaviour among university students in Uttarakhand. An online cross-sectional survey of 18-year-old university students in Uttarakhand was conducted between April 2 and May 13, 2022. The questionnaire comprised socio-demographic information, the Suicidal Behaviors' Questionnaire-Revised (SBQ-R) scale, and elements related to the physical and psychological health of COVID-19 (CRPPF). The statistical study included demographic information, basic statistics in terms of frequency and percentage, and logistic regression. In comparison to students with fewer than seven family members, students with more than seven family members were less likely to participate in suicide behaviour (AOR = 2.21;95% CI: 1.79 to 2.67) and vice versa (AOR = 0.81;95% CI: 0.56 to 0.97). According to the study, a substantial majority of students (76.35%) claimed that the lockdown implemented to stop the spread of COVID-19 was extremely upsetting for them and that the pandemic had caused them to miss their graduation (73.90%). Adjusted multivariate logistic regression shows that feelings of a burden on family, (AOR= 1.98, 95% CI: 1.09 to 2.82), distancing from family or friends, (AOR =1.66;95% CI: 1.26 to 2.01), having relationship dilemmas, (AOR= 2.31;95% CI: 1.84 to 2.97), and being anxious during the lockdown, (AOR= 1.84;95% CI: 1.08 to 2.27), are significant factors among participants that are linked to higher risk of engaging in suicidal behaviour. The possibility of university students engaging in suicide behaviour was significantly affected by numerous factors. In addition to defending the students' mental health, the concerned authorities should devise and implement strategies to safeguard the students' physical health. © 2023, Editorial board of Journal of Experimental Biology and Agricultural Sciences. All rights reserved.

3.
Application of Natural Products in SARS-CoV-2 ; : 463-489, 2022.
Article in English | Scopus | ID: covidwho-2252194

ABSTRACT

Coronavirus infection has become a common cause of sickness and death worldwide. Many drugs have been studied for the treatment of SARS-CoV-2 infections, and vaccines are injected to boost the immune system and safeguard people around the world. Many drug-like compounds are under clinical trials and have the potential to cure respiratory and viral diseases. Natural extracts and herbal products have been extensively used in traditional Chinese medicine and Indian Ayurveda. Natural medicines are more acceptable and are considered cheap and safe for COVID-19 treatment. This comprehensive chapter highlights in silico techniques for drug design and discovery using natural products against coronavirus infection. Especially computational studies of SARS-CoV-2 drugs have been explained. The effects of the mentioned natural metabolites repurposed for coronavirus diseases, especially for SARS-CoV-2, should be evaluated more by clinical investigation so that we may be able to develop potential drugs for most challenging respiratory diseases, especially SARS-CoV-2. © 2023 Elsevier Inc. All rights reserved.

4.
Journal of Pure and Applied Microbiology ; 17(1) (no pagination), 2023.
Article in English | EMBASE | ID: covidwho-2248282

ABSTRACT

ChAdOx1 nCoV-19 (AZD1222) is a replication-deficient chimpanzee adenovirus vectored vaccine developed by Oxford and AstraZeneca for a disease we all know as Coronavirus, or COVID-19. Ongoing clinical studies reveal that the ChAdOx1 nCoV-19 vaccine has a tolerable safety profile and is effective against symptomatic COVID-19. This vaccine may prove crucial in boosting herd immunity, averting life threatening illness, and relieving the current pandemic. In this mini review, we performed a thorough literature search through PubMed and Google Scholar and reported various case reports associated with complications of the adenovirus-vectored COVID-19 vaccine. Various adverse effects of the ChAdOx1 nCoV-19 vaccine were reported around the globe, which were often serious but rare and developed into life-threatening pathologies such as GBS, thrombocytopenia, demyelinating neuropathies, progressive dementia, cerebral infarction, IgA vasculitis, hemophagocytic lymphohistiocytosis, herpes zoster, cutaneous reactions, and vein thrombosis. These worldwide reported complications, which are usually rare and severe, will aid clinicians in understanding and managing unforeseen situations. There is a need for more research to find out more about these complications and their etiopathogenesis. However, the benefits of these vaccinations for stopping the spread of the outbreak and lowering the fatality rate outweigh the potential risk of the uncommon complications.Copyright © The Author(s) 2023.

