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1.
1st IEEE International Conference on Automation, Computing and Renewable Systems, ICACRS 2022 ; : 646-650, 2022.
Article in English | Scopus | ID: covidwho-2257062

ABSTRACT

The Covid-19 disease is caused by the severe acute respiratory (SAR) syndrome coronavirus-2 and becomes the reason for the Global Pandemic since 2019. Until July 2022, the total reported cases were 572 million and reported deaths were 6.38 million around the world. In many countries the infections caused severe damages. It not only took the precious lives but also caused few other national damages like economic crisis. The only solution to stop this pandemic is to increase the vaccination and reducing the spreads. The covid 19 virus is an airborne disease and spread when people breathe virus contaminated air. The WHO and all the nations were insisting to maintain social distance to control the virus spreading. But maintaining the social distance in public places is very hard. In this project we developed a method for detecting social distance. The system uses Raspberry Pi processor to detect the distance between two people from the live video stream. The YOLOv3 technique is used to detect the object from single frame of the video. © 2022 IEEE

2.
International Journal of Pharmaceutical Research and Allied Sciences ; 12(1), 2023.
Article in English | EMBASE | ID: covidwho-2240242

ABSTRACT

The main aim of this study is to determine the bioactive compounds which have drug-like properties and has the potential to combat the spike-glycoprotein of SARS-CoV-2. The 6LXT protein of covid-19 was chosen from the protein data bank as a target protein. The compounds which are potentially capable to bind with the target were picked from the PubChem database and docked using the tool Autodock 4.2. Molecular docking of the molecules was done with the best conformations of the ligands and grid size was selected according to the hit compounds' interaction with the target protein. The ligand binding sites with the target molecules were predicted using MetaPocket 2.0. The docking Score of 50 compounds wascarried out and also toxicity studies were carried out. The compounds selected were calculated to identify the best conformations having drug-likeness properties. The top 10 compounds were chosen for the structure-activity relationship based on their binding interactions with the protein and ligand. The ligands then underwent the pharmacokinetic analysis followed by Lipinski's and all the results were finalized and categorized. ManzamineA, Imatinib, and basotinib were elected as the peak compounds with the binding energy -9.01kcal/mol, -8.71kcal/mol, and -8.01kcal/mol.

3.
NeuroQuantology ; 20(11):4879-4888, 2022.
Article in English | EMBASE | ID: covidwho-2081053

ABSTRACT

The COVID-19 pandemic is having a significant negative impact on the private sector in developing economies, and businesses and individuals in fragile and conflict-affected situations are among the most severely affected. The pandemic has evolved rapidly from a health emergency to a global economic crisis, spreading through the real sector and posing growing risks to financial systems. The present study tries to study the impact of the pandemic on the small scale industries and its impact on small scale industries workers child towards pursuing education of Majuli district. The paper is descriptive in nature and both primary and secondary data is used for the study. The primary data is collected from the filed by using unstructured interview schedule. It is found that the small scale industry of Majuli during the covid period faced many problems but it resists the threats posed by the pandemic. Durability of products, products cost and benefits margins, robust nature of the products makes the small scale industry resistant to the nationwide lockdown. Education is a process of development.Proper education not only enhance the quality of life and life skill but also contributes towards socio economic development. Education plays an important role in the development of human life. COVID-19 pandemic affected the entire world and its influenced educational scenario of the world. Copyright © 2022, Anka Publishers. All rights reserved.

4.
NeuroQuantology ; 20(8):7451-7457, 2022.
Article in English | EMBASE | ID: covidwho-2010530

ABSTRACT

During the pandemic COVID-19 has been continuing to spread rapidly, and its impact and savage forced the governments all around the globe to shut down schools, colleges, and universities for an indefinite period. This prolonged situation has become a significant problem for the global educational community, and millions of students are detached temporarily from their institutes. Almost in every victim country, governments launched online platforms to sustain the educational industry. As a result, the educational system is changing with the distinctive emergence of online teaching and learning processes. The present chapter raises, discusses, and presents potential solutions to different affairs of the online teaching and learning process and presents a comparative analysis of Internet-based educational/teaching platforms being employed by educational practitioners all around the world during the global COVID-19 crises. It also analyzes a brief survey on Indian teachers about their experiences, expectations, and suggestions on online teaching and learning practices.

