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1.
Blood Cancer Discovery ; 3(3):181-193, 2022.
Article in English | MEDLINE | ID: covidwho-1832724

ABSTRACT

Patients with B-lymphoid malignancies have been consistently identified as a population at high risk of severe COVID-19. Whether this is exclusively due to cancer-related deficits in humoral and cellular immunity, or whether risk of severe COVID-19 is increased by anticancer therapy, is uncertain. Using data derived from the COVID-19 and Cancer Consortium (CCC19), we show that patients treated for B-lymphoid malignancies have an increased risk of severe COVID-19 compared with control populations of patients with non-B-lymphoid malignancies. Among patients with B-lymphoid malignancies, those who received anticancer therapy within 12 months of COVID-19 diagnosis experienced increased COVID-19 severity compared with patients with non-recently treated B-lymphoid malignancies, after adjustment for cancer status and several other prognostic factors. Our findings suggest that patients recently treated for a B-lymphoid malignancy are at uniquely high risk for severe COVID-19. SIGNIFICANCE: Our study suggests that recent therapy for a B-lymphoid malignancy is an independent risk factor for COVID-19 severity. These findings provide rationale to develop mitigation strategies targeted at the uniquely high-risk population of patients with recently treated B-lymphoid malignancies. This article is highlighted in the In This Issue feature, p. 171.

2.
Production and Operations Management ; 2022.
Article in English | Scopus | ID: covidwho-1832240

ABSTRACT

The Covid-19 pandemic is triggering several supply chain disruptions that have a tremendous impact on firms’ activities. Consequently, firms have pushed suppliers to develop their disruption orientation through the exchange of information and collaboration with the aim to enhance their own performance. Although this is important from the industry perspective, relationships among the focal firm's disruption orientation, the suppliers’ disruption orientation, and the focal firm's performances have not been investigated in the literature. Hence, in order to fill this important gap, we investigate both (i) how the suppliers’ disruption orientation helps translate the focal firm's disruption orientation into environmental and economic performances and (ii) how the supplier ecocentricity (ability to learn from nontraditional stakeholders) is related to these relationships. In order to analyze these issues, we draw upon the dynamic capabilities, relational view, and stakeholder resource-based view theories. Our results indicate that the focal firm's disruption orientation creates a positive association between its suppliers’ disruption orientation and its own environmental and economic performances. Further, our results reveal that the association between the firm's disruption orientation and environmental performance is not necessarily direct and occurs through the suppliers’ disruption orientation. Our study also reveals that the positive association between the focal firm's disruption orientation and environmental performance through suppliers’ disruption orientation is stronger under medium and high levels of suppliers’ ecocentricity. Our results provide useful managerial insights for supply chain stakeholders that could help in managing disruption orientation, especially during and after a pandemic. © 2022 Production and Operations Management Society.

3.
Journal of Acute Disease ; 11(2):45-51, 2022.
Article in English | EMBASE | ID: covidwho-1822496

ABSTRACT

Cardiovascular manifestations and electrocardiographic abnormalities have been reported among some prevalent infections in tropical regions, which lead to a great amount of morbidity and mortality. The major infectious diseases include chikungunya, dengue fever, H1N1 influenza, and coronavirus disease-19 (COVID-19) in the viral category, leptospirosis, salmonellosis, scrub typhus and tuberculosis in the bacterial category, and malaria in the protozoan parasite category. All these infirmities constitute a foremost infection burden worldwide and have been linked to the various cardiac rhythm aberrancies. So we aimed to identify and compile different studies on these infections and associated acute electrocardiographic (ECG) changes. The search was made in online international libraries like PubMed, Google Scholar, and EMBASE, and 38 most relevant articles, including original research, systematic reviews, and unique case reports were selected. All of them were evaluated thoroughly and information regarding ECG was collected. Myocarditis is the predominant underlying pathology for rhythm disturbance and can be affected either due to the direct pathogenic effect or the abnormal immune system activation. ECG variabilities in some infections like chikungunya, scrub typhus, and leptospirosis are associated with longer hospital stay and poor outcome. Tropical infective diseases are associated with prominent acute cardiac rhythm abnormalities due to myocarditis, which can be identified preliminarily by ECG changes.

