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1.
Drug Safety ; 45(10):1212-1213, 2022.
Article in English | EMBASE | ID: covidwho-2085640

ABSTRACT

Introduction: Several post-vaccination adverse events (AEFI) have been reported after anti-COVID 19 vaccine SPIKEVAX administration. By the way, we can mention cutaneous manifestations (1). Objective(s): We report 2 cases of women who presented ecchymotic skin plaques after vaccination with SPIKEVAX notified in the Regional Pharmacovigilance Service of Sfax. Method(s): The assessment of the causal link was made according to the method of the World Health Organization. Result(s): Two women, with no previous medical history, presented ecchymotic skin patches after SPIKEVAX-(Moderna) vaccination. Platelet and D-dimer levels were normal in both cases. But an immunological assessment was not requested. The first woman was 33 years old. She presented 2 days after the first dose of the vaccine generalized ecchymotic plaques which measured 7 cm of diameter and was located on the right flank. These plaques persisted for one month before disappearing. The second woman was 26 years old, she presented 20 days after the second dose of the vaccine, 3 ecchymotic plaques on one thigh followed. Two days later, another plaque was appeared on the other thigh. These lesions were associated with myalgias in the lower limbs and headaches and disappears after 2 months. A probable causal link was established in these patients. Conclusion(s): The ecchymotic plaques in our patients may suggest vascular involvement particularly a vasculitis. Few cases have been reported with anti-COVID 19 vaccination (1).

2.
Research Journal of Pharmacy and Technology ; 15(8):3717-3724, 2022.
Article in English | EMBASE | ID: covidwho-2067732

ABSTRACT

Background: Health care workers (HCWs), being in the front line dealing with COVID-19 patients, are facing various challenges. Therefore, being aware about COVID-19 is of high importance. The overall aim of this study is to evaluate the HCWs' knowledge and attitude about COVID-19. The objectives of the study are assessment of HCWs' knowledge and attitude about COVID-19 and determining the significant factors that influence their knowledge. Methods and Materials: a descriptive cross-sectional study was carried out among convenient sample (n=353) of HCWs in the UAE by using an online self-administrated questionnaire. The data was analyzed using the SPSS version 26. Mann Whitney u test and Kruskal Wallis test were used to test the differences in quantitative variables across groups. Multivariate logistic regression analysis was used to investigate the association between the knowledge about COVID-19 and significant factors. A p value <0.05 was chosen as the criteria to make decisions regarding statistical significance. Result(s): A total of (353) HCWs participated in the study and completed the whole questionnaire. The average knowledge score was 76.3% with a 95% confidence interval (CI) [75.2%, 77.5%]. Of the total participants, 122 (34.6%) have poor knowledge, 81 (22.9%) have acceptable knowledge and 150(42.5%) have good knowledge. In the present study, significantly higher knowledge scores were observed in Western participants (OR 2.83;95% CI 1.51 - 5.29), General practitioners (OR 1.319;95% CI 1.03 - 1.69), participants working in Dubai (OR 1.47;95 % CI 1.28- 1.69) and participants who had been in contact with suspected or confirmed COVID-19 cases (OR 1.235;95% CI 1.11- 1.37). On the other hand, significantly lower knowledge scores were observed in participants aged 30-39 years (OR 0.760;95% CI 0.647- 0.893), Arabian participants (OR 0.76;95 % CI 0.58- 0.98) and participants with less than 1year experience (OR 0.729;95% CI 0.601- 0.883). Conclusion(s): This study revealed that HCWs working in the UAE have a good level of general knowledge about COVID-19 symptoms, transmission, progression, and prevention. Questions about deeper knowledge revealed a lower level of knowledge. Therefore, tailored awareness campaigns may be required in order to meet HCWs' needs and enhance their levels of deep knowledge. Copyright © RJPT All right reserved.

