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1.
Chung-Hua Yu Fang i Hsueh Tsa Chih [Chinese Journal of Preventive Medicine] ; 56(12):1789-1794, 2022.
Article in Chinese | MEDLINE | ID: covidwho-2201079

ABSTRACT

Objective: To investigate a SARS-CoV-2 epidemic reported in Rongcheng City, Weihai, Shandong Province.

2.
Frontiers in Public Health ; 10, 2022.
Article in English | Web of Science | ID: covidwho-2199517

ABSTRACT

ObjectiveWe investigated the effects of COVID-19 fear on negative moods among college students, and assessed the efficacy of physical exercise behavior as a moderator variable. MethodsThis was a cross-sectional study. Students from three colleges and universities in Shangqiu City, Henan Province and Yangzhou City, Jiangsu Province were enrolled in this study, which was performed during the COVID-19 pandemic using an online questionnaire. A total of 3,133 college students completed the questionnaire. Measurement tools included the COVID-19 Phobia Scale (C19P-S), Depression-Anxiety-Stress Self-Rating Scale (DASS), and the Physical Activity Behavior Scale (PARS-3). ResultsDuring the COVID-19 pandemic, the rates of depression, anxiety, and stressful negative moods among college students were 35.5, 65.5, and 10.95%, respectively;there was a positive correlation between COVID-19 fear and negative moods among college students (r = 0.479, p < 0.001), which was negatively correlated with physical exercise behavior (r = -0.4, p < 0.001);the regulating effects of physical exercise behavior were significant (Delta R2 = 0.04, p < 0.001). ConclusionThe rate of negative moods among college students is high, and the fear for COVID-19 is one of the key factors that lead to negative moods. Physical exercise can modulate the impact of COVID-19 fear among college students on negative moods. Studies should elucidate on mental health issues among different populations during the COVID-19 pandemic.

3.
Frontiers in Pharmacology ; 13, 2022.
Article in English | Web of Science | ID: covidwho-2199112

ABSTRACT

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects both people and animals and may cause significant respiratory problems, including lung illness: Corona Virus Disease 2019 (COVID-19). Swabs taken from the throat and nose of people who have the illness or are suspected of having it have shown this pathogenic virus. When SARS-CoV-2 infects the upper and lower respiratory tracts, it may induce moderate to severe respiratory symptoms, as well as the release of pro-inflammatory cytokines including interleukin 6 (IL-6). COVID-19-induced reduction of IL-6 in an inflammatory state may have a hitherto undiscovered therapeutic impact. Many inflammatory disorders, including viral infections, has been found to be regulated by IL-6. In individuals with COVID-19, one of the primary inflammatory agents that causes inflammatory storm is IL-6. It promotes the inflammatory response of virus infection, including the virus infection caused by SARS-CoV-2, and provides a new diagnostic and therapeutic strategy. In this review article, we highlighted the functions of IL-6 in the coronavirus, especially in COVID-19, showing that IL-6 activation plays an important function in the progression of coronavirus and is a rational therapeutic goal for inflammation aimed at coronavirus.

4.
Front Microbiol ; 13, 2022.
Article in English | PubMed Central | ID: covidwho-2199026

ABSTRACT

Introduction: In December 2019, a novel epidemic of coronavirus pneumonia (COVID-19) was reported,and population-based studies had shown that cancer was a risk factor for death from COVID-19 infection. However, the molecular mechanism between COVID-19 and cancer remains indistinct. In this paper, we analyzed the nucleic acid sensor (DDX58) of SARS-CoV-2 virus, which is a significant gene related to virus infection. For purpose of clarifying the characteristics of DDX58 expression in malignant tumors, this study began to systematically analyze the DDX58 expression profile in the entire cancer type spectrum. Methods: Using TCGA pan-cancer database and related data resources, we analyzed the expression, survival analysis, methylation expression, mutation status, microsatellite instability (MSI), immune related microenvironment, gene related network, function and drug sensitivity of DDX58. Results: The expression level of DDX58 mRNA in most cancers was higher than the expression level in normal tissues. Through TIMER algorithm mining, we found that DDX58 expression was closely related to various levels of immune infiltration in pan-cancer. The promoter methylation level of DDX58 was significantly increased in multiple cancers. In addition, abnormal expression of DDX58 was related to MSI and TMB in multiple cancers, and the most common type of genomic mutation was "mutation.” In the protein–protein interaction (PPI) network, we found that type I interferon, phagocytosis, ubiquitinase, and tumor pathways were significantly enriched. Finally, according to the expression of DDX58 indicated potential sensitive drugs such as Cediranib, VE−821, Itraconazole, JNJ−42756493, IWR−1, and Linsitinib. Discussion: In conclusion, we had gained new insights into how DDX58 might contribute to tumor development, and DDX58 could be used as an immune-related biomarker and as a potential immunotherapeutic target for COVID-19 infected cancer patients.