4.
Canada Communicable Disease Report ; 48(4):140-145, 2022.
Article in English | MEDLINE | ID: covidwho-1818787

ABSTRACT

Background: Sixty-eight laboratory-confirmed cases of the coronavirus disease 2019 (COVID-19) (12 in Alberta [AB], 56 in Saskatchewan [SK]) were linked to a gathering at a hospital in Alberta on June 1-4, 2020, and a wake/funeral in a First Nations community in northern Saskatchewan on June 9-11, 2020. Objective: The objectives were to provide a comprehensive description of the epidemiology of the outbreak and describe the chains of transmission to inform the hypothesis that there were multiple introductions of COVID-19 at the wake/funeral. Methods: Case investigation and contact tracing was conducted by local public health in AB and SK. The Public Health Agency of Canada conducted a centralized case analysis. An epidemic curve and a Gantt chart for period of communicability were created to support or refute whether there had been multiple introductions of COVID-19 at the wake/funeral. Results: Illness onset dates ranged from May 31 to July 1, 2020. Ages ranged from 2 to 80 years (median age=43 years). Five cases were hospitalized;there were no deaths. The available case exposure information supports the hypothesis that there had been multiple introductions of COVID-19 at the wake/funeral. Public health authorities in AB and SK declared the outbreak over on July 20, 2020;based on two incubation periods (i.e. 28 days) following the illness onset of the last primary case. Conclusion: During multijurisdictional outbreaks, data sharing, coordination across health authorities and centralized analysis is essential to understanding the events that lead to the outbreak and possible hypotheses around chains of transmission.

5.
Clinical Cancer Research ; 27(6 SUPPL 1), 2021.
Article in English | EMBASE | ID: covidwho-1816894

ABSTRACT

Background: The impact of disease characteristics and androgen deprivation therapy (ADT) or other treatments for prostate cancer (PC) on severity of infection with Covid-19 has not been elucidated. We report results from our PC patients (pts) with Covid-19 in our registry of Covid-19 treated cancer patients at the Cleveland Clinic Foundation. Methods: We performed a retrospective analysis of PC pts who tested positive for Covid-19 between 3/16/2020 and 5/21/2020 at the Cleveland Clinic. Additional information including prostate specific antigen (PSA), Gleason score, disease extent, and current treatment were also obtained. Severe Covid-19 infection was defined as any pt requiring hospitalization, ICU care, and/or death. PSA values from prior to Covid-19 infection or first available after Covid-19 infected were collected. Analysis was carried out with Fisher's exact test and Wilcoxon rank sum test, as applicable, and overall survival (OS) by log rank test. Results: A total of 54 pts with prostate cancer that tested positive for Covid-19 were identified, of which 4 were receiving active treatment (2 with metastatic disease and 2 with localized disease). Of the 2 pts with metastatic disease, 1 was on docetaxel with ADT and other on abiraterone/prednisone with ADT. Of the 2 pts with localized disease, 1 was on ADT and bicalutamide and other on ADT alone. A total of 40 patients had severe Covid-19 disease. There was no correlation with ADT and Covid-19 disease severity (p=0.67). There were 22 pts with Gleason 6, 20 pts with Gleason 7, 6 pts with Gleason 8, 4 pts with Gleason 9, 1 pt with Gleason 10, and 1 pt with Gleason unknown PC. There was no correlation between absolute (p=0.21) or divided (p=0.65) Gleason score with disease severity. There were 4 pts with metastatic disease and 46 with localized disease and no correlation was seen with extent of disease and Covid-19 severity (p>0.99). Fifty pts had PSA data available, and there was no correlation of PSA with Covid-19 disease severity (p=0.28). The mortality from Covid-19 was 26% (14 out of 54 pts) in our cohort. Out of the 14 pts who died, 2 were on active treatment that included ADT. There was no association between Gleason score (p=0.2649), extent of disease (p=0.9642), or treatment (p=0.5998) and OS. Conclusions: In our registry of Covid-19 treated cancer patients, we did not see any correlation between PC disease-risk factors and treatment with Covid-19 severity. While the results are limited by small patient population, they provide valuable information that PC treatment did not affect severity of Covid-19.