5.
Journal of Experimental Biology and Agricultural Sciences ; 10(6):1215-1221, 2022.
Article in English | Scopus | ID: covidwho-2217792

ABSTRACT

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron versions have been the sole one circulating for quite some time. Subvariants BA.1, BA.2, BA.3, BA.4, and BA.5 of the Omicron emerged over time and through mutation, with BA.1 responsible for the most severe global pandemic between December 2021 and January 2022. Other Omicron subvariants such as BQ.1, BQ.1.1, BA.4.6, BF.7, BA.2.75.2, XBB.1 appeared recently and could cause a new wave of increased cases amid the ongoing COVID-19 pandemic. There is evidence that certain Omicron subvariants have increased transmissibility, extra spike mutations, and ability to overcome protective effects of COVID-19 neutralizing antibodies through immunological evasion. In recent months, the Omicron BF.7 subvariant has been in the news due to its spread in China and a small number of other countries, raising concerns about a possible rebound in COVID-19 cases. More recently, the Omicron XBB.1.5 subvariant has captured international attention due to an increase in cases in the United States. As a highly transmissible sublineage of Omicron BA.5, as well as having a shorter incubation time and the potential to reinfect or infect immune population, BF.7 has stronger infection ability. It appears that the regional immunological landscape is affected by the amount and timing of previous Omicron waves, as well as the COVID-19 vaccination coverage, which in turn determines whether the increased immune escape of BF.7 and XBB.1.5 subvariants is sufficient to drive new infection waves. Expanding our understanding of the transmission and efficacy of vaccines, immunotherapeutics, and antiviral drugs against newly emerging Omicron subvariants and lineages, as well as bolstering genomic facilities for tracking their spread and maintaining a constant vigilance, and shedding more light on their evolution and mutational events, would help in the development of effective mitigation strategies. Importantly, reducing the occurrence of mutations and recombination in the virus can be aided by bolstering One health approach and emphasizing its significance in combating zoonosis and reversal zoonosis linked with COVID-19. This article provides a brief overview on Omicron variant, its recently emerging lineages and subvairants with a special focus on BF.7 and XBB.1.5 as much more infectious and highly transmissible variations that may once again threaten a sharp increase in COVID-19 cases globally amid the currently ongoing pandemic, along with presenting salient mitigation measures. © 2022, Editorial board of Journal of Experimental Biology and Agricultural Sciences. All rights reserved.

6.
23rd International Conference on Artificial Intelligence in Education, AIED 2022 ; 13356 LNCS:453-457, 2022.
Article in English | Scopus | ID: covidwho-2013941

ABSTRACT

Students’ conversations in academic settings evolve over time and can be affected by events such as the COVID-19 pandemic. In this paper, we employ a Contextualized Topic Modeling technique to detect coherent topics from students’ posts in online discussion forums. We construct topic chains by connecting semantically similar topics across months using Word Mover’s Distance. Consistent academic discourse and contemporary events such as the COVID-19 outbreak and the Black Lives Matter movement were found among prominent topics. In later months, new themes around students’ lived experiences emerged and evolved into discussions reflecting the shift in educational experiences. Results revealed a significant increase in more general topics after the onset of pandemic. Our proposed framework can also be applied to other contexts investigating temporal topic trends in large-scale text data. © 2022, Springer Nature Switzerland AG.

7.
Journal of Association of Physicians of India ; 69(12):100-108, 2021.
Article in English | Scopus | ID: covidwho-1696178

ABSTRACT

Coronavirus disease 2019 (COVID-19) is a highly hypercoagulable viral infection complicated as COVID-inflicted coagulopathy (CIC), that is associated with increased risk of morbidity and mortality. International guidelines recommend low molecular weight heparin (LMWH) to treat CIC in both in-hospital and in-home settings. However, in India, using subcutaneous LMWH may not be a feasible option for a vast majority of patients under home management. Additionally, while some evidence advocates the use of novel oral anticoagulants (NOACs), in hospitalized settings, most guidelines find no role of NOACs in hospital settings. On the other hand, the resource crunch faced in recent COVID-19 pandemic in India forced physicians to treat many patients in home settings. These patients had been usually prescribed NOACs for ease of administration and adherence. Therefore, there is a need to form a consensus on the use of NOACs to manage CIC in India. © 2021 Journal of Association of Physicians of India. All rights reserved.