3.
Drug Safety ; 45(10):1212-1213, 2022.
Article in English | ProQuest Central | ID: covidwho-2045066

ABSTRACT

Introduction: Several post-vaccination adverse events (AEFI) have been reported after anti-COVID 19 vaccine SPIKEVAX® administration. By the way, we can mention cutaneous manifestations (1). Objective: We report 2 cases of women who presented ecchymotic skin plaques after vaccination with SPIKEVAX® notified in the Regional Pharmacovigilance Service of Sfax. Methods: The assessment of the causal link was made according to the method of the World Health Organization. Results: Two women, with no previous medical history, presented ecchymotic skin patches after SPIKEVAX®(Moderna) vaccination. Platelet and D-dimer levels were normal in both cases. But an immunological assessment was not requested. The first woman was 33 years old. She presented 2 days after the first dose of the vaccine generalized ecchymotic plaques which measured 7 cm of diameter and was located on the right flank. These plaques persisted for one month before disappearing. The second woman was 26 years old, she presented 20 days after the second dose of the vaccine, 3 ecchymotic plaques on one thigh followed. Two days later, another plaque was appeared on the other thigh. These lesions were associated with myalgias in the lower limbs and headaches and disappears after 2 months. A probable causal link was established in these patients. Conclusion: The ecchymotic plaques in our patients may suggest vascular involvement particularly a vasculitis. Few cases have been reported with anti-COVID 19 vaccination (1).

4.
3rd International Conference on Big Data and Security, ICBDS 2021 ; 1563 CCIS:563-574, 2022.
Article in English | Scopus | ID: covidwho-1777689

ABSTRACT

Academic research on E-learning system has been widely influenced by COVID-19 pandemic. As evaluating online learning can directly promote the design of more effective learning environments. As evaluating E-learning systems while considering factors such as system content, pedagogical issues, adaptation, learning agents and learning outcomes dimensions can be considered as a complex multi-criteria decision making problem. This paper presents a methodology to support researchers and practitioners in a effectively adopting analytical techniques such as Analytic hierarchy process, Entropy Method, and the Criteria Importance through Inter-criteria Correlation in E-learning evaluation. The paper experiments with multiple learning scenarios and the results provide various alternatives for decision making. © 2022, Springer Nature Singapore Pte Ltd.

5.
Ageing Res Rev ; 68: 101324, 2021 07.
Article in English | MEDLINE | ID: covidwho-1152265

ABSTRACT

Age-related diseases for which there are no effective treatments include cardiovascular diseases; neurodegenerative diseases such as Alzheimer's disease; eye disorders such as cataract and age-related macular degeneration; and, more recently, Severe Acute Respiratory Syndrome (SARS-CoV-2). These diseases are associated with plasma and/or tissue increases in cholesterol derivatives mainly formed by auto-oxidation: 7-ketocholesterol, also known as 7-oxo-cholesterol, and 7ß-hydroxycholesterol. The formation of these oxysterols can be considered as a consequence of mitochondrial and peroxisomal dysfunction, leading to increased in oxidative stress, which is accentuated with age. 7-ketocholesterol and 7ß-hydroxycholesterol cause a specific form of cytotoxic activity defined as oxiapoptophagy, including oxidative stress and induction of death by apoptosis associated with autophagic criteria. Oxiaptophagy is associated with organelle dysfunction and in particular with mitochondrial and peroxisomal alterations involved in the induction of cell death and in the rupture of redox balance. As the criteria characterizing 7-ketocholesterol- and 7ß-hydroxycholesterol-induced cytotoxicity are often simultaneously observed in major age-related diseases (cardiovascular diseases, age-related macular degeneration, Alzheimer's disease) the involvement of these oxysterols in the pathophysiology of the latter seems increasingly likely. It is therefore important to better understand the signalling pathways associated with the toxicity of 7-ketocholesterol and 7ß-hydroxycholesterol in order to identify pharmacological targets, nutrients and synthetic molecules attenuating or inhibiting the cytotoxic activities of these oxysterols. Numerous natural cytoprotective compounds have been identified: vitamins, fatty acids, polyphenols, terpenes, vegetal pigments, antioxidants, mixtures of compounds (oils, plant extracts) and bacterial enzymes. However, few synthetic molecules are able to prevent 7-ketocholesterol- and/or 7ß-hydroxycholesterol-induced cytotoxicity: dimethyl fumarate, monomethyl fumarate, the tyrosine kinase inhibitor AG126, memantine, simvastatine, Trolox, dimethylsufoxide, mangafodipir and mitochondrial permeability transition pore (MPTP) inhibitors. The effectiveness of these compounds, several of which are already in use in humans, makes it possible to consider using them for the treatment of certain age-related diseases associated with increased plasma and/or tissue levels of 7-ketocholesterol and/or 7ß-hydroxycholesterol.


Subject(s)
COVID-19 , Aging , Humans , Hydroxycholesterols , Ketocholesterols , Nutrients , Oils , SARS-CoV-2
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