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1.
Enfermedades Infecciosas y Microbiologia Clinica ; 06:06, 2022.
Article in Spanish | MEDLINE | ID: covidwho-2158757

ABSTRACT

INTRODUCTION: The objective of this report is to describe the clinical pathway for early treatment of patients with acute SARS-CoV-2 infection and to evaluate the first results of its implementation.

2.
24th International Conference on Engineering and Product Design Education: Disrupt, Innovate, Regenerate and Transform, E and PDE 2022 ; 2022.
Article in English | Scopus | ID: covidwho-2147542

ABSTRACT

Digital technologies have enabled design sketching to expand into new applications and domains. Inevitably, these new forms of visualisation require re-evaluating how we use drawing to see, visualise, understand, and fabricate products and services in design education and the profession. This paper presents a selection of discoveries after the authors performed research, made presentations and mediated workshops when face-to-face collaborations and travel were impossible because of the Covid-19 epidemic restrictions. Findings add to work intending to build a modern taxonomy for design sketching and visual knowledge while accounting for immersive virtual collaboration and distributed workflows from sketching to 3D CAD and 3D printing. These are among the first indications of a drive towards synthesising historically demarked design process stages into a singularity of actions that merge and move simultaneously among ideation, design, and production. Participants in two international conference workshops shared ideas and discussed their local circumstances relating to the potential use and acceptance of new technologies already researched and adopted in other disciplines such as computer science and entertainment. A critical consensus was that the challenge of new technologies for our design education and profession is not as much about technology and its tools as the process and steps that enable change. Significantly, conversation pointed towards a strategy that enhances and augments habits in design education and the profession as the means to modify and transform culture and practice. © Proceedings of the 24th International Conference on Engineering and Product Design Education: Disrupt, Innovate, Regenerate and Transform, E and PDE 2022. All rights reserved.

3.
Research and Practice in Thrombosis and Haemostasis Conference ; 6(Supplement 1), 2022.
Article in English | EMBASE | ID: covidwho-2128143

ABSTRACT

Background: One of the main complications of Covid-19 are the thrombotic events reported with different incidences in the different case series Aims: To identify the incidence of thrombotic events in patients affected by Covid-19 in a general hospital in Veracruz, Mexico during April to October 2020. Method(s): Descriptive and retrospective study in which the thrombotic events presented by patients who suffered from Covid-19 during the period from April to October 2020 are analyzed. Result(s): Data from 1,212 patients diagnosed with Covid-19 are included, 641 (53%) men and 571 (47%) women, with a mean age of 49 years. 663 (54.7%) patients suffered from some chronic disease, systemic arterial hypertension was the most common comorbidity (29.2%), followed by diabetes (29.1%), obesity (13.9%), cardiovascular disease (5.4%), asthma (4.5 %), chronic kidney disease (3.8%) and COPD (2.1%). Six cases with various thrombotic events (50% venous and 50% arterial) were identified, predominantly in women (66%) and with mild Covid-19 (66%), of which 1 had a poor prognosis (severe Covid). The incidence of thrombotic events was 0.5% in this case series. Conclusion(s): Thrombotic events, although of low incidence, should always be taken into account during the follow-up of patients with both mild and severe Covid-19, since they add greater morbidity and mortality. (Table Presented).