6.
European Journal of Neurology ; 28:28, 2022.
Article in English | MEDLINE | ID: covidwho-1816547

ABSTRACT

BACKGROUND: With the progression of Coronavirus infectious disease-19 (COVID-19), various neurological manifestations have been noticed in these patients and Bell's palsy is one of the peripheral neuropathies among those. Bell's palsy has been associated with various other viral agents. Its evidence in patients with COVID-19 signifies the possibility of association between Bell's Palsy and Severe acute respiratory syndrome coronavirus-2 (SARS-CoV2). OBJECTIVE: To evaluate the number of published cases of Bell's palsy as the only major neurological manifestation in patients with COVID-19 from March 2020 to December 2021 and to investigate the association of SARS-CoV2 and Bell's palsy. MATERIALS AND METHODS: A systematic review of the published English literature was performed using an electronic search in PubMed / Medline, Scopus, Research gate, Research square and Google Scholar databases, using keywords like 'COVID-19' OR/AND 'SARS-CoV-2', OR/AND 'Bell's palsy', OR/AND 'Facial nerve palsy', OR/AND 'Neurological', OR/AND 'Manifestation'. RESULTS: Search strategy revealed 32 relevant publications with a total of 46 patients. Bell's palsy was the initial manifestation in 37% cases and in 63% cases it developed after COVID-19 symptoms. 71.7% cases showed complete recovery and 21.7% showed only partial relief from BP. CONCLUSIONS: Although the number of documented cases in this research are not much, but evidence of Bell's palsy as the only major neurological manifestation in patients with COVID-19 signifies an important clinical finding and the possibility of another viral aetiology of BP. More evidence is needed to establish the exact co-relation between these two entities.

7.
Journal of Medical Pharmaceutical and Allied Sciences ; 10:113-116, 2021.
Article in English | Scopus | ID: covidwho-1811882

ABSTRACT

Tele medicine or Tele health services are available in the world before 1970. Recent surge has been observed in the tele medicine during Covid 19. It is observed that tele health services usage has increased from 11% to 70% and the satisfaction level among the patients is around 78% in US and China. As per the Press information bureau report, in India around 35000 patients use E Sanjeevni portal for tele health services. The purpose of the study is to assess the knowledge perception and attitude towards tele health services by the students because they are young generation and their adoption rate of technology and skill set in technology is very high. A questionnaire was floated through Google forms to students of various colleges in Uttarakhand primarily in the district of Dehradun, Haridwar and Nainital. Around 1000 students were targeted through their Gmail accounts and WhatsApp groups. It was found that there is lack of awareness among students about telemedicine apps and related aspects;there perception towards it is positive as they want to use it as well as willing to refer it as well. It is concluded that the tele health services can be boon for the state like Uttarakhand as the health infrastructure is poor in the state because of its geography. If the organisation providing tele health services will try to improve the awareness, the willingness to adapt tele health services will be very high. © The author(s) 2021.

8.
Journal of Medical Pharmaceutical and Allied Sciences ; 10:109-112, 2021.
Article in English | Scopus | ID: covidwho-1811881

ABSTRACT

Tele-health services area very old facility available, but it never became a forefront technology or option for patients. During Covid 19 lockdown, when all the hospitals OPD and Private Clinics were closed then there was certainly a need for a therapy that could be available, keeping the social distancing in mind. This study on Tele-health is both a primary and secondary data-based study. The first objective of the study is based on a survey of patients and service providers. The other two objectives are studied through secondary data. Options left for chronic patients were explored, their awareness and satisfaction regarding these options were studied if there is a surge in Tele-health services usage, then what strategies should organizations adopt for the continuous use of these services after covid was also studied. The study shows a surge in the usage of Tele-Health services and remote monitoring of patients. Approximately 80% of the patients have cancelled their personal visits to doctors, and patients' satisfaction rate is more than 70%. A survey on service providers was also carried out, and the satisfaction level of doctors in providing Tele-health services were more than 65%. The study reflects that Tele-health services can be a boon for a state like Uttarakhand, where health services are scarce and were treating patients in remote areas is challenging. © 2021 The authors.

