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Reumatismo ; 72(4): 189-196, 2021 Jan 18.
Article in English | MEDLINE | ID: covidwho-1055163


The role of 25-OH-vitamin D in the assessment of coronavirus disease 19 (COVID-19) has not been investigated. We sought to investigate the prevalence of 25-OH-vitamin D deficiency among COVID-19 patients, and to determine the associations between 25-OH-vitamin D status and the severity of the disease. We have conducted a retrospective observational study of COVID-19 patients admitted to the University of Verona Hospital Trust. Demographic, clinical and biochemical parameters were collected at hospital admission, and serum 25-OH-vitamin D levels were measured. The following outcomes were assessed: arterial partial oxygen pressure (PaO2); C-reactive protein (CRP); length of hospitalization; requirement of oxygen therapy; non-invasive ventilation (NIV); mechanical ventilation; and death. Among 61 patients enrolled, 72.1% was 25-OH-vitamin D deficient (<20 ng/mL) and 57.4% had 25-OHvitamin D <15 ng/mL. Patients with arterial PaO2 <60 mmHg had significantly lower mean 25-OH-vitamin D levels compared to patients with PaO2 ≥60 mmHg (13.3 ng/mL vs 20.4 ng/mL respectively, p=0.03). Vitamin D deficiency was associated with 3-fold higher risk of having arterial pO2 <60 mmHg. 25-OH-vitamin D deficiency was associated with increased CRP and dyspnea. 25-OH-vitamin D deficiency was associated with more severe systemic inflammatory response and respiratory failure in COVID-19 patients.

COVID-19/blood , Vitamin D/blood , Adult , Aged , Aged, 80 and over , C-Reactive Protein/analysis , COVID-19/epidemiology , Comorbidity , Disease Susceptibility , Dyspnea/etiology , Female , Fibrinogen/analysis , Humans , Italy/epidemiology , Length of Stay/statistics & numerical data , Male , Middle Aged , Oxygen/blood , Partial Pressure , Prevalence , Respiration, Artificial/statistics & numerical data , Retrospective Studies , Severity of Illness Index , Vitamin D Deficiency/blood , Vitamin D Deficiency/epidemiology