4.
Jimenez, S.; Miro, O.; Alquezar-Arbe, A.; Pinera, P.; Jacob, J.; Llorens, P.; Garcia-Lamberechts, E. J.; Martin-Sanchez, F. J.; Del Castillo, J. G.; Burillo-Putze, G.; Martin, A.; Grima, M. L. L.; Gomez, M. A. J.; Millan, J.; Lazaro, L. S.; Espinosa, B.; Paya, A. B.; Noceda, J.; Cano, M. J. C.; Serra, R. S.; Bayarri, M. J. F.; Suarez, F. J. S.; Tejera, M. G.; Porrino, J. M. M.; Maestre, M. R.; Melendez, N.; Albero, P. B.; Escolano, E. R.; Manrique, K. J. A.; Del Rio, R.; Mestre, A. M.; Garcia, C. P.; Amador, P. S.; Aznar, J. V. B.; Lopez, J. L. R.; Ponce, M. C.; Belda, M. B. R.; Fernandez, E. D.; Valero, C. C.; Gimenez, L. M.; Gomez, A. P.; Bellver, E. G.; Rizzi, M.; Suarez, C. C.; Cardozo, C.; Llopis-Roca, F.; Roset-Rigat, A.; Boter, N. R.; Rovira, M. A.; Tost, J.; Tejedo, A. A.; Lorenzo, I. C.; Palau-Vendrell, A.; Tur, R. G.; Munoz, M. A.; Ferrer, E. S.; Garcia, L. L.; Mojarro, E. M.; Jimenez, B. S. A.; Huerta, A.; Fragiel, M.; Quiros, A. M.; Del Val, E. M.; Del Arco Galan, C.; Jimenez, G. F.; Garate, R. T.; Borrego, B. V.; Arias, A. S.; Cabezas, V. P.; Aviles, R. M.; Gonzalez, S. R.; Ramos, M. E. B.; Alonso, M. A.; Martin-Borregon Bendito, P.; Aguado, A. C.; Martin, S. G.; Somohano, F. V.; Lopez-Laguna, N.; Panadero, R. P.; De Frutos, M. F.; Robledo, F. D.; Madrigal, A. A.; Castaneda, A. B.; Diez, M. P. L.; Izquierdo, R. L.; Ruperez, I. G.; Chaib, F. B.; Abdelkader, I. S. M.; Rafael, I. R.; Tornero, A. P.; Soriano, J. J. C.; Perez, E. M.; Urbano, C. A.; Soto, A. B. G.; Garcia, J. P.; De Simon Almela, A. F.; Lopez, R. C.; Diaz, J. J. L.; Vera, M. T. M.; Calveiro, R. R.; Lucas-Imbernon, F. J.; Moreno, M. R.; Martinez, F. G.; Olmeda, D. M.; Juarez, R.; Hernandez, P. E.; Rodriguez, M. E.; Monzo, J. P.; Gonzalez, N. C.; Herrera, D. M. V.; Bautista, B. M. M.; Alvarez, L. A.; Hevia, M. D. R. C.; Motto, E. Q.; Garcia, N. T.; Diaz, N. M.; Mercader, M. P. O.; De Lobera, N. R.; Amez, J. M. F.; Entrala, B. A..
Emergencias ; 34(5):369-376, 2022.
Article in Spanish | EMBASE | ID: covidwho-2111934

ABSTRACT

Objectives. To define quality of care indicators and care process standards for treating patients with COVID-19 in hospital emergency departments (EDs), to determine the level of adherence to standards during the first wave in 2020, and to detect factors associated with different levels of adherence. Methods. We selected care indicators and standards by applying the Delphi method. We then analyzed the level of adherence in the SIESTA cohort (registered by the Spanish Investigators in Emergency Situations Team). This cohort was comprised of patients with COVID-19 treated in 62 Spanish hospitals in March and April 2020. Adherence was compared according to pandemic-related ED caseload pressure, time periods during the wave (earlier and later), and age groups. Results. Fourteen quality indicators were identified. Three were adhered to in less than 50% of the patients. Polymerase chain reaction testing for SARS-CoV-2 infection was the indicator most often disregarded, in 29% of patients when the caseload was high vs 40% at other times (P <.001) and in 30% of patients in the later period vs 37% in the earlier period (P =.04). Adherence to the following indicators was better in the later part of the wave: Monitoring of oxygen saturation (100% vs 99%, P =.035), electrocardiogram monitoring in patients treated with hydroxychloroquine (87% vs 65%, P <.001), and avoiding of lopinavir/ritonavir treatment in patients with diarrhea (79% vs 53%, P <.001). No differences related to age groups were found. Conclusions. Adherence to certain quality indicators deteriorated during ED treatment of patients with COVID-19 during the first wave of the pandemic. Pressure from high caseloads may have exacerbated this deterioration. A learning effect led to improvement. No differences related to patient age were detected. Copyright © 2022, Saned. All rights reserved.

