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1.
3rd International Conference on Emerging Technologies in Data Mining and Information Security, IEMIS 2022 ; 491:673-685, 2023.
Article in English | Scopus | ID: covidwho-2094556

ABSTRACT

The recent times have seen the global rise in infection rates from the virus Covid-19, leading to a pandemic. The exponential rise in infections and deaths lead to panic and nation-wide lockdowns across the globe. Advancements in biotechnical and medical research have paved the way for the development and mass distribution of vaccines. To build an understanding of the current situation we did a comparative analysis of the rise in infection rates among citizens across the countries and also the growth in vaccinations in the pre-vaccination phase and the post-vaccination phase of the on-going pandemic to determine whether the rate of vaccination is more than the rate of infection or otherwise. Then, a comparison is done among two prediction models we built, one using polynomial regression and other using SVM to determine which model provides better prediction results of infection rates in a country. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

3.
NeuroQuantology ; 20(9):5453-5458, 2022.
Article in English | EMBASE | ID: covidwho-2090985

ABSTRACT

Purpose and Background: The goal of this study is to examine the efficacy of various medications that are recommended for the treatment of patients in India who are suffering from mild-to-severe cases of corona virus disease 2019 (COVID-19). Method(s): In study carried out a retrospective, cross-sectional, observational and descriptive study. Patients diagnosed with COVID-19 ranging from mild, moderate and severe were given as part of this treatment. The primary objectives are to compare the categorical treatment protocols for COVID-19 (as per NIH Treatment Guidelines) infected mild, moderate and severe patients. To evaluate the efficacy of the drugs on the basis of at the time of discharge improvement in SPO2, RR, D-Dimer, PCT, CRP and Ferritin Values. Result(s): A total of 266 patients included in this study mild to severe COVID 19 infection led to significant improvement in SPO2, Respiratory rate (RR), D-Dimer, Procalcitonin (PCT), C-Reactive Protein (CRP) and Ferritin level. Conclusion(s): Adult patients with mild, moderate and severe COVID-19 infection, when treated with different drug combination, were more likely to improve in terms of inflammatory markers and disease severity markers and were more likely to have a better clinical profile at the end of the treatment period. Copyright © 2022, Anka Publishers. All rights reserved.

4.
Neurología (English Edition) ; 37(9):820-823, 2022.
Article in English | ScienceDirect | ID: covidwho-2086597
5.
Industry 4.0 and Intelligent Business Analytics for Healthcare ; : 1-352, 2022.
Article in English | Scopus | ID: covidwho-2067728

ABSTRACT

In today’s world, there is nothing permanent except change. We have seen the advent of the Fourth Industrial Revolution or Industry 4.0 over the last couple of years. Now is a perfect time to think about Industry 4.0 technology and leverage its advantages for the benefit of mankind. It cannot prevent the onset of pandemics;however, it can help and has helped prevent spread, educate, warn, and empower those on the ground to be aware of the situation, and noticeably lessen the impact. Industry 4.0 can fulfill the requirements of customized facemasks, gloves, and collect information for healthcare systems for proper controlling and treating of COVID-19 patients. Major technologies of Industry 4.0 are required to solve the problems of this virus. It is useful to provide day-to-day updates of an infected patient, area-wise, age-wise and state-wise with proper surveillance systems. We also believe that the proper implementation of these technologies would help to enhance education and communication regarding public health. These Industry 4.0 technologies could provide a lot of innovative ideas and solutions for fighting local and global medical emergencies. Today, we need to focus on technologies like mobile, cloud, analytics, robotics, AI/ML, 4G/5G, and high-speed internet;it has become possible to test several innovative approaches to pandemic response. The objective of this book is to bring together leading academic scientists, research scholars and professionals to exchange and share their experiences and research results in Industry 4.0 and Intelligent Business Analytics. This research-oriented book will provide a common platform to all researchers in this domain. It covers different verticals of industry and academics, which is an added advantage of this book. © 2022 by Nova Science Publishers, Inc.

