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Front Med ; 15(4): 638-643, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1144391


The COVID-19 pandemic has caused numerous deaths around the world. A growing body of evidence points to the important role of overwhelming inflammatory responses in the pathogenesis of COVID-19 and the effectiveness of anti-inflammation therapy against COVID-19 is emerging. In addition to affecting the lungs, COVID-19 can be a severe systemic inflammatory disease that is related to endothelial dysfunction. We are calling for closer attention to endothelial dysfunction in COVID-19 not only for fully revealing the pathogenic mechanism of COVID-19 but also for properly adjusting the strategy of clinical intervention.

COVID-19 , SARS-CoV-2 , Endothelium , Humans , Inflammation , Pandemics
J Mol Cell Cardiol ; 145: 25-29, 2020 08.
Article in English | MEDLINE | ID: covidwho-596957


As the coronavirus disease 2019 (COVID-19) epidemic worsens, this global pandemic is impacting more than 200 countries/regions and more than 4,500,000 confirmed cases worldwide. COVID-19 is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which might attack not only the respiratory system, but also the other important organs, including the heart. It was reported that COVID-19 patients with a past history of cardiovascular diseases would have a higher mortality. Meanwhile, elevated troponin levels were frequently observed in COVID-19 cases. Besides the comprehensive treatments for COVID-19, as a cardiologist, we should also remain vigilant about the cardiac injuries, especially those with severe emergent cardiovascular symptoms.

Betacoronavirus , Coronary Disease/epidemiology , Coronavirus Infections/epidemiology , Myocarditis/epidemiology , Pneumonia, Viral/epidemiology , Adult , Biomarkers/blood , COVID-19 , Comorbidity , Coronary Disease/virology , Coronavirus Infections/immunology , Coronavirus Infections/mortality , Coronavirus Infections/virology , Humans , Interleukin-6/blood , Male , Myocarditis/drug therapy , Myocarditis/immunology , Myocarditis/virology , Natriuretic Peptide, Brain/blood , Pandemics , Peptide Fragments/blood , Pneumonia, Viral/immunology , Pneumonia, Viral/mortality , Pneumonia, Viral/virology , Risk Factors , SARS-CoV-2 , Treatment Outcome , Troponin I/blood