6.
Revista Universidad Y Sociedad ; 14:742-750, 2022.
Article in Spanish | Web of Science | ID: covidwho-2092690

ABSTRACT

Ethics is one of the oldest branches of philosophy, it studies good and evil, right from wrong, just and unjust, values, the duty to be happiness, its relations with morality and human behavior, as a value or because of its axiological character, deals with the behavior of human beings. Its application in the field of public management, manifests itself as an indispensable instrument when selecting the most suitable, disciplined public servants, with capacities, moral, ethical, honest, respectful values and committed to the common good, full of integrity, transparency, essential qualities that will undoubtedly limit acts of corruption. Its importance is linked to the transparency of public actions, a substantial element for the proper functioning and organization of public administrations, disrupted by acts of corruption that have overflowed, especially in recent years, as a result of the COVID 19 pandemic, and the objective of This article is to analyze the behavior of public administrators in the public exercise, determine if the rules of conduct could reduce acts of corruption allowing to recover the credibility and trust of the public service. Giving as a contribution to science that the application of standardized public ethics codes, of mandatory compliance, would allow more than a good public administration a correct selection of our rulers, creating rules of public conduct, a public awareness of the common good, in such virtue that citizens have a better image of public administrations, especially of the public service that has been affected by unfair, amoral practices that have caused so much damage to the image of a constitutional state of rights and justice.

7.
International Journal of Psychology and Psychological Therapy ; 22(3):331-344, 2022.
Article in English | Scopus | ID: covidwho-2084007

ABSTRACT

During the COVID-19 pandemic, elderly adults with type 2 diabetes mellitus (T2DM) have experienced difficulties to adhere to their therapy (TA), a situation which not only has had an impact on their glycemic control, but on their quality of life (QoL) as well. Telepsychology has proved to be an effective alternative to treat health-related complications in patients with this disease, however, results of same are unknown among the Latin American population. The aim of this study was determining the effect of Online Cognitive-Behavioral Therapy on TA, overall QoL and specific QoL in two elderly adults with T2DM. The case of a 62-year-old woman and a 60-year-old man who was offered an intervention consisting of nine sessions offered through a video conference platform is presented. The procedure included: psychoeducation, self-control training techniques, behavior reinforcement, feedback and problem solving. The Objective Clinical Change (OCC) evidences an increase in TA behaviors, such as use of medications, following a healthy diet (OCC≥ 0.20) and monitoring capillary blood glucose in the medium term (four months). Likewise, improve specific QoL for T2DM patients (OCC≤ -0.20). It is concluded that telepsychology is a low-cost, safe, feasible and effective type of therapy to increase and maintain TA behaviors, as well as to improve the QoL of patients suffering T2DM. Even though, more research is needed to increase the effectiveness of this therapy modality © 2022 AAC

9.
Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance ; : 261-304, 2022.
Article in English | Scopus | ID: covidwho-2048812

ABSTRACT

Antimicrobial resistance is one of the biggest problems that the healthcare system faces nowadays, with an increasing burden due to the COVID-19 pandemic. Different alternatives to the current treatments of bacterial infections have been studied far away from the use of traditional antibiotics. One of them is nanotechnology, which proposes a suitable solution without the associated problems. Still, the production of different nanomaterials often shows disadvantages, such as producing toxic by-products or the need for functionalization to deliver a suitable therapeutic effect. The implementation of green nanotechnology in nanomaterials synthesis shows great potential, with specific implementation in metal-based nanomaterials. As such, this chapter revised the state of biogenic or biologically produced metal nanoparticles produced by bacteria, fungi, and plant extracts with antimicrobial applications against antibiotic-resistant strains. The chapter summarizes and discusses some of the newest advances in the field to demonstrate that these nanostructures can become a significant enhancement in the fight towards superbugs. © 2022 Elsevier Inc. All rights reserved.

