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1.
Frontiers in Immunology ; 13:984789, 2022.
Article in English | MEDLINE | ID: covidwho-2198860

ABSTRACT

Objectives: Several COVID-19 vaccines list "uncontrolled epilepsy" as a contraindication for vaccination. This consequently restricts vaccination against COVID-19 in patients with epilepsy (PWE). However, there is no strong evidence that COVID-19 vaccination can exacerbate conditions in PWE. This study aims to determine the impact of COVID-19 vaccination on PWE.

2.
Nanoscale Advances ; 2022.
Article in English | Web of Science | ID: covidwho-2186150

ABSTRACT

The current COVID-19 pandemic, with its numerous variants including Omicron which is 50-70% more transmissible than the previously dominant Delta variant, demands a fast, robust, cheap, and easily deployed identification strategy to reduce the chain of transmission, for which biosensors have been shown as a feasible solution at the laboratory scale. The use of nanomaterials has significantly enhanced the performance of biosensors, and the addition of CNTs has increased detection capabilities to an unrivaled level. Among the various CNT-based detection systems, CNT-based field-effect transistors possess ultra-sensitivity and low-noise detection capacity, allowing for immediate analyte determination even in the presence of limited analyte concentrations, which would be typical of early infection stages. Recently, CNT field-effect transistor-type biosensors have been successfully used in the fast diagnosis of COVID-19, which has increased research and commercial interest in exploiting current developments of CNT field-effect transistors. Recent progress in the design and deployment of CNT-based biosensors for viral monitoring are covered in this paper, as are the remaining obstacles and prospects. This work also highlights the enormous potential for synergistic effects of CNTs used in combination with other nanomaterials for viral detection.

4.
Journal of Xi'an Jiaotong University (Medical Sciences) ; 43(4):528-533, 2022.
Article in Chinese | EMBASE | ID: covidwho-1969736

ABSTRACT

Objective: To investigate the clinical characteristics and potential mechanism of coronavirus disease 2019 (COVID-19) vaccine-related myocarditis. Methods: We made a systematic literature retrieval based on PubMed to search for all reports on COVID-19 vaccine-related myocarditis published by August 31, 2021. A total of 29 reports involving 71 patients with myocarditis were enrolled after screening. The patients' demographic data, vaccination, clinical manifestations, biochemical and imaging results, treatments, and outcomes were extracted and summarized. The patients were divided into prior COVID (n=12) and non-prior COVID (n=59) according to their previous medical history. Results: COVID vaccine-related myocarditis was more common in men (91.5%) and after the second dose of mRNA vaccine (81.7%). The average time to onset was 3 (1, 25) days, and the main symptoms included chest pain (94.4%), fever (45.1%), myalgia (26.8%), and shortness of breath (16.9%). Abnormal troponin level was present in almost all the patients, with a common elevation of C-reactive protein. Non-steroidal anti-inflammatory drugs and colchicine were widely used in clinical treatment, and the symptoms of one-fifth of the patients were relieved after symptomatic therapy, with 1 to 2 weeks' length of hospital stay. However, the risk of vaccine-related myocarditis was significantly increased in patients with previous COVID-19 infection, which was more common after the first dose of vaccine (58.3%) other than the second dose. And the clinical symptoms and outcomes were somewhat different from those without COVID-19 infection previously. Conclusion: Myocarditis is one of the serious adverse events related to COVID-19 vaccine, with an overall relatively low incidence, mild clinical severity, and favorable prognosis. Vaccine-related myocarditis may be a combined result of primed immune system and individual susceptibility after infection with COVID-19.

5.
8th International Conference on Human Aspects of IT for the Aged Population, ITAP 2022, held as part of the 24th International Conference, HCI International 2022 ; 13331 LNCS:320-332, 2022.
Article in English | Scopus | ID: covidwho-1898999

ABSTRACT

The aim of this study is to investigate the factors that influence the choice of health care for the elderly population after Covid-19. Based on previous studies, the study innovatively adds the influence of the improvement of digital medical technology and the degree of aging-friendly of different hospitals on the choice of medical institutions for the elderly. The study used a combination of literature research, questionnaires, interviews and factor analysis to identify the main factors influencing the choice of healthcare for the elderly. The results of the study showed that the three most important factors influencing older people's choice of medical seeking behavior were their willingness of treatment, community evaluation and the aging-friendly improvements. The data from this study will be used to analysis the pain points of the elderly in seeking medical treatment and to make recommendations to improve their medical experience. It is hoped that this study will provide some ideas for the development of a model of healthcare access for older people, and better guide them in their healthcare seeking behavior. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

