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1.
International Journal of Quantum Chemistry ; : 1, 2022.
Article in English | Academic Search Complete | ID: covidwho-1888806

ABSTRACT

In medical sciences, the molecular structure is discussed under the consideration of the topological index, and related biological, pharmaceutical, medical and chemical properties of various drugs are examined by computing topological indices. Many scientific experiments are ongoing for the medication of COVID‐19 by using redeliver. In this paper, our objective is to calculate the degree‐based temperature indices and their respective temperature entropies for the molecular graph of remdesivir R. In this study, we derived some degree‐based temperature descriptors. Also, we computed temperature entropies of molecular structure by constructing the relation of degree‐based temperature descriptors with the help of specific information functions. Moreover, we analyzed and provided a graphical comparison of the calculated outcomes. These computed results maybe lead to the discovery of more effective drugs and modified vaccines for the overcome with COVID‐19. [ FROM AUTHOR] Copyright of International Journal of Quantum Chemistry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

2.
J Prim Care Community Health ; 13: 21501319221099476, 2022.
Article in English | MEDLINE | ID: covidwho-1854739

ABSTRACT

Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is known for the multiple mutations and forms that have rapidly spread across the world. With the imminent challenges faced by low- and middle-income countries in curbing the public health fallbacks due to limited resources, mucormycosis emerged as a fungal infection associated with high mortality. In this rapid review, we explored MEDLINE, Cochrane, Web of Science, WHO Global Database, and the search engine-Google Scholar for articles listed until July 2021 and presented a narrative synthesis of findings from 39 articles. The epidemiology, causative factors, incidence parameters, pharmacological treatment, and recommendations for low- and middle-income countries are enlisted. This study concludes that a majority of the globally reported COVID-19 associated mucormycosis cases stemmed from India. Individuals receiving systemic corticosteroids or who have a history of diabetes mellitus are more prone to contracting the disease. Public health authorities in LMIC are recommended to strengthen antifungal therapies for COVID-19 associated mucormycosis and to strategize reduction in diabetes mellitus prevalence.


Subject(s)
COVID-19 , Diabetes Mellitus , Mucormycosis , Diabetes Mellitus/epidemiology , Diabetes Mellitus/therapy , Humans , India/epidemiology , Mucormycosis/complications , Mucormycosis/epidemiology , Mucormycosis/therapy , SARS-CoV-2
3.
Smart Medical Journal ; 4(3):143-153, 2021.
Article in Indonesian | Indonesian Research | ID: covidwho-1754944

ABSTRACT

Coronavirus disease 2019 (COVID-19) merupakan pandemi global yang menimbulkan manifestasi klinis yang luas termasuk gejala gastrointestinal. Beberapa studi telah meneliti tingkat keparahan dan mortalitas COVID-19 dengan manifestasi gastrointestinal tetapi hanya di tingkat regional. Penelitian ini bertujuan untuk menggabungkan beberapa literatur tentang keparahan dan mortalitas akibat COVID-19 dengan manifestasi gastrointestinal di beberapa pusat studi dari berbagai negara. Studi ini merupakan studi meta-analisis. Penelitian ini dilakukan dengan menggunakan data sekunder yang diperoleh dari proses pencarian dan pemilihan data dari studi klinis di seluruh dunia. Pencarian artikel melalui database yang sistematik dan komprehensif dari PubMed ScienceDirect Google Scholar ProQuest dan Springer Link. Artikel dikumpulkan dengan diagram PRISMA dilakukan telaah kritis menggunakan PRISMA checklist dan analisis PICO kemudian data dianalisis dengan menggunakan perangkat Review Manager 5.4.1 dengan Random Effect Model (REM). Hasil analisis yang didapatkan berupa besarnya efek heterogenitas dan model studi. Berdasarkan analisis data dari berbagai studi di beberapa negara hasil menunjukkan bahwa gejala gastrointestinal tidak memiliki hubungan signifikan terhadap peningkatan keparahan (aOR 0.77;95% CI 0.35-1.70;I2=0.73;p=0.52) dan mortalitas  (aOR 0.87;95% CI 0.34-2.21;I2=0.63;p=0.77) COVID-19. Kesimpulan: Pasien COVID-19 dengan gejala gastrointestinal lebih kecil kemungkinannya untuk mengalami penyakit yang parah serta mortalitas dibandingkan pasien tanpa gejala gastrointestinal.Kata Kunci: Gejala Gastrointestinal COVID-19 Faktor Prognosis Keparahan Kematian.