10.
Edunine2022 - Vi Ieee World Engineering Education Conference (Edunine): Rethinking Engineering Education after Covid-19: A Path to the New Normal ; 2022.
Article in English | Web of Science | ID: covidwho-2018720

ABSTRACT

This work proposes the design and development and validation of the mobile application Tsiimene aimed at preserving and rescuing the Bora language in times of pandemic, which currently faces extinction problems due to the few existing speakers. This work was carried out in the town of San Joaquin de Omaguas, located 64 km from the city of Iquitos. The application of the mobile device was carried out through traditional and experimental methodology in which the application was used. It has been validated that the use of a mobile application is more effective than traditional teaching, mainly in the learning of a native language.

11.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2009614

ABSTRACT

Background: In our experience during the first year of development of ACHOC-C19 study, we observed 26% mortality in patients with cancer and COVID 19 infection. The impact of vaccination was not evaluated prior to the implementation of this strategy worldwide in this kind of population. It was proposed to evaluate the effectiveness of immunization during the second phase of our investigation. Methods: Cohort study derived from the National Registry of Patients with Cancer and COVID-19 (ACHOCC-19). Data were collected from June 2021 since vaccine was available. Patients were: older than 18 years, diagnosed with cancer (solid tumors), treated and/or under follow-up, and with COVID-19 infection. The comparative analysis of the vaccinated and non-vaccinated cohort is presented. Outcomes included: all-cause mortality within 30 days of infection diagnosis, hospitalization, and mechanical ventilation. Effect estimation was performed through relative risk (RR) and multivariate analysis for each event, using generalized linear models of the binomial family. Results: 896 patients were included, 470 were older than 60 years (52.4%) and 59% women (n = 530). 172 patients were recruited in the vaccinated cohort and 724 in the non-vaccinated cohort (ratio: 1 to 4.2). The cumulative incidence of hospitalization among the unvaccinated was 42.4% (n = 307), and among the vaccinated, 29% (n = 50);invasive mechanical ventilation requirement was 8.4% (n = 61) in unvaccinated, and 4.6% (n = 8) in vaccinated. The cumulative incidence of mortality from all causes in the unvaccinated was 17% (n = 123) and in the vaccinated 4.65% (n = 8). Table summarizes the multivariate analysis. The adjusted RR for mortality for the unvaccinated is 3.4 (95% CI: 1.7-6.8), for hospitalization 1.36 (95% CI: 1.08-1.72), and for mechanical ventilation 2.1 (95% CI: 1.02-4.2). Conclusions: The incidence of complications and death in patients with cancer and COVID-19 infection is significantly higher in those who have not received a vaccination schedule compared to those who have been vaccinated. Immunization should be promoted and intensified in this population group.

12.
Annals of the Rheumatic Diseases ; 81:1678-1679, 2022.
Article in English | EMBASE | ID: covidwho-2008978

ABSTRACT

Background: According to the literature patients with autoimmune diseases (AID) have a high risk of develop serious infections due to the use of immunosuppressive treatment. In published clinical trials neither the risk nor the severity of COVID-19 infection in patients with AID seem to be higher than in the general population. Objectives: The objective of our study is to analyse the clinical course in patients with AID undergoing immunosuppressive treatments and infected by COVID-19. Methods: Patients were included after reviewing four rheumatology outpatient clinics from Ciudad Real University General Hospital between November 2020 and February 2021. The inclusion criteria were being older than 18 years and being positive for COVID-19 by epidemiological (positive molecular and/or antigen test) or clinical criteria (symptoms compatible between March and May 2020). We collected demographic data, cardiovascular comorbidities, AID, treatment with synthetic or biological DMARDs, immunomodulators or glucocor-ticoids;and progression of infection COVID-19. Results: We found a total of 210 patients that had suffered from SARS-COV2 of which 95 patients were affected by AID. The most prevalent pathology in our sample was spondylarthritis followed by arthritis rheumatoid and systemic lupus ery-thematosus of which 81.82%, 100% and one 92.86% respectively were receiving treatment to control the disease. Among the 95 patients suffering from COVID and AID a small number of patients did not follow any immunosuppressive treatment regimen (n=25) but most of our patients were undergoing immunosuppressors (n=70);the most used drugs were prednisone and methotrexate. No statistically signifcant differences were found between the treated versus untreated group in the studied variables, being similar the results relative to mean age, sex, presence of cardiovascular risk factors, absence of symptoms, number of admissions to hospital ward or in Intensive Care Unit, or complications during COVID-19 infection (Table 1). Conclusion: Patients treated with synthetic or biologicals DMARDs, immunomodulators or glucocorticoids do not seem have a higher rate of death or hospital admission respect to patients diagnosed of AID without such treatments.

