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American journal of physical medicine & rehabilitation ; 101(2):170-170, 2021.
Article in English | EuropePMC | ID: covidwho-1615362
Clinical and Experimental Neuroimmunology ; n/a(n/a), 2022.
Article in English | Wiley | ID: covidwho-1612857



Med Intensiva ; 2022 Jan 07.
Article in Spanish | MEDLINE | ID: covidwho-1611912
Journal of neuropathology and experimental neurology ; 80(11):1088-1090, 2021.
Article in English | EuropePMC | ID: covidwho-1601965
Cureus ; 13(11): e19987, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1604842


This is the first report of reversible cerebral vasoconstriction syndrome (RCVS) as a complication of a SARS-CoV-2 vaccination. A 38-year-old female developed visual impairment due to scotomas and thunderclap headache 18 days after the second shot of the Moderna SARS-CoV-2 vaccine. Multimodal cerebral MRI revealed an acute cortical ischemic lesion in the territory of the right posterior cerebral artery (PCA) on T2-weighted images, diffusion-weighted imaging (DWI), apparent diffusion coefficient (ADC) maps and absence of the PCA on magnetic resonance angiography (MRA). RCVS was diagnosed as the cause of the ischemic lesion. RCVS partially resolved upon nimodipine and anti-seizure drugs within nine days. In conclusion, this case shows that a SARS-CoV-2 vaccination can be followed by RCVS, manifesting as headache, stroke, and epileptiform discharges, and responding favorably to nimodipine.

Brain Hemorrhages ; 2021 Oct 28.
Article in English | MEDLINE | ID: covidwho-1593301


Vaccination against SARS-CoV-2 is beneficial but may be rarely accompanied by side effects. We report a 67yo female who developed visual impairment, dysarthria, confusion, and fatigue a few hours after a first dosage with an mRNA-based SARS-CoV-2 vaccine (Pfizer). Her previous history listed diabetes, arterial hypertension, arterial occlusive disease, a single renal cyst on the left side, smoking, and ischemic stroke 20y earlier. Stroke was complicated by normal pressure hydrocephalus requiring placement of a ventriculo-atrial (VA)-shunt. Cerebral imaging revealed a right-sided intracerebral bleeding with ventricular rupture and correct placement of the VA-shunt. Neurosurgeons decided against surgical treatment. The further course was dominated by prolonged confusion, visual impairment, and disorientation but ultimately only minor deficits. In conclusion, a single patient experienced intracerebral bleeding with ventricular rupture shortly after application of the first jab of an mRNA-based SARS-CoV-2 vaccine. Whether bleeding was causally related to the vaccination or occurred coincidentally, remains speculative.

Neurol Neurochir Pol ; 2021 Dec 23.
Article in English | MEDLINE | ID: covidwho-1593307
Brain Hemorrhages ; 2022 Jan 05.
Article in English | MEDLINE | ID: covidwho-1593304
Clin Neurol Neurosurg ; 213: 107106, 2021 Dec 29.
Article in English | MEDLINE | ID: covidwho-1588077
Egypt J Neurol Psychiatr Neurosurg ; 57(1): 179, 2021.
Article in English | MEDLINE | ID: covidwho-1581971


There is accumulating evidence that SARS-CoV-2 vaccinations can be complicated by venous sinus thrombosis (VST). This review aimed at summarising and discussing previous and recent advances regarding the diagnosis, pathogenesis, treatment, and outcome of post-SARS-CoV-2 vaccination VST. At least 308 patients with post-SARS-CoV-2 vaccination VST have been reported as per the end of July 2021. Ages among these 308 patients ranged between 22 and 81 years, 69 were male and 197 were female. Post-SARS-CoV-2 vaccination VST most commonly occurred with the ChAdOx1-S vaccine followed by the BNT126b2 vaccine. In the vast majority of cases, VST occurred after the first dose. Only in six patients did VST occur after the second dose. Latency between vaccination and onset of VST ranged between 0 and 24 days. Regarding treatment, most patients received heparin followed by oral anticoagulants. Seven patients received IVIGs and six patients received steroids because of concomitant vaccine-induced immune thrombotic thrombocytopenia. Complete recovery was reported in 5 patients. Partial recovery was reported in 9 patients. Eight patients were alive or discharged. Sixty-two patients died. The outcome was not specified in the remainder. In conclusion, SARS-CoV-2 vaccinations can be complicated by VST. There is female preponderance and the outcome is frequently poor.

J Food Biochem ; 45(12): e14009, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1570814