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11th Italian Forum on Ambient Assisted Living, ForItAAL 2020 ; 884 LNEE:50-72, 2022.
Article in English | Scopus | ID: covidwho-2013901

ABSTRACT

Technology plays an important role into the life of older people. With the increase of age, they are experiencing physical and cognitive frailties and they require assistance for the management of their daily activities. In this sense, digital technologies could offer a holistic ecosystem which could empower their daily life 24 h decreasing the caregiver burden. Multi-domains researchers are joining their efforts to propose a selection of services. In this context, this paper introduces the large scale pilot Pharaon project, pointing out the attention on the Italian pilot site. Within the Italian pilot, a personalized and integrated care service was and will be investigated in the forthcoming years to meet the challenge of older population. Particularly, the paper introduces the methodology and the actions performed to face the covid-19 pandemic which affect the first stage of the process, the service domains, and the methodology applied. Additionally, the paper presents and discusses the key performance indicators related to impact, business, social and clinical domains and how the technology is used within the Italian pilot to support the population during the pandemic emergency. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

3.
Multiple Sclerosis Journal ; 26(3 SUPPL):555, 2020.
Article in English | EMBASE | ID: covidwho-1067121

ABSTRACT

Background: Neurological disability progression occurs across the spectrum of people living with multiple sclerosis (PwMS). Currently, no treatments exist that substantially modify the course of clinical progression in MS, one of the greatest unmet needs in clinical practice. Characterizing the determinants of clinical progression is essential for the development of novel therapeutic agents and treatment approaches that target progression in PwMS. Objectives: The overarching aim of CanProCo is to evaluate a wide spectrum of factors associated with the onset and rate of disease progression in MS, and to describe how these factors interact with one another to influence progression. Methods: CanProCo is a prospective, observational cohort study aiming to recruit 1000 individuals with radiologically-isolated syndrome (RIS), relapsing-remitting MS (RRMS), and primary-progressive MS (PPMS) within 10-15 years of disease onset, and 50 healthy controls (HCs) from five large academic MS centers in Canada. Participants undergo detailed clinical evaluations annually. A subset of participants enrolled within 5-10 years of disease onset (n=500) also have blood, cerebrospinal fluid, and MRIs collected facilitating study of biological measures (e.g. single-cell RNAsequencing[ scRNASeq]), MRI-based microstructural assessment, participant characteristics (self-reported, performance-based, clinician- assessed, health-system based), and environmental factors as determinants contributing to the differential progression in MS. Results: Recruitment commenced in April/May 2019 and n=536 patients have been recruited to date (RRMS=457, PPMS=35, RIS=25, HC=19). Baseline age, sex distribution, and Expanded Disability Status Scale (EDSS) scores (median, range) of each subgroup are: RRMS=38 years, 73% female, EDSS=1.5 (0-6.0);PPMS=52 years, 40% female, EDSS=4.0 (1.5-6.5);RIS=41 years, 68% female, EDSS=0 (0-3.0);HC=37 years, 63% female. Recruitment has surpassed the 50% target but has been paused due to the COVID-19 pandemic. scRNASeq on frozen blood samples has been validated. Conclusions: Halting the progression of MS is a fundamental clinical need to improve the lives of PwMS. Achieving this requires leveraging transdisciplinary approaches to better characterize mechanisms underlying clinical progression. CanProCo is the first prospective cohort study aiming to characterize these determinants to inform the development and implementation of efficacious and effective interventions.

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