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Frontiers in Marine Science ; 9:7, 2022.
Article in English | Web of Science | ID: covidwho-1822365


The COVID-19 pandemic introduced many challenges for research scientists: reduction of lab and field observation collection and in-person meetings. These new constraints forced researchers to remote work and virtual networking, dramatically influencing scientific inquiry. Such challenges are compounded for those in early stages of their career, where data collection and networking are vital to be seen as productive. However, during this trying time of remote work, we, as a collective of early-career oceanographers, were actively developing and improving on an already-existent hybrid community of practice. Through our experiences, we believe this type of framework can enhance virtual collaboration to the point that it outlasts the pandemic and helps create new synergies that will diversify and enhance scientific inquiry within the ocean science community. We describe a hybrid community of practice and an example workflow that models effective collaboration. We have found that three components to this model are necessary for effective collaboration, inspiration, and communication: 1) openly accessible data, 2) software, computational, and professional-development resources, and 3) a team science approach. In our experience, both the in-person and remote aspects of the model are important. In person collaboration is key to expanding the community of practice and invigorating those already within the community. Remote collaboration has been critical for effective collaborations between in-person activities and has proven to maximize outputs during in-person collaborations. While the three components of this model are not new to the scientific community, we believe that utilizing them strategically post-pandemic will diversify and expand scientific collaboration in oceanography.

Non-conventional in English | National Technical Information Service, Grey literature | ID: grc-753589


The novel COVID-19 infection has demonstrated a spectrum of complications involving vascular, inflammatory, infectious, and metabolic conditions. These complications range from mild loss of smell to more severe acute respiratory distress syndrome (ARDS). Patients with more severe complications often require sedation and mechanical ventilation. Growing research has revealed the role of active malignancy and disease-in-remission status as possible risk factors contributing to the morbidity and mortality inCOVID-19 patients. In our descriptive case series, we present three unique cases of complicated COVID-19 infection in patients with hematologic-oncologic risk factors and review the imaging features of their complications. The first patient was a 33-year-old male with sickle cell trait who developed rhabdomyolysis and myonecrosis of the paraspinal muscle in the setting of a physical fitness test;he subsequently developed an abscess at this site, presumably exacerbated by the hypoxemic state of his COVID-19 pneumonia. Our second patient was a 37-year-old male with COVID-19 pneumonia and a history of stage IV Non-Hodgkin's lymphoma in remission who developed spontaneous pneumomediastinum in the absence of positive pressure ventilation. The third COVID-positive patient was a 54-year-old male with a past medical history significant for grade 1 follicular non-Hodgkin's lymphoma in remission with sputum culture positive for mycobacterium avium complex and bronchoscopy positive for candida growth. 18-FDG/PET imaging was performed and demonstrated diffuse intense uptake throughout the lungs reflecting both the COVID-19pneumonia and the multimicrobial superinfection.

Cancers (Basel) ; 13(18)2021 Sep 16.
Article in English | MEDLINE | ID: covidwho-1448842


In human and mouse, alternative splicing of tissue factor's primary transcript yields two mRNA species: one features all six TF exons and encodes full-length tissue factor (flTF), and the other lacks exon 5 and encodes alternatively spliced tissue factor (asTF). flTF, which is oftentimes referred to as "TF", is an integral membrane glycoprotein due to the presence of an alpha-helical domain in its C-terminus, while asTF is soluble due to the frameshift resulting from the joining of exon 4 directly to exon 6. In this review, we focus on asTF-the more recently discovered isoform of TF that appears to significantly contribute to the pathobiology of several solid malignancies. There is currently a consensus in the field that asTF, while dispensable to normal hemostasis, can activate a subset of integrins on benign and malignant cells and promote outside-in signaling eliciting angiogenesis; cancer cell proliferation, migration, and invasion; and monocyte recruitment. We provide a general overview of the pioneering, as well as more recent, asTF research; discuss the current concepts of how asTF contributes to cancer progression; and open a conversation about the emerging utility of asTF as a biomarker and a therapeutic target.

American Journal of Gastroenterology ; 115:S632-S633, 2020.
Article in English | Web of Science | ID: covidwho-1070171