5.
Biomacromolecules ; 23:23, 2022.
Article in English | MEDLINE | ID: covidwho-2185444

ABSTRACT

The coronavirus disease 2019 (COVID-19) pandemic has threatened the stability of global healthcare, which is becoming an endemic issue. Despite the development of various treatment strategies to fight COVID-19, the currently available treatment options have shown varied efficacy. Herein, we have developed an avidity-based SARS-CoV-2 antagonist using dendrimer-peptide conjugates (DPCs) for effective COVID-19 treatment. Two different peptide fragments obtained from angiotensin-converting enzyme 2 (ACE2) were integrated into a single sequence, followed by the conjugation to poly(amidoamine) (PAMAM) dendrimers. We hypothesized that the strong multivalent binding avidity endowed by dendrimers would help peptides effectively block the interaction between SARS-CoV-2 and ACE2, and this antagonist effect would be dependent upon the generation (size) of the dendrimers. To assess this, binding kinetics of the DPCs prepared from generation 4 (G4) and G7 PAMAM dendrimers to spike protein of SARS-CoV-2 were quantitatively measured using surface plasmon resonance. The larger dendrimer-based DPCs exhibited significantly enhanced binding strength by 3 orders of magnitude compared to the free peptides, whereas the smaller one showed a 12.8-fold increase only. An in vitro assay using SARS-CoV-2-mimicking microbeads also showed the improved SARS-CoV-2 blockade efficiency of the G7-peptide conjugates compared to G4. In addition, the interaction between the DPCs and SARS-CoV-2 was analyzed using molecular dynamics (MD) simulation, providing an insight into how the dendrimer-mediated multivalent binding effect can enhance the SARS-CoV-2 blockade. Our findings demonstrate that the DPCs having strong binding to SARS-CoV-2 effectively block the interaction between ACE2 and SARS-CoV-2, providing a potential as a high-affinity drug delivery system to direct anti-COVID payloads to the virus.

6.
Anal Biochem ; : 115046, 2023.
Article in English | PubMed | ID: covidwho-2175673

ABSTRACT

The early diagnosis of coronavirus disease 2019 (COVID-19) is dependent on the specific and sensitive detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA. Herein, we develop a highly sensitive and specific electrochemical biosensor for SARS-CoV-2 target RNA detection based on the integration of protospacer adjacent motif (PAM)-free cascaded toehold-mediated strand displacement reactions (TSDRs) and CRISPR-Cas12a (PfTSDR-CRISPR). In this study, each target is transformed into multiple DNA substrates with bubble structure in the seed region by the cascaded TSDRs, which can directly hybridize with guide RNA (gRNA) without PAM requirement and then activate CRISPR-Cas12a's trans-cleavage activity. Subsequently, the hairpin DNA modified with methylene blue (MB-HP) is cleaved by activated CRISPR-Cas12a. Therefore, as MB leaves the electrode surface, a decreased current signal is obtained. With the involvement of PAM-free cascaded TSDRs and CRISPR-Cas12a amplification strategy, the PfTSDR-CRISPR-based electrochemical biosensor achieves the detection of target RNA as low as 40 aM. The biosensor has high sequence specificity, reliability and robustness. Thanks to the PAM-free cascaded TSDRs, the biosensor can achieve universal detection of different target RNA without redesigning gRNA sequence of CRISPR-Cas12a. In addition, this biosensor successfully detects SARS-CoV-2 target RNA in complex samples, which highlights its potential for diagnosing COVID-19.

