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1.
National Science Review ; 9(11), 2022.
Article in English | Web of Science | ID: covidwho-2123132

ABSTRACT

This is the first study to characterize post-COVID-19 syndrome and identify risk factors for clinical and psychological sequelae of COVID-19 in two distinct cohorts of patients in China. This cross-sectional study evaluated the long-term health effects of coronavirus disease 2019 (COVID-19) in Jianghan District (Wuhan, China). The results showed that 61.4% of COVID-19 patients reported at least one symptom and 8.8% had depressive symptoms at the 17-month follow-up. The proportion of patients with chest radiographic abnormalities in Fangcang shelter hospitals and designated COVID-19 hospitals was 31.6% and 41.1%, respectively, and the proportion of patients with impaired pulmonary diffusion capacity in these hospitals was 52.8% and 60.9%, respectively. Female sex (odds ratio [OR] = 1.48, 95% confidence interval [CI]: 1.16-1.88), severe disease (OR = 1.46, 95% CI: 1.01-2.10) and a higher number of initial symptoms (OR = 1.31, 95% CI: 1.23-1.40) were associated with the development of sequelae symptoms at 17 months. This study involving community-dwelling COVID-19 adults may help determine the long-term effects of COVID-19 during the first pandemic wave. Nonetheless, larger follow-up studies are needed to characterize the post-COVID-19 condition.

2.
Applied Mathematical Modelling ; 114:133-146, 2023.
Article in English | Web of Science | ID: covidwho-2121141

ABSTRACT

More than 30 months into the novel coronavirus 2019 (COVID-19) pandemic, effort s to bring this prevalence under control have achieved tentative achievements in China. How-ever, the continuing increase in confirmed cases worldwide and the novel variants imply a severe risk of imported viruses. High-intensity non-pharmaceutical interventions (NPIs) are the mainly used measures of China's early response to COVID-19, which enabled effective control in the first wave of the epidemic. However, their efficiency is relatively low across China at the current stage. Therefore, this study focuses on whether measurable meteoro-logical variables be found through global data to learn more about COVID-19 and explore flexible controls. This study first examines the control measures, such as NPIs and vacci-nation, on COVID-19 transmission across 189 countries, especially in China. Subsequently, we estimate the association between meteorological factors and time-varying reproduction numbers based on the global data by meta-population epidemic model, eliminating the aforementioned anthropogenic factors. According to this study, we find that the basic re-production number of COVID-19 transmission varied wildly among Koppen-Geiger climate classifications, which is of great significance for the flexible adjustment of China's control protocols. We obtain that in southeast China, Koppen-Geiger climate sub-classifications, Cwb, Cfa, and Cfb, are more likely to spread COVID-19. In August, the RSIM of Cwb cli-mate subclassification is about three times that of Dwc in April, which implies that the intensity of control effort s in different sub-regions may differ three times under the same imported risk. However, BSk and BWk, the most widely distributed in northwest China, have smaller basic reproduction numbers than Cfa, distributed in southeast coastal areas. It indicates that northwest China's control intensity could be appropriately weaker than southeast China under the same prevention objectives.(c) 2022 Elsevier Inc. All rights reserved.

3.
Zhonghua Yu Fang Yi Xue Za Zhi ; 56(11): 1540-1542, 2022 Nov 06.
Article in Chinese | MEDLINE | ID: covidwho-2119293

ABSTRACT

Since the global pandemic of COVID-19, different countries have implemented various prevention and control measures, which has affected the epidemic characteristics of respiratory infectious diseases such as influenza. From 2020 to 2021, the level of influenza activity was relatively low, but it is necessary to be alert that with the adjustment of national prevention and control measures, influenza may have a relatively strong epidemic rebound. In order to deal with influenza epidemic, experts were organized to publish a series of influenza studies in this issue, suggesting that influenza prevention and control cannot be underestimated during the COVID-19 pandemic. It is suggested to carry out research on the interaction between COVID-19 and influenza to explore the epidemic characteristics of the disease, develop new technologies and tools to improve the efficiency of monitoring and early warning, identify obstacles to vaccination, promote the scientific implementation of intervention measures, and achieve joint prevention and control of multiple diseases.