6.
Journal of Indian Academy of Forensic Medicine ; 44(1):54-56, 2022.
Article in English | Scopus | ID: covidwho-2025244

ABSTRACT

The recent Covid-19 pandemic has raised a lot of questions regarding the mode of transmission of the virus. The rapid spread across the globe has compelled researchers to focus on this issue. Theories claiming droplet transmission, fbmites as well as airborne transmission have cropped up. The primary concern for the autopsy surgeons is whether the dead bodies harbor the virus and if so for how long. The present study was undertaken to find out the possibility of the virus being isolated from the human cadavers by testing at specified intervals after death. Out of the 74 cases examined, 59.5% of cases tested positive 1 day after death and 20.5% were still positive 5 days after death. The diflerence between males and females was not significant. The age of the subjects in our study ranged from 20 days to 90 years. The results of the study clearly indicate that the virus persists in the human cadavers for a sufficient period of time to act as a potential source of infection. Adequate precautionary measures while packing the body and autopsy examination are of utmost essential to prevent the spread of the disease among the dead body handlers and the family members while performing the last rites © 2022. Journal of Indian Academy of Forensic Medicine.All Rights Reserved.

7.
International Journal of Pharmaceutical Sciences Review and Research ; 75(2):196-199, 2022.
Article in English | EMBASE | ID: covidwho-2010619

ABSTRACT

Tomato flu is an infectious disease caused by an unexplained virus. The main symptoms of the infection are tomato-shaped blisters all over the body which enlarges to resemble the shape of a tomato, therefore being named as ‘Tomato flu’. Most commonly affects children below the age of 5 years. Tomato flu is considered a “Hand, Foot and Mouth disease”. The clinical manifestation of most cases is mild. It is a self-limiting infection;which gets resolved on its own in 7-10 days. The diagnosis is based on the clinical history and physical examination, especially in regions where there are outbreaks. This infectious disease etiological agent, its treatment regimen, and vaccination stills remain unknown and is a crucial area of research at present. COVID-19 has taught us lessons for outbreak preparedness and management of cases in emergency conditions by repurposing drugs and vaccines which is also synonymously being tried to curb the condition at present situation.

8.
International Journal of Pharmaceutical Sciences Review and Research ; 74(2):180-183, 2022.
Article in English | EMBASE | ID: covidwho-1980022

ABSTRACT

Infodemics, the information whether true or untrue have been seen to spread swiftly during the epidemic or pandemic or any other public health emergency situations. Among this information, the wrong and falsified ones create hindrances in the control measures amidst such situation leading to confusion and chaos among the public. Social media platforms play a crucial role in the spread of these false information and many people intentionally or unintentionally utilized the COVID-19 pandemic as a source for the spread of inaccurate and non-scientific things through social media platform. Therefore, management of infodemics is of utmost importance these days. Keeping this thing in our mind, we reviewed the scenario of spread of infodemics during the pandemic and how it affects the public health.

9.
Biocell ; 46(10):2201-2208, 2022.
Article in English | Web of Science | ID: covidwho-1918326

ABSTRACT

Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. MSCs played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material science. Recently, MSCs have been widely explored for their application in regenerative medicine and COVID-19 treatment. Different approaches to evaluate the future of biomaterials and stem cell properties have been developed. However, misconceptions and ethical issues still exist, such as MSCs being non-angiogenic, anti-apoptotic, and immunoregulatory competencies. Embryonic stem cells isolation primarily requires the consent of donors and can include the killing of fertilized eggs. These issues generate questions related to ethical and moral issues. However, MSCs have gained considerable attention for tissue regeneration owing to their differentiation ability with immunomodulatory effects. They are capable of secreting a broad range of biomolecules such as proteins, nucleic acids, exosomes, microRNAs, and membrane vesicles, collectively known as secretomes. Secretomes are released in response to the surrounding microenvironment. In this article, we briefly address topics related to the therapeutic potential of MSCs as an advanced approach in the field of regenerative medicine and various perspectives.

10.
American Journal of Respiratory and Critical Care Medicine ; 205:1, 2022.
Article in English | English Web of Science | ID: covidwho-1880318
11.
6th International Conference on Computational Intelligence in Data Mining, ICCIDM 2021 ; 281:211-223, 2022.
Article in English | Scopus | ID: covidwho-1872353

ABSTRACT

The origin of the COVID-19 pandemic lies at the wet market of Wuhan, China, which reportedly incepted from a person's consumption of a wild animal that was already infected with the disease. Since then, the virus has spread worldwide like wildfire and poses a major threat to the entirety of the human species itself. Coronavirus causes respiratory tract infections that can range from mild to lethal. This paper discusses the use of data analysis and machine learning to draw from the implications of the growth patterns of previous pandemics in general and projects that specifically predict future scenarios of COVID-19. It also compares and measures some of the present pandemic’s short- and long-span predictions with the equivalent real-world data observed during and after the said span. It also attempts to analyze how effective the lockdown has been across various countries and what India specifically must do to prevent a catastrophic outcome. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

