COVID-19 infection and vaccination in patients with hereditary angioedema: a multicentric study.

Summary: Background. Due to similarities between the pathophysiological mechanisms of hereditary angioedema (HAE) and COVID-19, it has been hypothesized that SARS-CoV-2 infection may trigger HAE attacks or, alternatively, that HAE patients may experience different of COVID-19 disease severity. Furthermore, the potential for COVID-19 vaccination to trigger angioedema attacks in patients with HAE is still not completely defined. The objective is to characterize the exacerbations and clinical manifestations associated with COVID-19 infection and describe the adverse effects of COVID-19 vaccination in patients with HAE.Methods. Retrospective observational, descriptive, non-interventional, multicenter study conducted in four Allergy Units and Departments in Central Portugal between March 2020 and July 2022. HAE patient data were obtained from electronic medical records. Results. The study included 34 patients (67.6% female): 26 with HAE type 1, 5 with HAE type 2, and 3 with HAE with normal C1 inhibitor. Most patients with HAE type 1 and 2 were receiving long-term prophylaxis. Among the 32 patients who received COVID-19 vaccination, 86 doses, were administered with one angioedema attack (1.2%) associated with vaccination. A small increase in the average number of attacks was observed in the year following COVID vaccination (7.1 versus 6.2 in the previous year, p = 0.029), however, this difference is unlikely to be clinically significant, as the context of the COVID-19 pandemic likely introduced numerous confounders. During the study period, 16 HAE patients had COVID-19, all presenting with mild disease. Four out of 16 patients (25%) reported angioedema attacks during COVID-19, and 43.8% during the convalescence period (3 months after infection). Conclusions. Patients with HAE can safely receive COVID-19 vaccination. The severity of COVID-19 infection does not appear to be increased in HAE patients.

History and Global Status of the New Coronavirus Covid-2019 and Aspects of Previous Infections of SARS-CoV and MERS-CoV: A Systematic Review

Introduction: Coronaviruses (CoV) is a diverse group of viruses that has been described in the literature since 1960, SARS, MERS, and the most recent SARS-CoV-2. This new virus is causing a worldwide pandemic outbreak in the first half of 2020, thousands of deaths, and a signifi-cant economic crisis. Objective(s): Due to this new context, the present study aimed to conduct a systematic study review of the new Coronavirus's global status (COVID-2019) and its aspects compared to the previous SARS-CoV infections MERS-CoV. Method(s): The study was conducted from January to September 2020, 89 clinical cases were sub-mitted to further analysis, and 77 studies were selected for systematic review under the PRISMA guidelines. Conclusion(s): In some countries, the SARS-CoV-2 pandemic appears to be out of control. In case of suspicion, tests are essential to identify the early stages of infection. If necessary, patients need to go into quarantine, and other public health measures should be taken following the World Health Organization guidelines. Advanced support is needed to identify and isolate infected patients, espe-cially vaccines and medicines that help control the virus and the epidemiological situation in each country. These measures are expected to reduce the rate of new cases of SARS-CoV-2.Copyright © 2021 Bentham Science Publishers.

Motivation contribution to religious learning behavior during the covid pandemic

The Indonesian Minister of Education designed the 2013 school curriculum (K13) to activate students’ learning behavior but there is low-intensity research in it. Hence, this study aims to explain the contribution of achievement, affiliation, power, and religious motivation to learning behavior in Islamic Religion that applies K13 during the pandemic in adolescent students. It employed a causal relationship-explanation design involving 201 samples selected through random stratification representing 795 student population aged 13-16 years, grades 7th, 8th, and 9th from 26 parallel classes. Data were collected through a five scales test for item validity ≥ 0.3 and Cronbach Alpha reliability by 0.6-0.904, and then analyzed via multiple regression. The results showed that the theoretical regression model was empirically fit (sig F (201) = 0.000 < 0.05). The contribution of the four predictor motivations in the model together was 72.9 percent on learning behavior. Achievement, affiliation, and religious motivation could contribute in increasing learning behavior, but power motivation demonstrated otherwise. Consequently, teachers need to guide adolescent students to increase achievement motivation, religion, and affiliation but reduce power motivation at an ideal level to improve student learning behavior. © 2022, author.

Racism and necropolitics: a debate between social theory and psychoanalysis

Taking Covid-19 Pandemic as a context and analyzer, this article discusses the historical links between racism and the medicalized management of the right to life and death in Brazil. It is based on the understanding that listening and clinical management of situations of psychological distress in the context of the medicalization of life (in Pandemic, and even outside it) necessarily imply making social criticism as well. To this end, we propose a debate that encapsulates clinical theory, the histories of social medicine and psychoanalysis in Brazil, and the concepts of bio and necropoli-tics. Our hypothesis is that if, on the one hand, on its arrival in Brazil, psychoanalysis was “co-opted” by a hygienist medical tradition (which for years polarized the way it was seen in our country), on the other, by its conceptual structure, by the initial counterpoint with Brazilian modernism, and by its current debate on segregation, this praxis can make explicit its anti-racist power and vocation. © 2020. All Rights Reserved.