4.
Polymer bulletin (Berlin, Germany) ; : 1-22, 2022.
Article in English | EuropePMC | ID: covidwho-1668145

ABSTRACT

Flavonoids are present naturally in many fruits and vegetables including onions, apples, tea, cabbage, cauliflower, berries and nuts which provide us with quercetin, a powerful natural antioxidant and cytotoxic compound. Due to antioxidant property, many nutraceuticals and cosmeceuticals products contain quercetin as a major ingredient nowadays. Current review enlightened sources and quercetin’s role as an antioxidant, antimicrobial, antidiabetic, anticancerous and anti-inflammatory agent in medical field during last 5 to 6 years. Literature search was systematically done using scientific for the published articles of quercetin. A total of 345 articles were reviewed, and it was observed that more than 40% of articles were about quercetin’s use as an antioxidant agent, more than 25% of studies were about its use as an anticancer agent, and articles on antimicrobial activity were more than 15%. 10% of the articles showed anti-inflamamatory effects of quercetin. Literature search also revealed that quercetin alone and its complexes with chitosan, metal ions and polymers possessed good antidiabetic properties. Thus, the review focuses on new therapeutic interventions and drug delivery system of quercetin in medical field for the benefit of mankind.

5.
Electronics ; 11(2):246, 2022.
Article in English | ProQuest Central | ID: covidwho-1638587

ABSTRACT

Recently, smartphone usage has increased tremendously, and smartphones are being used as a requirement of daily life, equally by all age groups. Smartphone operating systems such as Android and iOS have made it possible for anyone with development skills to create apps for smartphones. This has enabled smartphone users to download and install applications from stores such as Google Play, App Store, and several other third-party sites. During installation, these applications request resource access permissions from users. The resources include hardware and software like contact, memory, location, managing phone calls, device state, messages, camera, etc. As per Google’s permission policy, it is the responsibility of the user to allow or deny any permissions requested by an app. This leads to serious privacy violation issues when an app gets illegal permission granted by a user (e.g., an app might request for granted map permission and there is no need for map permission in the app, and someone can thereby access your location by this app). This study investigates the behavior of the user when it comes to safeguarding their privacy while installing apps from Google Play. In this research, first, seven different applications with irrelevant permission requests were developed and uploaded to two different Play Store accounts. The apps were live for more than 12 months and data were collected through Play Store analytics as well as the apps’ policy page. The preliminary data analysis shows that only 20% of users showed concern regarding their privacy and security either through interaction with the development team through email exchange or through commenting on the platform and other means accordingly.

6.
Jurnal Antropologi: Isu-Isu Sosial budaya ; 23(1):27-36, 2021.
Article in Indonesian | Indonesian Research | ID: covidwho-1552420

ABSTRACT

COVID-19 pandemic has caused massive and widespread fear from various walks of life. The COVID-19 outbreak has affected all aspects of human life. This social reality encourages the people of Madiun Regency to make an effort to respond the pandemic by relying on local wisdom. The purpose of the study is to analyze and explain the actions of the people of Madiun Regency in responding to the COVID-19 Pandemic. The study was conducted for a year using a qualitative ethnographic approach. Data were collected by doing interview observation and document recording. The informants were determined by the purposive sampling technique. Meanwhile the data analysis was using coding techniques. The results show that the community carries out mitigation through various activities vertically (supernatural powers) and horizontally (fellow humans and nature) in accordance with the philosophy of life of personal memayu hayuning memayu hayuning kulawarga memayu hayuning together memayu hayuning bawana including;(1) doing religious rituals (2) carrying out ˜peduli tangga teparo (a caring-neighbor movement) (3) encouraging mutual cooperation in various aspects of life fulfillment with the principles of togetherness mutual honing compassion and upbringing (4) activating and mobilizing food barns and barns food storage and growing medicinal plants and consuming them to increase immunity.

