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N Engl J Med ; 387(7): 611-619, 2022 08 18.
Article in English | MEDLINE | ID: covidwho-1991733

ABSTRACT

BACKGROUND: Since January 2022, there has been an increase in reports of cases of acute hepatitis of unknown cause in children. Although cases have been reported across multiple continents, most have been reported in the United Kingdom. Investigations are ongoing to identify the causative agent or agents. METHODS: We conducted a retrospective study involving children referred to a single pediatric liver-transplantation center in the United Kingdom between January 1 and April 11, 2022. These children were 10 years of age or younger and had hepatitis that met the case definition of the U.K. Health Security Agency for confirmed acute hepatitis that was not hepatitis A through E and did not have a metabolic, inherited or genetic, congenital, or mechanical cause, in the context of a serum aminotransferase level greater than 500 IU per liter. We reviewed medical records and documented demographic characteristics, clinical features, and results of liver biochemical, serologic, and molecular tests for hepatotropic and other viruses, as well as radiologic and clinical outcomes. The outcomes were classified as an improving condition, liver transplantation, or death. RESULTS: A total of 44 children had hepatitis that met the confirmed case definition, and most were previously healthy. The median age was 4 years (range, 1 to 7). Common presenting features were jaundice (in 93% of the children), vomiting (in 54%), and diarrhea (in 32%). Among the 30 patients who underwent molecular testing for human adenovirus, 27 (90%) were positive. Fulminant liver failure developed in 6 patients (14%), all of whom received a liver transplant. None of the patients died. All the children, including the 6 who received liver transplants, were discharged home. CONCLUSIONS: In this series involving 44 young children with acute hepatitis of uncertain cause, human adenovirus was isolated in most of the children, but its role in the pathogenesis of this illness has not been established.


Subject(s)
Hepatitis , Liver Failure, Acute , Liver Transplantation , Acute Disease , Child , Child, Preschool , Hepatitis/etiology , Hepatitis/surgery , Humans , Infant , Liver Failure, Acute/etiology , Liver Failure, Acute/surgery , Liver Transplantation/adverse effects , Retrospective Studies
2.
5th IEEE International Conference on Computational Systems and Information Technology for Sustainable Solutions, CSITSS 2021 ; 2021.
Article in English | Scopus | ID: covidwho-1741147

ABSTRACT

The Coronavirus epidemic has wreaked havoc on countries all over the world. People from all over the Globe have flocked to social network to voice their thoughts and feelings about the situation that has reached epidemic proportions. The need of this paper is to exemplify how social media users feel about COVID-19 in an extremely brief span of time, Twitter saw an unusual surge in tweets on the new Coronavirus. This study presents a global Sentiment Analysis of tweets related to COVID-19, as well as how people's sentiment in multiple nations has varied. The research study focuses on a period of time from march 2020 to april 2020. In the Sentiment Analysis, we fed dataset to different algorithms and estimate the best performance among them. As in secondly we also found the reliability on BERT model. Comparatively, BERT gave foremost accuracy amidst all. Besides, the accuracy of mentioned algorithms are well represented. © 2021 IEEE.

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