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1.
Journal of Investigative Dermatology ; 143(5 Supplement):S38, 2023.
Article in English | EMBASE | ID: covidwho-2294989

ABSTRACT

Vaccines based on recombinant mRNA technology helped to control the pandemic caused by the severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2). Clinical trials for showed that these vaccines are safe and effective and promote a strong type 1 driven T cell response. Yet, several reports claimed that SARS-CoV-2 mRNA vaccination might favor the onset, worsening or the reactivation of autoimmune disorders like pemphigus and bullous pemphigoid. However, no study demonstrated a direct immunological link between mRNA vaccination and disease appearance/worsening. We aimed to analyze the immunological and clinical effects exerted by mRNA booster vaccinations for SARS-CoV-2 in a cohort of patients with pemphigus (n=9), bullous pemphigoid (n=4) and in healthy individuals (n=5). Patients and healthy individuals were monitored at baseline, and after two and four weeks of mRNA vaccination. We assessed the clinical disease status, antibodies against the SARS-CoV-2 spike protein, antibody levels for BP180/230, DSG1/3 and tetanustoxoid. We also determined the distribution of peripheral T helper / T follicular cell subsets, intracellular cytokine production of T cells and cytokine serum levels. Our results show that booster vaccination increased anti spike protein IgG, while tetanustoxoid igC and skin-specific autoantibody titers were not or minimally affected. We observed an increase in Th1/Th17.1 cells, together with an increase in the intracellular production of IFN-gamma, IL-4 and IL-21 in peripheral T cells of pemphigus patients. Importantly, clinical activity in both remittent patients and in patients with active disease remained stable. In summary, vaccination with mRNA vaccines induced a specific activation of the humoral system with production of protective antibodies against the Sars-CoV-2 spike protein without affecting autoimmune disease activity in patients with pemphigus and bullous pemphigoid.Copyright © 2023

2.
Novedades En Poblacion ; 17(34):412-427, 2021.
Article in Spanish | Web of Science | ID: covidwho-1743617

ABSTRACT

An exploratory investigation was carried out with the aim of knowing the impact that the pandemic has had on couple relationships and their sexuality after more than a year, and if the changes already detected previously have been maintained, varied, or ones emerged. The instrument used was an anonymous online survey, through a Google Drive form. Of the 372 couples who participated, 181 (48.65%) reported the occurrence of changes in the sexual routine;12.09% indicated variations in the habitual preferences of sexual intercourse and 12.63% the appearance of some disorder or discomfort related to sexuality. 16.9% raised the occurrence of some manifestation of violence in their relationship, of which 55.5% worsened or appeared during the pandemic. From the analysis of the results, it was concluded that the most significant impact of the pandemic was the existence of changes in the sexual routine;reduction of conflicts in cohabiting couples;decrease and fluctuations in the frequency of sexual intercourse more than desires;increased use of alternatives for communication, erotic and sexual exchange;manifestations of violence in the intimate space of the couple and impact of emigration on the dynamics and satisfaction of couples' relationships.

4.
Palgrave Studies in Democracy, Innovation and Entrepreneurship for Growth ; : 241-267, 2022.
Article in English | Scopus | ID: covidwho-1680609

ABSTRACT

The unexpected appearance and expansion of the pandemic caused by COVID-19 have shown that both developed and less developed countries need strategic, scientific-technological capacities and an innovation ecosystem to respond quickly to these challenges. The objective of this research is to analyze the potential correlation between competitiveness and sustainable development for a global recovery. To carry out the study, five global indexes were considered: competitiveness, sustainability, innovation, impunity, and human development which were analyzed with a mixed-method approach, quantitative and qualitative analysis. Organizational and government leaders are facing significant collateral effects of the health pandemic including economic recession and social development regression;therefore, the road to recovery requires they work toward sustainable development to reach desired competitiveness. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

5.
Palgrave Studies in Democracy, Innovation and Entrepreneurship for Growth ; : 201-222, 2022.
Article in English | Scopus | ID: covidwho-1680607

ABSTRACT

Entire industries have been negatively impacted by the COVID-19 crisis. As a result, global supply chains, along with their collaborators, have been severely affected. The slow pace of recovery has raised many questions as it is not only a matter of vaccination and employment. Other issues that preceded the pandemic are pushing recovery further;inequality is at the center of these issues. If unequal conditions and practices do not change, is recovery even possible? Another issue that arises is the illustrious need to get back to normal, which leads to the questions: should we be striving for normal? Is it the ideal state? The study contributes to the understanding of recovery’s slow pace and proposes a conceptual model to foster socially responsible supply chain governance by means of individual and organizational resilience to close the inequality gap and recover. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

6.
Palgrave Studies in Democracy, Innovation and Entrepreneurship for Growth ; : 1-6, 2022.
Article in English | Scopus | ID: covidwho-1680599

ABSTRACT

COVID-19 has significantly impacted just about every sector around the world. The incomparable effects have posed important challenges to understand the virus, comprehend the widespread consequences and their implications, as well as survive. While we are still learning about the pandemic’s effects, we are tasked with the imperative need to devise strategic plans to recover. This chapter describes the content of the collaborative work which analyzes how various sectors are recovering from the pandemic and its collateral crises. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

7.
Revista Espanola De Salud Publica ; 95:22, 2021.
Article in Spanish | Web of Science | ID: covidwho-1615134

ABSTRACT

Ministry Background: Having certain open data means that this data is accessible and available to everyo-ne, without legal or technical restrictions. The public sector produces a wide variety of information (so-cial, economic, health, statistical) that is attractive, complete and reliable, coming directly from official sources. The aim of this study was to show the open data related to COVID-19 published by the regions of Spain and the Ministry of Health, and compare these data. Methods: Each of the open portals was accessed and an observation of the published data was made, analyzing since when they were published and their periodicity in the update. The Tim Berners-Lee tool was used to classify the degree of reuse of the data. Regarding the statistical treatment, a frequency analysis was carried out, to analyze which data are given in a greater number of times. Results: 15 regions publish open data related to COVID-19, as well as the Ministry of Health. The contents shown in the open data portals varied from one autonomous community to another, but the re-gions provided data confirmed by PCR. The data co-llection start date and the updating of the data varied. Conclusions: There is an enormous diversi-ty among de regions in terms of the publication of COVID data, in relation to indicators, dates. It shows a great existence of data and in reusable format, but you have to go to many sources to obtain information of the epidemiological situation at a national level.

8.
Revista Espanola De Salud Publica ; 95:15, 2021.
Article in English | Web of Science | ID: covidwho-1079989

ABSTRACT

In March 2020, the World Health Organization declared the 2019 coronavirus disease (COVID-19) outbreak a pandemic, with the coronavirus disease spreading worryingly fast. In this context, information systems, digital health (electronic health, mobile health), the Internet of things, play a key role, since they can contribute to fight against COVID-19 by introducing smarter solutions to achieve a rapid control in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the disease. However, these technologies need a solid regulatory framework that contributes to their implementation and integration in health systems, and to improve the national response in public health. In this context, coordination between administrations and the standardization and interoperability of information are necessary. Now is the time to establish the legal and knowledge bases so that everything that has been learned and advanced is integrated into health systems, promoting safe and evidence-based use.

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