13.
Multiple Sclerosis and Related Disorders ; 59, 2022.
Article in English | EMBASE | ID: covidwho-2004358

ABSTRACT

Objective(s): The aim of this study was to study the humoral immune response to SARS-CoV-2 following vaccination in MS patients. Material(s) and Method(s): We performed a prospective study including all MS patients receiving one of the approved COVID-19 vaccines since January to September 2021. Demographic characteristics, MS treatments and adverse events reports after COVID-19 vaccination of vaccinated MS patients were collected. We analyzed the antibody response to SARS-CoV-2 vaccines with a chemiluminescent microparticle immunoassay (CMIA) from Abbot in MS patients with different DMTs at week 3, week 6 and month 3 after the first dose. The positivity cutoff is ≥50 AU/ml (manufacturer defined). 200 Healthy healthcare professionals were the control group. Result(s): We analyzed 165 vaccinated MS patients: 106 with Pfizer, 14 with Moderna, 42 with both doses of Astra zeneca and 3 with Jannsen. The mean age of patients was 45 (range: 21-71) and 46 for the controls. The most frequent adverse events were pain at injection site, headache and fatigue for 24-48 hours. No differences between MS patients and controls. No increased risk of relapse was noted in the first six months. 120 patients have received both doses of mRNA vaccine. Overall, mean antibody titers response to SARS-CoV-2 SARS-CoV-2 at three weeks was 7910,3 AU/mL (range 0-74947), at 6 weeks 16347,9 UA/mL (range:0-52380,5) and at 3 months 8182,10 UA/ml (range:0-33752,4) in mRNA vaccinated patients. By the mRNA vaccinated control group mean antibody titers response to SARS-CoV-2 SARS-CoV-2 at three weeks was 9397 AU/mL and at 6 weeks 18120 UA/mL Performing a subanalysis of the different DMTs: Only 3 out of 20 patients treated with ocrelizumab developed antibodies. Six vaccinated patients treated with rituximab had no antibody response. Four from 16 patients treated with fingolimod failed to develop a post-vaccination humoral response (< 50 AU/ml). 4 of 5 patients treated with ofatumumab developed have an adequate humoral response. Patients treated with interferon Beta, glatiramer acetate, teriflunomide, dimethyl fumarate, vaccinated with mRNA vaccines developed a similar post vaccination humoral response than healthy controls. Conclusion(s): Most of MS treated patients developed enough antibodies to SARS-CoV-2. The adverse events on MS patients were similar to the general population. No increase of relapse activity was observed. Some patients treated with ocrelizumab, rituximab and fingolimod have no developed a humoral response to SARS-CoV-2 vaccination. Hence we conclude that all approved COVID-19 vaccines are safe in MS patients and effective in most patients. However vaccine strategy in patients treated with anti-CD20 and fingolimod need further studies.

14.
Economic Research-Ekonomska Istrazivanja ; : 34, 2022.
Article in English | Web of Science | ID: covidwho-1984660

ABSTRACT

The Incremental Borrowing Rate (IBR) is generally used by companies for discounting future lease payments and calculating the value of the lease assets and liabilities under IFRS 16. According to this standard, leased asset must be considered as a collateral, and therefore the yield to be used should reflect an adequate Loss-Given Default (LGD), which may vary depending on the estimated recovery rate of the asset (machinery, real estate, vehicles, etc.). There is a lack of accounting and finance literature focused on analysing how a standard IBR should be adjusted to reflect the expected underlying asset LGD in line with IFRS principles. In this context, we propose a model that uses bond quoted information as a basis for introducing an adjustment to the standard "unsecured" IBR. The model consists of replicating the change in a certain bond yield when there is a change in the LGD (usually due to a change in the seniority level). We empirically demonstrate that the model works by using data from real bond quotations (97 outstanding bonds quoted on several secondary markets such as NY, Vienna, Frankfurt and London). The empirical analysis has been performed for two different time periods: pre-COVID 19 and post-COVID 19.

