Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 9 de 9
Filter
1.
Salud Uninorte ; 38(2):386-401, 2022.
Article in Spanish | Scopus | ID: covidwho-2025685

ABSTRACT

Introduction: The COVID-19 pandemic has had a negative impact on global health, and Colombia and, specifically, the Valle del Cauca Department are no exception, making it necessary to implement, throughout the country, various monitoring and analysis systems of the virus, which continue to this date. Within the framework of this need, the present investigation is proposed, with the aim of estimating the excess mortality from all causes in the department, and compare it with the mortality burden of the virus. Methodology: A cross-sectional observational study of excess mortality from all causes was carried out for Valle del Cauca in 2020, using official non-fetal deaths from DANE (Na-tional Administrative Department of Statistics), calculating the excess mortality observed compared to the expected one, using projections from the linear regression. Results: an excess of mortality from all causes of 18.3% was found for 2020, the increase being greater in men and the population aged 45 and over. Conclusions: The excess mortality from all causes observed in 2020 is not explained by the spread of the pandemic, given that the volume of deaths observed exceeds by more than 700 cases the mortality expected according to historical behavior 2015-2019, showing a significant volume of under-records of mortality due to COVID-19 or explained by indirect causes of the virus. © 2022, Universidad del Norte. All rights reserved.

2.
Urology Practice ; 8(6):668-674, 2021.
Article in English | Web of Science | ID: covidwho-1713815

ABSTRACT

Introduction: The COVID-19 pandemic starkly affected all aspects of health care, forcing many to divert resources towards emergent patient needs while decreasing emphasis on routine cancer care. We compared prostate cancer care before and during the pandemic in a multi-institutional cohort. Methods: A prospective regional collaborative was queried to assess practice pattern variations relative to the initial COVID-19 lockdown (March 16 to May 15, 2020). The preceding 10 months were selected for comparison. The impact of the lockdown was evaluated on the basis of 1) weekly trends in biopsy and radical prostatectomy volumes, 2) comparisons between those undergoing prostate biopsy, and 3) clinicopathological characteristics within radical prostatectomy patients. Categorical variables were compared using Fisher's exact and Pearson's chi-square tests, and Wilcoxon rank sum test to evaluate continuous covariates. Results: Overall, there was a 55% and 39% decline in biopsy and prostatectomy volumes, respectively. During the pandemic, biopsy patients were younger with fewer COVID-19 severity risk factors (17.0% vs 9.7% no risk factors, p=0.023) and prostatectomy patients had higher grade group (GG;45.6% >GG 4 vs 28%, p=0.01). Large variation in the change in procedural volume was noted across practice sites. Conclusion: In a multi-institutional assessment of surgical and diagnostic delay for prostate cancer, we found a non-uniform decline in procedural volume across sites. Future analyses within this cohort are needed to further discern the effects of care delays related to COVID-19.

5.
Journal of Urology ; 206(SUPPL 3):e43, 2021.
Article in English | EMBASE | ID: covidwho-1483584

ABSTRACT

INTRODUCTION AND OBJECTIVE: Minority communities disproportionately shouldered poor COVID-19 outcomes, however the impact of the pandemic on prostate cancer (PCa) surgery is unknown. To that end, we sought to determine the racial impact on PCa care during the first wave of the pandemic. METHODS: Using a multi-institutional collaborative we evaluated practice patterns for Black and White patients with untreated non-metastatic PCa during the initial COVID-19 lockdown (March-May 2020) compared to prior (March-May 2019). Patient and practice characteristics were compared by race using Fisher's exact and Pearson's chi-square to compare categorical variables and Wilcoxon rank sum to evaluate continuous covariates. We determined the covariate-adjusted impact of year and race on surgery, using logistic regression models with a race year interaction term. RESULTS: Among the 647 men with non-metastatic PCa, 269 received care during the pandemic and 378 prior. Surgery was significantly less likely in Black men (1.3% v 25.9%;p<0.001), despite similar COVID-19 risk factors, biopsy Gleason grade group, and comparable surgery rates prior (17.7% vs. 19.1%;p=0.75). Black men had higher PSA (8.8 vs. 7.2 p=0.04) and were younger (38.2% vs. 24.4% <60 yr;p=0.09). Regression results demonstrated an 94% reduced odds of surgery (OR=0.06, 95% CI 0.007-0.43;p=0.006) for Black patients, with no change for White patients (OR=1.41, 95% CI 0.89-2.21;p=0.142), after adjusting for covariates. Changes in surgical volume varied by site (33% increase to complete shutdown), with sites that experienced the largest reduction in cancer surgery, caring for a greater proportion of Black patients (figure). CONCLUSIONS: In a large multi-institutional regional collaborative, odds of prostatectomy declined only among Black patients during the initial wave of the COVID-19 pandemic. While localized prostate cancer does not require immediate treatment, this study illuminates systemic inequities within healthcare. Public health efforts are needed to fully recognize the unintended consequence of diversion of cancer resources to the pandemic in order to develop balanced mitigation strategies as viral rates continue to fluctuate.