9.
Journal of Forensic Medicine and Toxicology ; 38(1):107-111, 2021.
Article in English | Scopus | ID: covidwho-1811181

ABSTRACT

Background-The general public’s interest in hand sanitizers has soared after the covid-19 pandemic pestilence. This gave rise to the notion that the use of such hand sanitizers may hinder the visibility of developed fingerprints. Methodology-Based on this hypothesis, a hand sanitizer was tested to see how it affected the detection of fingerprints left behind after use. Fingerprint detection techniques used included: ninhydrin, silver nitrate, iodine fuming and cyanoacrylate method. Result and conclusion-When hand sanitized fingerprints were compared to non-hand sanitized fingerprints, the alcohol-based hand sanitizers improved the visibility of fingerprints developed with ninhydrin and iodine fuming, and marginally improved those developed with silver nitrate and cyanoacrylate method. To determine the longevity of improved developed quality, various parameters such as time since hand sanitizer application prior to fingerprint deposition was tested. © 2021, Medico Legal Society. All rights reserved.

10.
J Clin Aesthet Dermatol ; 15(4):49-58, 2022.
Article in English | PubMed | ID: covidwho-1801664

ABSTRACT

OBJECTIVE: Mask usage and hand hygiene are the pillars of defense against the novel pathogen causing COVID-19. This study was conducted to compare these practices among healthcare workers (HCWs) and nonhealthcare workers (nonHCWs) and to examine the outlook toward the healthcare sector among the two. METHODS: A cross-sectional online survey (via Google forms) using snowball sampling was conducted. Appropriate ethical clearance was taken from the Institutional Ethical Committee (IEC). HCWs and nonHCWs 18 years of age or older with basic literacy in English and with internet access were included. RESULTS: There were 404 total respondents (M:F ratio: 0.87:1;mean age: 30.16±9.63 years). Among the respondents, 63.3 percent were HCWs while 35.6 percent were nonHCWs. Persons performing hand hygiene more than10 times/day were found to be almost three times more likely to develop skin dryness (odds ratio [OR]: 2.95, 95% confidence interval [CI]: 1.372, 6.362). Female participants were found to be 2.5 times more likely to develop dryness (odds ratio: 2.594, 95% CI: 1.590, 4.234). Use of gloves was found to be a protective factor against development of dryness (odds ratio: 0.485,95% CI: 0.287, 0.818). A statistically significant correlation was found between mask acne and female respondents (p-value=0.000), HCWs (p-value=0.000), and use of N95 mask in combination with surgical mask (p-value=0.04). LIMITATIONS: Being an online survey, responses could not be captured from people with limited internet access and of lower socio-economic strata. CONCLUSION: There is a considerable burden of preventive measures on HCWs and nonHCWs alike. Significant dermatological implications are seen with frequent hand hygiene and mask usage.

