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Transplant Proc ; 54(6): 1524-1527, 2022.
Article in English | MEDLINE | ID: covidwho-1867844


SARS­CoV­2 mostly affects the respiratory system with clinical patterns ranging from the common cold to fatal pneumonia. During the first wave of the COVID-19 pandemic, owing to the high number of patients who were infected with SARS­CoV­2 and subsequently recovered, it has been shown that some patients with post-COVID-19 terminal respiratory failure need lung transplantation for survival. There is increasing evidence coming from worldwide observations that this procedure can be performed successfully in post-COVID-19 patients. However, owing to the scarcity of organs, there is a need to define the safety and efficacy of lung transplant for post-COVID-19 patients as compared to patients waiting for a lung transplant for other pre-existing conditions, in order to ensure that sound ethical criteria are applied in organ allocation. The Milan's Policlinic Lung Transplant Surgery Unit, with the revision of the National Second Opinion for Infectious Diseases and the contribution of the Italian Lung Transplant Centres and the Italian National Transplant Centre, set up a pivotal observational protocol for the lung transplant of patients infected and successively turned negative for SARS­CoV­2, albeit with lung consequences such as acute respiratory distress syndrome or some chronic interstitial lung disease. The protocol was revised and approved by the Italian National Institute of Health Ethics Committee. Description of the protocol and some ethical considerations are reported in this article.

COVID-19 , Lung Transplantation , Respiratory Distress Syndrome , Humans , Lung Transplantation/adverse effects , Pandemics , SARS-CoV-2
Rapporti ISTISAN Istituto Superiore di Sanita ; 20(30), 2020.
Article in Italian | GIM | ID: covidwho-1139101


The Istituto Superiore di Sanita (the National Institute of Health in Italy), as the technical-scientific body of the Italian National Health Service, has a crucial role in the COVID-19 pandemic management in Italy. In this period the ISS Bioethics COVID-19 Working Group has been established to deal with the multiple ethical issues raised by the pandemic. The spread of SARS-CoV-2 has made it necessary to address both clinical ethics questions and public health ethics dilemmas. In the Working Group experts in multiple disciplines - i.e., clinical medicine, public health, epidemiology, paediatrics, palliative care, law, philosophy, biomedical research, nursing sciences and, of course, bioethics - have been debating. This volume contains different Working Group members' contributions and viewpoints, that reflect the multiplicity of disciplines and experiences in an epochal emergency.