7.
Journal of medical virology ; 07, 2023.
Article in English | EMBASE | ID: covidwho-2173235

ABSTRACT

OBJECTIVE: To analyze the dynamic changes of renal function longitudinally and investigate the cytokine profiles at 6 months in patients with Omicron COVID-19. METHOD(S): 47 patients with a proven diagnosis of Omicron COVID-19 from January 2022 to February 2022 attended a 6-month follow-up after discharge at Tianjin first Central Hospital. The demographic parameters, clinical features, and laboratory indexes were collected during hospitalization and 6 months after discharge. The serum cytokine levels at 6 months were also assessed. Patients were grouped according to with or without kidney involvement at admission. RESULT(S): The levels of serum creatinine and estimated glomerular filtration rate (eGFR) were all normal both in the hospital and at follow-up. Whereas, compared with renal function in hospital, serum creatinine levels at 6 months increased remarkably;meanwhile, eGFR decreased significantly in all patients. The serum levels of IL-2, IL-4, IL-5, IL-6, IL-10, and TNF-alpha and IFN-gamma significantly decreased and TGF-beta remarkably increased in the kidney involvement group. The serum levels of IL-2 and IL-5 were positively correlated with age;contrarily, TGF-beta showed a negative correlation with aging. The younger was an independent risk factor of the higher TGF-beta levels. CONCLUSION(S): Omicron patients showed a decline in renal function at follow-up reflecting the trend of CKD. Serum cytokine profiles were characterized with the majority of cytokines decreased and TGF-beta increased in the kidney involvement group;the latter may be used as a sign of CKD. The tendency of CKD is one of the manifestations of long COVID and deserves attention. This article is protected by copyright. All rights reserved.

8.
Journal of Medical Virology ; 27:27, 2022.
Article in English | MEDLINE | ID: covidwho-2173214

ABSTRACT

Emergence of various circulating SARS-CoV-2 variants of concern (VOCs) promotes the identification of pan-sarbecovirus vaccines and broadly neutralizing antibodies (bNAbs). Here, to characterize monoclonal antibodies cross-reactive against both SARS-CoV-1 and SARS-CoV-2 and to search the criterion for bNAbs against all emerging SARS-CoV-2, we isolated several SARS-CoV-1-cross-reactive monoclonal antibodies (mAbs) from a wildtype SARS-CoV-2 convalescent donor. These antibodies showed broad binding capacity and cross-neutralizing potency against various SARS-CoV-2 VOCs, including B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617.2 (Delta), but failed to efficiently neutralize Omicron variant and its sublineages. Structural analysis revealed how Omicron sublineages, but not other VOCs, efficiently evade an antibody family cross-reactive against SARS-CoV-1 through their escape mutations. Further evaluation of a series of SARS-CoV-1/2-cross-reactive bNAbs showed a negative correlation between the neutralizing activities against SARS-CoV-1 and SARS-CoV-2 Omicron variant. Together, these results suggest the necessity of using cross-neutralization against SARS-CoV-1 and SARS-CoV-2 Omicron as criteria for rational design and development of potent pan-sarbecovirus vaccines and bNAbs. This article is protected by copyright. All rights reserved.

9.
Frontiers in Environmental Science ; 10, 2022.
Article in English | Scopus | ID: covidwho-2163005

ABSTRACT

This study investigates the interaction between the accessibility of various urban public facilities and the price of urban space by analysing the influence of urban hospitals and rail accessibility on housing prices. In recent years, with the development of social civilisation and the influence of COVID-19, people have become increasingly interested in the quality of hospitals in their living environment. This makes medical convenience (hospital accessibility) a crucial element in determining housing prices. At the same time, people regard rail as one of the important means to access hospitals. Therefore, demonstrating the intrinsic value of accessibility to hospitals and rail in residential areas is essential. As a point of reference, this paper presents an empirical analysis of Fuzhou, Fujian Province, China, a city in a developing nation with relatively widespread access to hospitals during a significant rail construction period. The study demonstrates the interaction between hospital and rail accessibility and their moderate influence on housing prices, which is geographically heterogeneous. The study also determines the optimal metric model for assessing geographical interaction based on the significance and stability of the interaction in geographic space. It concludes with a discussion of the findings and social recommendations. Copyright © 2022 Chen, Lin, Cao, Han, You, Shyr, Lu and Huang.

