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1.
Sleep Science ; 15:29-30, 2022.
Article in English | EMBASE | ID: covidwho-1935358

ABSTRACT

Introduction: Sleep complaints are common in individuals with neurodevelopmental disorders. However, little is known about sleep alterations in children with cri du chat syndrome (CDC) and autism spectrum disorder (ASD) due to the social isolation resulting from the COVID-19 pandemic. Objective: To assess alterations in sleep quality and its associated parameters before and after quarantine resulting from COVID-19, comparing the results between CDC, ASD or neurotypical children. Methods: Sleep was investigated in 53 children with CDC and 106 with ASD using an adaptation of the Brief Infant Sleep Questionnaire (BISQ), assessing sleep patterns both before and during the COVID-19 pandemic. Data were evaluated in comparison to 160 neurotypical (NT) children. Results: Children with CDC and ASD already had higher chances of needing parental assistance to fall asleep, taking more than 30min to fall asleep and having a wake after sleep onset time (WASO) >30min when comparing to neurotypical children in the moment preceding quarantine. Having CDC significantly increased the odds of having awakenings during the night. During quarantine, the proportion of children sleeping in their own bedrooms had decreased and the odds of awakening during the night had increased in all groups. Children with CDC and ASD had significantly higher odds of taking more than 30min to fall asleep. The chance of having a WASO >30min increased in children with ASD but decreased in CDC ones. The quarantine period statistically increased the odds ratio of children having a sleep latency of >30min by nearly 5-fold for all groups. Conclusion: The CDC group presented worse sleep parameters overall, even before quarantine. In both the CDC and ASD group worse sleep indicators were found during the COVID-19 pandemic.

2.
Sleep ; 45(SUPPL 1):A215, 2022.
Article in English | EMBASE | ID: covidwho-1927413

ABSTRACT

Introduction: The COVID-19 pandemic has subjected most of the world population to changes in daily life activities, mostly related to social isolation, family distancing and home confinement. Children with autism spectrum disorder (ASD) and other neurodevelopmental syndromes, such as cri du chat syndrome (CDC) might be especially sensitive to the consequences of the pandemic, as they usually require a predefined and strictly controlled routine. Even before the pandemic, sleep disorders and complaints were more frequent in these children compared with neurotypical (NT) children. This study aimed to evaluate the sleep pattern of children with CDC and ASD before and during the pandemic, comparing it with NT children. Methods: Children and adolescents between 0-18 years' parents or legal guardians were asked to answer the adapted Brief Infant Sleep Questionnaire, related to both before and during the COVID- 19 pandemic. Results: Before quarantine, children with CDC and ASD had increased chances of sleeping in their parents' bed, of needing parental assistance to fall asleep, of taking >30min to fall asleep and of having a wake after sleep onset time >30min compared to children with typical development. Being part of the CDC group significantly increased the odds of having awakenings during the night. After quarantine, there were a decrease in the proportion of children sleeping in their own bedrooms and an increase in the odds of awakening during the night in all groups. Children with CDC and ASD had increased chances of sleeping in their parents' bed and had a significantly higher chance of taking more than 30min to fall asleep. Both the CDC and ASD group presented worse sleep patterns during the COVID-19 pandemic. Conclusion: Our results indicated that the ASD and CDC groups usually have more sleep problems and complaints than NT children. The CDC group showed worse sleep parameters overall, even before quarantine.

