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1.
Nephrology Dialysis Transplantation ; 37(SUPPL 3):i102-i103, 2022.
Article in English | EMBASE | ID: covidwho-1915669

ABSTRACT

BACKGROUND AND AIMS: Haemodialysis (HD) patients are at increased risk for adverse short-term consequences of COVID-19. In this study, we investigated the characteristics of chronic HD patients in the post-COVID-19 period and compared them with the control group. METHOD: We conducted a national multicentre observational study involving adult chronic HD patients recovering from COVID-19. The control HD group was selected from patients with similar characteristics who did not have COVID-19 in the same center. SARS-CoV-2 RT-PCR negative patients and patients in the active period of COVID-19 were not included. RESULTS: A total of 1223 patients (635 COVID-19 groups, 588 control groups) were included in the study from the data collected from 47 centres between 21 April 2021 and 11 June 2021. The patients' baseline demographics, comorbidities, medications, HD characteristics and basic laboratory tests were quite similar between the groups (Table 1). 28th-day mortality and between 28th day and 90th day mortality were higher in the COVID-19 group than in the control group [19 (3.0%) patients and 0 (0%) patients;15 (2.4%) patients and 4 (0.7%) patients, respectively]. Presence of respiratory symptoms, rehospitalization, need for home oxygen therapy, lower respiratory tract infection and A-V fistula thrombosis were significantly higher in the COVID-19 group in the first 28 days of illness and between 28 and 90 days. Mortality was significantly associated with preexisting COVID-19, age, current smoking, use of tunneled HD catheter, persistence of respiratory symptoms, rehospitalization, need for home oxygen support, presence of lower respiratory tract infection within 28 days and persistence of respiratory symptoms. CONCLUSION: In the post-COVID-19 period, mortality, rehospitalization, respiratory problems and vascular access problems are higher in maintenance HD patients who have had COVID-19 compared to control HD patients. (Table Presented).

2.
European Journal of Preventive Cardiology ; 29(SUPPL 1):i246-i247, 2022.
Article in English | EMBASE | ID: covidwho-1915585

ABSTRACT

Background: Although there is not enough data on pneumococcal vaccination status in patients with cardiovascular disease and or risk factors in our country, it is known that vaccination rates are quite low in the current data. Purpose: We aimed to evaluate the awareness of pneumococcal vaccination (PCV13, PPSV23) in general cardiology outpatient clinics and impact of physician's recommendation (with educational brochures) on vaccination rate. Methods: Awareness of vaccination, before COVID-19 pandemic, was measured in patients admitting to cardiology outpatient clinics from 40 center of our country by a questionnaire contained 19 questions. The demographics (including gender, age, educational level, awareness vaccination level) and comorbidities were obtained. The vaccination rates were calculated within 3-months follow-up from the admitting of patient to cardiology clinics. Results: The 403 (18.2%) of patients with previous pneumococcal vaccination were excluded from the study. The mean age of study population (n=1808) was 61.9±12.1 years and 55.4% were male. The 58.7% had coronary artery disease, hypertension (74.1%) was the most common risk factor and 32.7% of the patients had never been vaccinated although they had information about vaccination before. The 98.5% were referred to family medicine (n=1412, 78.1%) or vaccination outpatient clinics (n=370, 20.5%) and the vaccination rate was 62.1% during the follow-up period. The differences between vaccinated and not-vaccinated patients are presented in Table 1. The physician's recommendation was positively correlated with vaccination intention and behavior in our participants. Multivariate logistic regression analysis showed a significant between vaccination and female sex [OR=1.55 (95% CI=1.25-1.92), p<0.001], higher education level [OR=1.49 (95% CI=1.15-1.92), p=0.002] patients' knowledge [OR=1.93 (95% CI=1.56-2.40), p<0.001], and their physician's recommendation [OR=5.12 (95% CI=1.92-13.68), p=0.001]. Conclusion: To our knowledge this is the first report about the awareness pneumococcal vaccination rates and impact of physician's recommendation in patients with cardiovascular disease by high study population. These findings suggest providing information on the benefits of vaccination by physician's and educational advice was significantly associated with an increase vaccination rate and have a key role. (Table Presented).