7.
2021 IEEE Global Engineering Education Conference, EDUCON 2021 ; 2021-April:530-536, 2021.
Article in English | Scopus | ID: covidwho-1367177

ABSTRACT

Digital education has reached enormous advances and acceptance in the last decade. COVID 19 has triggered a boom in the digital education implementation. Those courses that never had been delivered in a digital format, suddenly were forced to be prepared and presented as digital education. The nature of different courses might facilitate this new reality, depending if they are theoretical, numerical or mixed. This paper has evaluated a set of characteristics deployed in different engineering courses transformed into digital courses, depending on its nature. On the other hand, this analysis had a focus on the women participation in engineering courses and their evaluations of such digital course's characteristics. The main purpose of the present paper is to answer the question of what characteristics within the course methodology design, works and are evaluated better by students. A survey was designed and applied to the 87% of the Industrial and Systems Engineering program population in Tecnologico de Monterrey, Sonora Mexico. Data was statistically analyzed to find if there were any difference between female and male opinions about the course characteristics and within each gender in each kind of course. Also, a correlation analysis was made to identify how the elements influenced each other and if they should be combined depending on the desired result. An additional analysis took place to identify the level of participation of female and male students before and during pandemic time. Findings reveal interesting coincidences and differences in evaluating some of those digital course's characteristics depending on the gender of students and course nature, such as women participation and the differences in perception of competitiveness among women and men. Some of these findings are: 1) In mixed subjects, male students identify a higher academic environment that encourages more competitiveness than female students. 2) Another finding is that men seem to have greater motivation to attend class sessions in numerical subjects. 3) Among female students a negative correlation between the frequency of the instructor request of a final reflection analysis of the session with considering a competitiveness academic environment. 4) Talking about mixed courses, all female students evaluated with the highest score in the question about motivation to be present in the session and the identification of moments and activities that allowed them to share opinions. To reinforce women participation in Industrial and Systems Engineering digital courses, those identified characteristics shall be included and developed in the course methodology design. © 2021 IEEE.