3.
Developmental Medicine and Child Neurology ; 64(SUPPL 3):31, 2022.
Article in English | EMBASE | ID: covidwho-1916112

ABSTRACT

Introduction: The COVID-19 pandemic has interrupted face-to- face health services, thus leveraging telehealth strategies. From parents' perspectives, we investigated the feasibility of a remote longitudinal assessment of function (RLAF) in children with neuromotor disabilities (CwND) during the COVID-19 pandemic. Patients and Methods: Parents of CwND (3-17 years) were invited to respond to a RLAF, including: electronic forms (EFs) assessing sociodemographic and pandemic experience;Social Support Scale;IPAQ-short version;PedsQL-FIM;PedsQl-4.0;feasibility of the RLAF (F-RLAF) according to parents' perspective and voice call (YC-PEM/ PEM-CY). The RLAF was performed twice, with 4 month's intervals. We tested correlation between F-RLAF and sociodemographic/ pandemic experience (p ≤0.05) for participants who completed booth assessments (AI and AII). Results: 122 mothers started AI, 59 fully completed the RLAF. Ninety-eight continued to AII, and 66 fully completed it. A total of 94.7% and 95.5% reported no difficulties in accessing/ answering the EFs in AI and AII, respectively. Between 81.8-86% considered that RLAF was a good size. All of them classified RLAF as viable in AI, and 98.5% in AII. Considering voice call, 93% (AI) and 89.4% (AII) reported no difficulties. Lower age was associated with greater (r = -0.269;p = 0.021) and lower (r = 0.272;p = 0.014) feasibility in AI and AII, respectively. In AII, greater F-RLAF was associated with mothers not social distancing completely (r = -0.205;p = 0.050) and working in person (r = 0.231;p = 0.031). Conclusion: RLAF showed to be feasible for mothers. Feasibility may be associated with experience in digital platforms, with inconclusive results about mothers' age. Mother's interest in participating is greater than the barriers of social distancing and work demands.

4.
PubMed; 2022.
Preprint in English | PubMed | ID: ppcovidwho-331303

ABSTRACT

The emergence of the new SARS-CoV-2 Omicron variant, which is known to accumulate a huge number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination. In this scenario, we evaluated the impact on antibody neutralization induction, against Omicron variant, by a booster dose of BNT162b2 mRNA vaccine after the CoronaVac primary vaccination scheme. The percentage of seroconverted individuals 30 and 60 days after CoronaVac scheme was 17% and 10%, respectively. After booster dose administration, the seroconvertion rate increased to 76.6%. The neutralization mean titer against Omicron in the CoronaVac protocol decreased over time, but after the booster dose, the mean titer increased 43.1 times, indicating a positive impact of this vaccine combination in the serological immune response.

5.
2021 International Conference on ENTERprise Information Systems, CENTERIS 2021 / ProjMAN 2021 - International Conference on Project MANagement / HCist 2021 and International Conference on Health and Social Care Information Systems and Technologies 2021 ; 196:724-731, 2021.
Article in English | Scopus | ID: covidwho-1641589

ABSTRACT

University-industry R&D collaborations (UICs) are becoming more critical for discovering innovations that can lead to the development of new products, services, and processes and, more broadly, social impact in terms of employment, economic development, and public health. The Covid-19 pandemic, for example, has seen an unprecedented rise in UICs and illustrates how vital their success can be for positively impacting the collaborators involved and society at large. Several challenges face the successful execution of UICs, not the least of which is the cultural difference between the collaborators. Overcoming these challenges is the subject of several research initiatives that seek to identify the critical success factors (CSFs) that UIC consortiums can use to develop their internal capabilities and project management maturity. The challenges facing one large UIC have been studied in Portugal. Practitioners and researchers were involved in generating insights into how the UIC could be more effective. This paper presents some of these challenges facing the UIC and how they were addressed. It also offers early results into the CSFs deemed essential by researchers and practitioners based on their experience together over seven years. Top CSFs include senior management commitment, effective communication, stakeholder engagement, good leadership, clear and realistic goals, mutual trust and respect, interpersonal teamwork, and clear roles and responsibilities. © 2021 Elsevier B.V. All rights reserved.

6.
Anais da Academia Brasileira de Ciencias ; 93(Suppl. 3), 2021.
Article in English | CAB Abstracts | ID: covidwho-1519394

ABSTRACT

A second deadlier wave of COVID-19 and the causes of the recent public health collapse of Manaus are compared with the Spanish flu events in that city, and Brazil. Historic sanitarian problems, and its hub position in the Brazilian airway network are combined drivers of deadly events related to COVID-19. These drivers were amplified by misleading governance, highly transmissible variants, and relaxation of social distancing. Several of these same factors may also have contributed to the dramatically severe outbreak of H1N1 in 1918, which caused the death of 10% of the population in seven months. We modelled Manaus parameters for the present pandemic and confirmed that lack of a proper social distancing might select the most transmissible variants. We succeeded to reproduce a first severe wave followed by a second stronger wave. The model also predicted that outbreaks may last for up to five and half years, slowing down gradually before the disease disappear. We validated the model by adjusting it to the Spanish Flu data for the city, and confirmed the pattern experienced by that time, of a first stronger wave in October-November 1918, followed by a second less intense wave in February-March 1919.

