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1.
Int J Environ Res Public Health ; 19(4)2022 02 17.
Article in English | MEDLINE | ID: covidwho-1704765

ABSTRACT

Healthcare workers (HCWs) are on the frontline, struggling with the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To describe recent or past infections, the serological assays enabled the assessment of the immune response developed in coronavirus disease (COVID-19) in the period when testing was hardly available. In this study, we investigated SARS-CoV-2 seroprevalence in HCWs in a Polish teaching hospital and the Regional Occupational Medicine Center after both the first and the second waves. ELISA-based tests for anti-SARS-CoV-2 IgA and IgG were used to determine immune response to SARS-CoV-2 in volunteer HCWs who worked in those institutions in May 2020 (208 participants aged 47.1 ± 12.5, 88% women) and in December 2020 (179 participants aged 45.2 ± 12.4, 86% woman). Risk factors for seropositivity were also assessed using a questionnaire filled out by all participants. We reported a significant increase in seroprevalence after the second wave (22.9%) compared with the first outbreak (2.4%) (OR 12.1; 95%CI 4.6-31.3; p < 0.0001). An association between IgG seroprevalence and severity of infections was noted. Furthermore, we demonstrated that amongst medical personnel, nurses exhibited a proportionally higher SARS-CoV-2 seroprevalence. Moreover, given the high seroprevalence in non-clinical group of HCWs, we suggest that community transmission can play a superior role to workplace exposure.


Subject(s)
COVID-19 , SARS-CoV-2 , Adult , Antibodies, Viral , COVID-19/epidemiology , Female , Health Personnel , Humans , Male , Middle Aged , Pandemics , Poland/epidemiology , Seroepidemiologic Studies , Vaccination
2.
Postepy Biochem ; 66(4): 309-315, 2020 12 31.
Article in Polish | MEDLINE | ID: covidwho-1068108

ABSTRACT

COVID-19 pandemic highlighted the importance of laboratory diagnostics to reduce the spread of SARSCoV-2 and to treat patients with severe coronaviral disease. The situation required a rapid development of molecular and serological tests to enable mass screening, testing of high-risk groups, and establishing epidemiological data. Knowledge of diagnostic methods is continuously evolving, so it is crucial to understand the nature of the tests and to be able to interpret their results. This review discusses the current literature on diagnostic methods, prognostic markers, diagnostic recommendations, choice of the appropriate test, type of biological material, and interpretation of results depending on test sensitivity and disease duration. Also, the percentage of positive results in the selected countries at two distant time points of the epidemic was analyzed. Further development of diagnostic techniques and incorporation of new technologies can provide more accurate and faster tools for control the epidemic.


Subject(s)
COVID-19 , SARS-CoV-2 , COVID-19 Testing , Humans
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