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1.
17th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications (VISIGRAPP) / 17th International Conference on Computer Vision Theory and Applications (VISAPP) ; : 672-678, 2022.
Article in English | Web of Science | ID: covidwho-1798802

ABSTRACT

Gender recognition from face images can be profitably used in several vertical markets, such as targeted advertising and cognitive robotics. However, in the last years, due to the COVID-19 pandemic, the unreliability of such systems when dealing with faces covered by a mask has emerged. In this paper, we propose a novel architecture based on attention layers and trained with a domain specific data augmentation technique for reliable gender recognition of masked faces. The proposed method has been experimentally evaluated on a huge dataset, namely VGGFace2-M, a masked version of the well known VGGFace2 dataset, and the achieved results confirm an improvement of around 4% with respect to traditional gender recognition algorithms, while preserving the performance on unmasked faces.

2.
Eur Rev Med Pharmacol Sci ; 26(3): 1042-1048, 2022 02.
Article in English | MEDLINE | ID: covidwho-1708605

ABSTRACT

OBJECTIVE: Alterations of the olfactory function in patients affected by COVID-19 often have an early onset and a variable duration ranging from a few weeks to months. The aim of this study was to evaluate olfactory dysfunction persistence after recovery from COVID-19, and potential related clinical-demographic conditions. PATIENTS AND METHODS: A total of 76 patients recovered from COVID-19 from at least 20 days with olfactory dysfunction during the infection were included in the study. For the subjective evaluation of olfactory function, a visual analogic scale (VAS) was used. The objective evaluation was performed with the use of the Sniffin' Sticks test. RESULTS: Objective assessment of olfactory function revealed that 48 (63.16%) patients were found to be normosmic (TDI ≥ 30.5), 26 (34.21%) were hyposmic (TDI from 30.5 to 16.5) and two (2.63%) were anosmic (TDI ≤ 16.5) at the time of the evaluation. These results did not show a significant difference between subjective and objective tests (p = 0.45). Most patients recovered their sense of smell within the first two months after recovery while a portion (22.2%) still experienced olfactory alterations 4-6 months after SARS-CoV-2 infection. Patients who had not recovered their sense of smell had a significantly longer period of SARS-CoV-2 positivity compared to patients that fully recovered (36.07 ± 7.78 days vs. 29 ± 7.89 days; p = 0.04). CONCLUSIONS: Our results suggest that the duration of the infection negatively correlates with the recovery of olfactory function.


Subject(s)
COVID-19/epidemiology , Olfaction Disorders/epidemiology , Adolescent , Adult , Aged , Anosmia/epidemiology , Anosmia/etiology , Anosmia/virology , COVID-19/complications , COVID-19/virology , Female , Humans , Italy/epidemiology , Male , Middle Aged , Olfaction Disorders/etiology , Olfaction Disorders/virology , Prospective Studies , Recovery of Function , SARS-CoV-2 , Smell , Young Adult
3.
Clin Ter ; 173(1): 64-66, 2022 Feb 07.
Article in English | MEDLINE | ID: covidwho-1687409

ABSTRACT

ABSTRACT: COVID-19 has dramatically affected working forces. We aim to report our occupational medicine service's experience in managing suspected COVID-19 cases during the pandemic through a retrospec-tive observational study. We compared the number of days employees were absent from work due to flu-like symptoms from March 2020 to February 2021 to the same period the previous year (2019-2020). Two hundred thirty-four patients (+47.2% compared to the previous year) who tested negative for SARS-CoV-2 reported flu-like symp-toms; the number of days of absence from work was 2812 (+190.2% compared to the previous year). On average, employees with flu-like symptoms lost 12.07 working days compared to 6.12 in the previous year (p<0.0001). In conclusion, in our sample COVID-19 has increased the number of working day loss. However, our approach proved to be important, especially during the first months of the pandemic, to limit SARS-CoV-2 spread in workplaces.


Subject(s)
COVID-19 , Pandemics , Humans , Italy/epidemiology , Rome/epidemiology , SARS-CoV-2
4.
Mecosan ; - (118):71-95, 2021.
Article in Italian | Scopus | ID: covidwho-1626743

ABSTRACT

In Switzerland, Ticino was one of the Cantons most affected by the Covid-19 pandemic and the reconfiguration of its hospital system relied on the creation of Covid-centers. This paper analyzes how the hospital “La Carità” in Locarno (ODL), appointed as reference Covid-center at the cantonal level in mid-March, has reorganized itself, playing a central active role in the response of the Ticino hospital system. The analysis, based on semi-structured interviews administered to six key actors of the hospital management, shed light on the main success factors of the response to the emergency. In particular, case study indicates some important drivers: the EOC multisite hospital model, an agile and coordinated structure at the institutional and operational level (fostering both unity of command and flexibility), the importance of public-private cooperation in a context of network governance, the management according to a logic of learning by doing and the orientation toward managerial and operational innovation. Copyright © FrancoAngeli