Subject(s)
COVID-19 , Communicable Diseases , Influenza, Human , Humans , Influenza, Human/epidemiology , Influenza, Human/prevention & control , Pandemics/prevention & control , Vaccination , Communicable Diseases/epidemiology
4.
Zhonghua Yu Fang Yi Xue Za Zhi ; 56(10): 1395-1400, 2022 Oct 06.
Article in Chinese | MEDLINE | ID: covidwho-2090421

ABSTRACT

In the context of the global pandemic of COVID-19, the epidemic intensity, epidemic characteristics and infection risk of influenza have presented new features. COVID-19 and influenza have simultaneously emerged in many regions of the world. COVID-19 and influenza are similar in terms of transmission mode, clinical symptoms and other aspects. There are also similarities in the mechanism of influenza virus and novel coronavirus on cells. At the same time, it is feasible and significant to do a good job in the prevention and control of COVID-19 and influenza. This paper discusses the relevant strategies and measures for the joint prevention and control of influenza and novel coronavirus from the aspects of influenza vaccination to prevent co-infection, simultaneous vaccination of influenza vaccine and novel coronavirus vaccine, etc., and puts forward corresponding thoughts and suggestions, in order to provide scientific support for the formulation of strategies on seasonal influenza vaccine and novel coronavirus vaccination.


Subject(s)
COVID-19 , Influenza Vaccines , Influenza, Human , Humans , Influenza, Human/prevention & control , Influenza, Human/epidemiology , COVID-19 Vaccines , COVID-19/prevention & control , Seasons , Vaccination , SARS-CoV-2
5.
Zhonghua Yi Xue Za Zhi ; 102(30): 2315-2318, 2022 Aug 16.
Article in Chinese | MEDLINE | ID: covidwho-1994236

ABSTRACT

On May 13, 2022, World Health Organization(WHO) Position Paper on Influenza Vaccine (2022 edition) was published. This position paper updates information on influenza epidemiology, high risk population, the impact of immunization on disease, influenza vaccines and effectiveness and safety, and propose WHO's position and recommendation that all countries should consider implementing seasonal influenza vaccine immunization programmes to prepare for an influenza pandemic. In addition, it proposes that the influenza surveillance platform can be integrated with the surveillance of other respiratory viruses, such as SARS-CoV-2 and Respiratory Syncytial Virus. This position paper has some implications for the prevention and control of influenza and other respiratory infectious diseases in China: (1) Optimize influenza vaccine policies to facilitate the implementation of immunization services; (2) Influenza prevention and control should from the perspective of Population Medicine focus on the individual and community to integrate with "Promotion, Prevention, Diagnosis, Control, Treatment, Rehabilitation"; (3) Incorporate prevention and control of other respiratory infectious diseases such as influenza, COVID-19, respiratory syncytial virus and adenovirus, and intelligently monitor by integrating multi-channel data to achieve the goal of co-prevention and control of multiple diseases.


Subject(s)
COVID-19 , Influenza Vaccines , Influenza, Human , Humans , Influenza, Human/epidemiology , Influenza, Human/prevention & control , SARS-CoV-2 , World Health Organization
6.
Zhonghua Yu Fang Yi Xue Za Zhi ; 56(6): 861-863, 2022 Jun 06.
Article in Chinese | MEDLINE | ID: covidwho-1924327

ABSTRACT

The COVID-19 continues to spread throughout the world, and local clusters and outbreaks related to overseas imports have occurred in many places in China. Vaccination against COVID-19 is one of the most effective tools to prevent disease, severe illness and death. For vaccines developed and used by China, it is particularly important for scientific and targeted prevention and control to study different outbreak scenarios, to conduct in-depth real-world research on SARS-CoV-2 variants, and to further promote vaccine development and technical reserves. This article commented the effectiveness of COVID-19 vaccine, and prospected the future research on vaccine efficacy, immunization strategy and vaccine development, which provided evidence for optimizing vaccination strategy.


