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American Journal of Respiratory and Critical Care Medicine ; 205:2, 2022.
Article in English | English Web of Science | ID: covidwho-1880122
Revista Mexicana de Angiologia ; 48(2):35-37, 2020.
Article in English | EMBASE | ID: covidwho-1737535


The development of coagulopathy is emerging as one of the most significant poor prognostic features in coronavirus disease (COVID)-19 pneumopathy. D-dimer, a protein product of fibrin degradation, has been found elevated in the most severe cases and correlated to mortality. Potentially involved factors in the impairment of coagulation caused by viral infection include the dysregulated inflammatory response, platelet, and endothelial dysfunction with impaired fibrinolysis. Heparin is an anticoagulant molecule that also showed anti-inflammatory properties and a potential antiviral effect. The use of low-molecular-weight heparin could prevent thromboembolic complications in COVID-19 pneumopathy. However, the correct timing of prophylaxis according to the stage of COVID-19 disease and the appropriate therapeutic dosage to use in severe cases needs further researches.

Revista De Estudos Constitucionais Hermeneutica E Teoria Do Direito-Rechtd ; 12(3):382-396, 2020.
Article in English | Web of Science | ID: covidwho-1063444


The paper examines the complex, multidisciplinary and multidimensional scope of the coronavirus pandemic, focusing on its intertwined implications for international, supranational and domestic laws. The global reach of the phenomenon has highlighted limits and structural gaps at all levels of government in human society, raising questions to which rulers will have to give precise answers.