11.
PubMed; 2020.
Preprint in English | PubMed | ID: ppcovidwho-333584

ABSTRACT

OBJECTIVES: Anti-type I interferon (IFN) autoantibodies have been reported in patients with systemic lupus erythematosus (SLE). Recently, an association of these autoantibodies with severe COVID-19 was reported in the general population. We assessed whether having pre-existing anti-IFNalpha autoantibodies was associated with COVID-19 infection in SLE patients. METHODS: Patients with SLE who developed COVID-19 between April 1st to October 1st, 2020 were studied. Biobanked pre-COVID-19 plasma from these SLE subjects and healthy controls were tested for anti-IFNalpha IgG autoantibodies by ELISA. The ability of plasma anti-IFNalpha autoantibodies to block signal transducer and activator of transcription 1 (STAT1) phosphorylation by recombinant human IFNalpha in vitro was assessed by flow cytometry. RESULTS: Ten SLE subjects with COVID-19 were identified. A 40% of these subjects had stable autoantibodies against IFNalpha for up to three years preceding COVID-19 diagnosis. A 50% of the subjects with these autoantibodies neutralized IFNalpha induced STAT1 phosphorylation. None of the other SLE samples blocked IFNalpha signaling. CONCLUSIONS: We noted an increased prevalence of pre-existing anti-IFNalpha autoantibodies in SLE patients with COVID-19 compared to the reported prevalence in lupus patients and the general population with severe COVID-19. Autoantibodies against IFNalpha in SLE patients may be pathogenic and patients with them maybe at-risk of developing COVID-19.

12.
Indian Journal of Transplantation ; 16(1):3-7, 2022.
Article in English | EMBASE | ID: covidwho-1798826

ABSTRACT

From the context of organ donation, COVID-19 vaccine-induced thrombotic thrombocytopenia (VITT) is important as there is an ethical dilemma in utilizing versus discarding organs from potential donors succumbing to VITT. This consensus statement is an attempt by the National Organ and Tissue Transplant Organization (NOTTO) apex technical committees, India, to formulate the guidelines for deceased organ donation and transplantation in relation to VITT to help in appropriate decision-making. VITT is a rare entity, but a meticulous approach should be taken by the organ procurement organization's (OPO) team in screening such cases. All such cases must be strictly notified to the national authorities (NOTTO) as a resource for data collection and ensuring compliance with protocols in the management of adverse events following immunization. Organs from any patient who developed thrombotic events up to 4 weeks after adenoviral vector-based vaccination should be considered to be linked to VITT and investigated appropriately. The viability of the organs must be thoroughly checked by the OPO, and the final decision in relation to organ use should be decided by the expert committee of the OPO team consisting of a virologist, a hematologist, and a treating team. Considering the organ shortage, in case of suspected/confirmed VITT, both clinicians and patients should consider the riskbenefit equation based on limited experience. An appropriate written informed consent of potential recipients and family members should be obtained before the transplantation of organs from suspected or proven VITT donors.

13.
Elife ; 11, 2022.
Article in English | PubMed | ID: covidwho-1791920

ABSTRACT

The pathogenesis and host-viral interactions of the Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) are convoluted and not well evaluated. Application of the multi-omics system biology approaches, including biological network analysis in elucidating the complex host-viral response, interrogates the viral pathogenesis. The present study aimed to fingerprint the system-level alterations during acute CCHFV-infection and the cellular immune responses during productive CCHFV-replication in vitro. We used system-wide network-based system biology analysis of peripheral blood mononuclear cells (PBMCs) from a longitudinal cohort of CCHF patients during the acute phase of infection and after one year of recovery (convalescent phase) followed by untargeted quantitative proteomics analysis of the most permissive CCHFV-infected Huh7 and SW13 cells. In the RNAseq analysis of the PBMCs, comparing the acute and convalescent-phase, we observed system-level host's metabolic reprogramming towards central carbon and energy metabolism (CCEM) with distinct upregulation of oxidative phosphorylation (OXPHOS) during CCHFV-infection. Upon application of network-based system biology methods, negative coordination of the biological signaling systems like FOXO/Notch axis and Akt/mTOR/HIF-1 signaling with metabolic pathways during CCHFV-infection were observed. The temporal quantitative proteomics in Huh7 showed a dynamic change in the CCEM over time and concordant with the cross-sectional proteomics in SW13 cells. By blocking the two key CCEM pathways, glycolysis and glutaminolysis, viral replication was inhibited in vitro. Activation of key interferon stimulating genes during infection suggested the role of type I and II interferon-mediated antiviral mechanisms both at the system level and during progressive replication. Crimean-Congo hemorrhagic fever (CCHF) is an emerging disease that is increasingly spreading to new populations. The condition is now endemic in almost 30 countries in sub-Saharan Africa, South-Eastern Europe, the Middle East and Central Asia. CCHF is caused by a tick-borne virus and can cause uncontrolled bleeding. It has a mortality rate of up to 40%, and there are currently no vaccines or effective treatments available. All viruses depend entirely on their hosts for reproduction, and they achieve this through hijacking the molecular machinery of the cells they infect. However, little is known about how the CCHF virus does this and how the cells respond. To understand more about the relationship between the cell’s metabolism and viral replication, Neogi, Elaldi et al. studied immune cells taken from patients during an infection and one year later. The gene activity of the cells showed that the virus prefers to hijack processes known as central carbon and energy metabolism. These are the main regulator of the cellular energy supply and the production of essential chemicals. By using cancer drugs to block these key pathways, Neogi, Elaldi et al. could reduce the viral reproduction in laboratory cells. These findings provide a clearer understanding of how the CCHF virus replicates inside human cells. By interfering with these processes, researchers could develop new antiviral strategies to treat the disease. One of the cancer drugs tested in cells, 2-DG, has been approved for emergency use against COVID-19 in some countries. Neogi, Elaldi et al. are now studying this further in animals with the hope of reaching clinical trials in the future. eng