8.
Journal of Clinical Oncology ; 39(15 SUPPL), 2021.
Article in English | EMBASE | ID: covidwho-1339359

ABSTRACT

Background: Minority communities have been disproportionately affected by COVID-19, however the impact of the pandemic on prostate cancer (PCa) treatment is unknown. To that end, we sought to determine the racial impact on PCa surgery during the first wave of the COVID-19 pandemic. Methods: After receiving institutional review board approval, the Pennsylvania Urologic Regional Collaborative (PURC) database was queried to evaluate practice patterns for Black and White patients with untreated non-metastatic PCa during the initial lockdown of the COVID-19 pandemic (March-May 2020) compared to prior (March-May 2019). PURC is a prospective collaborative, which includes private practice and academic institutions within both urban and rural settings including regional safety-net hospitals. As data entry was likely impacted by the pandemic, we limited our search to only practices that had data entered through June 1, 2020 (5 practice sites). We compared patient and disease characteristics by race using Fisher's exact and Pearson's chi-square to compare categorical variables and Wilcoxon rank sum to evaluate continuous covariates. Patients were stratified by risk factors for severe COVID-19 infection as described by the CDC. We determined the covariate-adjusted impact of year and race on surgery, using logistic regression models with a race∗year interaction term. Results: 647 men with untreated nonmetastatic PCa were identified, 269 during the pandemic and 378 from the year prior. During the pandemic, Black men were significantly less likely to undergo prostatectomy compared to White patients (1.3% v 25.9%;p < 0.001), despite similar COVID-19 risk-factors, biopsy Gleason grade group, and comparable surgery rates prior (17.7% vs. 19.1%;p = 0.75). White men had lower pre-biopsy PSA (7.2 vs. 8.8 vs. p = 0.04) and were older (24.4% vs. 38.2% < 60yr;p = 0.09). The regression model demonstrated an 94% decline in odds of surgery(OR = 0.06 95%CI 0.007-0.43;p = 0.006) for Black patients and increase odds of surgery for White patients (OR = 1.41 95%CI 0.89-2.21;p = 0.142), after adjusting for covariates. Changes in surgical volume varied by site (33% increase to complete shutdown), with sites that experienced the largest reduction in cancer surgery, caring for a greater proportion of Black patients. Conclusions: In a large multi-institutional regional collaborative, odds of PCa surgery declined only among Black patients during the initial wave of the COVID-19 pandemic. While localized prostate cancer does not require immediate treatment, the lessons from this study illuminate systemic inequities within healthcare, likely applicable across oncology. Public health efforts are needed to fully recognize the unintended consequence of diversion of cancer resources to the pandemic in order to develop balanced mitigation strategies as viral rates continue to fluctuate.

9.
Cytotherapy (Elsevier Inc.) ; 23:38-39, 2021.
Article in English | Academic Search Complete | ID: covidwho-1193379

ABSTRACT

Currently, there is no specific treatment for coronavirus disease, and some drugs and cell-based therapy have been tested as alternatives. This work aims to evaluate the effects of the combined use of humanized recombinant monoclonal antibody capable of binding the IL-6 receptor (Tocilizumab), and umbilical cord tissue-derived mesenchymal stromal cells (UCT-MSC) in the treatment of a patient with severe COVID-19 admitted to the intensive care unit (IUC) and submitted to mechanical ventilation. This study is part of a project approved by the National Research Ethics Commission (CONEP);CAAE: 30833820.8.0000.0020. The patient had a diagnostic criterion for the severe acute respiratory syndrome resulting from infection with SARS-CoV-2 and received two 400 mg doses of tocilizumab, three infusions of 500,000 CTM / kg plus full anticoagulation. TCU-MSC were obtained from healthy donors. The following parameters were evaluated in the pre-infusion of cells (D1), on the day following each infusion (D2, D4, and D6), on the 14th and 60th day after the first infusion (D14 and D60): viral load, immune response (Regulatory T lymphocytes), C-reactive protein level in plasma, oxygen saturation, respiratory rate, total lymphocyte count and subpopulations (platelets, inflammatory cells, and reticulocytes), TGO / TGP, increased prothrombin time, D-dimer, creatinine, troponin. The relative viral quantification decreased gradually from 1 (D1) to 0.06 (D6) RdRP / RNApol, undetectable in D14. An increase in the absolute number of total lymphocytes / µL has also been seen to have progressively increased from 281 (D1) to 954.9 (D6) and since then decreased to 641.6 in D60 in the same way as T lymphocytes 148.6 (D1) 642.6 (D6) 607.4 (D14) 485.7 (D60), CD4 T lymphocytes, 102 (D1) 481.2 (D6) 459.5 (D14) 358 (D60) and Treg lymphocytes 10.8 (D1) 34 (D6) 29.8 (D14), 25.9 (D60). Plasmablasts, in contrast, decreased from 52 (D1) to 4.5 (D6) to almost undetectable in D60 (0.2). Laboratory tests outside the reference values decreased during the follow-up from D1 to D14 were within the normal parameters at D60. The patient was extubated uneventfully on D6, discharged from the ICU on D10, and the hospital on D14. the combined use of tocilizumab and MSC is safe, without adverse effects, and the results of this case report prove to be a promising alternative in the treatment of patients with severe acute respiratory syndrome due to SARS-CoV-2. [ABSTRACT FROM AUTHOR] Copyright of Cytotherapy (Elsevier Inc.) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

SELECTION OF CITATIONS
SEARCH DETAIL