7.
Journal of Xiangya Medicine ; 6, 2021.
Article in English | Scopus | ID: covidwho-1350601

ABSTRACT

Background: At the end of 2019, a novel coronavirus was identified as the cause of a cluster of pneumonia cases in Wuhan, China. Due to its high rate of interpersonal transmission the disease rapidly spread in China resulting in an epidemic and subsequently a pandemic with severe impact on social, economic and medical systems globally. Our understanding of the SARS-CoV-2 virus and its effects on the human body continues to evolve as new information becomes available. This paper is an overview of ongoing clinical trials registered with ClinicalTrials.gov on August 3, 2020 to guide future research and clinical practice. Our objective is to do a systematic review of the existing trials registered with ClinicalTrials.gov related to COVID-19 and the cardiovascular (CV) system. The aim of this is to describe the ongoing research in order to guide future practice and evaluate areas of deficiencies. Methods: We conducted our search on ClinicalTrials.gov (https://clinicaltrials.gov/) on August 3, 2020 and used the key terms “COVID-19” and “cardiovascular. An independent two-person review was carried out for exclusion criteria. Exclusion criteria was defined as studies that were terminated, withdrawn, suspended, of unknown status, or had no connection to the CV system. Three duplicate studies were removed;141 studies were removed after an independent two person review determined that it did not hold any relevant connection to the CV system and two studies were removed from the data as they were withdrawn and suspended respectively. There were no conflicting opinions between the two researchers regarding the 141 clinical trials excluded. The remaining 122 studies included were then grouped together based on their primary and secondary objectives. The trial was conducted in accordance with the Declaration of Helsinki. No experiments involving humans were done by the researchers and therefore ethical approval was not required. Results: We found 122 studies applicable to our search criteria and then grouped them together based on topics of investigation as identified by primary and secondary objectives. The identified studies varied from observational, registry based and interventional with most of them falling into the first two categories. The studies were ongoing at that point and did not have results to report or analyze. Conclusions: Our search on ClinicalTrials.gov produced a variety of studies that investigate relationships between COVID-19 and the CV system. Our search identified the main areas with ongoing research that has the ability to resolve controversies regarding current management of patients with COVID-19 including the ideal thromboprophylaxis regimen;arrhythmogenic potential of patients with COVID-19 and appropriate monitoring of these patients and long term morbidity related to COVID-19 and the CV system. The key finding of our analysis is that the majority of the ongoing studies are observational in nature and not randomized controlled trials. Review of these ongoing studies can aid medical professionals and researchers in outlining current areas of clinical equipoise and help with planning prospective research study topics and design. © Journal of Xiangya Medicine. All rights reserved.

8.
Biomedicine (India) ; 41(2):268-273, 2021.
Article in English | EMBASE | ID: covidwho-1315207

ABSTRACT

Introduction and Aim: A novel beta-coronavirus emerged in Wuhan, China during the early December 2019 and spread globally. The clinical signs and symptoms and the disease severity in people infected with COVID-19 can be varied. The present study was conducted to study the biomarker profile and their association with disease severity in COVID-19. Materials and Methods: This was a single-centre Cohort study of data regarding epidemiological, clinical and biomarker parameters, and outcome of COVID-19 patients admitted in a tertiary care hospital in South India. CDC guidelines were followed for assessing disease severity. Results: A total of 336 COVID-19 patients were admitted during the study period. Of these 16 were excluded and 320 cases were analysed. Mean age of patients was 44.82 years. A male predominance was observed. Diabetes mellitus was the most common co-morbidity. Asymptomatic, Mild, moderate, severe and critical disease was seen in 15%, 52.5%, 20.3%, 6.3% and 5.9% patients respectively. ICU care was required in 15.3%. Overall mortality was 5.3%. The mean NLR, ALC, CRP, LCR, LDH, Ferritin and D-dimer in the severe group vs non-severe group were 19.03 vs 4.2, 1025cells/cu mm vs 1740cells/cu mm, 185.8mg/L vs 31.7mg/L, 17.1 vs 996.3, 552.8IU/L vs 252.7IU/L, 2531.9ng/ml vs 414.1ng/ml and 2245.5ng/ml vs 339.4ng/ml respectively. Conclusion: An increased NLR, CRP, LDH, Ferritin and D-dimer and a reduced ALC and LCR are significantly associated with disease severity, need for ICU and mortality. These biomarkers will be useful adjunct to clinical assessment in better categorising and management of COVID-19 patients.