14.
Ottoman: Journal of Tourism and Management Research ; 6(3):926-938, 2021.
Article in English | CAB Abstracts | ID: covidwho-1790260

ABSTRACT

The tourism and hospitality industry has badly infected by the spread of the corona virus. Such a slowdown for this industry has put millions of jobs at risk, thereby threatening the generation of GDP share through tourism activity. Tourists" preferences have changed with giving priority to safety measures in this "new normal" era. To regain the prosperity, it is essential to understand this changing perspective of tourists. A conjoint analysis is carried out in this paper to know the combination of preference factors of different attributes related with domestic tourism among the Indians during COVID-19 pandemic. Attributes and their different levels related to tourism were prepared according to experts" suggestion. Logistic regression has been performed to find out the demographic and socio-economic factors that influence the preferred level of the selected attributes. The idle combination for tour is found as short duration tour, train as transport vehicle, online booking, at least twice room cleanness, remote area, small group of accompany, hotel with medical facility, money spent towards health and hygiene, food service at hotel and mask carries by himself/herself. Order of the selected attributes has been assigned based on their importance. This study would help the tourism industry to think over the new preferences and provide better service to satisfy the tourist. This study may highlight a few policy recommendations so that tourism authority can design customized tourism packages.

15.
Economic and Political Weekly ; 57(5):62-67, 2022.
Article in English | Scopus | ID: covidwho-1787447

ABSTRACT

Delhi has witnessed a massive disruption of livelihood and economic activities due to COVID-19. With a historical context of an abandoned mine housing refugee families at the contours of the Asola Bhatti Wildlife Sanctuary in Chhatarpur, Sanjay Colony is a slum that is far removed from the everyday hustle of the city. This paper explores the ways in which initiatives by women during the COVID-19 pandemic changed the neighbourhood character and opened up the possibilities of reimagining place-making with the objective of establishing sustainable economic engagement. It focuses on the shift that has taken place from daily wage employment at nearby construction sites to self-employment by women. With initiatives like mobilising for relief work by the Bhatti Mahila Evam Bal Vikas Mandal to spearheading the renovation of the crematorium grounds, engaging in road construction, and even working towards organising a market led by women producers and sellers, the slum created opportunities to rethink street livelihood amidst the pandemic. This paper brings forth an ethnographic account of how women propelled the reimagination of the neighbourhood through their nano-enterpreneurship. © 2022 Economic and Political Weekly. All rights reserved.

