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1.
European Journal of Translational Myology ; 26:26, 2022.
Article in English | MEDLINE | ID: covidwho-2024650

ABSTRACT

Intensive Care Unit-Acquired Weakness (ICU-AW) is a generalized and symmetric neuromuscular dysfunction associated with critical illness and its treatments. Its incidence is approximately 80% in intensive care unit patients, and it manifests as critical illness polyneuropathy, critical illness myopathy, and muscle atrophy. Intensive care unit patients can lose an elevated percentage of their muscle mass in the first days after admission, producing short- and long-term sequelae that affect patients' quality of life, physical health, and mental health. In 2019, the world was faced with coronavirus disease 2019 (COVID-19), caused by the acute respiratory syndrome coronavirus 2. COVID-19 produces severe respiratory disorders, such as acute respiratory distress syndrome, which increases the risk of developing ICU-AW. COVID-19 patients treated in intensive care units have shown early diffuse and symmetrical muscle weakness, polyneuropathy, and myalgia, coinciding with the clinical presentation of ICU-AW. Besides, these patients require prolonged intensive care unit stays, invasive mechanical ventilation, and intensive care unit pharmacological therapy, which are risk factors for ICU-AW. Thus, the purposes of this review are to discuss the features of ICU-AW and its effects on skeletal muscle. Further, we will describe the mechanisms involved in the probable development of ICU-AW in severe COVID-19 patients.

2.
JMIR Mental Health ; 9(9):e39556, 2022.
Article in English | MEDLINE | ID: covidwho-2022416

ABSTRACT

BACKGROUND: Patients with limited English proficiency frequently receive substandard health care. Asynchronous telepsychiatry (ATP) has been established as a clinically valid method for psychiatric assessments. The addition of automated speech recognition (ASR) and automated machine translation (AMT) technologies to asynchronous telepsychiatry may be a viable artificial intelligence (AI)-language interpretation option. OBJECTIVE: This project measures the frequency and accuracy of the translation of figurative language devices (FLDs) and patient word count per minute, in a subset of psychiatric interviews from a larger trial, as an approximation to patient speech complexity and quantity in clinical encounters that require interpretation. METHODS: A total of 6 patients were selected from the original trial, where they had undergone 2 assessments, once by an English-speaking psychiatrist through a Spanish-speaking human interpreter and once in Spanish by a trained mental health interviewer-researcher with AI interpretation. 3 (50%) of the 6 selected patients were interviewed via videoconferencing because of the COVID-19 pandemic. Interview transcripts were created by automated speech recognition with manual corrections for transcriptional accuracy and assessment for translational accuracy of FLDs. RESULTS: AI-interpreted interviews were found to have a significant increase in the use of FLDs and patient word count per minute. Both human and AI-interpreted FLDs were frequently translated inaccurately, however FLD translation may be more accurate on videoconferencing. CONCLUSIONS: AI interpretation is currently not sufficiently accurate for use in clinical settings. However, this study suggests that alternatives to human interpretation are needed to circumvent modifications to patients' speech. While AI interpretation technologies are being further developed, using videoconferencing for human interpreting may be more accurate than in-person interpreting. TRIAL REGISTRATION: ClinicalTrials.gov NCT03538860;https://clinicaltrials.gov/ct2/show/NCT03538860.