Subject(s)
COVID-19 , COVID-19/prevention & control , COVID-19 Vaccines , Humans , Pandemics/prevention & control , SARS-CoV-2 , Vaccine Efficacy
7.
Zhonghua Yu Fang Yi Xue Za Zhi ; 56(2): 103-107, 2022 Feb 06.
Article in Chinese | MEDLINE | ID: covidwho-1600048

ABSTRACT

Influenza is an infectious respiratory disease caused by the influenza viruses. Older people, infants and people with underlying medical conditions could have a higher risk of severe influenza symptoms and complications. The co-infection of Coronavirus Diseases 2019 (COVID-19) with influenza viruses could lead to the complication of prevention, diagnosis, control, treatment, and recovery of COVID-19. Influenza vaccine and COVID-19 vaccine overlapped in target populations, vaccination time, and inoculation units. Although there was insufficient evidence on the immunogenicity and safety of co-administration of influenza vaccine and COVID-19 vaccine, World Health Organization and some countries recommended co-administration of inactivated influenza vaccine and COVID-19 vaccine. This review summarized domestic and international vaccination policies and research progress, and put forward corresponding suggestions in order to provide scientific support for the formulation of vaccination strategy on seasonal influenza vaccine and COVID-19 vaccine.


Subject(s)
COVID-19 , Influenza Vaccines , Influenza, Human , Aged , COVID-19 Vaccines , China , Humans , Infant , Influenza, Human/epidemiology , Influenza, Human/prevention & control , Pandemics/prevention & control , SARS-CoV-2 , Seasons , Vaccination
8.
Zhonghua Liu Xing Bing Xue Za Zhi ; 42(12): 2077-2081, 2021 Dec 10.
Article in Chinese | MEDLINE | ID: covidwho-1600024

ABSTRACT

Objective: To compare the immunogenicity and safety of an inactivated SARS-CoV-2 vaccine used for the vaccination in public security officers with different immunization schedules. Methods: From January to February, 2021, 405 public security officers in Taiyuan were randomly divided into 3 groups. Two doses of SARS-CoV-2 inactivated vaccine were injected according to the immunization schedule of 0-14 days, 0-21 days or 0-28 days, respectively. The nucleic acid of SARS-CoV-2 was detected by reverse transcription polymerase chain reaction. The neutralizing antibodies to SARS-CoV-2 were tested by microdose cytopathogenic efficiency assay of live virus. The GMT, seroconversion rate of SARS-CoV-2 neutralizing antibody and safety of the vaccine were analyzed for the 3 groups. Results: The seroconversion rate of SARS-CoV-2 neutralizing antibody was 100% in all the 3 groups. The SARS-CoV-2 neutralizing antibody level of 0-21 day group [166.70 (95%CI: 148.30-185.10)] was similar to that of 0-28 day group [179.50 (95%CI: 156.50-202.60)] (P>0.05), significantly higher than that of 0-14 day group [86.08 (95%CI: 72.36-99.80)] (P<0.001). The incidence rates of adverse reaction in the 3 groups were 1.48% (2/135), 0.74% (1/136) and 1.49% (2/134) respectively (P=0.750), all the adverse reactions were mild. Conclusions: The vaccination of inactivated SARS-CoV-2 vaccine with different immunization schedules in public security officers showed good safety and high seroconversion rate, and the GMTs of SARS-CoV-2 neutralizing antibody in 0-21 day group and 0-28 day group were higher than that in 0-14 day group.


Subject(s)
COVID-19 Vaccines , COVID-19 , Antibodies, Neutralizing , Antibodies, Viral , Humans , Immunization Schedule , SARS-CoV-2 , Vaccines, Inactivated
9.
Zhonghua Yi Xue Za Zhi ; 101(46): 3771-3774, 2021 Dec 14.
Article in Chinese | MEDLINE | ID: covidwho-1572699

ABSTRACT

The lower temperature in autumn-winter provides favorable conditions for the survival and spread of respiratory infectious diseases such as the corona virus disease 2019 (COVID-19) and influenza. It is likely that there will be a co-circulation of respiratory pathogens such as SARS-CoV-2 and influenza. In order to promote the prevention and control of influenza and the application of influenza vaccination during the COVID-19 pandemic in China, we separately discussed the risk of influenza epidemic in the 2021-2022 season, the influenza vaccination policies, and advocate influenza vaccination during the COVID-19 pandemic from the perspective of population medicine. We appeal that COVID-19 vaccination cannot delay the normal delivery of other vaccines in the national immunization programs and non-Expanded Program on Immunization (EPI) vaccines. Promoting influenza vaccination policies and improving immunization service convenience are necessary for increasing influenza vaccine coverage, protecting public health and assisting COVID-19 response.