6.
European Journal of Innovation Management ; 25(6):716-734, 2022.
Article in English | Web of Science | ID: covidwho-1853334

ABSTRACT

Purpose Additive manufacturing (AM) technologies, also known as three-dimensional printing (3DP), is a technological breakthrough that have the potential to disrupt the traditional operations of supply chains. They open the way to a supply chains innovation that can significantly benefit hospitals and health-related organizations in dealing with crises or unexpected events in a faster and more flexible way. In this study the authors identify the boundary of this potential support. Design/methodology/approach The authors adopt a case study approach to understand the dynamics behind a well-known best practice to identify the main opportunities and the main pitfalls that AM may pose to health-related organizations wanting to leverage them. Findings The case highlights that it is possible to increase hospital flexibility using AM and that by leveraging the Internet it is possible to spread the benefits faster than what it would be normally possible using traditional supply chain processes. At the same time the case highlights that leveraging these technologies needs buy-in from all the relevant stakeholders. Originality/value The paper is one of the first, to the best of the authors' knowledge, to highlight the main opportunities and difficulties of implementing 3DP technologies in hospital supply chain management.

7.
J Emerg Med ; 62(3): 332-336, 2022 03.
Article in English | MEDLINE | ID: covidwho-1624787

ABSTRACT

BACKGROUND: Hydroxychloroquine overdose is rare but potentially lethal. Hydroxychloroquine overdose symptoms are characterized by central nervous system toxicity, cardiac toxicity, and hypokalemia. Recommended treatment consists of epinephrine, high-dose diazepam, and careful potassium repletion. Few pediatric hydroxychloroquine overdoses have been reported. CASE REPORT: We describe a 14-year-old girl who ingested 10 g (172 mg/kg) of hydroxychloroquine. She developed tachycardia, hypotension, and hypokalemia. She was intubated and treated with diazepam and epinephrine infusions and potassium supplementation. Her serum hydroxychloroquine concentration obtained 10 h after ingestion was 13,000 ng/mL (reference range 500-2000 ng/mL). The patient made a full medical recovery. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Pediatric hydroxychloroquine overdoses are reported rarely, and the toxic and lethal doses of hydroxychloroquine ingestion have not been established. This case of a teenaged patient who ingested 10 g of hydroxychloroquine and survived provides additional information that may be used to help establish toxic and lethal doses of ingestion.


Subject(s)
Drug Overdose , Hypokalemia , Adolescent , Child , Diazepam/therapeutic use , Drug Overdose/drug therapy , Eating , Epinephrine/therapeutic use , Female , Humans , Hydroxychloroquine/adverse effects , Potassium/therapeutic use
8.
HemaSphere ; 5(SUPPL 2):547, 2021.
Article in English | EMBASE | ID: covidwho-1393359

