ABSTRACT
Objective: This study included participants from Hacettepe University 4th, 5th, and 6th-grade students of Medical School and 4th and 5th-grade students of Dental School;and aimed to evaluate the general health status, COVID-19 history, vaccination status, and SARS-CoV-2 antibody levels of the participants to support their physical and social health, during the pandemic period. Methods: A prospective cohort study was conducted with an integrated, matched, nested case-control study. Sociodemographic characteristics, life habits, COVID-19 history, vaccination status, compliance with mask-distance-hygiene rules, and risks (if any) for COVID-19 were inquired via online questionnaires. Physical examinations, complete blood count, biochemistry tests, and anti-SARS-CoV-2 anti-spike antibody tests were conducted for all consenting participants. All analyses were established using depersonalized data. Results: Of the 778 participants completing the baseline visit in June-July 2021, the percentages of those vaccinated with at least one, two, and three/more doses of COVID-19 vaccine were 99.1%, 98.0%, and 11.7%, respectively;one had four doses. The median (minimum-maximum) time since the last vaccination was 134 (34-166) days for those vaccinated with two doses [CoronaVac (Sinovac Life Sciences, Beijing, China)] and 25 (14-56) days for those vaccinated with three doses [two doses of CoronaVac and a last dose of Pfizer-BioNTech mRNA vaccine (ComirnatyR). The third dose was applied at a median of 164 (151-202) days after the second dose, and all were heterologous in type. The median (minimum-maximum) antibody level for the overall group was 53.55(0-5680) BAU/mL: 47.19 BAU/mL in those who received two doses, with a more than 100 times increase after a third dose (4943.64 BAU/mL). Of the 522 participants followed up to October 1, 2021, 6 PCR-positive symptomatic participants were diagnosed with COVID-19: the incidence rate was 4/1000 person-months. Conclusion: A 100-fold neutralizing antibody level following the third dose demonstrated the importance of a booster dose. Given the time lag between doses, antibody measurements of BioNTech recipients should be repeated in the upcoming months. Booster selection should involve antibody level, variant sensitivity of the vaccine, and individual characteristics of the recipient.
ABSTRACT
Objective: This study included participants from Hacettepe University 4th, 5th, and 6th-grade students of Medical School and 4th and 5th-grade students of Dental School;and aimed to evaluate the general health status, COVID-19 history, vaccination status, and SARS-CoV-2 antibody levels of the participants to support their physical and social health, during the pandemic period. Method(s): A prospective cohort study was conducted with an integrated, matched, nested case-control study. Sociode-mographic characteristics, life habits, COVID-19 history, vaccination status, compliance with mask-distance-hygiene rules, and risks (if any) for COVID-19 were inquired via online questionnaires. Physical examinations, complete blood count, biochemistry tests, and anti-SARS-CoV-2 anti-spike antibody tests were conducted for all consenting partici-pants. All analyses were established using depersonalized data. Result(s): Of the 778 participants completing the baseline visit in June-July 2021, the percentages of those vaccinated with at least one, two, and three/more doses of COVID-19 vaccine were 99.1%, 98.0%, and 11.7%, respectively;one had four doses. The median (minimum-maximum) time since the last vaccination was 134 (34-166) days for those vaccinated with two doses [CoronaVac (Sinovac Life Sciences, Beijing, China)] and 25 (14-56) days for those vaccinated with three doses [two doses of CoronaVac and a last dose of Pfizer-BioNTech mRNA vaccine (Comirnaty). The third dose was applied at a median of 164 (151-202) days after the second dose, and all were heterologous in type. The median (minimum-maximum) antibody level for the overall group was 53.55(0-5680) BAU/mL: 47.19 BAU/mL in those who received two doses, with a more than 100 times increase after a third dose (4943.64 BAU/mL). Of the 522 participants followed up to October 1, 2021, 6 PCR-positive symptomatic participants were diagnosed with COVID-19: the incidence rate was 4/1000 person-months. Conclusion(s): A 100-fold neutralizing antibody level following the third dose demonstrated the importance of a booster dose. Given the time lag between doses, antibody measurements of BioNTech recipients should be repeated in the upcoming months. Booster selection should involve antibody level, variant sensitivity of the vaccine, and individual characteristics of the recipient.Copyright © 2023, DOC Design and Informatics Co. Ltd.. All rights reserved.
ABSTRACT
Pandemic periods are one of the reasons patients have difficulty accessing healthcare services. Even diseases such as diabetes mellitus with a high prevalence and easy to diagnose today may delay the diagnosis of patients. Likewise, difficulties may be experienced in the follow-up of these patients due to pandemic period restrictions. We presented 1 diabetes mellitus patient delayed in diagnosis during the COVID-19 pandemic period and 2 diabetes mellitus patients who had difficulties in follow-up due to pandemic restrictions in this case reports. © 2017 AOS-Estratagia and Inovacao. All rights reserved.
ABSTRACT
Introduction: The aim of the study was to examine the sleep quality of healthcare professionals affected by the challenges they face during the pandemic. Materials and methods: An online survey was applied to the health care professionals who served in clinics and the departments established for pandemic and in pediatric/adult emergency rooms during the Covid-19 outbreak. Pittsburgh Sleep Quality Index (PSQI) and online survey consisting of demographic information were used to evaluate the healthcare professionals' sleep quality. SPSS 23.0 was used for statistical analysis. Results: 153 healthcare professionals were included in the study. 67.3% of them (n=103) were female and 32.7% (n=50) were male. The average PSQI of the participants was 10,61±6,35. It was10.22±6,31 for males, and 10.81±6,39 for females. Most of the participants (76.5%) (n=117) received the score above 5 points demonstrating bad sleep quality. No statistically significant relationship was found between the variables and the sleep quality. However the average PSQI was found to be higher than the level expected. Conclusion: It is known that sleep disorders is a common problem among the healthcare professionals working in busy and risky areas. It is clear that difficult working conditions and accordingly anxiety and depression can have a significant effect on sleep quality. Therefore, healthcare professionals will work more productively and willingly by decreasing the workload and arranging the working hours alternately during periods like pandemic when the workload is high and risky.