3.
Nicotine Tob Res ; 2022.
Article in English | Web of Science | ID: covidwho-2018021

ABSTRACT

INTRODUCTION: Available evidence is mixed concerning associations between smoking status and COVID-19 clinical outcomes. Effects of nicotine replacement therapy (NRT) and vaccination status on COVID-19 outcomes in smokers are unknown. METHODS: Electronic health record data from 104 590 COVID-19 patients hospitalized February 1, 2020 to September 30, 2021 in 21 U.S. health systems were analyzed to assess associations of smoking status, in-hospital NRT prescription, and vaccination status with in-hospital death and ICU admission. RESULTS: Current (n = 7764) and never smokers (n = 57 454) did not differ on outcomes after adjustment for age, sex, race, ethnicity, insurance, body mass index, and comorbidities. Former (vs never) smokers (n = 33 101) had higher adjusted odds of death (aOR, 1.11;95% CI, 1.06-1.17) and ICU admission (aOR, 1.07;95% CI, 1.04-1.11). Among current smokers, NRT prescription was associated with reduced mortality (aOR, 0.64;95% CI, 0.50-0.82). Vaccination effects were significantly moderated by smoking status;vaccination was more strongly associated with reduced mortality among current (aOR, 0.29;95% CI, 0.16-0.66) and former smokers (aOR, 0.47;95% CI, 0.39-0.57) than for never smokers (aOR, 0.67;95% CI, 0.57, 0.79). Vaccination was associated with reduced ICU admission more strongly among former (aOR, 0.74;95% CI, 0.66-0.83) than never smokers (aOR, 0.87;95% CI, 0.79-0.97). CONCLUSIONS: Former but not current smokers hospitalized with COVID-19 are at higher risk for severe outcomes. SARS-CoV-2 vaccination is associated with better hospital outcomes in COVID-19 patients, especially current and former smokers. NRT during COVID-19 hospitalization may reduce mortality for current smokers. IMPLICATIONS: Prior findings regarding associations between smoking and severe COVID-19 disease outcomes have been inconsistent. This large cohort study suggests potential beneficial effects of nicotine replacement therapy on COVID-19 outcomes in current smokers and outsized benefits of SARS-CoV-2 vaccination in current and former smokers. Such findings may influence clinical practice and prevention efforts and motivate additional research that explores mechanisms for these effects.

4.
Commun Biol ; 5(1):944, 2022.
Article in English | PubMed | ID: covidwho-2016855

ABSTRACT

Very long-chain fatty acids (VLCFA) are critical for human cytomegalovirus replication and accumulate upon infection. Here, we used Epstein-Barr virus (EBV) infection of human B cells to elucidate how herpesviruses target VLCFA metabolism. Gene expression profiling revealed that, despite a general induction of peroxisome-related genes, EBV early infection decreased expression of the peroxisomal VLCFA transporters ABCD1 and ABCD2, thus impairing VLCFA degradation. The mechanism underlying ABCD1 and ABCD2 repression involved RNA interference by the EBV-induced microRNAs miR-9-5p and miR-155, respectively, causing significantly increased VLCFA levels. Treatment with 25-hydroxycholesterol, an antiviral innate immune modulator produced by macrophages, restored ABCD1 expression and reduced VLCFA accumulation in EBV-infected B-lymphocytes, and, upon lytic reactivation, reduced virus production in control but not ABCD1-deficient cells. Finally, also other herpesviruses and coronaviruses target ABCD1 expression. Because viral infection might trigger neuroinflammation in X-linked adrenoleukodystrophy (X-ALD, inherited ABCD1 deficiency), we explored a possible link between EBV infection and cerebral X-ALD. However, neither immunohistochemistry of post-mortem brains nor analysis of EBV seropositivity in 35 X-ALD children supported involvement of EBV in the onset of neuroinflammation. Collectively, our findings indicate a previously unrecognized, pivotal role of ABCD1 in viral infection and host defence, prompting consideration of other viral triggers in cerebral X-ALD.

5.
Retos-Nuevas Tendencias En Educacion Fisica Deporte Y Recreacion ; - (46):767-773, 2022.
Article in Spanish | Web of Science | ID: covidwho-2011965

ABSTRACT

One of the main consequences of the current COVID-19 pandemic is the impact on anxiety and stress levels. Among the factors that must be taken into account to evaluate the psychosocial impact of COVID-19 on athletes are sociodemographic factors, so the objective of this study was to analyze if the perception of stress depends on gender and performance level in Mexican athletes during the COVID-19 pandemic. The sample of this study was made up of 596 Mexican athletes, of both sexes (women = 40.4%) and aged between 13 and 40 years (M = 22.3, SD = 6.87). The athletes answered the Perceived Stress Scale (PSS-10) and a questionnaire covering socio-demographic data. The results obtained through the comparison of groups, indicated that women presented higher levels of perceived stress than men. On the other hand, amateur athletes reported higher levels of perceived stress than professional athletes. The results of the difference analysis shows that the perception of stress depends on sex and performance level were predictors of perceived stress.

