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2.
Bioeng Transl Med ; 8(1): e10357, 2023 Jan.
Article in English | MEDLINE | ID: covidwho-2170275

ABSTRACT

Cytokine storm is a phenomenon whereby the overreaction of the human immune system leads to the release of inflammatory cytokines, which can lead to multiple organ dysfunction syndrome. At present, the existing drugs for the treatment of cytokine storm have limited efficacy and severe adverse effects. Here, we report a lymphatic targeting self-microemulsifying drug delivery system containing baicalein to effectively inhibit cytokine storm. Baicalein self-microemulsion with phospholipid complex as an intermediate carrier (BAPC-SME) prepared in this study could be spontaneously emulsified to form 12-nm oil-in-water nanoemulsion after administration. And then BAPC-SME underwent uptake by enterocyte through endocytosis mediated by lipid valve and clathrin, and had obvious characteristics of mesenteric lymph node targeting distribution. Oral administration of BAPC-SME could significantly inhibit the increase in plasma levels of 14 cytokines: TNF-α, IL-6, IFN-γ, MCP-1, IL-17A, IL-27, IL-1α, GM-CSF, MIG, IFN-ß, IL-12, MIP-3α, IL-23, and RANTES in mice experiencing systemic cytokine storm. BAPC-SME could also significantly improve the pathological injury and inflammatory cell infiltration of lung tissue in mice experiencing local cytokine storm. This study does not only provide a new lymphatic targeted drug delivery strategy for the treatment of cytokine storm but also has great practical significance for the clinical development of baicalein self-microemulsion therapies for cytokine storm.

3.
Engineering, Construction and Architectural Management ; 2022.
Article in English | Web of Science | ID: covidwho-2135929

ABSTRACT

PurposeThis paper aims to explore the influence of social support and the repatriation intention of expatriates in international constructions in the postpandemic era of COVID-19. Furthermore, test the mediation effect of team climate and individual resilience in this relationship.Design/methodology/approachA survey of 347 expatriates in international construction projects was conducted. A cross-level chain mediation model was employed to test the moderating effect of social support and repatriation intention. Then, statistical analysis with a bootstrap sample was used to test the mediation effect of the model.FindingsThe empirical results support that team climate, individual resilience and the chain mediating effect of team climate to individual resilience is significant among the influences of social support on repatriation intention. Social support can enhance the team climate of construction expatriates, promoting their resilience to reduce the repatriation intention further.Practical implicationsThis study provides guidelines for international construction enterprises and managers to decide when and which expatriates should return home and formulate a series of policies to support expatriates and maintain a good team climate.Originality/valueThis study contributes to expatriate management literature by establishing the relationship between social support and repatriation intention. It provides a better understanding of how team-level factors impact individual thought. It takes team climate as one of the protective factors affecting individual psychological resilience. Also it takes social support as the antecedents of team atmosphere in case of emergencies.

4.
Front Public Health ; 10: 961726, 2022.
Article in English | MEDLINE | ID: covidwho-1974697

ABSTRACT

The construction industry is labor-intensive, and employees' mental health has a significant impact on occupational health and job performance. In particular, expatriates in international projects under the normalization of the epidemic are under greater pressure than domestic project employees. This paper aims to explore the association of stressors and mental health in international constructions during COVID-19. Furthermore, test the mediation effect of psychological resilience and moderating effort of international experience in this relationship. A survey of 3,091 expatriates in international construction projects was conducted. A moderating mediation model was employed to test the effect of psychological resilience and international experience. Then, statistical analysis with a bootstrap sample was used to test the mediation effect of the model, and a simple slope was used to test the moderating effect. Moderated by experience, the slope of the effect of stressors on psychological resilience changed from -1.851 to -1.323. And the slope of the effect of psychological resilience on mental health outcomes reduced by about 0.1. This suggests that experience is one of the buffering factors for individual psychological resilience of expatriates to regulate stress. Theoretically, this study verifies the mediation effect of psychological resilience between COVID-19 related stressors and mental health outcomes and importance of an expatriate's experience in an international assignment. Practically, this study provides guidelines for international construction enterprises and managers to make an assistant plan for expatriates during this pandemic time and pay more attention to their psychological status. The research also suggests that the best choice for challenging assignments is choosing a more experienced employee.


Subject(s)
COVID-19 , Resilience, Psychological , COVID-19/epidemiology , Humans , Outcome Assessment, Health Care , Pandemics , Stress, Psychological/epidemiology
5.
Front Med (Lausanne) ; 8: 629828, 2021.
Article in English | MEDLINE | ID: covidwho-1127988

ABSTRACT

We reported that the complete genome sequence of SARS-Coronavirus-2 (SARS-CoV-2) was obtained from a cerebrospinal fluid (CSF) sample by ultrahigh-depth sequencing. Fourteen days after onset, seizures, maxillofacial convulsions, intractable hiccups and a significant increase in intracranial pressure developed in an adult coronavirus disease 2019 patient. The complete genome sequence of SARS-CoV-2 obtained from the cerebrospinal fluid indicates that SARS-CoV-2 can invade the central nervous system. In future, along with nervous system assessment, the pathogen genome detection and other indicators are needed for studying possible nervous system infection of SARS-CoV-2.

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