ABSTRACT

Background: Immune thrombocytopenia (ITP) is an acquired thrombocytopenia caused by immune-mediated platelet destruction and impaired platelet production. Recombinant human thrombopoietin (rhTPO) and Eltrombopag, a small molecule agonist of thrombopoietin receptor (TPO-RA), are both recommended as the subsequent treatment for ITP patients, which also already showed robust efficacy. They increase the number of platelets through different mechanisms, and previous studies demonstrated that they might exert synergic effect. During the COVID- 19 pandemic, the classical subsequent treatment regimen for ITP of immunosuppressants and/or steroids might increase patients' susceptibility of virus infections. The investigators hypothesized that the combination of these two agents could be a promising option for ITP treatment during the COVID-19 pandemic. To minimize ITP patients' risk during the COVID-19 global crisis and to improve treatment efficacy, this treatment regimen of Eltrombopag plus rhTPO should be investigated. This trial is registered with ClinicalTrials.gov, number NCT01667263. Aims: This study aimed to evaluate the sustained responses at 6 months and safety of Eltrombopag plus rhTPO as treatment for corticosteroid- resistant or relapsed ITP patients during the COVID-19 pandemic. Methods: In this open-label, randomized, phase 2 trial, we enrolled confirmed corticosteroid-resistant or relapsed adult ITP patients from 5 different tertiary medical centers in China. They were randomly assigned 1:1 with an interactive web-based response system to receive either Eltrombopag 25-75 mg oral daily according to platelet response plus rh-TPO 300U/kg subcutaneous injection once daily for 7 consecutive days, followed by a tapering dose in maintenance therapy or Eltrombopag monotherapy for 12 weeks (Figure 1). The primary endpoint was 6-month sustained response (SR) defined as platelet counts maintained > 30×109/L and at least a doubling of baseline platelet count. Key secondary endpoints were initial response by day 14, duration of response (DOR), TTR, bleeding scores, and adverse events (AEs). Results: Between August 2020, and March 2021, 60 patients were randomly allocated into either rh-TPO plus Eltrombopag (n=30) or Eltrombopag monotherapy (n=30). At the 6-month follow-up, the proportion of patients with SR was significantly higher in the rh-TPO plus Eltrombopag group than in the Eltrombopag monotherapy group (66.7% vs 36.7%, p= 0.020). The combination of rh-TPO and Eltrombopag resulted in a higher incidence of initial response by day 14 compared with Eltrombopag monotherapy (76.7% vs 60%, p= 0.165). Throughout the follow-up period, overall DOR was greater in the combination group, estimated by the Kaplan-Meier analysis. Bleeding was more effectively controlled in the rh-TPO plus Eltrombopag arm, with fewer bleeding events and lower bleeding scores. There was no difference between the 2 groups in terms of rescue treatments. All subjects tolerated the treatment well, and no grade 4 adverse events or treatment- related death were reported. No statistically significant differences were observed in the incidence of treatment-related AEs between the two groups. Summary/Conclusion: Rh-TPO plus Eltrombopag is an effective and safe treatment for corticosteroid-resistant or relapsed ITP patients during the COVID-19 pandemic. (NCT04516837).

9.
Covid-19 in Asia: Law and Policy Contexts ; : 365-378, 2021.
Article in English | Scopus | ID: covidwho-1370810

ABSTRACT

This chapter evaluates the deleterious effect of the Covid-19 pandemic on business enterprises in Asia. In these extraordinary and unprecedented circumstances, it was not surprising that governments stepped in to forestall a collapse of markets brought about by the simple fact that ordinary life had been disrupted. Beyond liquidity and stimulus measures taken by central banks that feature in many past recessions, many Asian jurisdictions saw unprecedented provision of financial support and measures to businesses and individuals to tide them over and lessen the risk of insolvency. These measures included temporary moratoriums on financial obligations and debt recovery, relief from other contractual obligations, employment support, increases to the debt thresholds for the commencement of insolvency proceedings, and infrastructure investments. These extraordinary measures, if effective, had the potential to become part of an expanded standard playbook to deal with future economic shocks, and the chapter focuses on them with particular reference to China, Hong Kong, Malaysia, and Singapore. © the several contributors 2021.

10.
AHFE Conference on Human Factors and Ergonomics in Healthcare and Medical Devices, 2021 ; 263:667-674, 2021.
Article in English | Scopus | ID: covidwho-1359908

ABSTRACT

During the global epidemic, the work pressure of pharmacy employees have increased significantly, and these medical system workers have played a key role in the recovery of the epidemic. Front-line employees in the pharmaceutical retail industry have to contact sick customers every day. They must not only ensure accurate medicine services to patients, but also ensure their safe and effective use of medicines. This study used literature analysis, questionnaire surveys, and the Decision-making Trial and Evaluation Laboratory (DEMATEL) method to analyze the key decision-making factors of job satisfaction, the correlation between those factors. The results show that salary and future development, workload and time occupation and pressure from supervisors are the main factors affecting the job satisfaction of pharmacy employees. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.