6.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2009568

ABSTRACT

Background: CDK4/6 inhibitors showed a favorable progression-free survival (PFS) in DD LPS, a sarcoma bearing 12q 13-15 amplicon that implies CDK4 amplification. The median PFS was 4 and 7 months (m) for palbociclib and abemaciclib, respectively. Preclinical experiments in 10 sarcoma cell lines and 6 PDX models, including only one DD LPS, showed higher efficacy of anti-CDK4 in cases with high expression of CDK4 and low expression of p16. This rationale supported the design of a phase II trial exploring palbociclib in a wide range of sarcomas, excluding DD LPS. Methods: Progressing pretreated advanced soft tissue sarcoma, excluding DD LPS, or osteosarcoma adult patients (pts), whose tumors overexpressed CDK4 and underexpressed CDKN2A mRNA in a baseline mandatory biopsy, were enrolled. CDK4 and CDKN2A expression were assessed by qRT-PCR, using an external control as reference (Universal human reference RNA;Agilent Technologies). The primary endpoint was 6-m PFS rate. Minimax Simon's two-stage with type 1 and 2 errors of 10%, and null and alternative hypothesis of H0 15%, H1 40%, 6-month PFS rates were specified. The study will warrant further investigation if 6 or more pts had a PFS > 6 m from 21 evaluable pts. Palbociclib was administered orally at 125 mg/ day 21 out of 28 days. Pre-screening intended to increase the probability of positive profile in the baseline biopsy. Results: A total of 214 pts with 236 CDK4/ CDKN2A determinations were assessed for enrolment;141 for prescreening, in archive tumor sample, and 95 for screening, in a baseline biopsy. There were 38/141 (27%) and 28/95 (29%) pts with favorable mRNA profile from pre and screening, respectively. Twenty-two pts were enrolled with a median of previous systemic lines of 3 (1- 5). There were 9 different sarcoma subtypes, including 2 osteosarcomas. With a median FU of 10 m (0.4-23.3), the median PFS was 4.2 m (95% CI 0.9-7.4), while the 6- and 12-m PFS rates were 30% (95% CI 9-51) and 18% (95% CI 12-48) respectively. From 19 evaluable pts (1 early death by COVID, 1 withdrew consent and for 1 it was too early to be assessed) 11 had stable disease (58%) and 8 progressed (42%) as the best response. Patients with CDK4 expression above the median value had significantly longer mPFS in the univariate analysis: 5.9 m (95% CI 1.4-10.4) vs 1.9 m (95% CI 0.6- 3.2), p = 0.046;and longer OS: 15.5 m (95% CI 6.8-24.3) vs 10.6 m (95% CI 0-23.2), p = 0.047, respectively. The probability to find a positive profile in the screening was 29%, but this proportion increased up to 41% if in pre-screening had been positive. Conclusions: Palbociclib showed to be effective in a wide variety of sarcoma subtypes, other than DD LPS, selected by CDK4/CDKN2A biomarkers.

7.
Piel ; 2022.
Article in English | EMBASE | ID: covidwho-2004411

ABSTRACT

Introduction: COVID-19 infection is a disease caused by the type 2 coronavirus that causes severe acute respiratory syndrome (SARS-CoV-2) that affects the respiratory mucosa and all those organs that present the type 2 angiotensin receptor (ACE2), within them the skin. Several authors have mentioned the importance of reporting and carrying out databases on skin lesions caused by this virus, since it is related to the detection, severity and prognosis of the systemic condition. Material and methods: A retrospective cross-sectional observational study was carried out on the cases of patients who presented dermatological manifestations due to COVID-19, registered in the physical database of the National Specialized Hospital of Villa Nueva, Guatemala, from January 1st to December 31, 2021. Results: A total of 144 patients presented dermatological manifestations due to COVID-19, which were: acral lesions (42%), rash (21%), subcutaneous emphysema (12%), oral mucosal lesions (7%), necrosis (6%), erythema multiforme (5%), telogen effluvium (2%), vesicular lesions (2%), urticaria (1%), pityriasis rosea Gibert (1%) and livedo-type lesion (1%). A statistically significant association (p = 0,00) was found in patients who presented dermatological manifestations with vasculonecrotic damage as they were more likely to suffer from severe to critical disease (OR 2,91;95% CI 1063-3083). Conclusions: Early identification of cutaneous semiology is essential for timely management of complications associated with COVID-19 disease.

