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1.
J Perinatol ; 42(10): 1346-1352, 2022 10.
Article in English | MEDLINE | ID: covidwho-1991551

ABSTRACT

OBJECTIVE: We aimed to determine whether coronavirus-disease-2019 (COVID-19) pandemic exposure duration was associated with PTB and if the pandemic modified racial disparities. STUDY DESIGN: We analyzed Philadelphia births and replicated in New Haven. Compared to matched months in two prior years, we analyzed overall PTB, specific PTB phenotypes, and stillbirth. RESULTS: Overall, PTB was similar between periods with the following exceptions. Compared to pre-pandemic, early pregnancy (<14 weeks') pandemic exposure was associated with lower risk of PTB < 28 weeks' (aRR 0.60 [0.30-1.10]) and later exposure with higher risk (aRR 1.77 [0.78-3.97]) (interaction p = 0.04). PTB < 32 weeks' among White patients decreased during the pandemic, resulting in non-significant widening of the Black-White disparity from aRR 2.51 (95%CI: 1.53-4.16) to aRR 4.07 (95%CI: 1.56-12.01) (interaction P = 0.41). No findings replicated in New Haven. CONCLUSION: We detected no overall pandemic effects on PTB, but potential indirect benefits for some patients which could widen disparities remains possible.


Subject(s)
COVID-19 , Premature Birth , Ethnicity , Female , Humans , Infant, Newborn , Pandemics , Pregnancy , Premature Birth/epidemiology , Risk Factors
2.
INTERNATIONAL JOURNAL OF EDUCATIONAL SCIENCES ; 36(1-3):54-60, 2022.
Article in English | Web of Science | ID: covidwho-1970010

ABSTRACT

As part of the development of technology, the usage of social media is increasing and e-learning is a part of every individual either in formal or in distance education. In the current study, the usage of social media and so the extent of the e-learning nature of teachers at Higher Secondary School level in Kerala state was established. A survey was conducted among 124 higher secondary school teachers using Google form platform. For the survey, an inventory for Social Media Usage developed and standardised by the investigators was utilised. The investigators found that both males and female teachers, were using social media effectively. The study also found that younger teachers use social media more frequently than older teachers.

3.
Non-conventional in English | National Technical Information Service, Grey literature | ID: grc-753726

ABSTRACT

A lateral patellar dislocation is a traumatic event associated with cartilage degradation and a high risk of progression to patellofemoral osteoarthritis. The study focuses on identification of patients likely to progress to recurrent dislocations, characterization of cartilage degradation due to delaying surgical intervention until after recurrent dislocations, and evaluation of reconstruction of the medial patellofemoral ligament (MPFL) as a surgical tool to restore patellar stability.

4.
PubMed; 2022.
Preprint in English | PubMed | ID: ppcovidwho-329282

ABSTRACT

COVID 19 is the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2;SC2) which has caused a world-wide pandemic with striking morbidity and mortality. Evaluation of SC2 strains demonstrated impressive genetic variability and many of these viral variants are now defined as variants of concern (VOC) that cause enhanced transmissibility, decreased susceptibility to antibody neutralization or therapeutics and or the ability to induce severe disease. Currently, the delta (delta) and omicron (o) variants are particularly problematic based on their impressive and unprecedented transmissibility and ability to cause break through infections. The delta variant also accumulates at high concentrations in host tissues and has caused waves of lethal disease. Because studies from our laboratory have demonstrated that chitinase 3-like-1 (CHI3L1) stimulates ACE2 and Spike (S) priming proteases that mediate SC2 infection, studies were undertaken to determine if interventions that target CHI3L1 are effective inhibitors of SC2 viral variant infection. Here we demonstrate that CHI3L1 augments epithelial cell infection by pseudoviruses that express the alpha, beta, gamma, delta or omicron S proteins and that the CHI3L1 inhibitors anti-CHI3L1 and kasugamycin inhibit epithelial cell infection by these VOC pseudovirus moieties. Thus, CHI3L1 is a universal, VOC-independent therapeutic target in COVID 19.

5.
chemRxiv;
Preprint in English | ChemRxiv | ID: ppcovidwho-325700

ABSTRACT

There is evidence that high levels of folic acid in human plasma may prevent SARS-CoV-2 infections or reduce its symptoms. However, the mechanisms that enable this inhibition are still unknown. This article proves, through molecular dynamics simulation, that folic acid metabolite 7,8-dihydrofolate (DHF) has high affinity to bind as ligands to the angiotensin-converting enzyme 2 (ACE2), and when this complex has been formed, the Wild type SARS-CoV-2 virus cannot bind to the ACE2 receptor, possibly inhibiting infection to the host cell. In contrast, the Beta and Delta variants of this same virus can join the ACE2 with high affinity even with the presence of DHF. This results lead to the conclusion that DHF may inhibit infection from the Wild type SARS-CoV-2 virus, but not its Beta and Delta variants. These results could explain the almost double increase in severe cases of COVID-19 due to the delta variant in pregnant women compared to the Wild type SARS-CoV-2.

