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Lung India ; 39(SUPPL 1):S137-S138, 2022.
Article in English | EMBASE | ID: covidwho-1857128


Background: We estimated levels of oxidative stress biomarkers (Lipid peroxidation (LPO) via Malondialdehyde MDA concentration , Superoxide dismutase (SOD), Glutathione Reductase (GR) and Total antioxidant activity (TAA) in patients who were symptomatic beyond 4 weeks of COVID infection. Methods: It's a single centre, hospital based case control study in which levels of oxidative stress biomarkers in 40 Long COVID patients and 40 healthy controls were compared and analysed with their clinico-radiological profile. Results: 1. Lipid peroxidation (MDA) was significantly higher (1155.9 ± 204.82nmole/ml) in Long COVID patients as compared to control (715.5 ± 85.51nmole/ml) (p value 0.0405) 2. SOD in Long COVID patients was lower (18.05 ± 2.83 unit/mg) as compared to control (27.36 ± 2.18 unit/ mg) (p value 0.0096) 3. GR was reduced in Long COVID patients (10.2 ± 1.26 unit/min/mg of protein) as compared to control (15.7 ± 1.42 unit/min/mg of protein) (p value 0.0356) 4. TAA was also moderated in Long COVID patients (94.61 ± 16.40mM) as compared to control (241.64 ± 12.95mM) , (p value 0.0486) 5. LPO was directly and remaining markers were inversely proportional to the Severity of COVID and Xray Severity score 6. The patients with added comorbidities showed even higher oxidative stress than those with no comorbidities (p value 0.05) 7. Lipid peroxidation was significantly high in patients who developed neurological sequelae after COVID infection (p value 0.0083). Conclusion: A subset of patients develop a sequelae to COVID infection and in those patients oxidative stress plays a major role.