9.
Revista Cubana de Salud Publica ; 48(2), 2022.
Article in Spanish | EMBASE | ID: covidwho-1976042

ABSTRACT

Introduction: Cuba is a country with development in the biotechnology and medicines field, where pharmacoeconomic studies provide significant evidence for decision-making;mainly at present when the country is immersed in the "Task of Ordering" and at the same time is affected by the pandemic of the new coronavirus. Objective: Characterize pharmacoeconomic studies in Cuba in the last 20 years. Methods: A bibliometric research was carried out for which the Cuban scientific production on pharmacoeconomics was recovered in the Scopus database for the period 2001-2020. Bibliometric indicators were used to obtain the number of documents, years of publication, sources, collaboration, type and patterns of institutional and country collaboration, as well as co-occurrence of keywords. Results: 648 documents were retrieved. The most productive year was 2010. The documents were published in 273 journals, 17 (6.2%) Cuban ones and 256 (93.8%) foreign. There were 449 documents (69.3%) in institutional collaboration and 199 (30.7%) without collaboration. The most productive institutions were the Center for Genetic Engineering and Biotechnology with 82 (12.7%) and the Center of Molecular Immunology, with 77 (11.9%). The collaboration network between countries showed three defined areas: Latin America, North America-Europe-India and Spain. The most published topics were effectiveness and safety of drugs, vaccines, and those related to cancer. Conclusions: The publications were characterized by being collaborative, with a slight predominance of national over international ones. Comprehensive economic assessments need to be expanded.

10.
ANUARIO TURISMO Y SOCIEDAD ; 31:25-47, 2022.
Article in Spanish | Web of Science | ID: covidwho-1969893

ABSTRACT

This paper analyzes the scientific production about tourism and Covid-19 on the Scopus database. The methodology is based on an exploratory-descriptive study with a hindsight design. The time frame studied was from 2019 to 2021. In a first instance, the methodological procedure included the definition of keywords for a generic search, followed by the standardization using the software EndNote X9 and last, the data analysis through Bibexcel, Microsoft Excel 2013, pAjEx, and Vosviewer. Four hundred eighty three papers were identified and most of them (72.26%) were academic articles. The scientific journals with the highest production are Tourism Geographies, Sustainability Switzerland y Current Issues in Tourism. By countries, institutions from USA, Uk and China lead the scientific production on this issue. The topics studied on the publications that were analysed show a similar evolution to the pandemic phases worldwide.

11.
Region ; 9(2):45-66, 2022.
Article in English | Scopus | ID: covidwho-1964868

ABSTRACT

Academic stays at higher education institutions located outside students’ usual environment for less than a year have become increasingly popular. The research reported in this article aimed to examine the current situation of international academic tourism in the region of Barcelona (Spain). The main objectives were to profile academic tourists, to analyse the impact of the COVID-19 pandemic on inbound academic tourism flows, and to explore the outcomes of academic travel experiences. Following a mixed-methods approach, two focus groups and three in-depth interviews were conducted to collect data from both a supply and demand perspective, in addition to a survey designed for international students. A total of 132 questionnaires were analysed by means of descriptive statistics and through chi-square and ANOVA tests. Qualitative data was processed by means of categorisation and content analysis using QDA Miner. The main results indicate that academic tourism has positive sustainable impacts and is conducive to transformational experiences. Tourists’ profile has been identified and the effects of the pandemic have been pinpointed. Due to COVID-19, academic tourism flows experienced a serious decline and the satisfaction degree with the academic travel experience was lower. Nonetheless, most of the respondents would recommend Barcelona as an academic destination. © 2022 by the authors.

