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Gynecologic Oncology ; 166:S179-S179, 2022.
Article in English | Web of Science | ID: covidwho-2102519
Innovation in Aging ; 5:94-94, 2021.
Article in English | Web of Science | ID: covidwho-2011802
Journal of Social and Personal Relationships ; 39(1):92-99, 2022.
Article in English | Web of Science | ID: covidwho-1582709
Frontiers in Communication ; 5:5, 2020.
Article in English | Web of Science | ID: covidwho-1339481


COVID-19 was declared a global pandemic by the World Health Organization on March 11, 2020. The COVID-19 pandemic and resulting social disruption has left many to struggle with changes to routines and feelings of uncertainty as the impact of the virus continues to unfold. Evidence suggests an increase in symptoms of anxiety, depression, and stress as a result. Given the well-documented association between physical activity and mental health-be it preventing the onset of depressive or anxious symptoms to minimizing the prognosis of certain conditions-we posit more emphasis be placed in health communications on physical activity as a coping strategy for Canadians. As the ramifications of COVID-19 continue, coupled with the concern of a pending second wave, identifying how Canadians are managing stress and mental health can inform the development of interventions aimed at mitigating the negative impact of COVID-19 on adults' overall wellness. Though social interactions and activities might look different right now, Canadians should be actively looking for safe ways to engage in health promoting and socializing behaviors-physical activity is one such behavior. Herein we explore how a representative sample of Canadian adults are coping with increased stress and mental health issues as a result of COVID-19 and identify a potential disconnect between considering physical activity as a strategy to support social connection and stress management and how Canadians are coping with the pandemic. Given the protective role of physical activity in supporting mental health, our perspective is that health communication efforts should focus on the mental health benefits of physical activity particularly during these uncertain times.

American Journal of Respiratory and Critical Care Medicine ; 203(9), 2021.
Article in English | EMBASE | ID: covidwho-1277752


Myriad compounds have desirable effects on specific cell subtypes but cannot be used as medications because of toxic effects on surrounding cells or organs. While nanomedicine, in particular targeted nanomedicine, has improved organ-level targeting, delivery of drug to a specific cell type remains challenging. We have previously demonstrated that red blood cells (RBC) can be used to as super-carriers that boost delivery of dual-targeted liposomes to the pulmonary endothelium such that up to 65% of the total dose is delivered to the lungs. In contrast, freely injected single-targeted liposomes deliver, at best, 25% of total dose to the lungs. These precisely designed liposomal drug carriers are coated with antibodies to both their RBC carriers and the destination target cell. We IV injected RBC-loaded dual-targeted liposomes into a murine model, allowed them to circulate for 30 minutes, then used flow cytometry to quantify liposome binding to endothelial cells and leukocytes. We found that, in addition to a > 2.5-fold increase in delivery to the lungs compared to freely injected single-targeted liposomes, there was an additional > 6-fold increase in delivery to the endothelial cell subpopulation. Specifically, the percent of endothelial cell population bound by liposomes increased from 4% to 85% using dual-targeted RBC-bound liposomes. This corresponds to an overall 55-fold increase in drug delivered to the pulmonary endothelium. As lipid-based nanocarriers such as those used in several cancer therapeutics and those used in Covid vaccines grow in popularity, targeting to specific cell populations will become increasingly important.

Emotional and Behavioural Difficulties ; 2021.
Article in English | EMBASE | ID: covidwho-1223231


This article draws on the impact of the ongoing pandemic to highlight the failure of the English legal regime to adequately protect children’s right to education, particularly equal access to education by especially vulnerable children. Ifirst outline key domestic and international legislative provisions positioned as securing children’s and parents’ rights in this context. Prior to the pandemic, there was growing recognition of the current regime's failings regarding illegal exclusions from school, children missing from education, and the lack of inclusive education for children with special educational needs and disabilities (‘SEND’). The protection of children’s rights relied on the benevolent exercise of discretion and key decision-makers not exploiting limited oversight and scrutiny in order to meet results-driven accountability measures. Second, I critically analyse pandemic law-making and regulation, particularly in relation to the exclusion process, the legal duty to provide education in an online environment, the law on Education, Health, and Care Plans (‘EHCPs’), and the de-registration and fines for non-attendance. Third, I argue that the educational impact of the pandemic highlights the need for law reform, rather than merely revisions to statutory guidance and focus on best practice. Such reform may also trigger improvement via the ‘reflexive regulation’ of the education system.