5.
European Review for Medical and Pharmacological Sciences ; 25(23):7268-7271, 2021.
Article in English | Web of Science | ID: covidwho-1576263

ABSTRACT

OBJECTIVE: The COVID-19 pandemic has severely affected otolaryngology and head and neck activities, also involving diagnosis and treatment of patients with oncology diseases with consequent delays and tumor upstaging. The aim of this study was to describe the experience of our otolaryngology unit during the pandemic on patients with cancer of the head and neck, comparing data on anatomical site of origin and preferred treatment with pre-pandemic data. PATIENTS AND METHODS: This study retrospectively analyzed the clinical records of patients treated for oncology disorders of the head and neck in the Otolaryngology Unit of the Policlinico Umberto I, Sapienza University of Rome, between March 10, 2020, and March 9, 2021. Data were compared with the same period of the previous year (March 10, 2019 - March 9, 2020). RESULTS: During the pandemic, we treated 92 patients with malignant tumor of the head and neck, compared to 101 patients treated during the same period of 2019 (-8.91%). The most common anatomical sites of origin of the neoplasms were larynx, oral cavity, and oropharynx. Surgical approach was preferred in 57 patients (61.95%);non-surgical treatments were performed in 35 cases (38.05%). Compared to the same period of the previous year, we found a 12.90% decrease in the number of oncology patients undergoing surgery. while patients treated exclusively with non-surgical approaches increased by 18.42%. CONCLUSIONS: Despite the impact of COVID-19 on the activity of our otolaryngology unit and on the whole healthcare system, diagnostic and therapeutic procedures for patients affected by malignancy of head and neck region were only minimally impacted.

6.
Psicologia della Salute ; - (3):45-51, 2021.
Article in Italian | Scopus | ID: covidwho-1559002

ABSTRACT

Can psychology be defined "only" as a health profession? The presence of psychology in health contexts is indispensable, but reducing it to this presence is inappropriate and impossible;in fact, "objects", "issues" and "contexts" relevant to health are not reducible to the health system and seem to require multidisciplinary and multisectoral approaches. Covid-19 makes it clear that a sectoral view is insufficient to address the devastating impact on society;Covid- 19 represents a challenge that seems to require a reorientation to a psychology which, while dutifully exercising an action to support individual traumas and frailties, cannot afford to reduce its presence and ability to intervene to. It is also along these problematic nuclei that a reterritorialization of psychology develops;in this way, through a not short process of revisiting the epistemological and methodological foundations of the practices and operationalities typical of the profession, psychology can assume a role of autonomous presence and influence in the system of health and social services. We therefore appeal to the Postgraduate Schools in Health Psychology to recognize themselves in the task of guiding this necessary transition towards a full transformative responsibility for psychology. © 2021 Franco Angeli Edizioni. All rights reserved.

8.
American Journal of Stem Cells ; 10(3):36-52, 2021.
Article in English | EMBASE | ID: covidwho-1489905

ABSTRACT

Background: The recent newly appeared Coronavirus disease (COVID-19), caused by an enveloped RNA virus named “severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)”, is associated with severe respiratory morbidity and mortality. Recent studies have shown that lymphopenia and a cytokine mass release represent important pathogenic features, with clinical evidence of dyspnea and hypoxemia, often leading to acute respiratory distress syndrome (ARDS), in severely ill patients, with a high death toll. Currently, stem cells are actively being investigated for their potential use in many “untreatable” diseases. In this regard and in particular, Mesenchymal Stem Cells (MSC), due to their intrinsic features, including either ability to impact on regulation of the immune system, or association with both anti-viral and anti-inflammatory properties, or potential for differentiation into several cell lineages, have become a promising tool for cell and molecular-based therapies. On this background, we wished to explore whether human umbilical cord-derived mesenchymal stem cells (hUCMS) would represent a potential viable therapeutic approach for the management of critically ill COVID19 patients. Methods: We tested the hUCMS effects on peripheral blood mononuclear cell (PBMCs) retrieved from patients with COVID19 (Ethical Committee CEAS Umbria, Italy CER N°3658/20 7, May, 2020), both as free cell monolayers and after envelopment in sodium alginate microcapsules. Both cell systems, after priming with IFN-γ, proved able to produce several immu-nomodulatory molecules such as IDO1 and HLAG5, although only the microencapsulated hUCMS were associated with massive and dose-dependent production of these factors. Results: The microencapsulated hUCMS improved allo-suppression in mixed lymphocytes reactions (MLRs), while also blunting T helper 1 and T helper 17 responses, that are involved with the cytokine storm and greatly contribute to the patient death. Moreover, we observed that both free and microencapsulated hUCMS permitted 5 days survival of in vitro culture maintained PBMCs extracted from very ill patients. Conclusion: We have provided evidence that microencapsulated hUCMS in vitro, seem to represent a powerful tool to impact on several immune pathways, clearly deranged in COVID19 patients. Further study is necessary to begin in vivo assessment of this experimental system, upon determining both, the most appropriate time of the disease onset for intervention, and cell dosage/patient of our experimental product.