3.
University of Toronto Medical Journal ; 99(2):53-59, 2022.
Article in English | Scopus | ID: covidwho-1857156

ABSTRACT

Coronavirus disease 2019 (COVID-19) could emerge not only as viral pneumonia but also as a cardiovascular disease. Thromboprophylaxis has been recommended by the current guidelines, especially COVID-19 patients who are hospitalized. On the other hand, these drugs might cause serious bleeding complications. Hereby, we aimed to report three cases with spontaneous rectus sheath hematoma (RSH) developed after being administered thromboprophylaxis for severe COVID-19 pneumonia. In this case series, we draw attention to the rare, but mortal complication of the COVID-19 thromboprophylaxis regimen. © 2022, University of Toronto. All rights reserved.

4.
International Journal of the Cardiovascular Academy ; 8(1):20-23, 2022.
Article in English | EMBASE | ID: covidwho-1792242

ABSTRACT

Introduction: Patients receiving anticoagulant therapy experience a serious problem at a time when the rates of outpatient visits for the international normalized ratio (INR) monitoring are gradually decreasing owing to the risk of virus transmission during the pandemic. The aim of this multicenter study was to investigate how the coronavirus disease 2019 pandemic affected the time in therapeutic range (TTR) value, which shows the use of effective doses of warfarin, and its monitoring in patients using warfarin. Materials and Methods: A total of 158 patients with 3 consecutive prepandemic INR levels and at least 3 postpandemic INR levels without time limitation were retrospectively evaluated. TTR values were calculated and the preepidemic and postepidemic values were compared. TTR was obtained using the conventional method. Results: The mean preepidemic and postepidemic TTR values were found to be 64.4 (61.8%-67.0%) and 34.9 (30.8%-39.0%), respectively. TTR rate was statistically significantly lower in the postpandemic period than in the prepandemic period (P < 0.001). While the prepandemic TTR of 68 (43%) patients was <60, the postpandemic TTR of 125 (79%) patients was <60. Discussion and Conclusion: Patients using warfarin were found to have lower TTR values during the pandemic. One of the most important reasons for this result is patients' delayed admission to the hospital due to fear of infection. The importance of regular follow-ups and alternative solutions should be emphasized for the effective treatment of these patients.

5.
Cell ; 185(3):493-+, 2022.
Article in English | Web of Science | ID: covidwho-1757189

ABSTRACT

Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathology, and it remains unclear whether T cells contribute to disease pathology. Here, we combined single-cell transcriptomics and single-cell proteomics with mechanistic studies to assess pathogenic T cell functions and inducing signals. We identified highly activated CD16(+) T cells with increased cytotoxic functions in severe COVID-19. CD16 expression enabled immune-complex-mediated, T cell receptor-independent degranulation and cytotoxicity not found in other diseases. CD16(+) T cells from COVID-19 patients promoted microvascular endothelial cell injury and release of neutrophil and monocyte chemoattractants. CD16(+) T cell clones persisted beyond acute disease maintaining their cytotoxic phenotype. Increased generation of C3a in severe COVID-19 induced activated CD16(+) cytotoxic T cells. Proportions of activated CD16(+) T cells and plasma levels of complement proteins upstream of C3a were associated with fatal outcome of COVID-19, supporting a pathological role of exacerbated cytotoxicity and complement activation in COVID-19.

6.
6th International Conference on Computer Science and Engineering, UBMK 2021 ; : 472-477, 2021.
Article in English | Scopus | ID: covidwho-1741302

ABSTRACT

The Covid-19 virus has made a major impact on the world and is still spreading rapidly. A reliable solution to prevent further damage, early diagnosis of coronavirus patients are incredibly important. While chest X-Ray diagnosis is the easiest and fastest solution for this, an average radiologist has only a 75% to 85% accuracy when evaluating X-Ray data, thus it is desirable to achieve an accurate artificial network for this. Throughout this study, chest X-Ray data and blood routine test data are utilised and compared. X-Ray data consists of 5000 chest X-Ray images which are gathered from an open-source research and from a local hospital in which both have anonymous data. The blood test results were also taken from the same hospital. For the chest X-Ray diagnosis we utilised two of the popular convolutional neural networks, which are Resnet18 and Squeezenet and concluded that Resnet18 provided slightly more accurate results, while both having almost 98% accuracy. For blood test diagnosis, a feed-forward multi layer neural network was used. Even though it was worked on an insufficient dataset, 72% accuracy was obtained, thus making it a feasible option for further research. Hence, we concluded that in general chest X-Ray diagnosis is preferable over routine blood test diagnosis and the usage of AI yields better approximate results than humans. © 2021 IEEE

