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Preprint in English | MEDLINE | ID: ppcovidwho-290700

ABSTRACT

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can result in a hyperinflammatory state, leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic complications, among other sequelae. Statins, which are known to have anti-inflammatory and antithrombotic properties, have been studied in the setting of other viral infections and ARDS, but their benefit has not been assessed in COVID-19. Thus, we sought to determine whether antecedent statin use is associated with lower in-hospital mortality in patients hospitalized for COVID-19. This is a retrospective analysis of patients admitted with COVID-19 from February 1 st through May 12 th , 2020 with study period ending on June 11 th , 2020. Antecedent statin use was assessed using medication information available in the electronic medical record. We constructed a multivariable logistic regression model to predict the propensity of receiving statins, adjusting for baseline socio-demographic and clinical characteristics, and outpatient medications. The primary endpoint included in-hospital mortality within 30 days. A total of 2626 patients were admitted during the study period, of whom 951 (36.2%) were antecedent statin users. Among 1296 patients (648 statin users, 648 non-statin users) identified with 1:1 propensity-score matching, demographic, baseline, and outpatient medication information were well balanced. Statin use was significantly associated with lower odds of the primary endpoint in the propensity-matched cohort (OR 0.48, 95% CI 0.36 a" 0.64, p<0.001). We conclude that antecedent statin use in patients hospitalized with COVID-19 was associated with lower inpatient mortality. Randomized clinical trials evaluating the utility of statin therapy in patients with COVID-19 are needed.

3.
Journal of Environmental Chemical Engineering ; : 104708, 2020.
Article in English | ScienceDirect | ID: covidwho-896823

ABSTRACT

This research study reports the formation of flexible and multifunctional organic-inorganic hybrid membranes (BC-SiO2-TiO2/Ag) based on bacterial cellulose (BC) that contain photoactive (TiO2) and antibacterial (Ag) components, rendering them photocatalytic, self-cleaning and UV-shielding properties (due to TiO2) as well as antibacterial activity. Coating of BC with sol-gel derived silica and titania particles was achieved through hydrolysis-polycondensation of tetraethyl orthosilicate and titanium (IV) isopropoxide and a soft hydrothermal treatment (140 °C, 20 h) was used to obtain well-crystalline TiO2. The prepared BC-SiO2-TiO2/Ag photoactive membranes were characterized by an array of analytical techniques including XRD, XRF, SEM-EDS, electronic absorption spectroscopy and vibrational spectroscopy. The morphology of TiO2 coatings changes from a homogenous film-like smooth one to a rougher one consisting of randomly oriented titania particles (170 ± 35 nm) upon increasing the TiO2 loading of the membranes. These prepared photoactive BC-SiO2-TiO2 membranes exhibited excellent TiO2-loading dependent photocatalytic/self-cleaning activity towards crystal violet dye deposited as an over-layer on the surface of the membranes, degrading 97% of the dye within 50 min of UV illumination. In addition to good photoactivity, the BC-SiO2-TiO2/Ag membranes demonstrated reasonable antibacterial activity against five different bacterial strains under dark conditions. These flexible BC-based hybrid membranes with photocatalytic, self-cleaning, antibacterial properties have the potential to be used in the design of self-cleaning and antibacterial surfaces, filters and facemasks that could be easily disinfected under UV irradiation from a lamp or natural sunlight and safely discarded and even recycled.

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