9.
Annales Francaises d'Oto-Rhino-Laryngologie et de Pathologie Cervico-Faciale ; 138(4):321-322, 2021.
Article in French | Scopus | ID: covidwho-1401138
10.
Transplant International ; 34:352-352, 2021.
Article in English | Web of Science | ID: covidwho-1396241
11.
HemaSphere ; 5(SUPPL 2):293-294, 2021.
Article in English | EMBASE | ID: covidwho-1393432

ABSTRACT

Background: Given the multifactorial immune defect characterizing chronic lymphocytic leukemia (CLL), it appears conceivable that these patients have risk factors that increase their likelihood of complications and death from COVID-19. Aims: To evaluate incidence and severity of COVID-19 cases in a well-defined cohort of patients with CLL receiving venetoclax-based combinations. Methods: We administered a survey to a cohort of CLL treating hematologists from hematological centers in southern Italy. Participants were asked: a) to indicate whether they had offered a test for detection of COVID-19 infection (mainly nasopharyngeal swabs) only to CLL patients who reported symptoms or universally;b) to provide information on the incidence of COVID-19 infection and its severity;c) to specify reasons of possible treatment modifications. The survey was restricted to relapsed-refractory (R/R) CLL patients treated from Feb 1st to Dec 31th 2020 with time-limited venetoclax/rituximab (VR) combination as recommended by MURANO protocol (venetoclax for up to 2 years plus rituximab for the first 6 months), within their clinical practice. Results: A specific questionnaire was sent to 30 CLL hematologists, but only 26 responded to all questions. We considered suitable for the present analysis the 24 questionnaires compiled by hematologists who declared to have treated at least one patient with VR combination in the observation period. Of those, 20.8% worked in academic hospitals. Overall, the survey allowed to collect data on 124 patients who were treated with VR combination. The median number of patients treated in each center was 5 (range,1-15).COVID-19 surveillance tests consisted of viral RNA reverse transcriptase PCR (RT-PCR) on nasopharyngeal swabs. Generally, a policy of universal SARS-CoV-2 testing to be performed on patients at different time-points of therapy was used. Most patients (83/124, 66.9%) were tested before beginning the ramp-up with venetoclax;moreover 66/124 (53.2%) were regularly tested before each rituximab infusion (Fig 1).Reasons for potential change of the schedule of treatment were also investigated. The survey revealed that adherence to treatment was relatively high (70.8%). Only 29.1% physicians modified the therapeutic program mainly because of grade 3 neutropenia. Changes consisted of transient interruption of venetoclax, reduction of doses, and delay of rituximab infusion.Only 2/124 patients (1.6%) had a symptomatic RT-PCR proven diagnosis of COVID-19 infection and required hospitalization. Both patients needed oxygen therapy and admission into an intensive care unit. Of those, 1 patient who was receiving VR combination at the time of COVID infection, eventually died. The second patient developed COVID-19 infection while receiving venetoclax monotherapy (after the VR combination period). He recovered from COVID-19 infection and after 21 days of treatment interruption, he was able to restart venetoclax. Summary/Conclusion: Results of the present survey provide information, thus far lacking, on the use in real-world clinical practice of VR combination during the COVID19 pandemic in 2020. Current literature on the prevalence of COVID-19 infection in CLL, has some limitations (i.e., small size sample, heterogeneity of treatment, restriction to only the first pandemic wave);this survey, performed on a large number of CLL patients treated with VR combination only seems to provide additional information on safe management of CLL treatment during the COVID19 pandemic.

12.
Eur Rev Med Pharmacol Sci ; 25(16): 5318-5321, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1395679

ABSTRACT

Post-COVID-19 syndrome was defined as a persistent and protracted illness, which follows acute COVID-19 infection. This condition continues for more than 12 weeks and cannot be attributed to other clinical situations. Researchers and clinicians are allied in unraveling the molecular pathogenetic mechanisms and the clinical development of this unexpected SARS-CoV-2 infectious evolution. Anosmia, dysgeusia, fatigue, dyspnea, and 'brain fog' are common symptoms observed in the Post-COVID-19 syndrome, depicting a multiorgan involvement associated with injuries involving mainly cardiovascular, pulmonary, musculoskeletal, and neuropsychiatric systems. This commentary analyzes the state of the art of Post-COVID-19 interdisciplinary studies, confirming that we are facing a truly intricate biomedicine story.