10.
Front Endocrinol (Lausanne) ; 13, 2022.
Article in English | PubMed Central | ID: covidwho-2163001

ABSTRACT

Introduction: The COVID lockdown has posted a great challenge to paediatric patients with type 1 diabetes (T1D) and their caregivers on the disease management. This systematic review and meta-analysis sought to compare the glycaemic control among paediatric patients with T1D (aged under 18 years) pre- during, and post-lockdown period. Methods and materials: We did a systematic search of three databases (PubMed, Embase, and the WHO COVID‐19 Global literature) for the literature published between 1 Jan 2019 to 10 Sep 2022. Studies meeting the following inclusion criteria were eligible for this study: (1) a COVID-19 related study;(2) inclusion of children aged 18 years old or under with established T1D;(3) comparing the outcomes of interest during or after the COVID lockdown with that before the lockdown. Study endpoints included mean difference (MD) in HbA1c, blood glucose, time in range (TIR, 70-180 mg/dl), time above range (TAR, >180mg/dl), time below range (TBR,<70mg/dl) and glucose variability (coefficient of variation [CV]) between pre-lockdown and during lockdown and/or between pre- and post-lockdown period. The MD and its corresponding 95% CI of each endpoint were pooled using random-effect model considering the potential between-study heterogeneity in COVID restrictions and T1D management. Results: Initial search identified 4488 records and 22 studies with 2106 paediatric patients with T1D were included in the final analysis. Compared with pre-lockdown period, blood glucose was significantly decreased by 0.11 mmol/L (95%CI: -0.18, -0.04) during lockdown period and by 0.42 mmol/L (95%CI: -0.73, -0.11) after lockdown. The improvement was also found for TIR, TAR, TBR, and CV during and post-lockdown (all p values<0.05) except for the post-lockdown TBR (p =0.35). No significant change in HbA1c was observed during and post- lockdown period when compared with the pre-lockdown value. There was moderate to high between-study heterogeneity for most of the analyses. Conclusion: Compared with pre-lockdown period, there was significant improvement in T1D paediatric patients' glucose metrics during and post-lockdown. The underlying reasons for this positive impact warrant further investigation to inform future paediatric diabetes management. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022359213.

11.
Eur Heart J ; 43(Suppl 2), 2022.
Article in English | PubMed Central | ID: covidwho-2107420

ABSTRACT

Introduction: Although most patients recovering from acute COVID-19 infection have complete resolution of symptoms, some have cardiopulmonary symptoms lingering long after the acute phase of the disease. One proposed mechanism involves chronicity of COVID-19 associated with myocarditis and endotheliopathy. Purpose: To determine the coronary microvascular health of patients with prior COVID-19 and no known coronary artery disease (CAD) using positron emission tomography (PET). Methods: Cases consisting of patients without known CAD but previous COVID-19 infection who had clinically indicated PET imaging were matched 1:4 on clinical and cardiovascular risk factors to controls having no prior COVID-19 infection. Myocardial blood flow (MBF) in ml/gm/min was obtained from dynamic images at rest and peak hyperemia. The coronary flow reserve (CFR) was calculated as the ratio of stress to rest MBF of the left ventricle. Coronary microvascular dysfunction (CMD) was defined as CFR<2. Results: The study population consisted of 315 patients, 25% (n=80) of which had prior COVID-19 infection (mean±SD age 64±11 years, 46% men). The median (IQR) number of days between COVID-19 infection and PET imaging was 190 (85–268) days. After adjusting for age, gender and cardiovascular risk factors, patients with prior COVID-19 and no known CAD had a statistically significant higher odds of having a CFR <2 (OR 4.9, 95% CI 2.3–10.1 p<0.001) and CFR <2 normalized to patient's rate-systolic blood pressure product (OR 2.8, 95% CI 1.6–5.0 p=0.001). The annualized event rate for the composite outcome of all-cause death, myocardial infarction, admission for heart failure exacerbation and late revascularization was higher in cases vs controls and in those with CMD. Conclusion: Our analysis showed that patients with prior COVID-19 and no known CAD had higher rates of CMD, and that the presence of CMD was associated with higher risk of incident cardiovascular events. Funding Acknowledgement: Type of funding sources: None.