16.
Journal of Heart & Lung Transplantation ; 41(4):S392-S392, 2022.
Article in English | Academic Search Complete | ID: covidwho-1783391

ABSTRACT

The characteristics and outcomes, including acute cellular rejection (ACR), of lung transplant recipients (LTR) post COVID-19 infection are incompletely studied. We sought to show whether or not COVID-19 infection in LTR is associated with ACR. This single center, retrospective study of LTR examined data among those who contracted COVID-19 between June 2020 and May 2021. Patient demographics, immunosuppression regimen, and hospital course related to COVID-19 infection were recorded. Subsequent spirometry, imaging, and biopsy results were documented. We identified 16 LTR who tested positive for COVID by PCR testing. Acute radiographic changes were detected in half (8) of the cohort, 3 patients eventually required ICU admission, 1 which required venovenous extracorporeal membrane oxygenation. The median drop in FEV1 and FVC after COVID-19 infection was -375 (-1140 to +120) and -260mL (-1790 to +410), respectively. ACR was diagnosed in 2 patients at 6 weeks post COVID-19 infection. Both of the patients who were diagnosed with ACR required hospitalization, and one required ICU admission. There was 1 death at >6 months after infection due to progressive chronic lung allograft dysfunction and renal failure. This analysis characterizes short and intermediate term outcomes of LTR after COVID-19 infection. Specifically, the association between such infection and both rates of ACR and allograft function is uniquely described. ACR was observed in 12.5% of patients 6 weeks post COVID-19 infection. There was a notable reduction in lung function, which was mostly accounted for by the 3 patients in our cohort who required ICU admission. This study has several limitations. The sample size is small and involves a single center. It is also retrospective in nature, and there were a large number of asymptomatic patients included. Further analyses, to further assess the incidence of ACR in LTR are warranted to determine the associated factors and optimize management in this at risk patient population. [ FROM AUTHOR] Copyright of Journal of Heart & Lung Transplantation is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

17.
Journal of Clinical Oncology ; 40(6 SUPPL), 2022.
Article in English | EMBASE | ID: covidwho-1779702

ABSTRACT

Background: The treatment landscape of metastatic renal cell carcinoma (mRCC) has evolved over the last few years with several systemic anti-cancer therapies (SACT) licensed across different lines of treatment. A previous real world study in the UK had demonstrated a significant attrition rate between each line of therapy suggesting less than half of patients who received first line SACT then received second line therapy and less than a fifth of first line SACT patients reach third line. Methods: We conducted a retrospective analysis of all patients treated between January 2018 and end of June 2021 to see if advancement in treatment options had impacted on the drop-off rates. Data was collected from 5 UK sites. Patients were identified from electronic SACT database. All reimbursed treatment options including the COVID interim treatment guidelines options were included. Patients who received SACT as part of a clinical trial were also included. Patients who remained on the respective lines of treatment were censored. Results: Data for 515 patients (372 male: 143 female) who received first-line SACT for mRCC were included in the analyses. IMDC prognostic groups were 103 favourable, 236 intermediate, 127 poor (49 not available). On progression 69% of patients were able to receive second-line therapy and 34% were able to receive third-line therapy. Of the 515 first-line therapies, 24% of patients received frontline ipilimumab and nivolumab, 10% received TKI and IO combination and 63% received single agent VEGF TKI. Second-line nivolumab or cabozantinib (43% and 40% respectively) were the most commonly prescribed options. Third-line cabozantinib 61% and nivolumab 16% remain the most used options. Across all lines of therapy progressive disease was the primary reason for discontinuation. 5% switched treatment due to toxicity. Conclusions: These results suggest that, with more treatment options available, including combination/ immunotherapy therapies, more patients are able to receive second and third-line therapies. Despite this, nearly one third of patients only receive one line of treatment which highlights the need to deliver the most efficacious treatments first to optimise patient outcomes. Moreover, single agent TKI was the most commonly used first-line SACT despite advances in the management pathway. Data analysing the impact of COVID on treatment selection will be presented.