12.
International Journal of Pharmaceutical Sciences Review and Research ; 73(1):114-119, 2022.
Article in English | EMBASE | ID: covidwho-1798544

ABSTRACT

Covid-19 pandemic has impacted the lives of everyone in one way or another. The healthcare workers being the group directly or indirectly working with the covid patients are at higher risk which can lead to increased anxiety among them. This is a prospective, cross-sectional, observational study among healthcare workers who were involved with patient care during the initial stages of the pandemic. Generalized Anxiety Disorder Assessment scale (GAD-7 scale) and WHO-5 wellbeing scale were distributed among healthcare workers through an online survey as a google form. Out of 95 participants who consented about 80% were frontline workers among which the majority (82%) were doctors and nursing staff (11.6%). The mean GAD-7 score observed was 6.06 ± 5.12 with a majority of the participants having minimal anxiety (44.44%). The mean WHO-5 wellbeing score was 55.83 ± 26.57. The present study showed a majority of the health care worker has minimal anxiety but the low mood was prevalent in many which could be due to increased workload and stress.

13.
Environmental Treatment Technologies for Municipal, Industrial and Medical Wastes: Remedial Scope and Efficacy ; : 1-236, 2021.
Article in English | Scopus | ID: covidwho-1753145

ABSTRACT

Environmental Treatment Technologies for Municipal, Industrial and Medical Wastes will provide the reader with a simple and clear path to analyze the full range of options to manage/treat any solid, hazardous, or medical waste problems/issues at hand. This book aims to disseminate information on available remediation treatment technologies to developing and developed countries. It also includes adequate information on all available treatment technologies for different types and categories of waste (hazardous, non-hazardous municipal solid waste, and medical waste). The technologies are grouped into the following categories: Containment technology;Soil washing;Thermal treatment;Vapor extraction;Bioremediation including Phytoremediation;Plasma/Incineration;Other Physical/Chemical treatments. It enlightens the effect of emissions during remediation activities on climate change and suggests measures to identify and control such emissions. It also covers the application of remote sensing technologies with examples and the impending issues of proper disinfection and disposal of COVID-19 related waste pertaining to the current pandemic. It is intended for almost anyone - ranging from college students and early career professionals interested in environmental pollution control, to graduate students, researchers and experienced professionals. This book will: cover several recent developments on various treatment technologies, including in situ applications and their emission/migration control methods including remote sensing technologies;deal with municipal solid waste, their treatment/disposal methods, recycling, and reuse in addition to the hazardous and medical waste management program;assist civil/environmental engineering students and local community organizations in evaluating the impact of an industry and its associated waste produced on-site;and cover how best to treat/manage the waste to arrive at a safe operation without impacting human health and the local environment. © 2022 Taylor & Francis Group, London, UK. All rights reserved.

15.
Embase;
Preprint in English | EMBASE | ID: ppcovidwho-326939

ABSTRACT

Vaccine hesitancy and continuing emergence of SARS-CoV-2 variants of concern that may escape vaccine-induced immune responses highlight the urgent need for effective COVID-19 therapeutics. Monoclonal antibodies used in the clinic have varying efficacies against distinct SARS-CoV-2 variants;thus, there is considerable interest in engineered ACE2 peptides with augmented binding affinities for SARS-CoV-2 Spike protein. These could have therapeutic benefit against multiple viral variants. Using molecular dynamics simulations, we show how three amino acid substitutions in an engineered soluble ACE2 peptide (sACE22.v2.4-IgG1) markedly increase affinity for the SARS-CoV-2 Spike (S) protein. We demonstrate high binding affinity to S protein of the early SARS-CoV-2 WA-1/2020 isolate and also to multiple variants of concern: B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), and B.1.617.2 (Delta) SARS-CoV-2 variants. In humanized K18-hACE2 mice, prophylactic and therapeutic administration of sACE22.v2.4-IgG1 peptide prevented acute lung vascular endothelial injury and lung edema (essential features of ARDS) and significantly improved survival after infection by SARS-CoV-2 WA-1/2020 as well as P.1 variant of concern. These studies demonstrate for the first time broad efficacy in vivo of an ACE2 decoy peptide against multiple SARS-CoV-2 variants and point to its therapeutic potential.