12.
Proceedings of the 31st Usenix Security Symposium ; : 1487-1504, 2022.
Article in English | Web of Science | ID: covidwho-2092502

ABSTRACT

Secure two-party protocols that compute intersection-related statistics have attracted much attention from the industry. These protocols enable two organizations to jointly compute a function (e.g., count and sum) over the intersection of their sets without explicitly revealing this intersection. However, most of such protocols will reveal the intersection size of the two sets in the end. In this work, we are interested in how well an attacker can leverage the revealed intersection sizes to infer some elements' membership of one organization's set. Even disclosing an element's membership of one organization's set to the other organization may violate privacy regulations (e.g., GDPR) since such an element is usually used to identify a person between two organizations. We are the first to study this set membership leakage in intersection-size-revealing protocols. We propose two attacks, namely, baseline attack and feature-aware attack, to evaluate this leakage in realistic scenarios. In particular, our feature-aware attack exploits the realistic set bias that elements with specific features are more likely to be the members of one organization's set. The results show that our two attacks can infer 2.0 similar to 72.7 set members on average in three realistic scenarios. If the set bias is not weak, the feature-aware attack will outperform the baseline one. For example, in COVID-19 contact tracing, the feature-aware attack can find 25.9 tokens of infected patients in 135 protocol invocations, 1.5 x more than the baseline attack. We discuss how such results may cause negative real-world impacts and propose possible defenses against our attacks.

13.
Lwt-Food Science and Technology ; 167, 2022.
Article in English | Web of Science | ID: covidwho-2069457

ABSTRACT

Campylobacter is one of the most common foodborne pathogens worldwide. A new smartphone-assisted high-throughput integrated color-sensing platform, called the HICS platform, was developed for the rapid detection of Campylobacter coli. This platform was based on the visual loop-mediated isothermal amplification method. Using this system, as many as 64 samples could be assessed in less than an hour after enrichment. 60 meat samples were tested to compare the performance of the HICS platform and other methods. Having the consistent detection result with TaqMan qPCR (Quantitative Real-time Polymerase Chain Reaction), the HICS platform was able to reliably detect C. coli in meat samples, and its limit of detection is 550 CFU/mL and 120 copies/mu L, which was 10-fold higher than that of the PCR (Polymerase Chain Reaction) method. To conclude, considering that our platform showed robust performance and does not require any expensive equipment, it can also be reliably applied for the high-throughput detection of other pathogens.

14.
22nd COTA International Conference of Transportation Professionals, CICTP 2022 ; : 940-951, 2022.
Article in English | Scopus | ID: covidwho-2062370

ABSTRACT

COVID-19 has had a large impact on tourism demands, preferences, and behaviors. Understanding tourist congestion perception during normal and abnormal events has become a key to formulate tourist flow control schemes and develop tourism demand management in the post-COVID period. This paper explores the correlation mechanism among tourist congestion perception, tourism information services, and tourists travel behaviors in normal and abnormal conditions. To acquire tourist travel behavior, congestion perception, and tourists' socioeconomic attributes, a stated preference survey was done. The changes in travel information demand during different COVID-19 pandemic levels with different congestion perceptions were analyzed, and the effects of influencing factors such as information obtained from different tourism stages and tourist density were qualitatively analyzed. A tourist congestion perception model was established. The analysis provides basic data for establishment of tourist flow control schemes in tourist attractions and reasonable tourism information dissemination in the post-COVID-19 period. © ASCE.

