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1.
Yaoxue Xuebao ; 58(4):826-833, 2023.
Article in Chinese | EMBASE | ID: covidwho-20234481

ABSTRACT

Nucleic acids, as a next generation of biotechnology drugs, not only can fundamentally treat diseases, but also own significant platform characteristics in view of technology and production. Therefore, nucleic acid-based drugs have broad clinical applications in biomedical fields. However, nucleic acids are degradable and unstable, and have very low intracellular delivery efficiency in vitro and in vivo, which greatly limits their applications. In recent years, ionizable lipid-based lipid nanoparticles have shown promising application potentials and have been successfully applied to COVID-19 (Coronavirus Disease 2019) vaccines in clinic. Lipid nanoparticles demonstrate high in vivo delivery efficiency and good safety profile due to their unique structural and physicochemical properties, which provides many possibilities for their clinical applications for nucleic acid delivery in the future. This review focused on the characteristics of nucleic acid drugs and their delivery barriers, and discussed the approved nucleic acid drugs to illustrate the key aspects of the success of their delivery carrier system. In addition, problems to be solved in the field were highlighted.Copyright © 2023, Chinese Pharmaceutical Association. All rights reserved.

2.
Yaoxue Xuebao ; 58(4):826-833, 2023.
Article in Chinese | EMBASE | ID: covidwho-2322579

ABSTRACT

Nucleic acids, as a next generation of biotechnology drugs, not only can fundamentally treat diseases, but also own significant platform characteristics in view of technology and production. Therefore, nucleic acid-based drugs have broad clinical applications in biomedical fields. However, nucleic acids are degradable and unstable, and have very low intracellular delivery efficiency in vitro and in vivo, which greatly limits their applications. In recent years, ionizable lipid-based lipid nanoparticles have shown promising application potentials and have been successfully applied to COVID-19 (Coronavirus Disease 2019) vaccines in clinic. Lipid nanoparticles demonstrate high in vivo delivery efficiency and good safety profile due to their unique structural and physicochemical properties, which provides many possibilities for their clinical applications for nucleic acid delivery in the future. This review focused on the characteristics of nucleic acid drugs and their delivery barriers, and discussed the approved nucleic acid drugs to illustrate the key aspects of the success of their delivery carrier system. In addition, problems to be solved in the field were highlighted.Copyright © 2023, Chinese Pharmaceutical Association. All rights reserved.

3.
Chinese Traditional and Herbal Drugs ; 52(4):1063-1072, 2021.
Article in Chinese | EMBASE | ID: covidwho-1110718

ABSTRACT

Objective: Deep venous thrombosis is an important cause of death and poor prognosis in critically ill patients with COVID-19. This paper excavates the prescription rules of TCM in preventing and treating thrombosis, so as to provide reference for Chinese medicine in preventing and treating deep venous thrombosis in critically ill patients with COVID-19. Methods: Based on the journal literature collected from CNKI and Wan-fang database, excel 2010 and Clementine 12.0 software were used to analyze the association rules of the included standard traditional Chinese medicine, and analyze the enrichment of GO and KEGG in the core drug groups with the method of network pharmacology. The mechanism of action was studied and verified by molecular docking. Results: A total of 356 antithrombotic prescriptions were screened from CNKI and Wan-fang database, 25 high-frequency herbs were found, and seven high-frequency drug groups were obtained by further correlation analysis. Among them, there were 23 effective chemical components in the core drug group "Honghua (Carthami Flos)-Taoren (Persicae Semen)-Chishao (Paeoniae Radix Rubra)-Chuanxiong (Chuanxiong Rhizoma)", 41 intersection targets between core drug group and thrombus. PPI network mainly involved key target proteins such as IL6, VEGFA, CASP3, ALB, EGFR, MAPK8, etc. Go functional enrichment analysis revealed 971 biological process entries (P < 0.05), and 105 pathways (P < 0.05) were obtained from KEGG enrichment, which mainly involved Kaposi's sarcoma herpes virus infection, human cytomegalovirus infection, fluid shear force, atherosclerosis, hepatitis B and other pathways. The results showed that luteolin, quercetin and baicalein were the active components with better binding ability to IL-6. Conclusion: The key active components in the core drug group can play an antithrombotic role by regulating key targets such as IL-6, and by means of the pathways of Kaposi's sarcoma herpesvirus infection, human cytomegalovirus infection, fluid shear force, atherosclerosis, hepatitis B, etc., with view to providing a reference for the prevention and treatment of deep vein thrombosis in critically ill patients with COVID-19.

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