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1.
The Iraqi Journal of Agricultural Science ; 52(4):971-976, 2021.
Article in English | ProQuest Central | ID: covidwho-1469230

ABSTRACT

A field experiment was conducted during two spring seasons in 2019 and 2020 to achieve rapid, uniform, and high ratio of field emergence of maize seeds (cv. Baghdad3). Randomize complete block design was used with three replications. Seeds were soaked in acids of ascorbic and citric (100 mg l-1) and humic (1 ml 1-1) for 18 hours, as well as control treatment (seeds soaking in distilled water only). The results showed the significant superiority of soaking treatment in humic acid, which gave averages of field emergence properties in both seasons as follows: last day of field emergence (12.6 and 12.9 days), difference between first and last day of field emergence (4.8 and 4.9 days), ratio of field emergence at first count (49.5 and 55.5%), ratio of field emergence at final count (93.2 and 93.2%), daily average of field emergence (7.8 and 7.8 days), average of field emergence time (9.0 and 8.8 days) and index of field emergence average (10.5 and 10.7 days). It can be concluded that seeds soaking in humic acid improved properties of emergence and seedlings;therefore it can be recommended to soak maize seeds in humic acid (1 ml l-1) for 18 hours when planting in the spring season.

2.
Tropical Journal of Natural Product Research ; 5(1):165-177, 2021.
Article in English | Scopus | ID: covidwho-1090087

ABSTRACT

The Coronavirus Disease 2019 (COVID-19) pandemic ravages the globe causing unprecedented health and economic challenges. As the world prospects for a cure, scientists are looking critically at strategic protein targets within the SARS-CoV-2 that have therapeutic significance. The Helicase is one of such targets and it is an enzyme that affects all facets of the SARS-CoV-2 RNA metabolism. This study is aimed at identifying small molecules from natural products that have strong binding affinity with and exhibit inhibitory activity against an allosteric site (Pocket 26) on the SARS-CoV-2 Helicase. The molecular docking simulations of SARS-CoV-2 Helicase (QHD43415-12.pdb) against a library of small molecules obtained from edible African plants was executed using PyRx. Triphenylmethane, which had a docking score of-7.4 kcal/mol on SARS CoV-2 Helicase was chosen as a reference compound. Based on the molecular descriptors of the compounds as provided by PubChem, a virtual screening for oral bioavailability was performed. Further screening for molar refractivity, pharmacokinetic properties, and bioactivity were performed using SwissADME, pkCSM, and Molinspiration webservers respectively. Molecular dynamic simulation and analyses were performed using the Galaxy webserver which uses the GROMACS software. The lead compounds are Gibberellin A12, A20, and A51 obtained from Green peas and the Okra plant. Gibberellin A20 and A51 were predicted to perform better than the standard and Gibberellin A51 showed the greatest inhibitory activity against SARS-CoV-2 Helicase. © 2021 Rowaiye et al and the authors.

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