6.
IEEE Sens J ; 21(21): 24740-24748, 2021 Nov 01.
Article in English | MEDLINE | ID: covidwho-1511247

ABSTRACT

Influenza is an acute viral respiratory disease that is currently causing severe financial and resource strains worldwide. With the COVID-19 pandemic exceeding 153 million cases worldwide, there is a need for a low-cost and contactless surveillance system to detect symptomatic individuals. The objective of this study was to develop FluNet, a novel, proof-of-concept, low-cost and contactless device for the detection of high-risk individuals. The system conducts face detection in the LWIR with a precision rating of 0.98, a recall of 0.91, an F-score of 0.96, and a mean intersection over union of 0.74 while sequentially taking the temperature trend of faces with a thermal accuracy of ± 1 K. In parallel, determining if someone is coughing by using a custom lightweight deep convolutional neural network with a precision rating of 0.95, a recall of 0.92, an F-score of 0.94 and an AUC of 0.98. We concluded this study by testing the accuracy of the direction of arrival estimation for the cough detection revealing an error of ± 4.78°. If a subject is symptomatic, a photo is taken with a specified region of interest using a visible light camera. Two datasets have been constructed, one for face detection in the LWIR consisting of 250 images of 20 participants' faces at various rotations and coverings, including face masks. The other for the real-time detection of coughs comprised of 40,482 cough / not cough sounds. These findings could be helpful for future low-cost edge computing applications for influenza-like monitoring.

7.
Medicina (Brazil) ; 54, 2021.
Article in Portuguese | EMBASE | ID: covidwho-1380118

ABSTRACT

All accumulated knowledge about the teaching and learning process, considering the best teaching practices and the concepts of adult learning, meaningful learning and student-centered learning must be continually exercised and revisited, regardless of the format: face-to-face, remote teaching (ER) or distance learning (EaD). The need to expand the use of emergency ER, determined by the pandemic crisis of 2020, has brought new challenges for teachers and students worldwide. Among the challenges is the reinterpretation of the concepts present in the teaching and learning process under the lens of the digital world. This review aims to present the best practices from the perspective of the new context of digital life in teaching for the health professions, including here the opportunities offered by the pandemic.

8.
J Pediatr Urol ; 17(4): 478.e1-478.e6, 2021 08.
Article in English | MEDLINE | ID: covidwho-1142076

ABSTRACT

BACKGROUND: Testicular torsion is a surgical emergency, and time to detorsion is imperative for testicular salvage. During the COVID-19 pandemic, patients may delay emergency care due to stay-at-home orders and concern of COVID-19 exposure. OBJECTIVE: To assess whether emergency presentation for testicular torsion was delayed during the COVID-19 pandemic, and whether the rate of orchiectomy increased compared to a retrospective period. STUDY DESIGN: Patients were prospectively enrolled in a multicenter study from seven institutions in the United States and Canada. Inclusion criteria were patients two months to 18 years of age with acute testicular torsion from March through July 2020. The retrospective group included patients from January 2019 through February 2020. Statistical analysis was performed using Kruskal-Wallis tests, Chi-square tests, and logistic regression. RESULTS: A total of 221 patients were included: 84 patients in the COVID-19 cohort and 137 in the retrospective cohort. Median times from symptom onset to emergency department presentation during COVID-19 compared to the retrospective period were 17.9 h (IQR 5.5-48.0) and 7.5 h (IQR 4.0-28.0) respectively (p = 0.04). In the COVID-19 cohort, 42% of patients underwent orchiectomy compared to 29% of pre-pandemic controls (p = 0.06). During COVID-19, 46% of patients endorsed delay in presentation compared to 33% in the retrospective group (p = 0.04). DISCUSSION: We found a significantly longer time from testicular torsion symptom onset to presentation during the pandemic and a higher proportion of patients reported delaying care. Strengths of the study include the number of included patients and the multicenter prospective design during the pandemic. Limitations include a retrospective pre-pandemic comparison group. CONCLUSIONS: In a large multicenter study we found a significantly longer time from testicular torsion symptom onset to presentation during the pandemic and a significantly higher proportion of patients reported delaying care. Based on the findings of this study, more patient education is needed on the management of testicular torsion during a pandemic.


Subject(s)
COVID-19 , Spermatic Cord Torsion , Humans , Male , Orchiectomy , Pandemics , Prospective Studies , Retrospective Studies , SARS-CoV-2 , Spermatic Cord Torsion/diagnosis , Spermatic Cord Torsion/epidemiology , Spermatic Cord Torsion/surgery
9.
Cardiol Res ; 12(1): 47-50, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1005143

ABSTRACT

BACKGROUND: We sought to investigate the trajectory of cardiac catheterizations for acute coronary syndrome (ACS) and out-of-hospital cardiac arrest (OHCA) during the pre-isolation (PI), strict-isolation (SI), and relaxed-isolation (RI) periods of the coronavirus disease 2019 (COVID-19) pandemic at three hospitals in Los Angeles, CA, USA. METHODS: A retrospective analysis was conducted on adult patients undergoing urgent or emergent cardiac catheterization for suspected ACS or OHCA between January 1, 2020 and June 2, 2020 at three hospitals in Los Angeles, CA, USA. We designated January 1, 2020 to March 17, 2020 as the PI COVID-19 period, March 18, 2020 to May 5, 2020 as the SI COVID-19 period, and May 6, 2020 to June 2, 2020 as the RI COVID-19 period. RESULTS: From PI to SI, there was a significant reduction in mean weekly cases of catheterizations for non-ST elevation myocardial infarction/unstable angina (NSTEMI/UA) (8.29 vs. 12.5, P = 0.019), with all other clinical categories trending downwards. From SI to RI, mean weekly cases of catheterizations for total ACS increased by 17%, NSTEMI/UA increased by 27%, and OHCA increased by 32%, demonstrating a "rebound effect". CONCLUSIONS: Cardiac catheterizations for ACS and NSTEMI/UA exhibited a "rebound effect" once social isolation was relaxed.

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