Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 9 de 9
Filter
1.
Journal of the Academy of Consultation-Liaison Psychiatry ; 63(Supplement 2):S156, 2022.
Article in English | EMBASE | ID: covidwho-2179918

ABSTRACT

Background: The relationship between neuropsychiatric disorders and cobalamin deficiency is well known, but little information is available on psychiatric complications of inborn errors of intracellular cobalamin metabolism. These patients present with developmental delay, seizures, dementia and psychosis, causing elevated levels of homocysteine and intrinsic vitamin B12 deficiency (Watkins, 2011). In this report, we describe the manifestations and successful psychiatric treatment of a patient with an inborn error of cobalamin metabolism. Case: Mr. W is a 23-year-old male with cobalamin G defect, who was hospitalized for encephalopathy and hallucinations. Notable past medical history includes chronic kidney disease, seizures, intellectual disability, and hypothyroidism. He has no significant past psychiatric history. Due to the COVID-19 pandemic, the patient was increasingly isolated. Psychosis began with disorganized thoughts, progressing to delusions and eventually both auditory and visual hallucinations. Other notable exam findings include blunted affect and psychomotor retardation. Homocysteine levels were elevated from baseline. Cerebrospinal fluid showed elevated protein levels with the presence of 3-0-meythldopa. Risperidone was initiated, then switched to olanzapine due to reported side effects with persistence of psychosis. He was switched from olanzapine to aripiprazole after cross-titration and optimized on aripiprazole 10mg nightly, leading to a resolution in his psychiatric symptoms. Discussion(s): Mr. W's increased isolation may have led to increased stress, which has been associated with high levels of homocysteine in the literature (Gun Kang, 2005). Elevated homocysteine is reported in individuals with neuropsychiatric disorders (Moustafa, 2014). Additionally, high levels of homocysteine are linked with inflammatory bio-makers (Li, 2015). Aripiprazole and risperidone have been shown to decrease inflammatory biomarkers in patients with psychosis (Juncal-Ruiz, 2018). Conclusion(s): Patients with inborn errors of cobalamin metabolism have increased levels of homocysteine, which is associated with an inflammatory response and neuropsychiatric disorders. We recommend that psychosis in patients with an inborn error of cobalamin metabolism be initially treated with risperidone, and aripiprazole as a second-line treatment. Learning Objectives: 1. Describe the relationship between metabolic cobalamin deficiency and psychosis. 2. Question the role of transient biomarker elevation and psychosis. 3. Assess the treatment considerations for patients with metabolic cobalamin deficiency. References: 1. Watkins, D. & Rosenblatt, D. S. Inborn errors of cobalamin absorption and metabolism. American Journal of Medical Genetics 2011:157:33-44. 2. Gun Kang, M. et al. Job stress and cardiovascular risk factors in male workers. Preventive Medicine 2005;40:583-588. 3. Moustafa, A. et al. Homocysteine levels in schizophrenia and affective disorders-focus on cognition. Front Behav Neurosci 2014;8:343. 4. Li, T. et al. Serum Homocysteine Concentration Is Significantly Associated with Inflammatory/Immune Factors. PLOS ONE 2015;10:e0138099. 5. Juncal-Ruiz, M. et al. Comparison of the anti-inflammatory effect of aripiprazole and risperidone in 75 drug-naive first episode psychosis individuals: A 3 months randomized study. Schizophrenia Research 2018;202:226-233. Copyright © 2022

5.
Journal of African Media Studies ; 13(3):333-350, 2021.
Article in English | Scopus | ID: covidwho-1496549

ABSTRACT

The ongoing coronavirus pandemic has led to unprecedented media coverage globally and in South Africa where, at the time of writing, over 20,000 people had died from the virus. This article explores how mainstream print media covered the COVID-19 pandemic during this time of crisis. The news media play a key role in keeping the public informed during such health crises and potentially shape citizens’ perceptions of the pandemic. Drawing on a content analysis of 681 front-page news stories across eleven English-language publications, we found that nearly half of the stories used an alarmist narrative, more than half of the stories had a negative tone, and most publications reported in an episodic rather than thematic manner. Most of the stories focused on impacts of the pandemic and included high levels of sensationalism. In addition, despite the alarmist and negative nature of the reporting, most of the front-page reports did not provide information about ways to limit the spread of the virus or attempt to counter misinformation about the pandemic, raising key issues about the roles and responsibilities of the South African media during the COVID-19 pandemic. This study shows that South African newspaper coverage of COVID-19 was largely negative, possibly to attract audience attention and increase market share, but that this alarmist coverage left little possibility for citizens’ individual agency and selfefficacy in navigating the pandemic. © 2021 Intellect Ltd Article.