7.
Front Mol Biosci ; 8: 724208, 2021.
Article in English | MEDLINE | ID: covidwho-1512043

ABSTRACT

The COVID-19 pandemic has been evolving in Pakistan with the emergence of the United Kingdom, South African, and Brazilian variants. These variants of concern (VOC) are known for increased transmissibility and can also be responsible for avoiding immune responses. The gold standard to detect VOC is sequencing, however routine genomic surveillance in resource-limited countries like Pakistan is not always readily available. The inadvertent detection of the B.1.1.7 (United Kingdom) VOC by a target failure due to the key deletion in spike Δ69-70 by commercially available PCR assay helps to understand target failures as an alternative approach to detect variants. In pursuit of VOC it was further discovered that a deletion in the ORF1a gene (ORF1a Δ3675-3677) is common in B.1.1.7, B.1.351 (South African), and P.1 (Brazilian) VOC. The Real-Time Quantitative PCR (RT-qPCR) assay can distinguish target failures and can discriminate SARS-CoV-2 VOC. The study uses positive samples archived in respective labs. Samples were divided into two groups. Group I constitutes 261 positive samples out of total of 16,964 (1.53%) performed from August till September 2020, while group II consists of 3501 positive samples out of a total of 46,041 (7.60%) performed, from November 2020 till January 2021. The RT-qPCR analysis showed that no VOC was present in positive samples of group I. However, a staggering difference in results was noted in group II where the positivity ratio increased exponentially and the VOC started appearing in significant numbers (53.64%). This concludes that the third wave in Pakistan is due to the importation of SARS-CoV-2 variants.

8.
Earth Syst Environ ; 5(3): 785-798, 2021.
Article in English | MEDLINE | ID: covidwho-1491529

ABSTRACT

The current study identifies the spatial distribution of COVID-19 cases and its association with meteorological and social variables in Punjab (densely populated province of Pakistan). To identify the COVID-19 propagation, the weekly growth, recovery, and deaths rate have also been calculated. The geographic information system (GIS) has used to determine COVID-19 impacts on gender (male/female), age groups, and causalities over an affected population (km-2) for the period of 11th March to 12th August, 2020 in each district of province. Our results show that 43 peak days (where daily positive cases were above 900) have been observed in Punjab during 27th May to 8th July, 2020. The high population density districts, i.e., Lahore and Islamabad, have been affected (five persons per square kilometers) due to COVID-19, whereas the maximum death tolls (> 50 persons per millions) have also been observed in these urban districts. The meteorological variables (temperature, humidity, heat index, and ultraviolet index) show negative significant relationship to basic reproduction number (R0), whereas daily COVID-19 cases are positively correlated to aerosols concentration at 95% confidence level. The government intervention (stringency index) shows a positive impact to reduce the COVID-19 cases over the province. Keeping in view the COVID-19 behavior and climatology of the region, it has been identified that the COVID-19 cases may likely to increase during the dry period (high concentration of aerosols) i.e., October-December, 2020 and post-spring season (April to June), 2021 in urban areas of Pakistan. This study provides an overview on districts vulnerability that would help the policy makers, health agencies to plan their activities to reduce the COVID-19 impacts.