10.
Journal of Thoracic Oncology ; 16(3):S306-S306, 2021.
Article in English | Web of Science | ID: covidwho-1210404
11.
Journal of Thoracic Oncology ; 16(3):S285-S286, 2021.
Article in English | EMBASE | ID: covidwho-1159457

ABSTRACT

Introduction: The first patient with COVID-19 in Portugal was diagnosed on March 2. There was a lack of knowledge concerning the risks of COVID-19 infection in lung cancer patients, prognostic factors, the influence of cancer treatments and cure criteria. Treatments and consultations were readjusted in order to maintain the ones that increase patients’ survival, while reducing the risks of SARS-CoV-2 infection. International and national “guidelines” were followed, but each hospital had its own strategies to reduce COVID-19 risk. Purpose: The Portuguese Lung Cancer Study Group launched a survey in order to study the early impact of COVID-19 in lung cancer patients, changes in treatments and the way of implementation of COVID-free circuits. Methods: A survey was sent to lung cancer doctors of all the Portuguese hospitals. Results: At the data cut-off, information from twenty one hospitals was collected, corresponding to about 66% (n=3.446) of each year new diagnoses of lung cancer in Portugal. In March and April there was a reduction in newly lung cancer diagnosed patients while comparing with 2019: in March, 86% had a reduction;in April, 90% of the hospitals reported a reduction and it was greater than 40% in eight hospitals (38%). About 62% of the doctors considered less referral from primary care as a cause, and 33% delayed biopsies or other imaging exams. The most difficult exams to obtain were CT guided biopsies and EBUS for 48%. The majority of the hospitals (57%) were also referral for COVID-19 patients’ treatment. In 48% of the lung cancer treating departments’ there were doctors reallocated to COVID-19 treatment areas. In 48% the assistance teams were divided into teams that weren’t previously working together. The majority of doctors (90%) reported having individual protection equipment available. Hospitals performed teleconsultation (100%), and, in seven hospitals (33%), more than half of the consultations were done using communication technology. All the hospitals were able to perform SARS-CoV-2 testing. It was done before every cycle of chemotherapy in 90% of the hospitals. In the majority (67%) it was only performed before day D1, in D1 and D8 chemotherapy protocols. About 19% reported changes in prescription of adjuvant chemotherapy and in maintenance chemotherapy, 33% increased the prescription of oral chemotherapy, 33% changed the periodicity, 29% reported reduction in inclusion in clinical trials. In 33% there was an earlier end of chemotherapy in ECOG2 and vulnerable patients. In 38% the prescription of G-CSF (Granulocity-colony stimulating factor) increased, being used for prophylaxis if the risk of febrile neutropenia was more than 10-15%. The periodicity of consultations was changed for patients under TKI treatment in 86%, and 67% hospitals reported changes in immune checkpoint inhibitor treatment schedule. In 29% oral drugs could be delivered at patients’ home. All the patients admitted for surgery were tested for SARS-CoV-2, and 86% performed SARS-COV-2 testing before radiotherapy. Conclusion: Portuguese hospitals responded to the sudden need of creation of COVID-free circuits, change protocols and even teleconsultation. With a larger follow up we will study the late consequences of COVID-19 pandemic in lung cancer diagnosis and treatment. Keywords: COVID-19, survey, Portuguese Lung Cancer Study Group