5.
J Photochem Photobiol B ; 234: 112545, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1996389

ABSTRACT

Clinical diagnostics for SARS-CoV-2 infection usually comprises the sampling of throat or nasopharyngeal swabs that are invasive and create patient discomfort. Hence, saliva is attempted as a sample of choice for the management of COVID-19 outbreaks that cripples the global healthcare system. Although limited by the risk of eliciting false-negative and positive results, tedious test procedures, requirement of specialized laboratories, and expensive reagents, nucleic acid-based tests remain the gold standard for COVID-19 diagnostics. However, genetic diversity of the virus due to rapid mutations limits the efficiency of nucleic acid-based tests. Herein, we have demonstrated the simplest screening modality based on label-free surface enhanced Raman scattering (LF-SERS) for scrutinizing the SARS-CoV-2-mediated molecular-level changes of the saliva samples among healthy, COVID-19 infected and COVID-19 recovered subjects. Moreover, our LF-SERS technique enabled to differentiate the three classes of corona virus spike protein derived from SARS-CoV-2, SARS-CoV and MERS-CoV. Raman spectral data was further decoded, segregated and effectively managed with the aid of machine learning algorithms. The classification models built upon biochemical signature-based discrimination method of the COVID-19 condition from the patient saliva ensured high accuracy, specificity, and sensitivity. The trained support vector machine (SVM) classifier achieved a prediction accuracy of 95% and F1-score of 94.73%, and 95.28% for healthy and COVID-19 infected patients respectively. The current approach not only differentiate SARS-CoV-2 infection with healthy controls but also predicted a distinct fingerprint for different stages of patient recovery. Employing portable hand-held Raman spectrophotometer as the instrument and saliva as the sample of choice will guarantee a rapid and non-invasive diagnostic strategy to warrant or assure patient comfort and large-scale population screening for SARS-CoV-2 infection and monitoring the recovery process.


Subject(s)
COVID-19 , Nucleic Acids , Artificial Intelligence , COVID-19/diagnosis , COVID-19 Testing , Delivery of Health Care , Humans , SARS-CoV-2 , Saliva
6.
Oxidation Communications ; 45(2):238-253, 2022.
Article in English | Scopus | ID: covidwho-1958418

ABSTRACT

Viral diseases continue to cause serious morbidity and mortality worldwide. For several virus infections, no antiviral medications are presently available especially for Covid-19. There is a clear need for new antiviral agents with new mechanisms of action or broad-spectrum activity, to face the issues of drug-resistant mutant viruses or emerging and neglected viruses. The benzilic acid thiazolidinone derivatives were prepared by reaction of alkyl/arylthiosemicarbazides with 2-bromopropionate in the presence of anhydrous sodium acetate in absolute ethanol from benzilic acid hydrazide. Compounds, which consist of (–C=N–N–) – the two interlinked nitrogen atoms, have been found to possess many biological activities. Viral diseases continue to cause serious morbidity and mortality worldwide. For several virus infections, no antiviral medications are presently available especially for Covid-19. There is a clear need for new antiviral agents with new mechanisms of action or broad-spectrum activity, to face the issues of drug-resistant mutant viruses or emerging and neglected viruses. The present work is an extension of our ongoing efforts toward developing promising biologically active agents using a hybrid pharmacophore approach. © 2022, Scibulcom Ltd.. All rights reserved.

7.
Oxidation Communications ; 45(2):225-237, 2022.
Article in English | Scopus | ID: covidwho-1957911

ABSTRACT

In today’s world wide viral diseases caused by viruses cause severe morbidity and mortality. Most of the viral infections do not have any proper medications including corona viruses caused infection. The present work emphasises the development of potent inhibitors towards the Covid-19 virus using a hybrid pharmacophore approach. The benzilic acid thiazolidinone derivatives were prepared by reaction of alkyl/ar-ylthiosemicarbazides with 2-bromopropionate in the presence of anhydrous sodium acetate in absolute ethanol from benzilic acid hydrazide. Compound which consists of (–C=N–N–), the two interlinked nitrogen atoms have been found to possess many biological activities. The compound (Z)-2,2-bis(4-chlorophenyl)-N′-(3-ethyl-5-methyl-4-oxothiazolidin-2-ylidene)-2-hydroxyacetohydrazide (TZD-7) showed good docking score –10.21 kcal/mol when compared to the reference ligand used for the study. Also the compounds has good interaction with the active site of the protein with the aminoacids His41, Tyr54, Phe140, Leu141, Asn142, Gly143, Ser144, Cys145, His163, His164, Met165, Glu166, Leu167, Pro168, His172, Asp187, Arg188, Gln189, Thr190, Gln192 which makes the molecule more potent. By improving the discovery of new potent inhibitors with new mechanisms, the mutant viruses can be neglected and with new antiviral agents with new mechanisms the drug resistant pathogens can be eradicated. © 2022, Scibulcom Ltd.. All rights reserved.

8.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND ALLIED SCIENCES ; 11(2):52-61, 2022.
Article in English | Web of Science | ID: covidwho-1912794

ABSTRACT

During the recent pandemic, COVID-19 (SARS-CoV-2) was the causative agent of the severe acute respiratory syndrome, which resulted in thousands of cases and high mortality rates in all the countries affected. This review focuses on immune-therapy techniques for treating COVID-19. The distinctive immunotherapeutic techniques are interferon administration, convalescent plasma, intravenous immunoglobulin, monoclonal antibodies, cellular treatments, and immunomodulatory drugs. Aside from antivirals, immunotherapy is recommended because of the immunity against the antigen in the infected patient and interferon activation is inhibited by the virus to avoid the immune response against it. In certain stages, interferons are used to cure the infection. Convalescent plasma therapy is used for patients with severe COVID-19 infection, all over the globe. A variety of antibodies fight against SARS-CoV-2 at different stages of its development and neutralize the virus.JAK inhibitors, corticosteroids, and others are used to modulate the immune response to control cytokine storms brought on by COVID-19 in its late phase. The changes in the cytokine storm and antibody reaction against SARS-CoV-2 require newly modified treatment for the patients to fight the infection. Researching about the manner of development, the immune response against the infectionandviral-mediated reactions help to find an efficient preventive and therapeutic medication.