18.
Journal of Clinical & Translational Research ; 8(2):125-137, 2022.
Article in English | MEDLINE | ID: covidwho-1777224

ABSTRACT

Background and Aim: The present study intends to investigate COVID-19 by targeting their main proteins with 17 selected drugs used for treating Oral Lichen Planus (OLP) which is a chronic muco-cutaneous disorder. Here, an attempt is made to gain better insight into the structure of various drugs targeting specific proteins which will be helpful in developing drugs useful for therapeutic and preventive measures. Method: In silico studies, molecular docking and molecular dynamic simulations were performed to repurpose the therapeutic drugs (n = 17) which were used to treat OLP against COVID-19. In addition, the maximum binding affinities of the key protein spike glycoprotein, main-protease (Mpro) of coronavirus, and Angiotensin-Converting Enzyme-2 (ACE-2) in the human body were evaluated with the selected drugs. Results: Epigallocatechin-3-gallate (EGCG) showed the highest docking values among the drugs selected for repurposing. Among the target proteins, EGCG has shown maximum binding affinity with ACE-2 receptor. Further, according to the molecular dynamic simulation studies, EGCG has shown the least conformational fluctuations with Mpro. Conclusion: EGCG can be a potential inhibitor drug which can bind with ACE-2 receptor thus inhibiting the interaction of mainly Mpro protein and spike glycoprotein of SARS-CoV-2. Relevance for Patients: EGCG, a natural compound shows antiviral potential having considerably high affinity and stability with SARS-CoV-2. It might be further employed as a lead drug against selective inhibitors of SARS-CoV-2 for the therapeutic management of COVID-19 patients after necessary clinical trials.

19.
International Journal of Pharmaceutical and Clinical Research ; 14(2):257-264, 2022.
Article in English | EMBASE | ID: covidwho-1777064

ABSTRACT

Background: Corona virus disease 2019 is a highly infectious disease which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2. SARS-CoV-2 is transmitted from person to person mainly by respiratory droplets and aerosols as well as by direct or indirect contact. Aims and objective: To compare different RNA extraction methods for detection of SARSCov-2 RNA from nasopharyngeal and oropharyngeal swabs using three different methods which are based on different techniques. Material and methods: This analytical observational study was conducted in the department of Microbiology, Sawai Man Singh Medical College Jaipur, Rajasthan from December 2020 to January 2021. We selected 200 confirmed positive (extracted by Easy Mag automated system) (remnant) samples showing a wide range of different Ct values and 20 confirmed negative samples stored in Viral Transport Media VTM for this study. In order to compare quality of three extractions methods, all samples were aliquoted separately for each extraction technique. (1) Extraction by manual method (spin column base): was done by as per manufacturer’s instructions. (2) Extraction by QIA cube HT (vaccum column base): was done by as per manufacturer’s instructions. (3) Extraction by Perkins Elmer chemagic 360: (magnetic beads based). Result: A panel consisting of 200 Covid-19 positive and 20 Covid-19 negative samples were extracted by three methods (i.e. Manual column based, automated column-based and automated magnetic beads-based method). The extracted material/elutes were put for realtime RT-PCR assay for the detection of SARS CoV-2 RNA. There was no major difference seen in individual samples’ ct values between three extraction system. CONCLUSION: In conclusion, we recommended all three RNA extraction methods (i.e. magnetic beads & silica column-based) are interchangeable in a diagnostic workflow for the SARS CoV-2 by RTPCR and can be taken into account for SARS CoV-2 detection in possible future shortage of one kit or times of crisis in such pandemic time.

20.
Journal of Medical Pharmaceutical and Allied Sciences ; 10:102-108, 2021.
Article in English | Scopus | ID: covidwho-1776777

ABSTRACT

Nowadays, after coronavirus COVID 19, dengue fever is a problem of human beings that is spread by the Aedes aegypti mosquitoes. If proper protection arrangements from the particular mosquitoes are not done, this problem may lead to a pandemic. The main problem of this fever is that the starting symptoms are the same as viral fever as high fever, myalgia, muscular and joint pain, hemorrhagic episodes, and cutaneous rash. The purpose of this manuscript is to aware people of this health problem. Near the rain season, the problems of mosquitoes are increased. The awareness of the people could prevent this disease. In this manuscript, an analytic study on the worldwide dengue fever has been made. It is observed that after 2010, the cases of dengue fever are increased continuously. People should keep neat and clean their surroundings and cover maximum part of the body. © 2021 The authors.

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