12.
PROCEEDINGS OF THE 6TH INTERNATIONAL CONFERENCE ON COMPLEXITY, FUTURE INFORMATION SYSTEMS AND RISK (COMPLEXIS) ; : 91-99, 2021.
Article in English | Web of Science | ID: covidwho-1939301

ABSTRACT

Contact tracing determines the chain of contacts of an infected person to isolate them. Implementing contact tracing requires an enormous effort that generally falls on the different governments and their respective health authorities. Emerging technologies can be quite useful in supporting contact tracing. The most relevant advantages of using mobile applications based on digital technologies to perform contact tracing are the fast collection of reliable data and the rapid detection of possible contacts at risk. However, despite these advantages, many countries have not reported a high penetration of these tools. As a relevant and actual research area, this paper presents a critical overview of the current literature regarding contact tracing applications to answer the following research questions: What is the most used technology to develop contact tracing apps? What were the main lessons on using contact tracing applications so far?, How are ethics, privacy, and security issues handled?, What is the use that is given to the data collected by the applications, and what happens to them? Who applies these types of tools, and what implications did they have?

13.
Bonplandia ; 31(2), 2022.
Article in Spanish | CAB Abstracts | ID: covidwho-1934961

ABSTRACT

The normal management of plant germplasm conservation laboratories involves carrying out numerous and diverse activities, which were affected by the coronavirus pandemic (COVID-19). The objective of this publication was to review the evolution of the cassava in vitro germplasm bank at the FCA-UNNE and IBONE (CONICET-UNNE) and to tell about usual management practices and the procedures to preserve living plant material and the personnel's life involved in pre-pandemic and COVID-19 pandemic times. Teachers, researchers, undergraduate and graduate students carried out, for almost 40 years, the in vitro conservation of 56 cassava cultivars from different countries. Before March 2020, the bank management consisted mainly in scientific-technological activities for the conservation of the material and the search for parameters to establish an order of subcultures. Having decreed Social, Preventive and Compulsory Isolation in Argentina, conservation activities continued applying the usual practices by following political-institutional sanitary measures. To face the new sanitary scenarios, methodologies must be adjusted so that they are effective at maintaining viability of the plant material and at prolonging conservation time.

14.
J Healthc Qual Res ; 2022 Mar 10.
Article in English | MEDLINE | ID: covidwho-1921080

ABSTRACT

INTRODUCTION AND OBJECTIVES: The outbreak of COVID-19 has overwhelmed healthcare systems all over the world. The aim of this article is to describe the process of transforming the Vall d'Hebron University Hospital, the second largest hospital in Spain, into a COVID-19 centre coordinating response to the pandemic in its reference area. MATERIALS AND METHODS: The study draws on the experience of the authors in transforming the hospital into a comprehensive resource in response to the COVID-19 pandemic. The strategy is based on four central strategies: early planning, coordination of all healthcare agents in its reference area, definition of clear leadership roles, and the organisation of care based on multidisciplinary teams with minimal recruitment of new staff. RESULTS: The transformation strategy enabled the hospital to cope with the surge in patients without exceeding its capacity. During the response phases, which amounted to a period of 57 days, 3106 patients consulted the ER and 2054 were admitted, 346 of whom were treated at the ICU. To accommodate the number of adult COVID-19 patients, adult ICU availability was progressive increased by 371%, and ordinary beds increased by 240. A total of 671 staff members went on sick leave after testing positive for COVID-19. CONCLUSION: The transformation experience of the hospital provides insight into how effectively adapt the structures and functioning of large hospitals. The relevance of territorial coordination during the pandemic is stressed as an effective strategy that contributed coping the pandemic.

15.
Proceedings of the European Conference on Agricultural Engineering, AgEng2021, Evora, Portugal ; 2021.
Article in English | CAB Abstracts | ID: covidwho-1918822