8.
Journal of the Association of Physicians of India ; 68(August):76-81, 2020.
Article in English | GIM | ID: covidwho-1139065

ABSTRACT

This document highlights the clinical challenges and systematic guidelines, as well as proposals to inform clinical decision-making among physicians and cardiologists for the care of ST-elevation myocardial infarction (STEMI) patients during the COVID-19 pandemic. These include: (1) appropriateness of invasive procedures during COVID-19 pandemic;(2) screening of all patients;(3) defining patient's risk category;(4) decision on reperfusion strategy;(5) pharmacoinvasive strategy;(6) selective PCI;(7) cath laboratory measures to minimize risk;and (8) protection of healthcare staff. Among these strategies, the pharmacoinvasive approach for STEMI care is the preferred solution in the COVID era because it is the most effective and practical approach to reduce STEMI inflicted morbidity and mortality with enormous limitations in the era of COVID-19. However, PPCI is the most promising gold standard approach for STEMI care. Selective PPCI may be recommended in large anterior wall MI, cardiogenic shock, hemodynamically unstable patients in the setting of malignant arrhythmias and when there are contraindications to thrombolytic therapy.

9.
Indian Heart J ; 72(3): 145-150, 2020.
Article in English | MEDLINE | ID: covidwho-378208

ABSTRACT

An echocardiographic investigation is one of the key modalities of diagnosis in cardiology. There has been a rising presence of cardiological comorbidities in patients positive for COVID-19. Hence, it is becoming extremely essential to look into the correct safety precautions, healthcare professionals must take while conducting an echo investigation. The decision matrix formulated for conducting an echocardiographic evaluation is based on presence or absence of cardiological comorbidity vis-à-vis positive, suspected or negative for COVID-19. The safety measures have been constructed keeping in mind the current safety precautions by WHO, CDC and MoHFW, India.


Subject(s)
Cardiovascular Diseases/diagnostic imaging , Coronavirus Infections/prevention & control , Cross Infection/prevention & control , Echocardiography/methods , Pandemics/prevention & control , Patient Safety , Pneumonia, Viral/prevention & control , COVID-19 , Cardiology , Cardiovascular Diseases/epidemiology , Coronavirus Infections/epidemiology , Female , Humans , India , Infection Control/methods , Male , Pandemics/statistics & numerical data , Pneumonia, Viral/epidemiology , Practice Guidelines as Topic , Severe Acute Respiratory Syndrome/epidemiology , Severe Acute Respiratory Syndrome/prevention & control , Societies, Medical
11.
Indian Heart J ; 72(2): 70-74, 2020.
Article in English | MEDLINE | ID: covidwho-186678

ABSTRACT

The unprecedented and rapidly spreading Coronavirus Disease-19 (COVID-19) pandemic has challenged public health care systems globally. Based on worldwide experience, India has initiated a nationwide lockdown to prevent the exponential surge of cases. During COVID-19, management of cardiovascular emergencies like acute Myocardial Infarction (MI) may be compromised. Cardiological Society of India (CSI) has ventured in this moment of crisis to evolve a consensus document for care of acute MI. However, this care should be individualized, based on local expertise and governmental advisories.


Subject(s)
Communicable Disease Control/organization & administration , Coronavirus Infections/prevention & control , Myocardial Infarction/therapy , Outcome Assessment, Health Care , Pandemics/prevention & control , Pneumonia, Viral/prevention & control , Practice Guidelines as Topic/standards , COVID-19 , Cardiology , Coronavirus Infections/epidemiology , Disease Management , Female , Humans , India , Male , Myocardial Infarction/diagnosis , Pandemics/statistics & numerical data , Patient Selection , Pneumonia, Viral/epidemiology , Societies, Medical/organization & administration , Treatment Outcome
SELECTION OF CITATIONS
SEARCH DETAIL