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Thromb Res ; 196: 209-212, 2020 12.
Article in English | MEDLINE | ID: covidwho-741510

ABSTRACT

BACKGROUND: In the recent outbreak of COVID-19 pandemic, increased D-dimer levels and high rates of venous thromboembolic events were reported. We aimed to compare coagulation parameters on admission between COVID-19 patients and non-COVID-19 patients with acute respiratory insufficiency and to describe VTE diagnosed at entry. METHODS: In this single-centre, observational retrospective study consecutive patients admitted for fever and acute respiratory failure were included. Patients underwent laboratory tests, arterial blood gas, chest X-ray, point of care ultrasound (POCUS), limited compression ultrasonography of the lower limbs (L-CUS), chest CT-scan if necessary, and swab test for COVID-19. RESULTS: Of 324 patients, 50% had COVID-19. COVID19 patients had significantly lower mean white blood cells, neutrophils, platelet count, and pCT values, and significantly higher CRP, LDH, and ferritin levels than non-COVID19 patients. D-dimer was increased in 86.5% COVID19 patients and in 84.9% non-COVID19 patients; mean values were similar (2185 ng/mL and 2814 ng/mL, respectively, p = n.s.). After multivariate analysis, results were unchanged (Odds Ratio 1.00 95%CI: 0.99-1.00, p = 0.21). PT and aPTT values were also similar between the two groups, fibrinogen levels were higher in COVID19 than in non-COVID19 patients (684 and 496 mg/dL, respectively, p < 0.0001). Five patients had asymptomatic proximal deep vein thrombosis detected by L-CUS (3 COVID19) and 2 patients had symptomatic pulmonary embolism (both non-COVID19). CONCLUSIONS: D-dimer levels were similarly increased in patients with and without SARS-CoV 2 related disease. There were few cases of asymptomatic deep vein thrombosis or symptomatic pulmonary embolism at first day of admission, similarly distributed between COVID19 patients and non-COVID19 patients.


Subject(s)
Blood Coagulation , COVID-19/complications , Emergency Service, Hospital , Patient Admission , Pulmonary Embolism/etiology , Respiratory Insufficiency/etiology , Venous Thromboembolism/etiology , Venous Thrombosis/etiology , Aged , Aged, 80 and over , Biomarkers/blood , COVID-19/blood , COVID-19/diagnosis , Female , Fibrin Fibrinogen Degradation Products/analysis , Humans , Male , Middle Aged , Prognosis , Pulmonary Embolism/blood , Pulmonary Embolism/diagnosis , Respiratory Insufficiency/diagnosis , Retrospective Studies , Risk Factors , Up-Regulation , Venous Thromboembolism/blood , Venous Thromboembolism/diagnosis , Venous Thrombosis/blood , Venous Thrombosis/diagnosis
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