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1.
SciFinder; 2020.
Preprint | SciFinder | ID: ppcovidwho-4098

ABSTRACT

A review. Since Sept., 2019, COVID-19 spreads all over 26 countries, and more than 70 000 people got infected till Feb. 22th, 2020. COVID-19 has strong infectivity and can result in acute respiratory distress syndrome and multiple organ failure. These severe complications are believed to be the consequence of cytokine storm caused by the virus infection. In the "diagnosis and treatment of novel coronavirus pneumonia", glucocorticoid is recommended as the immunosuppressive agents to prevent acute immune reaction. But the usage of glucocorticoid may bring risks such as superinfection, prolonged course of disease or severe residual effects. Traditional Chinese Medicine might have advantages in the moderation of immune system. Actually, Traditional Chinese Medicine is now applied in the treatment of COVID-19 clin., and exhibits excellent therapeutic effects. In this review, the potential usage of Traditional Chinese drugs or Traditional prescriptions in inhibiting cytokine storm and acute lung injury are analyzed, which would be an effective strategy for the treatment of COVID-19.

2.
Chin. Trad. Herbal Drugs ; 6(51): 1375-1385, 20200328.
Article in Chinese | WHO COVID, ELSEVIER | ID: covidwho-380619

ABSTRACT

At the end of December, 2019, a novel coronavirus disease (COVID-19) outbreak was found in China. COVID-19 spreads all over 268 countries, and more than 70 000 people got infected till February 23th, 2020. COVID-19 can result in acute respiratory distress syndrome and multiple organ failure due to its strong infectivity and extensive spread. These severe complications are believed to be the consequence of cytokine storm caused by the virus infection. In the “Diagnosis and treatment of novel coronavirus pneumonia”, glucocorticoid is recommended as the immunosuppressive agents to prevent acute immune reaction in critical patients. However, the usage of glucocorticoid may bring severe residual effects such as superinfection risks, prolonged course of disease. Traditional Chinese medicine might have advantages in the moderation of immune system. Actually, TCM is now applied in the treatment of COVID-19 clinically, and exhibits excellent therapeutic effects. In this review, the potential usage of TCM or traditional prescriptions in inhibiting cytokine storm and treating in acute lung injury were analyzed, which would be an effective strategy for the treatment of COVID-19.

3.
Chin. Trad. Herbal Drugs ; 7(51): 1685-1693, 20200412.
Article in Chinese | WHO COVID, ELSEVIER | ID: covidwho-379968

ABSTRACT

Objective: To explore the effective chemical constituents of Jinhua Qinggan Granules for treatment of coronavirus disease 2019 (COVID-19). Methods: The compounds and action targets of eleven herbal medicines in Jinhua Qinggan Granules were collected via TCMSP. The genes corresponding to the targets were queried by the UniProt database, then the “herbal medicine-compound-target” network was established by Cytoscape software. The gene ontology (GO) function enrichment analysis and KEGG pathway enrichment analysis were performed by DAVID to predict their mechanism. Molecular docking was used to analyze the binding force of the core effective compounds in the “herbal medicine-compound-target” network with SARS-CoV-2 3CL hydrolase and angiotensin converting enzyme II (ACE2). Results: The “herbal medicine-compound-target” network contained 154 compounds and 276 targets, and the key targets involved PTGS2, HSP90AB1, HSP90AA1, PTGS1, NCOA2, etc. GO function enrichment analysis revealed 278 items, including ATP binding, transcription factor activation and regulation of apoptosis process, etc. KEGG pathway enrichment screened 127 signaling pathways, including TNF, PI3K/Akt and HIF-1 signaling pathways related to lung injury protection. The results of molecular docking showed that formononetin, stigmasterol, beta-sitosterol, anhydroicaritin and other key compounds have a certain degree of affinity with SARS-CoV-2 3CL hydrolase and ACE2. Conclusion: The effective compounds in Jinhua Qinggan Granules regulate multiple signaling pathways via binding ACE2 and acting on targets such as PTGS2, HSP90AB1, HSP90AA1, PTGS1, NCOA2 for the prevention of COVID-19.

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