7.
The Effects of the Global Pandemic Process on the Social and Economic Structure and Public Policies in Combating the Pandemic ; : 1-228, 2021.
Article in English | Scopus | ID: covidwho-1732299

ABSTRACT

The COVID-19 affects both people’s health and socio-economic structures around the world. Measures were adopted to contain the pandemic suppressed economic activity, leading to stagnation and contraction. Such contractions impacted on employment;losing jobs and income levels turned the contractions into severe fiscal and economic crisis. The study examines the effects of the pandemic on socio-economic structures and the effectiveness of public policies. It reveals that some countries successfully managed the pandemic while others lead to deepen its negative effects. Social and economic policies that were decisive in successes and failures are examined through comparative descriptive analyses within a framework in each chapter. This study is hoped to serve as a guide for policy-makers in such circumstances. © Peter Lang GmbH Internationaler Verlag der Wissenschaften Berlin 2021.

8.
The Effects of the Global Pandemic Process on the Social and Economic Structure and Public Policies in Combating the Pandemic ; : 17-36, 2021.
Article in English | Scopus | ID: covidwho-1728128

ABSTRACT

The outbreak, which was mostly regional and had limited effects at the beginning, soon became a pandemic on a global scale, affecting the entire world. The fact that COVID-19 has been a global pandemic, without a doubt, caused its social and economic outcomes to also be experienced on a global scale. The fact that the pandemic has been threatening public health, as well as economic systems and functions, has made it difficult to fight it, making it a requirement to adopt public policies. Public policies and policy tools determined by the public have been the main driver of the response against the pandemic in almost every country. The success of measures adopted to combat the pandemic has been an area widely discussed recently. Similar measures in many countries have differed significantly. While some countries have been able to prevent deepening the crisis by managing the pandemic successfully, others have not been able to succeed despite adopting the same public policies, deepening the crisis. This study evaluates the COVID-19 pandemic and analyzed the fiscal policies adopted in China, the US, Germany, the UK, Turkey, and Spain to counter the pandemic and the effectiveness of these policies. © Peter Lang GmbH Internationaler Verlag der Wissenschaften Berlin 2021.

9.
European Journal of Immunology ; 51:102-102, 2021.
Article in English | Web of Science | ID: covidwho-1716952
10.
Haseki Tip Bulteni ; 60(1):89-91, 2022.
Article in English | Scopus | ID: covidwho-1715951

ABSTRACT

Coronavirus disease-2019 (COVID-19) is known to cause sepsis-associated hypercoagulopathy. Thromboembolic complications affecting many systems associated with COVID-19 disease have been described in the literature. The direct effect of this virus on male urogenital organs and possible testicular damage is still being evaluated. Follow-up studies in recovering male patients are necessary to investigate the possibility of testicular damage. In this article, we aimed to present a 30-year-old patient who presented with acute testicular pain and was diagnosed with testicular infarction due to COVID-19 with ultrasonography and contrast-enhanced magnetic resonance imaging findings. © 2022 by The Medical Bulletin of Istanbul Haseki Training and Research Hospital.

11.
Eurasian Journal of Emergency Medicine ; 20(4):241-254, 2021.
Article in English | Web of Science | ID: covidwho-1707344

ABSTRACT

Aim: This study aimed to investigate the stress experienced by emergency medicine physicians working in emergency departments during the coronavirus disease-2019 (COVID-19) pandemic, the factors they stated to be effective against stress, and their coping approaches to stressful situations. Materials and Methods: The study was designed in a general screening model, and 200 emergency medicine physicians participated via e-mail who work in emergency departments in Turkey. The sources of stress related to the pandemic, the factors that they find effective in combating stress, and their strategies to cope with stress were investigated with relation to their gender, marital status, after-shift accommodation, manner of working in a shift, smoking behavior, having a chronic disease, having children, and spouse's job as a healthcare professional. Results: While the primary source of stress of emergency medicine physicians during the pandemic was the risk of transmitting the virus to their families, the most influential factor in combating stress was leisure activities. Emergency physicians' approaches to coping with stress were significantly predicted by the variables of using full personal protective equipment while working, having an adequate sleep and resting opportunities, obtaining additional economic income, and not knowing the pandemic's end date. Conclusion: Emergency medicine physicians used active problem-oriented approaches, and among these, they used the social support seeking approach the most during the pandemic. It is necessary to provide social support, take precautions to care for healthcare workers' families and arrange emergency physicians' shifts to allocate their time to their leisure activities appropriately to reduce stress.