Subject(s)
COVID-19 , Influenza, Human , COVID-19 Vaccines , Humans , Influenza, Human/epidemiology , Influenza, Human/prevention & control , Pandemics , SARS-CoV-2 , Seasons , Vaccination
10.
Zhongguo Huanjing Kexue/China Environmental Science ; 41(10):4703-4711, 2021.
Article in Chinese | Scopus | ID: covidwho-1489586

ABSTRACT

Wastewater-based epidemiology was applied to study the impact of the COVID-19 in 2020 on occurrence and consumption of methamphetamine and ketamine before, during, and after the outbreak in a city of Guangdong province. To estimate the total consumption during the outbreak, mobile data of the city was used to study the dynamics of the population in the towns and districts of the city. The concept of composite population was brought about for the first time and calculated to estimate total drug consumptions of each towns or districts. The population during the outbreak decreased by about 45% relative to before the outbreak. The total consumptions of the two drugs declined by about 75% during the outbreak relative to before the outbreak. However, the decrease to this extent rather implies the persistence of abuse of the two drugs, given the extremely strict control measures. The consumptions of the two drugs were found to decrease by approximately 50% relative to before the outbreak. The consumptions of the drugs rebounded to the level before the outbreak, further demonstrating the persistence of the abuse. © 2021, Editorial Board of China Environmental Science. All right reserved.

11.
Zhonghua Liu Xing Bing Xue Za Zhi ; 42(8): 1330-1335, 2021 Aug 10.
Article in Chinese | MEDLINE | ID: covidwho-1362625

ABSTRACT

This paper summarizes the basic principles and models of early warning for infectious disease outbreaks, introduces the early warning systems for infectious disease based on different data sources and their applications, and discusses the application potential of big data and their analysing techniques, which have been studied and used in the prevention and control of COVID-19 pandemic, including internet inquiry, social media, mobile positioning, in the early warning of infectious diseases in order to provide reference for the establishment of an intelligent early warning mechanism and platform for infectious diseases based on multi-source big data.


Subject(s)
COVID-19 , Communicable Diseases , Communicable Diseases/epidemiology , Disease Outbreaks/prevention & control , Humans , Pandemics , SARS-CoV-2
12.
Zhonghua Yi Xue Za Zhi ; 101(26): 2029-2036, 2021 Jul 13.
Article in Chinese | MEDLINE | ID: covidwho-1317266

ABSTRACT

The disease burden and economic burden of seasonal influenza is substantial in China, and the Coronavirus disease 2019 (COVID-19) pandemic has brought new challenges to the prevention and control of influenza. As a priority group of influenza vaccination, the elderly are at higher risk of influenza-associated severe symptoms and deaths, and they are more price-sensitive vaccine users with better cost-effectiveness of vaccination program. Therefore, a reasonable financing mechanism of influenza vaccination should be designed for the elderly to increase their vaccination rate. This study proposes three financing strategies of influenza vaccination for the elderly in China, trying to explore the distribution of vaccination costs among individuals, central government and local governments under different financing strategies, including the individual-central-local mechanism (strategy 1), the central-local mechanism (strategy 2), and the local payment mechanism (strategy 3). Strategy 1 is feasible and sustainable for most regions in the short term. Strategy 2 is conducive to further increasing the vaccine coverage rate of the elderly. Strategy 3 encourages local fiscal payments to help relieve the financial pressure of the central government. The results revealed a relatively heavy financial burden of influenza vaccination for the elderly, and it is recommended to promote the development of a multiparty co-payment mechanism gradually based on local conditions.