15.
Political, Economic And Social Dimensions Of Labour Markets: A Global Insight ; : 245-275, 2022.
Article in English | Scopus | ID: covidwho-2053304

ABSTRACT

This chapter investigates the characteristics of labour demanding during the post-Covid-19 period in China. We extract information from the recruitment advertisements in online job portals. We find that the job requirements vary across sectors for the potential employees. The candidates' background, relevant knowledge and professional skills are more important in the technology and finance industries. The common skills required are communication, execution and marketing skills. Secondly, the technology industry hires the most people among all industries, especially in metropolis areas. Our findings imply that during the post-pandemic period of Covid-19, the technology industry draws more and more attention. The government and universities could provide more courses to fulfil the requirements of the high-demand industry. © 2022 World Scientific Publishing Company.

16.
2022 IEEE International Conference on Communications, ICC 2022 ; 2022-May:1196-1201, 2022.
Article in English | Scopus | ID: covidwho-2029229

ABSTRACT

Spurred by the severe restrictions on mobility due to the COVID-19 pandemic, there is currently intense interest in developing the Metaverse, to offer virtual services/business online. A key enabler of such virtual service is the digital twin, i.e., a digital replication of real-world entities in the Metaverse, e.g., city twin, avatars, etc. The real-world data collected by IoT devices and sensors are key for synchronizing the two worlds. In this paper, we consider the scenario in which a group of IoT devices are employed by the Metaverse platform to collect such data on behalf of virtual service providers (VSPs). Device owners, who are self-interested, dynamically select a VSP to maximize rewards. We adopt hybrid evolutionary dynamics, in which heterogeneous device owner populations can employ different revision protocols to update their strategies. Extensive simulations demonstrate that a hybrid protocol can lead to evolutionary stable states. © 2022 IEEE.

17.
2022 3rd International Conference on Computer Information and Big Data Applications, CIBDA 2022 ; : 101-105, 2022.
Article in English | Scopus | ID: covidwho-2011515

ABSTRACT

Since the outbreak of COVID-19, thousands of rumors have occurred on social media, and it is significant to identify opinion leaders who play decisive roles during rumor spreading. However, existing literature lacks such opinion leaders identification and following analysis of COVID-19 background. So this paper takes a COVID-19 case as an example and collects data from Sina Weibo, which is a popular twitter-like social media in China. Then three different centrality measures are applied. Finally, a venn diagram is used to analyze opinion leaders identified, and profiles of them on Weibo are taken into consideration. In conclusion, the paper finds that opinion leaders identified during rumor spreading are institutional and individual accounts with a huge number of followers. But in terms of numbers, government institutions spread information to more people;in terms of breadth, impactful individual accounts deliver more information to more people from all walks of life. © VDE VERLAG GMBH - Berlin - Offenbach.

18.
Cancer Research ; 82(12), 2022.
Article in English | EMBASE | ID: covidwho-1986502

ABSTRACT

Background: The coronavirus disease 2019 (COVID-19) pandemic has affected not only the control and management of infectious diseases, but also those of other diseases by deteriorating the general healthcare systems worldwide. In accordance with the suggestion by the WHO for postponement of non-urgent procedures, diagnosis and treatment strategies for the patients with malignancy have been changed. The aim of this study was to investigate the impact of COVID-19 pandemic on primary colorectal cancer (CRC) from multi-institutions in Korea. Methods: Medical records of consecutive patients with CRC between March 2019 and February 2021 in six university hospitals were reviewed. Recurrent diseases, admission for management of complications or enterostomy repair, and other pathologies than adenocarcinoma were excluded. Baseline characteristics and perioperative outcomes were compared after a cohort was divided into the two groups: before and after around March 2020, when the COVID-19 test has been mandatory for all admitted patients in most institutions. Treatment characteristics and pathologic outcomes were also compared between the two groups. Results: A total of 3895 patients with CRC admitted during the study period. After 454 patients were excluded, 1820 and 1621 patients were assigned to the pre-pandemic and pandemic groups. The proportion of patients who could not receive curative or palliative surgery for stage IV diseases was not different (88 vs. 91, P>0.999), and 3262 patients underwent surgery for primary CRC. Among them, the pandemic group showed more previous abdominal surgery (21.2% vs. 15.4%, P<0.001), higher preoperative CEA level (46.7 vs. 16.0 ng/mL, P=0.021), and less stent insertion for obstructive lesion (33% vs. 46.4%, P=0.043). There was no difference in sex, age, the ASA grade, and tumor location between the groups. Perioperative outcomes including operation time, operation method, operation type, and postoperative complication rates were not different, whereas more stoma formation was performed in the pandemic group (15.3% vs. 12.4%, P=0.024). Pathologic outcomes including TNM stage, tumor diameter, harvested lymph nodes, and lymphovascular invasion were not different. However, the pandemic group showed higher tendency of lymph node metastasis (44% vs. 40.6%, P=0.070) and more adjuvant chemotherapy (26.4% vs. 20.1%, P<0.001). Conclusions: Although a few factors indicated more advanced CRC, clinical features and perioperative outcomes of the patients in COVID-19 pandemic seemed not to be aggravated in Korea. The national healthcare system which was not shut down in the pandemic, and relatively small number of COVID-19 prevalence might influence these results, although patients' access and medical checkup seemed to decrease slightly. The cause and effect of decreased medical access would be clarified by long-term follow up data.

