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Cardiology in the Young ; 32(Supplement 2):S103, 2022.
Article in English | EMBASE | ID: covidwho-2062128


Background and Aim: Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) is a postim-munological reaction after SARS-CoV-2 infection. Various car-diac manifestations of PIMS-TS have been reported, namely pericardial effusion, ventricular arrhythmia, myocarditis, valvular regurgitation, and pericarditis. The aim of this study was to analyze clinical and laboratory features to distinguish any possible predic-tion for cardiac involvement in children with PIMS. Method(s): The PIMS patients under 18 years old treated in our center between July 2020 and December 2021 were included. Data of the patients were retrospectively obtained from their medical records. Result(s): A total of 46 patients with PIMS were examined during the study period. The mean age of study group was 9.4 +/- 4.6 years, 18/46 were female and 3 groups were formed according to their age ranges. Among them, seventeen patients (37%) had cardiac involvement with mean age was 8.7 years. Impaired cardiac func-tions were seen more in male patients (n: 10/17). Coronary artery dilatation seen in seven patients especially with mean age of 5.2 years (Age group 1,2,3;%36.4,%14.3,%0;p = 0.033;respectively) and especially related to high troponin T levels (p = 0.006). In our study group, cardiac involvement was shown more related to ProBNP and Troponin T (p = 0.008;p = 0.003). The cut-off val-ues of proBNP and troponin T for predicting in cardiac dysfunc-tion were 2759 pg/mL (95% confidence interval (CI), 0,83-1;sensitivity, 0.86;specificity, 0.93;AUC:0.92, p lt;0,001). Conclusion(s): Although there is a wide variability of symptoms, MIS-C is a rare, severe, less understood complication of COVID-19 that may cause multisystemic involvement in the patients. Clinicians should be aware of this condition in children with persistent fever and a family history of COVID-19. Cardiac involvement in chil-dren with PIMS may strongly be predicted by levels of Troponin T and ProBNP. Further more younger age and high Troponin T levels are the independent predictors for the coronary artery dila-tation among children with PIMS.

Cardiology in the Young ; 32(Supplement 2):S229, 2022.
Article in English | EMBASE | ID: covidwho-2062111


Background and Aim: Chest pain is a one of the most common com-plaints in children admitted to the Hospitals. Although it was among the most common reasons for referral to the pediatric car-diologist before COVID-19 era, this tendency is changed during covid pandemic. The primary objective of this study was to inves-tigate the aetiological causes, clinical characteristics and the follow up symptoms in terms of changing habits of parents and children admitted to the ED for acute chest pain during pandemic. Method(s): We reviewed the medical records of children under the age of 18 who presented with chest pain as the chief complaint from 1 January 2020 to 1 April 2021, at Istanbul University-Cerrahpasa Pediatric Emergency Clinic retrospectively from the hospital data-base. The study population comprised 128 boys and 119 girls. Result(s): All the children underwent ECG examination. While the ECG results of 239 children were normal, 6 sinus tachycardia, 1 supra-ventricular tachycardia and 1 incomplete left bundle branch block were observed. 33 patients had an echocardiography. Eight patients with an abnormal Echo result already had been examined and diag-nosed prior to their emergency admission. Blood samples were taken from 48 children for troponin. 17 samples wereabove the cut-off value which was set to 0.004 g/dl A total of 32 SARS-Cov2 swab samples were taken from suspicious cases and analyzed with RT-PCR. Consequently, 8 of these children were Covid-19 positive. 7 patients had no history of chronic disease, while 1 patient had ALL. All of these patients had mild symptoms and none of them required hospitali-zation. The total number of children who were referred to a pediatric cardiologist for a further examination together with the follow-up patients of the pediatric cardiology department is 52 Conclusion(s): In conclusion, Chest pain is a common referral com-plaint in children and is rarely due to cardiac diseases. To date car-diac reasons of chest pain was the major concern of patients and families attending the ED. However we found that Patient/family concerns regarding 'vulnerability to the severe covid infection has emerged as an important discourse during the pandemic on attend-ences to ED because of chest pain.