12.
Agricultural Systems ; 190:103098, 2021.
Article in English | ScienceDirect | ID: covidwho-1118305

ABSTRACT

CONTEXT In Latin America, the so-called informal sector associated with family farming and the agroecology movements were instrumental at coping with and adapting to the COVID-19 challenges. OBJECTIVE To assess the nature and extent of the early initiatives (first three months) deployed by this informal sector to cope with and adapt to the impacts of the COVID-19 pandemic on food production and consumption in several countries of the region. METHODS We used key used informant consultation (n = 168), an online survey (n = 125) and the detailed characterisation of regional case studies (n = 4). Textual data was analysed and categorised using Reinert’s method, combined with similarity analysis. RESULTS AND CONCLUSIONS 65% of the initiatives were ‘local’ in terms of geographic reach, 30% of them started within the first month after the pandemic and most of them were urban or urban-rural, whereas only 29% of them were exclusively rural. The analysis of the textual information captured through the survey revealed four major types of initiatives that were deployed or adapted in response to COVID-19:1.Direct producer-to-consumer food sales, generally existing before the COVID-19 crisis but adapted/strengthened to cope with it;2.Short value chains that linked rural and urban organisations and individuals supported by national or local governments, readapted through new health and safety protocols;3.Newly developed support and training programs on sustainable food production for self-consumption or local commerce, in rural, urban or peri-urban settings;4.Food assistance and aid initiatives focusing on vulnerable populations, relying on solidarity networks associated with the agroecological movement. SIGNIFICANCE The pandemic highlighted the key role played by local food systems and value chains and the need to strengthening them through public policies, as a way to build food resilience in times of crisis.

13.
SIGGRAPH Asia Emerg. Technol., SA ; 2020.
Article in English | Scopus | ID: covidwho-991909

ABSTRACT

During the pandemic, wearables such as face masks and face shields have become broadly adopted, these solutions do reduce infection but do not eliminate infectious agents from surfaces and objects the person may touch. Therefore, regular disinfection of hands and frequently touched surfaces is a critical factor in preventing the spread of infectious diseases ranging from the common cold and flu to SARS and COVID-19. This activity of frequent disinfection requires a high degree of discipline and leads to increased cognitive and physical effort involved in frequent washing of hands or use of a pocket sanitizer. We present an open-source, wearable sanitizer that provides just-in-time, automatic dispensing of alcohol to the wearer's hand or nearby objects using sensors and programmable cues. We systematically explore the design space aiming to create a device that not only seamlessly integrates with the user's body and behavior but also frees their physical and mental faculties for other tasks. © 2020 Owner/Author.

14.
Revista de Administracao Publica ; 54(4):595-613, 2020.
Article in English, Portuguese | Scopus | ID: covidwho-902139

ABSTRACT

The improvement of rules to fund the Brazilian health system (SUS) in states and municipalities is one of the major public health challenges in Brazil. The purpose of this article is to contribute to this broad debate, analyzing the government's response to the challenge of combating COVID-19, from the perspective of public financing of health services of Brazilian subnational governments. A qualitative and quantitative approach is adopted, combining documentary analysis and regression analysis. The results show that there was no substantive change in the criteria for transfers, which are not sensitive to epidemiological factors. Adjustments to the application rules were made to speed up spending. Population size, production of local wealth, and the number of hospital beds are the main factors that define the distribution of resources. The funding design for combating COVID-19, as well as the volume of resources, are insufficient in view of the scale of the crisis. © 2020, Fundacao Getulio Vargas. All rights reserved.

15.
An Acad Bras Cienc ; 92(4):e20201139, 2020.
Article in English | PubMed | ID: covidwho-788923

ABSTRACT

The spread of SARS-CoV-2 and the distribution of cases worldwide followed no clear biogeographic, climatic, or cultural trend. Conversely, the internationally busiest cities in all countries tended to be the hardest hit, suggesting a basic, mathematically neutral pattern of the new coronavirus early dissemination. We tested whether the number of flight passengers per time and the number of international frontiers could explain the number of cases of COVID-19 worldwide by a stepwise regression. Analysis were taken by 22 May 2020, a period when one would claim that early patterns of the pandemic establishment were still detectable, despite of community transmission in various places. The number of passengers arriving in a country and the number of international borders explained significantly 49% of the variance in the distribution of the number of cases of COVID-19, and number of passengers explained significantly 14.2% of data variance for cases per million inhabitants. Ecological neutral theory may explain a considerable part of the early distribution of SARS-CoV-2 and should be taken into consideration to define preventive international actions before a next pandemic.

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