Clinical Experience With Severe Acute Respiratory Syndrome Coronavirus 2-Related Illness in Children: Hospital Experience in Cape Town, South Africa.

BACKGROUND: Children seem relatively protected from serious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related disease, but little is known about children living in settings with high tuberculosis and human immunodeficiency virus (HIV) burden. This study reflects clinical data on South African children with SARS-CoV-2. METHODS: We collected clinical data of children aged <13 years with laboratory-confirmed SARS-CoV-2 presenting to Tygerberg Hospital, Cape Town, between 17 April and 24 July 2020. RESULTS: One hundred fifty-nine children (median age, 48.0 months [interquartile range {IQR}, 12.0-106.0 months]) were included. Hospitalized children (n = 62), with a median age of 13.5 months (IQR, 1.8-43.5 months) were younger than children not admitted (n = 97; median age, 81.0 months [IQR, 34.5-120.5 months]; P < .01.). Thirty-three of 159 (20.8%) children had preexisting medical conditions. Fifty-one of 62 (82.3%) hospitalized children were symptomatic; lower respiratory tract infection was diagnosed in 21 of 51 (41.2%) children, and in 11 of 16 (68.8%) children <3 months of age. Respiratory support was required in 25 of 51 (49.0%) children; 13 of these (52.0%) were <3 months of age. One child was HIV infected and 11 of 51 (21.2%) were HIV exposed but uninfected, and 7 of 51 (13.7%) children had a recent or new diagnosis of tuberculosis. CONCLUSIONS: Children <1 year of age hospitalized with SARS-CoV-2 in Cape Town frequently required respiratory support. Access to oxygen may be limited in some low- and middle-income countries, which could potentially drive morbidity and mortality. HIV infection was uncommon but a relationship between HIV exposure, tuberculosis, and SARS-CoV-2 should be explored.

High level of infection by toxoplasma gondii in pigs slaughtered in the city of são luís, maranhão

The article presents an exploratory, descriptive study on Bad News Communication skills (CMN) of medical interns. The student’s perception was on learning for the CMN was investigated with a cross-sectional design and a mixed approach. A questionnaire was applied, 176 participants were obtained, and a focus group was held with 12 students. The data were analyzed through the calculation of means and standard deviations for quantitative variables and the focus group reports were subjected to Content Analysis. It was observed that in the group that had training, compared to the one who did not, ocurred twice frequency with more skill for CMN. In the CMN’s management, it was considered harder to be “honest without taking away hope” (69%) and “to deal with the patient’s emotion” (59%). 99.4% knew the SPIKES protocol, of which 41.5% considered the expression of emotions as its most difficult stage. Communication and handling of emotions were pointed out as the main difficulties in the doctorpatient relationship, with deficits in the teaching of CMN. It was found that CMN is not limited to the technical issue, but it involves attitudes that need to be addressed with different methodologies, as well as the implementation of educational policies in the medical field, especially given the demands that emerges with the covid-19 pandemic. © 2021, Brazilain Coll Veterinary Parasitology. All rights reserved.

Occupational therapy telehealth groups in Covid-19 pandemic: perspectives from a Mental Health Day Hospital

COVID-19 pandemic had a serious occupational impact on people with preexisting mental disorders. To deliver care in this context, telehealth groups were a therapeutic option for occupational therapists for mental health care. This paper presents an occupational therapy experience with telehealth groups in Brazil, sustained by the Dynamic Occupational Therapy Method, seeking to discuss the use of technology during the COVID-19 outbreak, the limits and potential of occupational therapy in the face of the necessary change in work with groups. The paper is a critical analysis of practice sustained by a practice-based evidence perspective through a collaborative partnership between practitioners and academics from Brazil and the UK. Practitioners reflected on their professional skills in an online context, highlighting their initial concerns and their discoveries within this new practice scenario. The delivery of telehealth groupwork in occupational therapy in mental health practice requires multiple digital tools, and the occupational therapist needs to understand digital inequity issues (digital access or skills), be digitally upskilled to meet client needs, and also be guided by clear occupational therapy theoretical and methodological frameworks that underpin telehealth practices.

PHYSICAL EDUCATION REMOTE TEACHING IN NARRATIVE: ON THE RUPTURES AND LEARNING IN EXPERIENCES WITH TECHNOLOGY

Literature has focused on the co-evolutionary understanding between technology and education, highlighting the teacher as a key player in this process. The objective of the text is to problematize the pedagogical experience of a Physical Education teacher from the state education network during the Covid-19 pandemic, under the lens of neotechnicism and emerging literacies. A qualitative methodology was adopted based on narrative studies, pedagogical cases and their contributions to teacher training. As a result, it was noticed the feeling of incompetence to deal with digital platforms, the support of a peer collaboration network, the urgency of "how to use technological tools" and, in the background, "what to teach". Finally, it is considered that thinking about remote Physical Education teaching in the pandemic is more than thinking about technology, but rather it is reflecting on how the teacher is formed by experience and the possibilities of modifying the perception of Physical Education classes in this context.