10.
Biomedica ; 36:183-189, 2020.
Article in English | Academic Search Complete | ID: covidwho-1451598

ABSTRACT

A bat-borne disease is any infectious disease whose primary reservoir is any species of bat. It is not a coincidence that some of the deadly viral disease outbreaks in recent years like severe acute respiratory syndrome (SARS), Middle East respiratory disorder (MERS), Ebola, Marburg and the new 2019-nCoV virus are speculated to be originated in bats. Rarely some bacterial and fungal diseases are also related to certain species of bats. Such illnesses are part of Zoonosis, which refers to the human diseases of animal origin. In this review we highlight some of the bat-borne diseases with emphasis on the viral outbreaks as bats world-wide harbor a greater proportion of viruses than several other groups of mammals. [ABSTRACT FROM AUTHOR] Copyright of Biomedica is the property of Knowledge Bylanes and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

11.
Ann Med Surg (Lond) ; 69: 102828, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1401167

ABSTRACT

Coronavirus Disease 19 (COVID-19) has led to a global pandemic and has been the center of attention across the entire medical community. This novel virus was initially thought to affect primarily the respiratory system, but now it is evident that it has a multitude of effects on the human body. Our point of interest is to establish the effect of COVID-19 infection on the conducting system of the heart. We present a case series of four patients who developed complete heart block (CHB) shortly after being infected with COVID-19 without any previous known risk factors of complete heart block. There have only been a few previous case reports on the occurrence of CHB in COVID-19 patients highlighting the importance and the need of our case series to the literature of cardiovascular outcomes in COVID-19 patients. Our case series highlight that COVID-19 can indeed affect the conduction system of the heart and cause CHB in patients who then recovered spontaneously further elucidating the transient nature of cardiovascular effects caused by the novel virus.

12.
J Coll Physicians Surg Pak ; 31(7): S125-S126, 2021 07.
Article in English | MEDLINE | ID: covidwho-1317403

ABSTRACT

Coronavirus disease 2019 (COVID-19) initially emerged in Wuhan, China, in December 2019, and now it has been declared a pandemic by the World Health Organization. COVID-19 commonly presents with respiratory manifestations like fever, cough, body aches, and shortness of breath. Neurological, myocardial, renal and gastrointestinal complications secondary to SARS-CoV-2 infection have been reported in the literature. Gastrointestinal symptoms reported with COVID-19 are mostly nausea, vomiting, and diarrhea. COVID-19 can rarely present with acute hepatitis. Here, we report a case of a 45-year male who presented with signs and symptoms of acute hepatitis secondary to SARS-CoV-2 infection. Key Words: SARS-CoV-2, COVID-19, Acute hepatitis.


Subject(s)
COVID-19 , Hepatitis , China , Hepatitis/diagnosis , Hepatitis/etiology , Humans , Male , Pandemics , SARS-CoV-2
13.
J Coll Physicians Surg Pak ; 31(7): S123-S124, 2021 07.
Article in English | MEDLINE | ID: covidwho-1317402

ABSTRACT

SARS-CoV-2 causing COVID-19 initially began in Wuhan, China and now has been declared a pandemic by the World Health Organization (WHO). In addition to respiratory symptoms, it can cause various complications ranging from neurological to myocardial injuries. Guillain-Barre Syndrome (GBS) is an acute polyradiculoneuropathy affecting more often lower limbs than upper limbs and is often related to previous infectious diseases. We, herein, describe a case of a young female who presented with typical symptoms of GBS after having COVID-19 and was later on confirmed with nerve conduction study and lumbar puncture. Key Words: COVID-19, SARS-CoV-2, Guillain-barre syndrome.


Subject(s)
COVID-19 , Guillain-Barre Syndrome , COVID-19/complications , China , Female , Guillain-Barre Syndrome/etiology , Humans , Pandemics , SARS-CoV-2
14.
J Coll Physicians Surg Pak ; 31(7): S120-S122, 2021 07.
Article in English | MEDLINE | ID: covidwho-1317401

ABSTRACT

Coronavirus disease-2019 (COVID-19) emerged as a cluster of atypical pneumonia in Wuhan, China in December 2019. This disease has been declared a pandemic by the World Health Organization. COVID-19 patients mostly present with upper respiratory symptoms like dyspnea, cough and fever. Various neurological, myocardial, renal and gastrointestinal complications have been reported associated with SARS-CoV-2. Acute pancreatitis is one of the common causes of upper abdominal pain, caused by alcohol consumption, gall stones and various viruses and drugs. We present a case of a young female, who was recently diagnosed as COVID-19 and later on developed acute pancreatitis without any other risk factors.  Key Words: COVID-19, SARS-CoV-2, Acute pancreatitis.


