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1.
Front Psychol ; 14: 1106483, 2023.
Article in English | MEDLINE | ID: covidwho-2258675

ABSTRACT

Introduction: In the context of the continuous progress of the "Internet+" era and the exceptionally severe outbreak of the Covid-19, online education confronts many challenges and also brings unlimited development opportunities. Methods: In this paper, taking six universities with sports majors in Chongqing as the research objects, we analyze the current situation and problems of the development and construction of online education resources for sports in colleges and universities by browsing the official websites of colleges and universities, investigating the cooperation between colleges and universities and Massive Open Online Course (MOOC), and conducting a questionnaire survey on students. Results: The results show that it is necessary to innovate the traditional inefficient classroom teaching model based on the values of adapting to the characteristics of the "Internet+" era and learning advanced teaching rules, thus optimizing teaching effectiveness and fostering students' independent learning, thinking and innovation. Discussion: We investigated students' online learning habits, their experience of using online education platform and the difficulties they encountered in the process, based on which two issues were raised: learning needs and learning experience.

2.
Acta Veterinaria et Zootechnica Sinica ; 53(7):2260-2267, 2022.
Article in Chinese | EMBASE | ID: covidwho-2245652

ABSTRACT

The C-terminal domain (CTD) of porcine deltacoronavirus S1 subunit is the main region which induces the neutralizing antibody. S1-CTD was expressed by HEK-293T eukaryotic expression system and purified, and porcine ileal epithelium cells membrane proteins were extracted to investigate porcine host proteins that interact with it. Thirty-two suspected interacting host proteins were obtained by co-inmunprecipitation (Co-IP) and mass spectrometry. Eukaryotic expression plasmid of KIF1 binding protein (KIFBP) was constructed, and the interaction between KIFBP and S1-CTD was identified by Co-IP and laser confocal microscopy. All results proved that KIFBP interacted with S1-CTD and co-located in cytoplasm. Further research indicated that overexpression of KIFBP could effectively reduce the viral mRNA level and the viral titer in which the mRNA level decreased by about 70%, and the viral titer decreased by 101.6TCID50. In conclusion, a host protein KIFBP interacting with PDCoV S1-CTD was screened and identified in this study which provides a theoretical basis for understanding the pathogenesis of PDCoV.

3.
The Lancet Regional Health - Western Pacific ; 31, 2023.
Article in English | Scopus | ID: covidwho-2241568

ABSTRACT

Overall survival (OS) is considered the standard clinical endpoint to support effectiveness claims in new drug applications globally, particularly for lethal conditions such as cancer. However, the source and reliability of OS in the setting of clinical trials have seldom been doubted and discussed. This study first raised the common issue that data integrity and reliability are doubtful when we collect OS information or other time-to-event endpoints based solely on simple follow-up records by investigators without supporting material, especially since the 2019 COVID-19 pandemic. Then, two rounds of discussions with 30 Chinese experts were held and 12 potential source scenarios of three methods for obtaining the time of death of participants, including death certificate, death record and follow-up record, were sorted out and analysed. With a comprehensive assessment of the 12 scenarios by legitimacy, data reliability, data acquisition efficiency, difficulty of data acquisition, and coverage of participants, both short-term and long-term recommended sources, overall strategies and detailed measures for improving the integrity and reliability of death date are presented. In the short term, we suggest integrated sources such as public security systems made available to drug inspection centres appropriately as soon as possible to strengthen supervision. Death certificates provided by participants' family members and detailed standard follow-up records are recommended to investigators as the two channels of mutual compensation, and the acquisition of supporting materials is encouraged as long as it is not prohibited legally. Moreover, we expect that the sharing of electronic medical records and the legal disclosure of death records in established health registries can be realized with the joint efforts of the whole industry in the long-term. The above proposed solutions are mainly based on the context of China and can also provide reference for other countries in the world. © 2022 The Authors

4.
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration ; 23(Supplement 1):187, 2022.
Article in English | EMBASE | ID: covidwho-2160821

ABSTRACT

Background: Multidisciplinary care has been shown to improve life expectancy and quality of life in patients with ALS (pALS) and is the cornerstone of pALS management. During the COVID 19 pandemic public safety precautions patients on noninvasive ventilation (NIV) and invasive ventilation were not seen in person due to hospital-wide infectious disease guidelines. Additionally, only one caregiver was permitted with each pALS during multidisciplinary clinic appointments. Objective(s): To facilitate the adoption of video-based telemedicine for discussion of goals of care in advanced ALS. Method(s): During the COVID 19 pandemic period ranging from 3/15/2020 to 5/10/2022, pALS enrolled in the VCU Health ALS clinic participated in in-person clinic visits as well as videobased telemedicine visits with the multi-disciplinary team. The pALS on NIV and invasive ventilation were seen, per VCU ALS clinic protocols, every 1-2 months by home care respiratory therapists (RT). The home care RT protocols alerted the team to a pALS vital capacity approaching 30% of normal. This triggered a goals of care discussion with the patient, family members, and caregivers. The neurologist, nurse navigator, respiratory therapist, and social worker discussed the two options for goals of care at this point in the disease process. One option involved discussion of all aspects of choosing a scheduled tracheostomy and long-term 24-hour care requirements for pALS by their caregivers. The second goals of care option presented to pALS was palliative care to manage symptoms and hospice at home. Telemedicine also enabled pALS to DocuSign Durable Do Not Resuscitate forms that were reviewed by the hospital attorney and placed in the electronic medical record. Out of the 53 patients who died during this time frame, 33 had the goals of care discussion via telemedicine. In-person discussions took place with 7 pALS. One pALS committed suicide 2 months after diagnosis and 2 pALS were lost to follow up. Ten pALS had no documented goals of care discussion prior to their death, per chart review. Two pALS, one via telemedicine and one in person, chose tracheostomy after the goals of care discussion. Conclusion(s): More patients had goals of care discussion via telemedicine (62%) than in person (13.2%) suggesting that video technology telemedicine with the multi-disciplinary team helped establish relationships with the team members and facilitated rapid access to the team for pALS. Telemedicine allowed the multi-disciplinary team to discuss at length with pALS and all their family members goals of care when pre-specified clinical end points of their disease were reached. Telemedicine was adopted by our clinic for discussion of withdrawal of invasive ventilator support on one patient who had been ventilated for several years. Further studies would be beneficial to gauge patient and caregiver satisfaction with goals of care discussion via telemedicine appointments.