15.
Journal of the International Aids Society ; 25:17-18, 2022.
Article in English | Web of Science | ID: covidwho-1980277
18.
REVISTA UNIVERSIDAD Y SOCIEDAD ; 14(3):775-783, 2022.
Article in Spanish | Web of Science | ID: covidwho-1965445

ABSTRACT

The study was based on the evaluation of the correlation between remote education and academic stress in Peruvian university students in times of the covid-19 pandemic. The methodology used considered that the study according to its type was basic, with a quantitative approach, a correlational level and a non-experimental design. The universe of study was made up of 230 students of the administration career of a Peruvian university. A probabilistic sampling was carried out, considering that the size of the population was known, resulting in a sample of 144 students. The survey was used as a technique and the questionnaire was used as a data collection instrument, of which two were made, the first for the remote education variable, with 27 questions related to the variable and the second for the academic stress variable, adapted according to the SISCO Inventory, also with 27 questions. In both questionnaires, the questions had 5 response options according to a Likert-type scale. The descriptive analysis of the results was performed by calculating absolute and relative frequencies. The data were subjected to the Kolmogorov-Smirnov test to determine their normality. The inferential analysis was performed using the Spearman's Rho statistic.

19.
IEEE International Conference on Electrical, Computer, and Energy Technologies (ICECET) ; : 2201-2204, 2021.
Article in English | Web of Science | ID: covidwho-1927524

ABSTRACT

Currently, recognition systems based on Artificial Intelligence and Computer Vision have enabled various applications in fields such as Medicine, Industrial Engineering, and in an emerging way in the field of Public Safety as a useful and necessary tool in smart cities that favours the control, management and prevention of criminal acts. Given that violence is a very frequent social problem in Latin American countries. A pilot case has been proposed in the city of Iquitos, Peru, with a tool generated to recognise violent actions from a video or image captured from a mobile phone. This work proposes the application of a mobile tool that facilitates the recognition of high-frequency violent actions on public roads. A bank of 500 images has been generated for each class of violent action prioritised in this work, then a manual labelling tool called "LabelImg" has been used with the extraction of FPS from videos, and the convolutional neural network algorithm YOLO v3 has been used with the Darknet variant. The results of the experiment achieved an accuracy of 94% in the detection of 4 violent actions: punching, kicking, grappling and strangling.

20.
Revista De Salud Ambiental ; 22(1):100-112, 2022.
Article in Spanish | Web of Science | ID: covidwho-1925246

ABSTRACT

Some pollutants like PM10, NO2 and O-3 are detrimental to people's health, as numerous studies have shown, and they are related to short-term and long-term mortality. A sample of 9 out of the 52 Spanish provinces was studied. Generalized linear models (GLM) with a Poisson link function were developed during the time periods corresponding to the first and second waves of the daily average values of the independent variables (PM10, NO2 and O-3, as atmospheric pollutants, and meteorological variables such as the daily maximum temperature and the absolute humidity) versus the dependent variable (COVID-19 mortality rate, or CMR) during said first and second waves. Statistically significant lags between the independent variables and the dependent variable were established. The associated relative risks were calculated from the estimators obtained in the GLMs, with increases of 10 mu g/m(3) for atmospheric pollutants, 1 degrees C for the maximum temperature and 1 g/m(3) for the absolute humidity. The results show that NO2 has a stronger relationship with the CMR than the other air pollutants. The meteorological variables examined did not show a robust relationship between both waves, which indicates that they played a minor role in the CMR. In conclusion, air pollutants such as to NO2 and PM10 had a statistically significant relationship with the CMR, although it is limited and subordinate to other factors such as the public health measures that were taken, the presence of comorbidities and the age of the patient.

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