Subject(s)
COVID-19 , Pancreatitis , Acute Disease , China , Female , Humans , Pancreatitis/etiology , SARS-CoV-2
16.
Biochem Mol Biol Educ ; 49(3): 320-322, 2021 05.
Article in English | MEDLINE | ID: covidwho-1173781

ABSTRACT

The COVID-19 pandemic led to an abrupt suspension of face-to-face teaching activities in higher education institutions across the globe. The instructors and faculty at most institutions have had to adapt, invent, and implement adjustments quickly to adopt an online learning environment. This has been an extraordinarily challenging time for both students and instructors, particularly as many were not aware of the affordances and weaknesses of the online learning environment before it was uptaken. Particularly for chemistry and related disciplines, this change in delivery mode is even more disruptive in courses that have laboratory components due to loss of access to laboratories. As a teaching community, it was our responsibility to respond quickly and effectively to students' learning needs during this unprecedented global crisis. In our course, we provided succinct pre-recorded lecture-videos by topic rather than live-streaming of lectures. The recordings were made available to students a minimum of 24 h before the scheduled lecture time. Students were then provided opportunities to attend live tutorial sessions (held on Zoom and live Q&A feature on Piazza) if they had any questions that they wanted to ask the lecturer directly. We believe that the asynchronous sessions were more equitable than synchronous ones. This meant that students with difficult and challenging home/learning environments (i.e., disruptions at home, work/family schedules, poor internet, limited access to devices, etc.) were minimally disadvantaged. The approach worked well in general for teaching chemistry to pharmacy students and we believe that it can be adopted for other subjects.


Subject(s)
COVID-19 , Chemistry/education , Education, Distance , COVID-19/epidemiology , Chemistry, Pharmaceutical/education , Curriculum , Education, Pharmacy/methods , Humans , New Zealand/epidemiology , Pandemics , SARS-CoV-2 , Universities
17.
Cureus ; 13(1): e12953, 2021 Jan 28.
Article in English | MEDLINE | ID: covidwho-1115539

ABSTRACT

Gastrointestinal symptoms, such as diarrhea (most common among gastrointestinal symptoms), nausea/vomiting, anorexia, abdominal pain, abnormal liver enzymes, and pancreatitis, are being increasingly recognized in patients with coronavirus disease 2019 (COVID-19). Moreover, COVID-19 has also been implicated in coagulopathy, especially in patients with severe disease. Here, we report a case of acute intestinal ischemia secondary to superior mesenteric thrombosis in a young female patient with mild COVID-19.

19.
Journal of Ayub Medical College ; 32(4 Suppl. 1):602-606, 2020.
Article in English | CAB Abstracts | ID: covidwho-1085734

ABSTRACT

Background: Acute respiratory illness caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) involved the whole globe within no time. Various studies published globally have shown variable severity of disease and mortality. The objective of our study was to describe clinical and epidemiological characteristics of the disease in our setup.

20.
Cureus ; 12(11): e11690, 2020 Nov 24.
Article in English | MEDLINE | ID: covidwho-1005827

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing lung injury has been well documented in the literature recently. They do so primarily by binding to the membrane-bound form of angiotensin-converting enzyme 2 (ACE-2) receptors. However, since these receptors are also expressed in the heart and blood vessels, coronavirus can also cause damage to these organs by binding to the ACE-2 receptors. A typical case of coronavirus disease 2019 (COVID-19) usually presents with respiratory symptoms like cough and shortness of breath accompanied by fever. The literature regarding this pandemic has been growing and now we know very well that the effect of this deadly virus is not restricted to the lungs alone. It can, unfortunately, cause various other complications ranging from neurological damage to even myocardial injury in rare cases. We present an interesting case of a 40-year-old male patient who presented to us with shortness of breath. When further investigated, the patient was found to have a new onset of heart failure secondary to COVID-19 induced myocarditis.

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