5.
Kybernetes ; 2022.
Article in English | Scopus | ID: covidwho-1642508

ABSTRACT

Purpose: The teenager community is the most affected community by cybercrime in the COVID-19 era. Increasing social networks and facilitating teenager access to the Internet have increased the probability of cybercrimes. On the other hand, entertainment such as mobile and computer games is top-rated among teenagers. Teenagers' tendency to cybercrime may be influenced by individual, parent, social, economic and political factors. Studying the impact of social networks, mobile games and parents' religious attitudes on teenagers' tendency to cybercrimes in the COVID-19 era is the primary goal of this paper. Design/methodology/approach: The outbreak of COVID-19 caused a considerable change in the world and the lifestyle of all people. Information and Communication Technology (ICT) was also affected by the special conditions of this virus. Changes in ICT and rapid access to it have empowered individuals and organizations, and people have increased civic participation and interaction through ICT. However, the outbreak of COVID-19 has created new challenges for the government and citizens and may cause new crimes. Cybercrime is a type of crime that occurs in a cyber environment. These crimes range from invasions of privacy to crimes in which the offender vaguely paralyzes the macroeconomic. In this research, 265 students of high schools and universities are used for collecting data by utilizing a survey. Measuring actions have been done in all surveys employing a Likert scale. The causal pattern is assessed through a constructional equation modeling procedure to study the scheme's validity and reliability. Findings: The outcomes have indicated that social networks have no significant relationship with teenagers' tendency to cybercrimes in the COVID-19 era. Mobile games have a mild effect on teenagers' tendency to cybercrimes in the COVID-19 era, and parents' religious attitudes significantly impact teenagers' tendency to cybercrimes in the COVID-19 era. Research limitations/implications: Current research also has some restrictions that must be noticed in assessing the outcomes. First, sample research was selected from high schools and universities in one city. So, the size of the model is small, and the generalization of results is limited. Second, this research may have ignored other variables that affect the tendency of teenagers' to cybercrime. Future researchers intend to investigate the parents' upbringing system's impact on teenager's trend to cybercrime in the COVID-19 era. Future research can also examine practical factors such as parental upbringing, attitudes toward technology development and virtual addiction in the COVID-19 era. Originality/value: In this study, teenagers' tendency to cybercrimes in the COVID-19 era is investigated, and a procedure is applied depending on a practical occasion. This article's offered sample provides a perfect framework for influencing parents' social networks, mobile games and religious attitudes on teenagers' tendency to cybercrimes in the COVID-19 era. © 2021, Emerald Publishing Limited.

6.
Qiangjiguang Yu Lizishu/High Power Laser and Particle Beams ; 33(11), 2021.
Article in Chinese | Scopus | ID: covidwho-1600028

ABSTRACT

Surface-enhanced Raman spectroscopy (SERS) technology has been widely used in viral molecular detection due to its high sensitivity, simple operation and rapid detection. The research of virus detection by Raman technology at home and abroad mainly focuses on the detection of the SERS spectrum of viral nucleic acids and various bases that make up the nucleic acids, and detection of viral proteins is rare. In this paper, the S protein of the new coronavirus (SARS-CoV-2) is used as the detection object, and with the label-free SERS detection method, the ordinary Raman spectra of solid and saturated liquid S protein of the SARS-CoV-2 and the SERS spectra of the low-concentration S protein of SARS-CoV-2 on the substrate of gold nanoparticles with a size of 40 nm are compared. The results show that it is completely feasible to use SERS technology to detect the S protein of SARS-CoV-2 on the substrate of 40 nm gold nanoparticles. The carboxyl groups in the S protein molecule of SARS-CoV-2 and gold nanoparticles are molecularly enhanced, and the amino groups and gold nanoparticles are electromagnetically enhanced, so that the Raman effect of the S protein of the SARS-CoV-2 is enhanced and the peak position is moved to a certain extent. The experiments obtained relatively good SERS spectra of the low-concentration S protein of SARS-CoV-2, which provides a method for the establishment of a sensitive, specific and rapid detection technology for the S protein of the SARS-CoV-2. © 2021, Editorial Office of High Power Laser and Particle Beams. All right reserved.

7.
2nd IEEE Asia-Pacific Conference on Image Processing, Electronics and Computers, IPEC 2021 ; : 733-737, 2021.
Article in English | Scopus | ID: covidwho-1247073

ABSTRACT

This article analyzes the epidemic situation in all provinces of China, considering the impact of population mobility in all provinces during the Spring Festival transportation without restricting people's free movement in Wuhan. According to the characteristics of novel Coronavirus, we choose the SEIR model to establish the required differential equations. On this basis, we establish different differential equations according to the characteristics of Wuhan and all provinces of China. By collecting relevant data and using particle swarm optimization algorithm for data fitting, we predict the epidemic situation of domestic provinces during the period from the first case to March 1

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