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Sci Adv ; 6(24): eaba8399, 2020 06.
Article in English | MEDLINE | ID: covidwho-617060

ABSTRACT

Developing a vaccine to protect against the lethal effects of the many strains of coronavirus is critical given the current global pandemic. For Middle East respiratory syndrome coronavirus (MERS-CoV), we show that rhesus macaques seroconverted rapidly after a single intramuscular vaccination with ChAdOx1 MERS. The vaccine protected against respiratory injury and pneumonia and reduced viral load in lung tissue by several orders of magnitude. MERS-CoV replication in type I and II pneumocytes of ChAdOx1 MERS-vaccinated animals was absent. A prime-boost regimen of ChAdOx1 MERS boosted antibody titers, and viral replication was completely absent from the respiratory tract tissue of these rhesus macaques. We also found that antibodies elicited by ChAdOx1 MERS in rhesus macaques neutralized six different MERS-CoV strains. Transgenic human dipeptidyl peptidase 4 mice vaccinated with ChAdOx1 MERS were completely protected against disease and lethality for all different MERS-CoV strains. The data support further clinical development of ChAdOx1 MERS.


Subject(s)
Immunogenicity, Vaccine/immunology , Middle East Respiratory Syndrome Coronavirus/immunology , Vaccination , Viral Vaccines/administration & dosage , Viral Vaccines/therapeutic use , Animals , Antibodies, Neutralizing/blood , Antibodies, Neutralizing/immunology , Antibodies, Viral/blood , Antibodies, Viral/immunology , Coronavirus Infections/immunology , Coronavirus Infections/prevention & control , Dipeptidyl Peptidase 4/genetics , Female , Humans , Injections, Intramuscular , Macaca mulatta , Male , Mice , Mice, Transgenic , Pneumonia, Viral/prevention & control , Severity of Illness Index , Treatment Outcome , Vaccines, DNA , Viral Vaccines/immunology , Virus Replication/immunology
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