12.
Cryobiology ; 103:183, 2021.
Article in English | EMBASE | ID: covidwho-1587992

ABSTRACT

There is an increased number of publications on biosensors addressing substances such as pollutants, toxins, or viruses, like SARS-CoV-2. Cell-based biosensors, which use cells as biorecognition elements (bioreceptor), offer outstanding advantages regarding a fast and sensitive detection of these substances. However, there are only a few cell-based biosensors available on the market because such sensor chip contains a ‘living’ component (e.g., adherent mammalian cells), which is very vulnerable and demanding for certain vital parameters (e.g., oxygen, nutrients, pH) as well as temperature during storage and transportation to the end-user. This challenge often hinders the commercialization and practical applicability of cell-based biosensors. There is still an urgent need for preservation tools and methods to enable “off-the-shelf” format as well as ready-to-use on-site systems. Herein, we studied a strategy named “on-sensor cryopreservation (OSC)”, a method for preserving this living component by freezing it (-80 °C) directly on the biosensor surface. However, it is found that cryo-injury on cells occurs over a freeze-thaw cycle, which is most likely due to a mismatch in the coefficient of linear thermal expansion between the frozen cell membrane and the typically rigid sensor surface in contact. Thus, to protect the cells from cryo-injury by absorbing this mismatch energy, the rigid sensor surface was modified with elastic electrospun fibers composed of a polymer (polyethylene vinyl acetate), which has a low glass-transition temperature and a high thermal expansion coefficient. The modified sensor chip is then integrated into a microfluidic system to obtain a so-called cryo-chip. The presented cryo-chip is found to be effective for keeping cells viable during cryopreservation as well as for post-thaw monitoring of extracellular acidification, exemplarily demonstrated for CHO-K1 cells. Cryopreservation of the chips containing cells at the manufacturing stage and transporting them through cold-chain transport can pave the way for “all-in-one” format and “off-the-shelf” applicability. Funding: DÖ would like to acknowledge the Ph.D. research scholarship grant from the Scientific and Technological Research Council of Turkey (TÜBITAK). The authors gratefully thank the Federal Ministry of Education and Research of Germany (Opto-Switch FKZ: 13N12585). Conflict of Interest: None to disclose

13.
Namik Kemal Tip Dergisi / Namik Kemal Medical Journal ; 9(2):152-165, 2021.
Article in English | CAB Abstracts | ID: covidwho-1497594

ABSTRACT

Aim: The aim of study is to determine the attitude of the Turkish people (in cognitive, affective and behavioral dimensions) and the factors affecting this attitude during the coronavirus epidemic that has affected the whole world since December 2019. Materials and Methods: The data collected by a scale were modeled with explanatory factor analysis (EFA), confirmatory factor analysis (CFA) and structural equation modeling (SEM), and the effects of the dimensions and the importance of the effective items in each dimension were determined.

14.
Journal of the American Society of Nephrology ; 31:284, 2020.
Article in English | EMBASE | ID: covidwho-984258

ABSTRACT

Background: Management of COVID-19 in kidney transplant recipients (KTR) should include treatment of infection and regulation of immunosuppression but there is no consensus on this issue yet. In this study, we aimed to describe our experience in KTR with COVID-19. Methods: In this retrospective cohort study, we included KTR who diagnosed with COVID-19 from five centers. The patients were categorized into two groups for the analysis. Patients had respiratory failure and multiple organ dysfunctions were defined as severe pneumonia. All other cases were classified as moderate pneumonia. The primary endpoint was all-cause mortality. Results: 40 patients (20 female) were reviewed over a median follow-up of 32 days (IQR, 14-51 days) after COVID-19. 5 patients died during the follow-up. The frequency of graft dysfunction was similar between groups (n=12 and n=2;p=0.615, respectively). The frequency of previous induction (n=18 and n=7;p=0.016, respectively) and rejection therapy (n=4 and n=3;p=0.023, respectively) was significantly increased in the group with severe pneumonia compared to the moderate pneumonia group. None of the patients using cyclosporine A developed severe pneumonia. Also, multivariate logistic regression analysis revealed that previous anti-rejection therapy (9.75 [95% CI, 1.223 to 77.724;P=0.032]) was the independent predictor for mortality. Conclusions: COVID-19 more commonly causes moderate or severe pneumonia in KTR. Immunosuppression should be carefully reduced in KTR. Induction therapy with lymphocyte depleting agents should be carefully avoided in KTR during the pandemic period.

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