9.
New Journal of Chemistry ; 45(38):17777-17781, 2021.
Article in English | ProQuest Central | ID: covidwho-1450298

ABSTRACT

The recent outbreak of the COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which infects human epithelial tissue by interaction of the receptor-binding domain of its spike protein (S-protein) with angiotensin-converting enzyme 2 (ACE2). Herein, we synthesized suitably configured Tröger's bases (TB-1/2/3) and investigated molecular docking of TBs at the interface of SARS-CoV-2 S-protein and ACE2, which revealed a high docking score indicating strong binding. Detailed analysis of docking highlights strong binding of TB-2 into the interfacial domain of SARS-CoV-2 S-protein and ACE2. Furthermore, for the first time, we explored surface-enhanced Raman scattering (SERS) modality to assess intermolecular interactions between TBs and SARS-CoV-2 S-protein and ACE2.

10.
6th IEEE International Conference on Communication and Electronics Systems, ICCES 2021 ; : 752-757, 2021.
Article in English | Scopus | ID: covidwho-1393711

ABSTRACT

Android is an Operating System that is based on Linux. It was predominantly designed for touch screen devices like tablets and smartphones. Android Application is a software application running on the Android platform. This paper presents an Android application which is used for virtual celebration. It is shared to surprise the near and dear on their birthdays, especially during these difficult times of the pandemic. This application is developed in Android Studio using activities and fragments. It contains images and texts from the sender, wishing the receiver a 'Happy Birthday'. Each screen is assigned a stipulated amount of time after which the next screen appears. Due to the 'Covid-19 Pandemic', people could not meet their friends and family. As a small step towards overcoming this longing, this research work presents an Android application which is a virtual birthday present. Virtual birthday present makes users feel intimate and elated, following all the Covid-19 protocols simultaneously. Moreover, using this project, there is no limit to the number of photos one can share, nor it takes extra time to download each media file. Once the app is downloaded everything is at the user's fingertip. © 2021 IEEE.

11.
Pharmacogenomics ; 22(10): 603-618, 2021 07.
Article in English | MEDLINE | ID: covidwho-1278319

ABSTRACT

Aim: Numerous drugs are being widely prescribed for COVID-19 treatment without any direct evidence for the drug safety/efficacy in patients across diverse ethnic populations. Materials & methods: We analyzed whole genomes of 1029 Indian individuals (IndiGen) to understand the extent of drug-gene (pharmacogenetic), drug-drug and drug-drug-gene interactions associated with COVID-19 therapy in the Indian population. Results: We identified 30 clinically significant pharmacogenetic variants and 73 predicted deleterious pharmacogenetic variants. COVID-19-associated pharmacogenes were substantially overlapped with those of metabolic disorder therapeutics. CYP3A4, ABCB1 and ALB are the most shared pharmacogenes. Fifteen COVID-19 therapeutics were predicted as likely drug-drug interaction candidates when used with four CYP inhibitor drugs. Conclusion: Our findings provide actionable insights for future validation studies and improved clinical decisions for COVID-19 therapy in Indians.


Subject(s)
COVID-19 Drug Treatment , COVID-19/genetics , Antiviral Agents/therapeutic use , Asian People , Drug Interactions/genetics , Genome/genetics , Genotype , Humans , India , Pharmacogenetics/methods , Pharmacogenomic Testing/methods , Pharmacogenomic Variants/genetics , SARS-CoV-2/drug effects
12.
Biomedical and Pharmacology Journal ; 13(3):1185-1193, 2020.
Article in English | EMBASE | ID: covidwho-922962

ABSTRACT

Coronavirus disease (covid-19) is a pandemic of international concern. It creates serious health risk all around the globe and it has no effective treatment. Doxycycline and Quinine are the drugs used as ligands in the study as these drugs has proved in vitro antiviral activity against dengue virus and herpes simplex virus. These compounds were targeted against non structural protein (nsp 12) which plays a vital role in replication and transcription of Corona viral genome. The protein 6 NUR that showed maximal identity of target protein nsp 12 was retrieved using BLASTp. Further the protein was modelled and the compounds were docked using AUTODOCK software and to study the structure activity relationship of ligand with target protein and biochemical information of ligand receptor interaction was done. Both the compounds, Doxycycline and Quinine were well engaged into the active site of target protein nsp 12 with strong hydrogen bond interaction and non polar interaction with active site of the protein. The Docking score of Doxycycline is found to be - 7.34 kcal/mol while that of Quinine being -6.14 Kcal/mol. This indicates the potential of these drugs as a lead against the nsp target protein of Corona virus which need further analysis and Optimisation studies.

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