16.
Mendel ; 27(2):80-89, 2021.
Article in English | Scopus | ID: covidwho-1675276

ABSTRACT

One of the record killers in the world is lung disease. Lung disease denotes to many disorders affecting the lungs. These diseases can be identified through Chest X-Ray, Computed Tomography CT, Ultrasound tests. This study provides a systematic review on different types of Deep Learning (DL) designs, methods, techniques used by different researchers in diagnosing COVID-19, Pneumonia, Tuberculosis, Lung tumor, etc. In the present research study, a systematic review and analysis is carried by following PRISMA research methodology. For this study, more than 900 research articles are considered from various indexing sources such as Scopus and Web of Science. After several selection steps, finally a 40 quality research articles are included for detailed analysis. From this study, it is observed that majority of the research articles focused on DL techniques with Chest X-Ray images and few articles focused on CT scan images and very few have focused on Ultrasound images to identify the lung disease. © 2021, Brno University of Technology. All rights reserved.

17.
Neurologia ; 37(9): 820-823, 2022.
Article in English | MEDLINE | ID: covidwho-1665326
18.
Biomedical and Pharmacology Journal ; 14(4):2245-2247, 2021.
Article in English | EMBASE | ID: covidwho-1637507
19.
Physiological Research ; 19:19, 2022.
Article in English | MEDLINE | ID: covidwho-1628253

ABSTRACT

Few peculiarities have been observed in the aetiology of coronavirus disease 2019 (COVID-19), one such being its greater prevalence in men than women partly due to the higher expressions of angiotensin-converting enzyme-2 (ACE2) in the male reproductive tissues. Recent scientific reports are in line with some of the evidence-based hypotheses in the initial phase of the COVID-19 pandemic, regarding the involvement of oxidative stress (OS) and oxidant-sensitive pathways in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-mediated male reproductive disruptions. The seminal dissemination of SARS-CoV-2 or its components, testicular disruptions due to viral infection and oxidative damage in the testis have all been evidenced recently. High-dose of antioxidants, such as vitamin C, have been shown to be a useful treatment for COVID-19 patients, to alleviate systemic inflammation and OS. In addition, vitamin C is a major testicular antioxidant that neutralizes excess reactive oxygen species (ROS), prevents sperm agglutination, prevents lipid peroxidation, recycles vitamin E, and protects against DNA damage. Thus, the present review aims to discuss the mechanism of COVID-19-mediated male reproductive dysfunctions, based on the evidence available so far, and explore the possibility of using vitamin C in alleviating testicular OS and associated damage caused by COVID-19.

20.
Immunity Boosting Functional Foods to Combat COVID-19 ; : 91-101, 2021.
Article in English | Scopus | ID: covidwho-1519201

ABSTRACT

During current COVID- 19 pandemic situation where preventive and curative medicines are unavailable, strong immune system is one of the best weapons to deal with it at individual level. Functional foods and dietary modification can decrease any kind of infections (viral as well as other infections) risk including COVID-19 and build up our immunity. Persons with strong immunity are able to recover any infectious disease conditions within short period of time. Main concern of this content is to support the principle that flax seed, a plant-derived omega-3 (ù-3) polyunsaturated fatty acids (rich in a-linolenic acid) can activate both adaptive and innate immune functions, altered macrophage function through production and secretion of cytokines and chemokines, improve phagocytosis capacity leads to increase immunity. Two bioactive compounds lignans and fiber are also present in flax seed. Flax seed reduces inflammation oxidative stress, and shows lipid modulating properties also. Omega -3 fatty acids popular for its health benefits against comorbidities in the COVID-19 patients including hypertension, respiratory system disease and cardiovascular disease, diabetes, cancer. Flax seed helps to maintain intestinal environment, function and immunity through modulating the gut microbiota composition, improve intestinal wall integrity, production of short chain fatty acids (due to fermentation of flaxseed fiber by gut microbiota). However it is established that the inclusion of sufficient amount of flax seed as whole, powder, oil, or fortified form in our regular diet helps to boost immunity against infectious disease. © 2021, Narendra Publishing House, Delhi, India.

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