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Journal of the American Association for Laboratory Animal Science ; JOUR:580, 61(5).
Article in English | EMBASE | ID: covidwho-2092325


COVID-19, caused by SARS-CoV-2, and its chronic form, Post-Acute Sequelae of COVID-19 (PASC), remain significant public health concerns. Transgenic mice are an effective model for acute COVID-19 research, but PASC studies are currently lacking due to the prohibitive costs of performing such studies in an Animal Biosafety Level 3 (ABSL-3) containment setting. The goal of this study was to determine the natural timing of clearance of the SARS-CoV-2 virus from mice and establish a protocol for transfer of animals from ABSL- 3 to ABSL-2 for PASC studies. We hypothesized that infected mice would clear viral infection by approximately 3 to 4 wk postinfection (WPI). Six- to 18-wk-old, B6.Cg-Tg(K18-ACE2)2Prlmn/J (hACE2) mice (N = 48/sex) were intranasally inoculated with a pre-alpha strain of SARS-CoV-2 in an ABSL-3 containment setting. Environmental samples, oral swabs, and fecal samples were collected weekly up to 8 wk postinoculation and cohorts of surviving mice were necropsied at 4, 7, and 8 WPI when lung and brain were collected. Viral loads in all samples were quantified via RT-qPCR. Survival was significantly affected by sex, with males more susceptible (P = 0.002), but not age (P = 0.005). SARS-CoV-2 viral RNA copies were present in the lungs of mice at 4, 7, and 8 WPI, indicating that the mice had not yet cleared infection by the culmination of the study and raising the possibility of persistent infection.

Couple and Family Psychology-Research and Practice ; : 8, 2021.
Article in English | Web of Science | ID: covidwho-1586030


Intimate partner violence (IPV) is a considerable public health problem that has garnered increased attention in the past several years. Prevalence rates of IPV in the United States are high, with upwards of one in three women and nine men experiencing IPV during their lifetime (Smith et al., 2018). The onset of the Coronavirus disease 2019 (COVID-19) pandemic brought statewide stay at home directives and nationwide recommendations for social distancing that aim to reduce infections but are also likely to inadvertently influence intimate partners and families in ways that increase rates and consequences of IPV. Indeed, previous research has shown that violence increases during and after disease outbreaks (Peterman et al., 2020), but little is written about reasons for the surges. Thus, this paper serves to discuss reasons for a rise in IPV experiences during the COVID-19 pandemic and current and future opportunities for prevention and intervention.