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1.
Journal of Iranian Medical Council ; 5(2):352-354, 2022.
Article in English | Scopus | ID: covidwho-2204601

ABSTRACT

Organoids are a miniature, simplified version of a human organ that are produced in three dimensions in the laboratory and show the true anatomical array. These organelles originate from one or more cells - embryonic stem cells or induced multipotent stem cells - that can organize themselves in three-dimensional culture media. The use of stem cells due to the unlimited capacity of tissue division and regeneration is a great promise as a therapeutic tool. These three-dimensional models of human tissue can be used to test drugs before they are tested on humans. Lung organoids are one of the different types of organoids that, like other organoids, can be formed through a process of self-organizing stem cells or specific parts of an organ. These organoids can also be utilized as a useful tool for screening drugs and vaccines for infections such as the novel SARS-COV-2 infection. The aim of this study was to investigate the potential of lung organoids in the treatment of pulmonary diseases. Copyright 2022, Journal of Iranian Medical Council. All rights reserved.

2.
Archives of Clinical Infectious Diseases ; 17(4), 2022.
Article in English | EMBASE | ID: covidwho-2067098

ABSTRACT

Background: The application of methylprednisolone in ARDS patients has led to a sustained reduction in inflammatory plasma cytokines and chemokines and has recently been used in the treatment of patients with SARS-CoV-2 infection. Objectives: In this study, the effect of methylprednisolone on clinical symptoms and antioxidant changes of patients with COVID-19 has been investigated. Methods: In the present study, patients with moderate to severe COVID-19 who required hospitalization were entered into the study phase. Then, in addition to standard treatment, patients received methylprednisolone at a dose of 250 mg intravenously over three days. Necessary evaluations include analysis of arterial blood gases, pulse oximetry, monitoring of patient clinical signs, examination of inflammatory biomarkers, and also receiving 10 cc of peripheral blood samples to check for antioxidant changes, at the beginning of the study, after 24 hours, and 72 hours after receiving methylprednisolone was on the agenda. Results: Changes in fever, superoxide dismutase (SOD, Glutathione-S-Transferase (GST, the ferric reducing ability of plasma (FRAP, malondialdehyde (MDA, Nitric oxide, Ferritin, and TNF-α before treatment and 72 hours after treatment were significantly different between the two stages (P < 0.05). Conclusions: The use of methylprednisolone improves the balance of antioxidants and immunological factors in patients with COVID-19 and thus improves some clinical indicators in these patients.

3.
30th International Conference on Electrical Engineering, ICEE 2022 ; : 356-361, 2022.
Article in English | Scopus | ID: covidwho-1992643

ABSTRACT

The outbreak of the novel coronavirus (COVID-19) is currently considered a great challenge to the health of human society. In this study, since the COVID-19 vaccines are currently being developed, a vaccine allocation as an effective pharmaceutical strategy to immunize people against disease is being considered. To this end, a new extended SIR-type model including vaccination compartment and reinfection transmission to predict disease behavior in Iran has been formulated. The mathematical analysis of the model is investigated to verify that the proposed model is well-posed epidemiologically. The biological parameters are evaluated via a nonlinear least-square fitting approach. Finally, to investigate the impact of preventive pharmaceutical measures on flattening the curve of the COVID-19 incidence in Iran, the optimal control strategy is applied. The results of numerical simulations and the optimal control analysis illustrate that the combined implementation of time-dependent measures has a drastic impact on disease burden reduction. © 2022 IEEE.

4.
8th International Conference on Control, Instrumentation and Automation, ICCIA 2022 ; 2022.
Article in English | Scopus | ID: covidwho-1788693

ABSTRACT

The novel coronavirus (COVID-19) is a major health threat caused by a virus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). COVID-19 can cause acute respiratory illness, which is deadly in some people. Epidemio-logically, vaccination is the safest and most effective approach to gaining immunity and fighting against viral diseases. In this paper, the extended compartmental SEIR model, considering vaccination as a pharmaceutical intervention, to assess the behavior of the COVID-19 outbreak in Iran is proposed. Initially, some mathematical analysis of the model, including positivity, boundedness, the basic reproduction number, and herd immunity is investigated. In order to validate the proposed model, the biological parameters of the model are estimated based on real-confirmed cases in Iran at a specified interval of time. Finally, to examine the concept of flattening the curve of the disease outbreak, the impacts of physical distancing and vaccination on mitigating the burden of the epidemic are compared graphically. © 2022 IEEE.

5.
TANAFFOS Journal of Respiratory Disease, Thoracic Surgery, Intensive Care and Tuberculosis ; 19(2):91-99, 2020.
Article in English | CAB Abstracts | ID: covidwho-1489864

ABSTRACT

This article presents the guideline released by the National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital COVID-19 Expert Group, that aims to help the clinicians caring for patients admitted to hospitals with confirmed or suspected SARS-CoV-2 infection. This guideline includes classification of disease severity, makes use of the indications of a virological assay, of an imaging study, and that of hospital admission. In addition, protocol of treatment is also presented, with chloroquine, lopinavir/ritonavir, remdesivir, favipiravir, umifenovir, oseltamivir, and ribavirin as possible medications, and interferon beta-1a, steroids, intravenous immunoglobulin (IVIG), tocilizumab, and convalescent plasma for severe cases. This guidelines also discusses details on ICU care, hospital discharge planning, and follow up.

6.
Tanaffus ; 20(1):71-74, 2021.
Article in English | MEDLINE | ID: covidwho-1357847

ABSTRACT

COVID-19 pneumonia has invaded the world and continues to expand. The current evidence of the immune system reaction to this viral pneumonia shows that the post-infectious immunity against the virus may be temporary, and the virus may reinfect the patients after healing from the previous one. Here is presented a 55-year-old female patient, as a known case of Hodgkin lymphoma, diagnosed with COVID-19 reinfection during 40 days. Such evidence may be helpful in further understanding the immunology of the disease.

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