ABSTRACT

Involving students in collaborative projects and experiential learning helps develop transversal skills that, with passive learning, do not usually have specific training or reinforcement. Additionally, certain transversal skills such as the ability to communicate and coordinate in interdisciplinary work groups are essential for our graduates in their professional activity. The project consisted of a simulation of a real work environment in which a multidisciplinary team, made up of students from two different subjects of different degrees, must coordinate their efforts to propose a coherent solution to a problem. This project aims to reinforce the skills and competencies necessary both for the development of the rest of the subjects and for the subsequent exercise of the profession. These skills require reinforcement not only from the teacher but also from the classmates themselves, who would be competitors, students and the jury at the same time when assessing the results of the rest of the students. The problem to be solved focused on a proposal related to the supply of energy for a hypothetical agricultural industry, where agricultural engineering students carried out a design project for an electrical installation and the building students participated in the project by conducting an energy audit. Through collaborative work, it has been seen that students show a total willingness to work with students of other degrees and that the learning process improves since there is a greater interaction of skills and knowledge, which gives them an interdisciplinary vision of what it would perform a real job. Despite the difficult situation motivated by COVID pandemic, the project was successful and in total 25 students participated demonstrating that cooperative learning improves transversal skills.

16.
European Journal of Hospital Pharmacy ; 29(SUPPL 1):A33, 2022.
Article in English | EMBASE | ID: covidwho-1916406

ABSTRACT

Background and importance Although clinical trials of the BNT162b2 mRNA vaccine against COVID-19 (Pfizer-BioNTech) have shown acceptable levels of safety, continuous monitoring of the reactogenicity of the vaccine outside of controlled settings in clinical trials can provide additional information for patients, health professionals and the general population on local and systemic reactions after vaccination. Aim and objectives To analyse the reactogenicity of the first and second doses of the mRNA vaccine against COVID-19 BNT162b2 (Pfizer-BioNTech) in a sample of tertiary hospital workers. Material and methods 295 tertiary hospital workers who received the BNT162b2 vaccine against COVID-19 between January and March 2021 answered a questionnaire on sociodemographic variables, previous COVID-19 infection, and local and systemic reactions after the first and second doses of the vaccine. Results 291 completed the questionnaire after the first and second doses of the vaccine (response rate of 95.4%), which constituted the final sample of the study. Of these, 200 were women (68.7%), and the mean age was 48.46 (SD 11.77) years. 81.8% and 84.0% of the participants indicated having experienced at least one adverse reaction after the first and second doses of the vaccine, respectively. The most commonly reported reaction was pain at the injection site, being more frequent after the first dose of the vaccine. Systemic reactions evaluated were reported more frequently after the second dose of the vaccine. The most frequent reactions to the first dose were pain at the injection site (74.6%), headache (11.3%) and fatigue (9.3%). In the second dose, the most frequent reactions were pain at the injection site (64.8%), general malaise (30.7%) and headache (26.8%). Women, younger adults and people with a previous COVID- 19 infection reported increased reactogenicity. Furthermore, a high reactogenicity after the first dose was related to a higher number of adverse reactions after the second dose of the vaccine. Conclusion and relevance The distribution of reactogenicity in the present study is consistent with the data reported in the studies conducted with the BNT162b2 vaccine, especially in terms of association with the characteristics of the participants. These findings can facilitate the identification of people with a higher probability of having a high reactogenicity to the vaccine, allowing them to anticipate its appearance.

17.
Basic and Clinical Pharmacology and Toxicology ; 130(SUPPL 2):25-26, 2022.
Article in English | EMBASE | ID: covidwho-1916044

ABSTRACT

Objective: To describe the suspected adverse reactions (SADRs) associated with drugs used to treat COVID-19. Material and/or methods: This is an observational, retrospective study of SADRs identified by the Bellvitge Hospital Pharmacovigilance Program (PFVHUB). All patients admitted and treated with specific drugs for COVID-19, from 10 to 28 March 2020 were included. Data were collected regarding patients' characteristics, medications and suspected ADRs. Information was obtained from clinical records. Results: A total of 760 patients were included, out of which 95 (12.5%) presented 105 SADRs, being 176 drugs implicated. The mean age was 65 years old and 470 (62%) were men. From a total of 677 (89%) patients with pneumonia, 251 (37%) were considered severe. There were 161 (21.2%) deaths. The medication administered was: hydroxychloroquine (737 [97%]), ritonavir/lopinavir combination (542 [71%]), beta-Interferon (196 [25.8%]), tocilizumab (114 [15%]) and remdesivir (9 [1.2%]). The most frequent SADRs were: diarrhoea (55 [52.4%]), QT lengthening (18 [17%]), hepatitis (7 [6.7%]), nausea (5 [4.7%]) and acute renal failure (3 [2.8%]). Regarding the 95 patients with suspected ADRs, median age was 61.5 years and 54 (57.4%) were men;89 (94%) had pneumonia;and 24 (27%) cases were severe. There was no case of SADR-related death. In 65 cases (63%) the drug was withdrawn. Recovery was achieved in 97 (92.4%) cases, with a median duration until recovery of 4 days (IQR 2-7). According to the causality algorithm of the Spanish Pharmacovigilance System, causality was deemed probable for 139 (79%) of the drugs involved. Conclusions: SADRs correspond to the known risk profile of the drugs used. Although the majority of cases recovered in approximately 4 days, more than half of the cases required the medication to be withdrawn.