19.
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences ; 54(4):770-773, 2022.
Article in Chinese | EuropePMC | ID: covidwho-1980682

ABSTRACT

According to literature reports, the injury rate of the athletes in Olympic Winter Games recent years was as high as 10%-14%. Combined with the background of corona virus disease 2019 (COVID-19), the medical insurance work of the 24th Olympic Winter Games held in Beijing had put forward more complicated requirements and more severe challenges. In order to better optimize anesthesia management, this article summarized the perioperative treatment of athletes in Olympic Winter Games, the safety protection strategy of medical staff under general anesthesia, and the potential impact of peri-operative drugs on athletes. Anesthesiologists, as the core members of the rescue team, should be familiar with the particularity of operative anesthesia of athletes, sum up relevant experience to ensure the safety of perioperative patients. So all kinds of technical measures should be taken in the process of operation to minimize the indoor pollution caused by the patient's cough. For example, all the patients should wear N95 masks from the ward to the operating room, and after the operation, wear the N95 masks back to the ward. Although the International Olympic Committee had banned more than 200 drugs for participants and athletes who had to strictly follow International Olympic Committee requirements during anesthesia, the athletes were no longer participating in this Olympic Winter Games, so opioids (sufentanil and remifentanil) and glucocorticoid (dexamethasone) could be used according to the actual needs of surgery and anesthesia. Five athletes in Yanqing competition area underwent surgical anesthesia in Peking University Third Hospital Yanqing Hospital. All the five patients received general anesthesia, of whom four underwent orthopaedic surgery and one underwent laparoscopic cholecystectomy. General anesthesia with laryngeal mask airway was the first choice in the five patients. And the pain after orthopaedic surgery was severe and nerve block technique could effectively relieve the pain after surgery. Three patients received ultrasound-guided nerve block analgesia, the postoperative analgesia lasted 36 h. After the operation, non-steroidal anti-inflammatory drug (NSAID) was infused intravenously in the ward and all the patients recovered uneventfully. As the core member of the trauma rescue team, anesthesiologists should be familiar with the particularity of the athletes' surgical anesthesia, do a good job in medical security, and summarize relevant experience to ensure the life safety of the perioperative patients.

20.
CALL-EJ ; 23(2 Special Issue):131-151, 2022.
Article in English | Scopus | ID: covidwho-1958010

ABSTRACT

As humans may need to co-exist with the Covid-19 in the long term, course delivery in higher education is increasingly dependent on technology-mediated learning. However, research on the impact of technology-mediated learning on student satisfaction is not sufficiently addressed in academic English learning. Questionnaires were administered to 282 Chinese undergraduate students to examine their perceptions of the three instruction models (face-to-face, blended learning, and flipped learning) from six dimensions. Six semi-structured student interviews were conducted to explore their feelings toward the learning models based on the self-determination theory (SDT). Three major findings were reported. First, the technology-mediated learning environment facilitates students’ needs for SDT. Second, FL learning did not significantly increase student satisfaction with BL learning. Third, besides SDT factors, students also had psychological needs to ease tension. The findings shed light on the need for future instructional designs in technology-mediated learning models in academic English learning. © 2022, CALL-EJ. All rights reserved.

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