Subject(s)
COVID-19 , Influenza, Human , Aged , China , Cost-Benefit Analysis , Humans , Influenza, Human/prevention & control , SARS-CoV-2 , Vaccination
13.
Zhonghua Liu Xing Bing Xue Za Zhi ; 42(6): 983-991, 2021 Jun 10.
Article in Chinese | MEDLINE | ID: covidwho-1314797

ABSTRACT

Objective: To rapidly evaluate the level of healthcare resource demand for laboratory testing and prevention and control of corona virus disease 2019 (COVID-19) in different epidemic situation, and prepare for the capacity planning, stockpile distribution, and funding raising for infectious disease epidemic response. Methods: An susceptible, exposed, infectious, removed infectious disease dynamics model with confirmed asymptomatic infection cases and symptomatic hospitalized patients was introduced to simulate different COVID-19 epidemic situation and predict the numbers of hospitalized or isolated patients, and based on the current COVID-19 prevention and control measures in China, the demands of resources for laboratory testing and prevention and control of COVID-19 were evaluated. Results: When community or local transmission or outbreaks occur and total population nucleic acid testing is implemented, the need for human resources is 3.3-89.1 times higher than the reserved, and the current resources of medical personal protective equipment and instruments can meet the need. The surge in asymptomatic infections can also increase the human resource demand for laboratory testing and pose challenge to the prevention and control of the disease. When vaccine protection coverage reach ≥50%, appropriate adjustment of the prevention and control measures can reduce the need for laboratory and human resources. Conclusions: There is a great need in our country to reserve the human resources for laboratory testing and disease prevention and control for the response of the possible epidemic of COVID-19. Challenges to human resources resulted from total population nucleic acid testing and its necessity need to be considered. Conducting non-pharmaceutical interventions and encouraging more people to be vaccinated can mitigate the shock on healthcare resource demand in COVID-19 prevention and control.


Subject(s)
COVID-19 , Pandemics , Humans , Pandemics/prevention & control , Personal Protective Equipment , SARS-CoV-2
14.
Zhonghua Yi Xue Za Zhi ; 101(8): 527-529, 2021 Mar 02.
Article in Chinese | MEDLINE | ID: covidwho-1119575

ABSTRACT

Series of the studies and consensus on the basic research on seasonal and animal influenza virus, clinical characteristics of patients with pneumonia caused by influenza A (H1N1) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), disease burden of influenza, and promotion of influenza vaccination for the elderly were published in this special issue, aiming to describe the feature of influenza virological and clinical characteristics, health and economic burden, and vaccination. These researches emphasized the importance of the integration between basic medicine, clinical medicine, public health and preventive medicine in the prevention and control of infectious diseases. Based on the concept of population medicine, promoting the integration of multidisciplinary and strengthening prevention, control and pandemic preparedness on influenza, corona virus disease 2019 and other infectious diseases, could consolidate the foundation of surveillance and early warning, prevention and control, diagnosis and treatment of emerging infectious diseases, as well as improve the ability of emergency preparedness for public health events.


Subject(s)
COVID-19 , Influenza A Virus, H1N1 Subtype , Influenza, Human , Aged , Humans , Influenza, Human/epidemiology , Influenza, Human/prevention & control , SARS-CoV-2 , Vaccination
15.
Zhonghua Yu Fang Yi Xue Za Zhi ; 54(3): 239-244, 2020 Mar 06.
Article in Chinese | MEDLINE | ID: covidwho-1159

ABSTRACT

In December 2019, novel coronavirus pneumonia epidemic occurred in Wuhan, Hubei Province, and spread rapidly across the country. In the early stages of the epidemic, China adopted the containment strategy and implemented a series of core measures around this strategic point, including social mobilization, strengthening case isolation and close contacts tracking management, blocking epidemic areas and traffic control to reduce personnel movements and increase social distance, environmental measures and personal protection, with a view to controlling the epidemic as soon as possible in limited areas such as Wuhan. This article summarizes the background, key points and core measures in the country and provinces. It sent prospects for future prevention and control strategies.


Subject(s)
Communicable Disease Control/methods , Coronavirus Infections/prevention & control , Pandemics/prevention & control , Pneumonia, Viral/prevention & control , Betacoronavirus , COVID-19 , China , Contact Tracing , Humans , Quarantine , SARS-CoV-2
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