11.
AHFE Conference on Human Factors and Ergonomics in Healthcare and Medical Devices, 2021 ; 263:555-562, 2021.
Article in English | Scopus | ID: covidwho-1359894

ABSTRACT

Since the end of 2019, the coronavirus epidemic ‘COVID-19’ began to sweep the world, which led to some fundamental changes in people’s exercise methods. In this term exergames with small footprints, diversification and narrative design gradually began to be popular, which had a huge influence on people’s motivation of exercise. This study used the famous exergame “Fitness Ring Adventure” as the research and experimental platform, combined with literature and questionnaire research, the research set 5 dimensions and 15 factors. This study used the decision-making laboratory method (DEMATEL) to analyze the influence between its narrative and exercise motivation, aimed to find the characteristics and attributes that can guide future designs. This research found that explore willingness, attention and cost of study were the most influencing factors to motivation. And narrative carrier, localization and narrative interaction are more influential to other factors. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.

12.
9th International Conference on Culture and Computing, C and C 2021, Held as Part of the 23rd HCI International Conference, HCII 2021 ; 12794 LNCS:467-482, 2021.
Article in English | Scopus | ID: covidwho-1359832

ABSTRACT

This research aimed to investigate the relevant factors that influence users’ choice of online art forms during the Covid-19 pandemic. The research used interview, questionnaire survey and literature research combined with factor analysis to summarize 10 major influencing factors on users’ choice of online art forms. The depth interviews were deployed with Decision-Making Trial and Evaluation Laboratory (DEMATEL) questionnaires to evaluate the influencing directions and the degrees of the interactions among the 10 influencing factors. The finding showed that three key factors that affect users’ choice of online art form are performance-price ratio, required equipments and technical means, and these three factors can greatly affect other influencing factors. According to the influential relation diagram, three key influencing factors were used as entry points to fully explore the role and advantages of online art. A user satisfaction optimization model of online art service was proposed, aiming at providing a feasible way to enhance the user experience of online art, and to propose suggestions on optimizing online art forms. It is hoped that in the post-pandemic era, this research can help the online art continue to flourish and complement offline art forms to enrich the art field, and improve the art cognition level of the public. © 2021, Springer Nature Switzerland AG.

13.
2020 Ieee Globecom Workshops ; 2020.
Article in English | Web of Science | ID: covidwho-1307625

ABSTRACT

Sneezes play a key role in transferring respiratory diseases such as COVID-19 between infectious and susceptible individuals where the timely monitoring and alerting for sneezes can be important in preventing the spread of such diseases. This paper presents Wi-Sneeze, a Wi-Fi based passive radar for sneeze sensing using Wi-Fi signals, as a promising solution to detect the potentially harmful exhaled volume-based sneeze droplets. Using the size distributions of the droplets exhaled by sneezes, an accurate volume RCS for the sneeze droplets is calculated, leading to the computation of the SNR which enable the range prediction for detecting the sneeze droplets. Experimental trials are conducted for real human sneezes and using the associated signal processing schemes, the Doppler frequency of the sneeze droplets can be prominently detected and localized in range. In addition, advanced signal processing techniques are used to improve the performance of the sneeze droplets detections. These promising results clearly validated the concept and feasibility of Wi-Sneeze in a practical environment.

14.
Nan Fang Yi Ke Da Xue Xue Bao ; 41(4): 628-632, 2021 Apr 20.
Article in Chinese | MEDLINE | ID: covidwho-1219329

ABSTRACT

The high comorbidity between cardiovascular and metabolic diseases (CVMD) and coronavirus disease 2019 (COVID-19) and the consequent high mortality and the potential risk of cardiovascular damage have brought great challenges to the clinical diagnosis and treatment of the condition. The latest studies found that advanced age, immune function defects, inflammatory factor storms and oxidative stress damage all potentially contribute to the high comorbidity of the two. Direct virus invasion, myocardial oxygen supply and demand imbalance and vascular endothelial and coagulation dysfunction may be important mechanisms for cardiovascular injury in COVID-19 patients. In addition, the expression level of ACE2 (the cell membrane receptor of SARS-CoV-2) in various organs and the peripheral blood not only mediates the direct invasion and damage of the organs, but also participates in regulation of the balance of systematic inflammation and oxidative stress, thus affecting the susceptibility and outcomes of the patients. Herein we review the recent research progress in the comorbidity between COVID-19 and CVMD and explore the mechanisms of cardiovascular damage caused by SARS-CoV-2, thus to provide a theoretical basis for the clinical diagnosis and treatment of COVID-19 with underlying CVMD.