Subject(s)
COVID-19/complications , COVID-19/diagnosis , COVID-19/metabolism , Humans , SARS-CoV-2/isolation & purification
13.
25th International Conference on Pattern Recognition Workshops, ICPR 2020 ; 12662 LNCS:472-486, 2021.
Article in English | Scopus | ID: covidwho-1330358

ABSTRACT

In retail environments, it is important to acquire information about customers entering in a selling area, by counting them, but also by understanding stable traits (such as gender, age, or ethnicity) and temporary feelings (such as the emotion). Anyway, in the last year, due to the COVID-19 pandemic, it is becoming mandatory to wear a mask, covering at least half of the face, thus making the above mentioned face analysis tasks definitely more challenging. In this paper, we evaluate the drop in the performance of these analytics when the face is partially covered by a mask, in order to evaluate how existing face analysis applications can perform with occluded faces. According to our knowledge, this is the first time a similar analysis has been performed. Furthermore, we also propose two new datasets, designed as extensions with masked faces of the widely adopted VGG-Face and RAF-DB datasets, that we make publicly available for benchmarking purposes. The analysis we conducted demonstrates that, except for gender and ethnicity recognition whose accuracy drop is quite limited (less than 10%), further investigations are necessary for increasing the performance of methods for age estimation (MAE drop between 4 and 10 years) and emotion recognition (accuracy decrease between 45% and 55%). © Springer Nature Switzerland AG 2021.

14.
15.
Clin Ter ; 171(1): e30-e36, 2021.
Article in English | MEDLINE | ID: covidwho-994183

ABSTRACT

Midwives are multifaceted healthcare professionals whose competence spectrum includes a large variety of knowledge and skills going from antenatal care to education and research. The aim of this review is to suggest the future challenges midwives are going to face in the upcoming decade of this Century. COVID-19 and other infections will reasonably impact healthcare workers all over the world. Midwives are frontline healthcare professionals who are constantly at risk of contagion as their job implies close contact with women, physical support and hand touch. Also, menstruation waste plays a large role in the pollution of waters, severely impacting hygiene in the developing countries and fueling climate change. Appropriate disposal of used menstrual material is still insufficient in many countries of the world especially because of lack of sanitary education on girls. As educators, midwives will be more involved into preventing inappropriate disposal of menstrual hygiene devices by educating girls around the world about the green alternatives to the commercial ones. Despite the evidences about the fertility decrement that occurs with aging, women keep postponing reproduction and increasing their chance being childless or suffering complications related to the advanced maternal age. Teen pregnancies are as well an important issue for midwives who will be called to face more age-related issues and use a tailored case to case approach, enhancing their family planning skills. Another crucial role of midwifery regards the information about the risk of drinking alcohol during gestation. Alcohol assumption during pregnancy is responsible for serious damage to the fetus causing a wide range of pathological conditions related to Fetal Alcoholic Spectrum Disorder, leading cause of mental retardation in children of western countries. On the whole, midwives have demonstrated their willingness to expand their practice through continuing professional development, and through specialist and advanced roles especially in preventive and educational positions.


Subject(s)
Alcohol Drinking , COVID-19 , Health Education , Maternal Age , Midwifery , Adolescent , COVID-19/prevention & control , Climate Change , Female , Feminine Hygiene Products , Humans , Pregnancy , Pregnancy Complications/prevention & control , Pregnancy in Adolescence , Professional Role , Refuse Disposal , SARS-CoV-2
16.
Eur Rev Med Pharmacol Sci ; 24(18): 9705-9711, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-814891

ABSTRACT

OBJECTIVE: Since the COVID-19 outbreak, otolaryngologists, ophthalmologists and dentists have been severely affected, both for the transmission routes and for the diagnostical and therapeutic procedures typical of these disciplines. MATERIALS AND METHODS: In this article, we discuss the transmission routes, the potential risk of contagion for patients and healthcare providers during procedures, and comment on the changes that will affect head and neck clinical practice in the future of outpatient and surgical activities. RESULTS: Otolaryngologists, ophthalmologists and dentists are at high risk for infection contagion and spread because they perform diagnostic and therapeutic procedures that generate aerosol and droplets thus facilitating virus transmission. Furthermore, examination involves close doctor-patient contact and otolaryngologists and dentists have to remove patient's protective devices during the visit. CONCLUSIONS: Special attention to prevention protocols for diagnostic and therapeutic procedures and the use of protective equipment is of utmost importance to limit contagion and prevent a new virus spread in the near future.


Subject(s)
Coronavirus Infections/prevention & control , Dental Clinics/methods , Ophthalmology/methods , Otolaryngology/methods , Pandemics/prevention & control , Pneumonia, Viral/prevention & control , Betacoronavirus , COVID-19 , Coronavirus Infections/transmission , Forecasting , Humans , Pneumonia, Viral/transmission , SARS-CoV-2
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