ABSTRACT
In Germany, a total of five SARS-CoV-2 vaccines are approved. This review does not cover the Nuvaxovid/Novovax vaccine. Side effects have been reported in 1.6/1000 vaccinations, severe side effects in 0.2/1000 vaccinations. Headache and fatigue frequently occurred also in the placebo arms (nocebo effect). An increased risk for myocarditis or pericarditis is discussed with mRNA-vaccines. After vector-based vaccines rarely a vaccine-induced immunogenic thrombotic thrombocytopenia (VITT) with sinusthrombosis may occur, caused by platelet factor 4 antibodies. Intravenous immunoglobulins are effective. Possible neurologic vaccine complications include Bell`s palsy, plexopathies, Guillain-Barré syndrome, transverse myelitis, encephalitis and acute disseminated encephalomyelitis.
ABSTRACT
In the context of COVID-19 infection, 0.5% to 2 % of affected patients will suffer a stroke. The strokes are usually severe with an unfavorable prognosis. Most patients suffer from an occlusion of the large brain-supplying arteries caused by the COVID-19 induced coagulation disorder. In the context of COVID-19 infection, there has been a dramatic temporary decrease in the number of stroke patients treated in stroke units. The situation has since returned to normal.