6.
13th International Conference on Quality of Multimedia Experience, QoMEX 2021 ; : 25-30, 2021.
Article in English | Scopus | ID: covidwho-1393773

ABSTRACT

Due to COVID-19, crowdsourcing has gained momentum as an alternative methodology for continuing research and for Quality of Experience (QoE) assessment. Employing this approach, we remotely evaluated the user perceived QoE of two different visual rendering formats as part of an Autonomous Vehicles (AVs) simulation. The aim was to investigate the participant's QoE when testing AV technology in distinct visual rendering qualities (lowpoly vs high-poly) of an online streamed 360° car riding experience. In addition, a scoring model based on the expected reliability of each level of the remote assessment was designed. Findings suggest that the consumer's preferences towards the adoption of AV technology is highly determined by the system and human effects on Influence Factors (IFs). Moreover, the adequacy of reliability into a mathematical model is highlighted as a potential turning point for QoE assessment, by carrying out the evaluation tasks from the laboratory environment into the internet, particularly relevant in pandemic times. © 2021 IEEE.

7.
Sexually Transmitted Infections ; 97(SUPPL 1):A92, 2021.
Article in English | EMBASE | ID: covidwho-1379642

ABSTRACT

Background COVID-19 disrupted in-person clinical research activities. In response, the Adolescent Medicine Trials Network (ATN) CARES study instituted mail-based testing for human immunodeficiency virus (HIV), sexually transmitted infections (STIs), and substance use screening. We assessed the acceptability and feasibility of the ATN CARES mail-based testing program. Methods From September 2020- December 2020, trained study staff sent myLAB Box mail-based test kits and written instructions to gay, bisexual, and transgender study participants between the ages of 16-26 years. The test kits included a dried blood spot collection card for HIV (4th generation antigen/ antibody EIA) and syphilis (TP-EIA) testing, swabs and a urine collection kit for the detection of extragenital and genital Chlamydia trachomatis and Neisseria gonorrhoeae infection, and a urine collection kit for the screening of six substances. Staff tracked shipment status, and when delivery was identified, contacted participants to assist them with selfcollection and test kit return. Results Of the 65 youth who participated to date, 49.2% (32/ 65) returned their kit and completed at least one test. Those 32 participants had a median age of 23.5 years (IQR 22-25). The median number of days from test kit ordered to results was 18.5 days (IQR 15-23.5);median number of days from collection to results was 10 days (IQR 8.5-12). MyLAB Box reported a total of 219 test Results 30 HIV, 22 syphilis, 56 chlamydia, 56 gonorrhea, and 55 drug tests processed. Of the 219 tests, 7.3% (16) were rejected due to specimen inadequacy (6 dried blood spot cards, 2 anal swabs, 8 urine specimens). Conclusions Mail-based testing is a promising way to monitor a variety of biological study outcomes among adolescent study participants. Future studies should further investigate how to strengthen utilization and fidelity of mail-based testing.

8.
Estudios Irlandeses ; - (16):303-312, 2021.
Article in English | Web of Science | ID: covidwho-1210413
9.
European Urology Open Science ; 20:S21, 2020.
Article in English | EMBASE | ID: covidwho-1108859

ABSTRACT

Introduction: Ireland has the one of the lowest urologist per population ratios in Europe1. Out-patient department (OPD) visits are time consuming, costly and frequently patients cannot be reviewed in the intended timeframe2. With the COVID-19 crisis innovative virtual models of care are essential. Methods: Patients for OPD review were assessed by a Consultant in a “virtual” clinic using electronic records (letters, imaging, blood results) and chart review if required. Patients were either discharged, discharged for GP testing with specified re-referral criteria, phone/letter follow up by a LUTS clinical nurse specialist, investigated and reviewed by phone/letter, or returned for face-to-face consultation. Results: 400 patients were assessed. The majority were seen previously by SHO or junior registrar. 160 (40%) patients were discharged directly via letter and advice. 121 (30%) required further imaging and could be contacted by phone with the results. 79 (20%) could be contacted by the LUTS clinical nurse specialist for phone/written review. 40 (10%) necessitated face-to-face OPD review for clinical assessment or investigation review. In 47 patients there was insufficient information available in the electronic platforms, thus requiring formal chart review. Overall, 360 patients could be managed via “virtual” means. The potential out-patient cost savings were estimated at €27,000. Conclusion: With this COVID-19 pandemic, innovative models of care are necessitated. Introduction of a “virtual” OPD clinic allows reliable review of patients with reduced face-to-face follow-up attendances. Further study of staff training and patient satisfaction is required.

SELECTION OF CITATIONS
SEARCH DETAIL