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Journal of Clinical Rheumatology ; 27(SUPPL 1):S19, 2021.
Article in English | EMBASE | ID: covidwho-1368233


Objectives: To determine the main risk factors associated with COVID-19 in SLE patients. Methods: The Reuma CoV Brazil is a multicenter, observational, prospective cohort designed to monitor immune-mediated rheumatic diseases patients during SARS-CoV-2 pandemic in Brazil. SLE adult patients according to SLE SLICC criteria classification (2012), with and without (control group-CG) COVID-19 diagnosis were matched. Demographic data, managing of COVID-19, comorbidities, clinical characteristics (disease activity: Patient Report Outcomes-PROs, Physician Global Assessment and SLEDAI-2 K)were collected. Results: From May 2020 to January 2021, 604 SLE patients were included, 317 (52.4%) with COVID-19 and 287 (47.6%) in the CG. Both groups were homogeneous and comparable regarding sex and comorbidities. SLE patients with COVID-19 declared a lower level of social isolation (49.5% vs. 61.9%;p = 0.002), worked more commonly in health professions (10.4% vs. 3.5%;p = 0.002), presented more frequently joint (32.5% vs. 22.0%;p = 0.004) and hematological manifestations (18.0% vs. 11.5%;p = 0.025). SLEDAI-2 K did not differ among groups prior and after COVID-19 infection. However, considering the mean duration of COVID-19 symptoms (12.1 ± 8.8 days), infected patients had more severe disease activity's PROs after resolution of COVID-19 symptoms (2.9 ± 2.9 vs. 2.3 ± 2.6;p = 0.031). The hospitalization rate was 20.5% (n = 65), of whom 23 (7.2%) needed intensive care unit and 14 (4.4%) patients died. Hypertension [5,26 (1,9714,07);p = 0.001] and recently cyclophosphamide pulses [39,21 (4,17-368,53);p = 0.001] were associated with hospitalization and patients who received telemedicine medical care presented 72% less chance of hospitalization [0.28 (0.09-0.83);p = 0.023). Conclusion: COVID-19 was associated with a lower level of declared social isolation and more severe disease activity perception after SARS-CoV-2 infection according to PROs. Hypertension and cyclophosphamide were associated with hospitalization and telemedicine can be a useful tool for SLE patients with COVID-19. These data should be considered to perform public health policy and national guidelines to manage SLE patients during the pandemic, as well as to prioritize some special groups for the immunization program.

Journal of Clinical Rheumatology ; 27(SUPPL 1):S114, 2021.
Article in English | EMBASE | ID: covidwho-1368218


Objectives: The engagement of undergraduate medical students (MS) in clinical research may lead to improvement in scientific method critical analysis, better performance as young physicians, awareness of innovation, and the development of leadership skills and teamwork perspectives (1). This study evaluated changings in daily routine and the awareness of patients' realities reported by MS participating on a research project involving rheumatic patients in Brazil during the COVID-19 pandemic. Methods: A secondary analysis of a web-based cross-sectional survey (2) including MS participating of Mário Pinotti II study (MPII) (3) was performed. Demographic characterization and the description of the MS impressions of the impact of participating of MPII are reported. Results: A total of 228 (58%) MS involved in MPII responded to the survey: 151 (66%) were women with (Mean(SD)) 22.8 (2.8) years of age, most were studying in public (N = 135 (59%)) medical schools, from 10 Brazilian states. Figures 1 and 2 summarizeMS' reports on the impact of participating of MPII on their daily routine and increased awareness of patient's realities. Conclusion: MS participating on the MPII study reported a better understanding of rheumatic patients' fears and uncertainties during the COVID-19 pandemic, including hydroxychloroquine shortage, lack of medical appointments and an unmet need related to more adequate information addressed to the rheumatic diseases. Furthermore, the close interaction among rheumatic patients, faculty, rheumatologists, and otherMShave provided a significant improvement in their feelings of usefulness during the pandemic and could contribute to their future professional activities.