Subject(s)
COVID-19 , Cardiovascular Diseases , Metabolic Diseases , Cardiovascular Diseases/epidemiology , Comorbidity , Humans , Metabolic Diseases/complications , Metabolic Diseases/epidemiology , SARS-CoV-2
15.
IEEE Globecom Workshops, GC Wkshps - Proc. ; 2020.
Article in English | Scopus | ID: covidwho-1151558
16.
Milli Egitim ; 49(1):1059-1078, 2020.
Article in English, Turkish | Scopus | ID: covidwho-1061379

ABSTRACT

The aim of this study is to investigate the flow experiences of foreign language (EFL) learners in online classes during Covid-19 pandemic outbreak. The participants were 84 university students as EFL learners. Data were collected from a perception survey, a background questionnaire and open-ended questions to provide triangulation. The results showed that participants had flow experiences with different levels of different categories of flow. The results also showed that there was no significant difference in terms of gender. Additionally, the findings proved that participants’ flow experiences were partially interrupted by some problems they faced during their online classes. © 2020. All rights reserved.

17.
Journal of Xi'an Jiaotong University (Medical Sciences) ; 42(1):132-136, 2021.
Article in Chinese | EMBASE | ID: covidwho-1042268

ABSTRACT

Objective: To investigate the negative emotions among university students during home quarantine under the epidemic of coronavirus disease 2019 (COVID-19) so as to provide scientific basis for psychological counseling. Methods: We conducted an online questionnaire survey to collect 405 undergraduates' and postgraduates' DASS-21 scale scores and responses to epidemic prevention knowledge, and analyzed the university students' negative emotions during the epidemic and influencing factors. Results: Of the 405 students surveyed, 178 individuals (44.0%) had depression, 171(42.2%) felt anxious, and 119(29.4%) felt stressed. Individuals in the DASS21+ group spent much time on entertainment on the cell phone daily than those in the DASS21- group (P< 0.001), and the degree of impact by COVID-19 on daily life was significantly higher (P< 0.001). Correlation analysis showed that entertainment time on the cell phone, the severity of COVID-19, and the impact of the epidemic were positively related to DASS-21 scores, with correlation coefficients of 0.231, 0.143 and 0.259, respectively (all P< 0.01). Binary logistic regression analysis found that mobile entertainment time for over 5 hours per day (OR=3.370, 95% CI: 1.369-8.294, P=0.008) was a risk factor for negative emotions during quarantine at home. Conclusion: During quarantine at home in the epidemic of COVID-19, nearly half of university students are prone to breed negative emotions, like depression, anxiety or stress, which may be related to long-term mobile phone entertainment.

18.
Am J Transl Res ; 12(10):6434-6444, 2020.
Article in English | PubMed | ID: covidwho-923141

ABSTRACT

Coronavirus Disease 2019 (COVID-19) pandemic has rapidly spread across the globe while little multi-center research about the epidemiological characteristics of cluster transmission is conducted. To provide a more comprehensive description of the epidemiological characteristics of cluster transmission and the virulence of SARS-CoV-2 carried by asymptomatic carriers, we studied the epidemiological characteristics of 70 clusters. 70 clusters including 311 consecutive subjects from January 20, 2020, to March 10, 2020, were enrolled. Of 70 clusters, 5 were infected by asymptomatic or presymptomatic carriers. We gathered and analyzed information about their demographic, epidemiological, clinical, diagnostic classification, and cluster characteristics. Among the 66 asymptomatic carriers in Jiangsu Province, 49 asymptomatic were observed in 311 subjects distributed in 70 clusters. We demonstrated that there is a significance between the severity of cases infected by asymptomatic carriers and cases infected by symptomatic patients (P=0.033) and the former usually presented with milder symptoms. A significant difference was shown regarding the level distribution of age (P=0.006) and the frequency distribution of gender (P=0.014) and disease severity of COVID-19 (P=0.008) among the seven groups classified by the relationship with the index cases. The average age of infected medical staff was the youngest and the majority of infected medical are females while the infected patients were generally oldest and usually accompanied by severest symptoms. We concluded that asymptomatic carriers are mainly screened out of clusters and the patients infected by asymptomatic carriers present with milder symptoms than those infected by symptomatic patients, which indicated that the SARS-CoV-2 shares decreased virulence among asymptomatic carriers. Effective measures should be taken to prevent transmission in hospitals to protect doctors, nurses, and patients.

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