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Clinical Chemistry and Laboratory Medicine ; 58(7):1081-1088, 2020.
Article | WHO COVID | ID: covidwho-937249

ABSTRACT

Background: Coronavirus disease 2019, abbreviated to COVID-19, represents an emerging health threat worldwide as, after initial reports in China, it has continued to spread rapidly The clinical spectrum of the disease varies from mild to severe acute respiratory distress syndrome (ARDS) Moreover, many patients can be asymptomatic, thus increasing the uncertainty of the diagnostic work-up Laboratory tests play a pivotal role in the diagnosis and management of COVID-19, the current gold standard being real-time reverse transcription polymerase chain reaction (rRT-PCR) on respiratory tract specimens However, the diagnostic accuracy of rRT-PCR depends on many pre-analytical and analytical variables The measurement of specific COVID-19 antibodies (both IgG and IgM) should serve as an additional, non-invasive tool for disease detection and management

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