Association of deletion polymorphisms of GSTM1 and GSTT1 genes with the degree of lung damage in elderly people after COVID-19

To analyze the association of polymorphisms of the GSTM1 and GSTT1 genes with the degree of lung damage in elderly people in Yakutia who suffered from COVID-19, a survey of volunteers who had a coronavirus infection aged 60 to 75 years (average age 64.470 +/- 0.602 years) was conducted. The results of our study find out that the combination of zero deletion genotypes GSTM1 and GSTT1 is a risk factor for the development of severe lung lesions in the elderly.

The Influence of Herpes Family Viruses on the Course of Novel Coronavirus Infection

We have analyzed the impact of herpes virus infection on the course of a new coronavirus infection (NCVI). Infection of the examined contingent with herpes family viruses reached 95.3-100%. An association of NCVI with herpes simplex viruses 1, 2 types (HSV 1, 2 types) was found, but no correlation was found between the positivity coefficient (CP) of HSV 1, type 2 and the severity of NCVI. This can be explained by the fact that the sampling was carried out in the remote period after the transferred NKVI. Considering that both herpes viruses and the SARS-CoV-2 virus cause multiple organ damage and can aggravate each other, the study of co-infection seems to be very relevant.

Results of the Survey of Patients Who Underwent Covid-19

Sources indicate that being infected with COVID-19 leaves patients with undesirable symptoms that form a new disease - post-covid syndrome. We examined the health status of 155 people who suffered a coronavirus infection. Informed consent to the study was obtained from all participants. They were interviewed, asked to fill out a series of questionnaires to assess symptoms and quality of life, and underwent a medical examination. Our results showed that after 8 months, people who have had COVID-19 complain about the symptoms of post-covid syndrome. At the same time, the most common clinical manifestations were sleep disorders (50.9%), hypertension (47.7%), weakness (33.5%), dizziness (32.9%), shortness of breath (27.7%), headaches (24.5%), gastrointestinal disorders (diarrhea, abdominal pain) (18.7%). Our statistical analysis showed a significant dependence of increased blood pressure (1.7 times higher) with the degree of lung damage.