18.
Basic and Clinical Pharmacology and Toxicology ; 130(SUPPL 2):26, 2022.
Article in English | EMBASE | ID: covidwho-1916043

ABSTRACT

Objective: To describe the COVID-19 vaccine-related suspected adverse reactions (ADRs) reported to the Catalan Pharmacovigilance Center (CFVC) by the Bellvitge Hospital Pharmacovigilance Program (PFVHUB). Material and/or methods: This is an observational, retrospective study of suspected ADRs not stated in the Summary of Product Characteristics at the time of authorization and reported between January and October 2021. Suspected ADRs, both in healthcare professionals or their patients, were identified through spontaneous notifications made by these professionals themselves. Information was collected on patients' characteristics, adverse events, type of vaccine administered, severity, outcome and degree of accountability. Results: In total, 920 suspected ADRs were reported (894 in healthcare professionals and 26 in patients). Of these, 42 suspected ADRs among professionals were reported to the CFVC and 24 among patients. The mean age was 46.6 years, 70% were in women and 7 cases had COVID-19 previously. In 56% of the cases, the suspected ADR occurred after the first dose and in 5 cases it happened once again after the second dose. In 55 (83%) cases, the administered vaccine was Comirnaty®. The most frequent suspected ADRs were herpes zoster and simplex, oral fungal infection, paresthesia, pruritic rash, urticaria, myocarditis/pericarditis, thrombosis, cytolytic hepatitis, facial paralysis, flu-like syndrome, vertigo and thoracoepigastric vein phlebitis. In 88% of the cases, the median duration of the ADR until recovery was of 7 days (IQR 2-15). According to the causality algorithm of the Spanish Pharmacovigilance System, causality was probable or possible in 89% of the cases. Conclusions: Suspected ADRs identified by means of the PFVHUB have contributed to improve the knowledge regarding the toxicity profile of COVID-19 vaccines.

20.
Rev Esp Quimioter ; 35(4): 401-405, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1904218

ABSTRACT

OBJECTIVE: Since the first cases of SARS-CoV-2 appeared, there have been numerous techniques that have been developed for the diagnosis or monitoring of infection, both direct and serological techniques. Choosing a good diagnostic tool is essential for epidemiological control. The objective was to compare five commercialized RT-PCR techniques in real time, in sensitivity, specificity and agreement for the detection of SARS-CoV-2. METHODS: Five commercial RT-PCR kits for the detection of SARS-CoV-2 were compared. Eight known positive samples were taken and subjected to seven different dilutions or concentrations, and another 135 negative samples were used to determine sensitivity, specificity, and agreement values. RESULTS: The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for the Palex, Roche and GeneXpert techniques with respect to Seegene were identical, corresponding to 98.21%, 100%, 100% and 99.26% respectively. For Becton Dickinson the sensitivity was 89.28%, the specificity of 100%, the PPV of 100% and the NPV of 95.74%. The agreement using the Kappa index for Palex, Roche and GeneXpert was 0.9892, while the agreement for Becton Dickinson was with a Kappa index of 0.9215. CONCLUSIONS: All commercial RT-PCR kits had high sensitivities and specificities, as well as PPV, NPV, and concordance.


Subject(s)
COVID-19 , SARS-CoV-2 , COVID-19/diagnosis , COVID-19 Testing , Humans , Polymerase Chain Reaction , SARS-CoV-2/genetics , Sensitivity and Specificity
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